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  1. Article ; Online: Double cone coil repetitive transcranial magnetic stimulation for severe obsessive-compulsive disorder after reversible cerebral vasoconstriction syndrome with intracerebral hemorrhage: a case report.

    Silveira, Julia Belizário / Damiano, Rodolfo Furlan / Abelama Neto, Emilio / Gomes, Raphael Neves Dos Santos Mosqueira / Klein, Izio / Borrione, Lucas / Sudbrack, Pedro / Gentil, André Felix / Shephard, Elizabeth / Brunoni, André Russowski / Miguel, Eurípedes Constantino / Echevarria, Marco Antonio Nocito

    Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)

    2022  Volume 44, Issue 5, Page(s) 562–564

    MeSH term(s) Humans ; Transcranial Magnetic Stimulation ; Vasoconstriction ; Obsessive-Compulsive Disorder/therapy ; Cerebrovascular Disorders ; Cerebral Hemorrhage/therapy
    Language English
    Publishing date 2022-08-23
    Publishing country Brazil
    Document type Case Reports ; Letter
    ZDB-ID 2024119-7
    ISSN 1809-452X ; 1809-452X
    ISSN (online) 1809-452X
    ISSN 1809-452X
    DOI 10.47626/1516-4446-2022-2556
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Brazilian Research Consortium on Obsessive-Compulsive Spectrum Disorders guidelines for the treatment of adult obsessive-compulsive disorder. Part I: pharmacological treatment.

    de Oliveira, Marcos Vinícius Sousa / de Barros, Pedro Macul Ferreira / de Mathis, Maria Alice / Boavista, Rodrigo / Chacon, Priscila / Echevarria, Marco Antonio Nocito / Ferrão, Ygor Arzeno / Vattimo, Edoardo Felippo de Queiroz / Lopes, Antônio Carlos / Torres, Albina Rodrigues / Diniz, Juliana Belo / Fontenelle, Leonardo F / Rosário, Maria Conceição do / Shavitt, Roseli Gedanke / Miguel, Eurípedes Constantino / da Silva, Renata de Melo Felipe / Costa, Daniel Lucas da Conceição

    Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)

    2023  Volume 45, Issue 2, Page(s) 146–161

    Abstract: Objectives: To summarize evidence-based pharmacological treatments and provide guidance on clinical interventions for adult patients with obsessive-compulsive disorder (OCD).: Methods: The American Psychiatric Association (APA) guidelines for the ... ...

    Abstract Objectives: To summarize evidence-based pharmacological treatments and provide guidance on clinical interventions for adult patients with obsessive-compulsive disorder (OCD).
    Methods: The American Psychiatric Association (APA) guidelines for the treatment of OCD (2013) were updated with a systematic review assessing the efficacy of pharmacological treatments for adult OCD, comprising monotherapy with selective serotonin reuptake inhibitors (SSRIs), clomipramine, serotonin and norepinephrine reuptake inhibitors (SNRIs), and augmentation strategies with clomipramine, antipsychotics, and glutamate-modulating agents. We searched for the literature published from 2013-2020 in five databases, considering the design of the study, primary outcome measures, types of publication, and language. Selected articles had their quality assessed with validated tools. Treatment recommendations were classified according to levels of evidence developed by the American College of Cardiology and the American Heart Association (ACC/AHA).
    Results: We examined 57 new studies to update the 2013 APA guidelines. High-quality evidence supports SSRIs for first-line pharmacological treatment of OCD. Moreover, augmentation of SSRIs with antipsychotics (risperidone, aripiprazole) is the most evidence-based pharmacological intervention for SSRI-resistant OCD.
    Conclusion: SSRIs, in the highest recommended or tolerable doses for 8-12 weeks, remain the first-line treatment for adult OCD. Optimal augmentation strategies for SSRI-resistant OCD include low doses of risperidone or aripiprazole. Pharmacological treatments considered ineffective or potentially harmful, such as monotherapy with antipsychotics or augmentation with ketamine, lamotrigine, or N-acetylcysteine, have also been detailed.
    MeSH term(s) Humans ; Adult ; Antipsychotic Agents/therapeutic use ; Selective Serotonin Reuptake Inhibitors/therapeutic use ; Clomipramine/therapeutic use ; Aripiprazole/therapeutic use ; Risperidone ; Brazil ; Treatment Outcome ; Obsessive-Compulsive Disorder/drug therapy ; Obsessive-Compulsive Disorder/psychology
    Chemical Substances Antipsychotic Agents ; Selective Serotonin Reuptake Inhibitors ; Clomipramine (NUV44L116D) ; Aripiprazole (82VFR53I78) ; Risperidone (L6UH7ZF8HC)
    Language English
    Publishing date 2023-05-11
    Publishing country Brazil
    Document type Systematic Review ; Journal Article
    ZDB-ID 2024119-7
    ISSN 1809-452X ; 1809-452X
    ISSN (online) 1809-452X
    ISSN 1809-452X
    DOI 10.47626/1516-4446-2022-2891
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Brazilian research consortium on obsessive-compulsive spectrum disorders guidelines for the treatment of adult obsessive-compulsive disorder. Part II: Cognitive-Behavior Therapy treatment.

