Article: Salivary gland scintigraphy: the use of semiquantitative analysis for uptake and clearance.
Journal of nuclear medicine technology
2003 Volume 31, Issue 2, Page(s) 81–85
Abstract: Objective: Quantitative analysis of (99m)Tc-pertechnetate salivary gland scintigraphy has been used in the evaluation of salivary gland function, but so far no one method can be considered optimal for this task. In this study, a semiquantitative method ... ...
| Abstract | Objective: Quantitative analysis of (99m)Tc-pertechnetate salivary gland scintigraphy has been used in the evaluation of salivary gland function, but so far no one method can be considered optimal for this task. In this study, a semiquantitative method providing 2 functional parameters for objective assessment of salivary gland function by scintillation camera imaging was tested. Methods: Twenty-one patients referred for (99m)Tc-pertechnetate thyroid scanning were studied. Two patients with salivary complaints were also included. Dynamic imaging of the anterior head using a scintillation camera was started after a bolus intravenous injection of 185 MBq (5 mCi) (99m)Tc-pertechnetate at 1 frame per 30 s for 30 min. At 15 min after injection, diluted lemon juice was administered orally. Analysis of the dynamic study included time-activity curves of 4 salivary glands (right and left parotid and right and left submandibular). Two parameters of function were defined: uptake rate, taken as the value of the initial slope of the time-activity curve, and washout fraction, which was the relative mobilizable radioactivity from each salivary gland after ingestion of the sialogogue. A parametric image of the washout fraction was also generated. Results: The images showed gradual uptake in the parotid and submandibular glands. Washout was noted immediately after ingestion of the lemon juice. The pattern of the time-activity curve in all glands showed an early fast-rising part followed by a slow-rising component to nearly a plateau within 6-10 min after injection. The mean value of the uptake rate parameter was 0.10 +/- 0.09 cps/s. There was no significant difference between the parotid and submandibular glands or the right and left sides. Uptake in the parotid gland was 1.5-2 times that in the submandibular gland. The washout fraction was 1.40 +/- 1.60 for the parotid glands and 0.77 +/- 0.41 for the submandibular glands (P = 0.005). Conclusion: The quantitative analysis method including the uptake rate and the washout fraction parameters would enable objective assessment of salivary function and provide a reproducible means for follow-up of functional impairment in certain diseases. |
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| MeSH term(s) | Adolescent ; Adult ; Humans ; Male ; Metabolic Clearance Rate ; Middle Aged ; Models, Biological ; Parotid Gland/diagnostic imaging ; Parotid Gland/metabolism ; Radiography ; Radioisotope Dilution Technique ; Radionuclide Imaging ; Radiopharmaceuticals/pharmacokinetics ; Reproducibility of Results ; Salivary Gland Diseases/diagnostic imaging ; Salivary Gland Diseases/metabolism ; Salivary Glands/diagnostic imaging ; Salivary Glands/metabolism ; Sensitivity and Specificity ; Sjogren's Syndrome/diagnostic imaging ; Sjogren's Syndrome/metabolism ; Sodium Pertechnetate Tc 99m/pharmacokinetics ; Submandibular Gland/diagnostic imaging | |||||
| Chemical Substances | Radiopharmaceuticals ; Sodium Pertechnetate Tc 99m (A0730CX801) | |||||
| Language | English | |||||
| Publishing date | 2003-06 | |||||
| Publishing country | United States | |||||
| Document type | Clinical Trial ; Comparative Study ; Controlled Clinical Trial ; Journal Article | |||||
| ZDB-ID | 189163-7 | |||||
| ISSN | 1535-5675 ; 0091-4916 | |||||
| ISSN (online) | 1535-5675 | |||||
| ISSN | 0091-4916 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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