    de Mathis, Maria Alice / Chacon, Priscila / Boavista, Rodrigo / de Oliveira, Marcos Vinícius Sousa / de Barros, Pedro Macul Ferreira / Echevarria, Marco Antonio Nocito / Ferrão, Ygor Arzeno / Vattimo, Edoardo Felippo de Queiroz / Lopes, Antônio Carlos / Torres, Albina Rodrigues / Diniz, Juliana Belo / Fontenelle, Leonardo / do Rosário, Maria Conceição / Shavitt, Roseli Gedanke / da Silva, Renata de Melo Felipe / Miguel, Eurípedes Constantino / Costa, Daniel Lucas da Conceição

    Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)

    2023  

    Abstract: Objective: To summarize the evidence-based cognitive-behavioral therapy (CBT) treatment and propose clinical interventions for adult patients with obsessive-compulsive disorder (OCD).: Methods: A systematic review of the literature on CBT ... ...

    Abstract Objective: To summarize the evidence-based cognitive-behavioral therapy (CBT) treatment and propose clinical interventions for adult patients with obsessive-compulsive disorder (OCD).
    Methods: A systematic review of the literature on CBT interventions for the treatment of adult OCD, comprising behavior therapy and exposure and response prevention (ERP) was done. The objective of this study is to present updated clinical guidelines to clinicians, providing comprehensive details regarding the necessary procedures to be incorporated into the CBT protocol. We searched the literature published from 2013-2020 in five databases (PubMed, Cochrane, Embase, Psycinfo and Lilacs), considering: study design, primary outcome measures, type of publication and language. Selected articles were assessed for quality with validated tools. Treatment recommendations were classified according to levels of evidence developed by the American College of Cardiology and the American Heart Association (ACC/AHA).
    Results: We examined 44 new studies used to update the APA guidelines from 2013. High-quality evidence supports CBT including ERP techniques as the first-line CBT treatment for OCD. In addition, protocols for internet-delivered CBT have also demonstrated their efficacy for the treatment of adults with OCD.
    Conclusion: CBT based on ERP is a widely used treatment according to high-quality scientific evidence to treat adults with OCD.
    Language English
    Publishing date 2023-09-17
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 2024119-7
    ISSN 1809-452X ; 1809-452X
    ISSN (online) 1809-452X
    ISSN 1809-452X
    DOI 10.47626/1516-4446-2023-3081
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: N-acetylcysteine for treating cocaine addiction - A systematic review.

    Nocito Echevarria, Marco Antonio / Andrade Reis, Tassio / Ruffo Capatti, Giulianno / Siciliano Soares, Victor / da Silveira, Dartiu Xavier / Fidalgo, Thiago Marques

    Psychiatry research

    2017  Volume 251, Page(s) 197–203

    Abstract: The aim of this paper is to extensively review the current literature available on N-acetylcysteine (NAC) treatment for cocaine dependence (clinical and experimental studies). We screened all articles published before February 2016 reporting on the use ... ...

    Abstract The aim of this paper is to extensively review the current literature available on N-acetylcysteine (NAC) treatment for cocaine dependence (clinical and experimental studies). We screened all articles published before February 2016 reporting on the use of NAC as a pharmacological intervention for cocaine dependence or discussed its potential as a therapeutic approach for cocaine dependence. We described our results qualitatively. 21 studies matched our search criteria: 6 clinical trials and 15 animal studies. Four clinical studies showed NAC's capacity to reduce craving, desire to use cocaine, cocaine-cue viewing-time and cocaine-related spending. Studies in animal models also support this reinstatement prevention application of NAC. NAC reverses the disruption of glutamate homeostasis caused by long-term cocaine use restoring function of the cystine-glutamate exchanger in glial cells and reversing the downregulated GLT-1 receptor. Current data suggest promising potential for NAC as an anti-relapse agent, as a double-blind placebo trial was mainly negative, except in the subgroup of patients who were already abstinent. An optimal dose for relapse prevention may be one that restores extrasynaptic glutamate to physiological levels and predominantly activates mGluR2 and 3, but not mGluR5 receptors, which are linked to relapse. NAC may be better suited for avoiding relapse in already abstinent subjects.
    MeSH term(s) Acetylcysteine/pharmacology ; Animals ; Cocaine-Related Disorders/drug therapy ; Female ; Free Radical Scavengers/pharmacology ; Glutamic Acid/drug effects ; Humans ; Male ; Receptor, Metabotropic Glutamate 5/drug effects ; Receptors, Metabotropic Glutamate/drug effects ; Recurrence ; Secondary Prevention ; Treatment Outcome
    Chemical Substances Free Radical Scavengers ; Receptor, Metabotropic Glutamate 5 ; Receptors, Metabotropic Glutamate ; metabotropic glutamate receptor 2 ; metabotropic glutamate receptor 3 ; Glutamic Acid (3KX376GY7L) ; Acetylcysteine (WYQ7N0BPYC)
    Language English
    Publishing date 2017-02-11
    Publishing country Ireland
    Document type Journal Article ; Review ; Systematic Review
    ZDB-ID 445361-x
    ISSN 1872-7123 ; 1872-7506 ; 0925-4927 ; 0165-1781
    ISSN (online) 1872-7123 ; 1872-7506
    ISSN 0925-4927 ; 0165-1781
    DOI 10.1016/j.psychres.2017.02.024
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1541: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  5. Article ; Online: Constraining the Side Chain of C-Terminal Amino Acids in Apelin-13 Greatly Increases Affinity, Modulates Signaling, and Improves the Pharmacokinetic Profile.

    Trân, Kien / Van Den Hauwe, Robin / Sainsily, Xavier / Couvineau, Pierre / Côté, Jérôme / Simard, Louise / Echevarria, Marco / Murza, Alexandre / Serre, Alexandra / Théroux, Léa / Saibi, Sabrina / Haroune, Lounès / Longpré, Jean-Michel / Lesur, Olivier / Auger-Messier, Mannix / Spino, Claude / Bouvier, Michel / Sarret, Philippe / Ballet, Steven /
    Marsault, Éric

    Journal of medicinal chemistry

    2021  Volume 64, Issue 9, Page(s) 5345–5364

    Abstract: Side-chain-constrained amino acids are useful tools to modulate the biological properties of peptides. In this study, we applied side-chain constraints to apelin-13 (Ape13) by substituting the Pro12 and Phe13 positions, affecting the binding affinity and ...

    Abstract Side-chain-constrained amino acids are useful tools to modulate the biological properties of peptides. In this study, we applied side-chain constraints to apelin-13 (Ape13) by substituting the Pro12 and Phe13 positions, affecting the binding affinity and signaling profile on the apelin receptor (APJ). The residues 1Nal, Trp, and Aia were found to be beneficial substitutions for Pro12, and the resulting analogues displayed high affinity for APJ (
    MeSH term(s) Amino Acid Sequence ; Amino Acid Substitution ; Animals ; Apelin Receptors/chemistry ; Apelin Receptors/metabolism ; Blood Pressure/drug effects ; GTP-Binding Protein alpha Subunits, G12-G13/chemistry ; GTP-Binding Protein alpha Subunits, G12-G13/metabolism ; Half-Life ; Humans ; Intercellular Signaling Peptides and Proteins/chemistry ; Intercellular Signaling Peptides and Proteins/metabolism ; Intercellular Signaling Peptides and Proteins/pharmacology ; Male ; Protein Binding ; Protein Stability ; Rats ; Rats, Sprague-Dawley ; Signal Transduction/drug effects
    Chemical Substances Apelin Receptors ; Intercellular Signaling Peptides and Proteins ; apelin-13 peptide ; GTP-Binding Protein alpha Subunits, G12-G13 (EC 3.6.5.1)
    Language English
    Publishing date 2021-02-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 218133-2
    ISSN 1520-4804 ; 0022-2623
    ISSN (online) 1520-4804
    ISSN 0022-2623
    DOI 10.1021/acs.jmedchem.0c01941
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Correction: The functional connectome in obsessive-compulsive disorder: resting-state mega-analysis and machine learning classification for the ENIGMA-OCD consortium.

    Bruin, Willem B / Abe, Yoshinari / Alonso, Pino / Anticevic, Alan / Backhausen, Lea L / Balachander, Srinivas / Bargallo, Nuria / Batistuzzo, Marcelo C / Benedetti, Francesco / Bertolin Triquell, Sara / Brem, Silvia / Calesella, Federico / Couto, Beatriz / Denys, Damiaan A J P / Echevarria, Marco A N / Eng, Goi Khia / Ferreira, Sónia / Feusner, Jamie D / Grazioplene, Rachael G /
    Gruner, Patricia / Guo, Joyce Y / Hagen, Kristen / Hansen, Bjarne / Hirano, Yoshiyuki / Hoexter, Marcelo Q / Jahanshad, Neda / Jaspers-Fayer, Fern / Kasprzak, Selina / Kim, Minah / Koch, Kathrin / Bin Kwak, Yoo / Kwon, Jun Soo / Lazaro, Luisa / Li, Chiang-Shan R / Lochner, Christine / Marsh, Rachel / Martínez-Zalacaín, Ignacio / Menchon, Jose M / Moreira, Pedro S / Morgado, Pedro / Nakagawa, Akiko / Nakao, Tomohiro / Narayanaswamy, Janardhanan C / Nurmi, Erika L / Zorrilla, Jose C Pariente / Piacentini, John / Picó-Pérez, Maria / Piras, Fabrizio / Piras, Federica / Pittenger, Christopher / Reddy, Janardhan Y C / Rodriguez-Manrique, Daniela / Sakai, Yuki / Shimizu, Eiji / Shivakumar, Venkataram / Simpson, Blair H / Soriano-Mas, Carles / Sousa, Nuno / Spalletta, Gianfranco / Stern, Emily R / Evelyn Stewart, S / Szeszko, Philip R / Tang, Jinsong / Thomopoulos, Sophia I / Thorsen, Anders L / Yoshida, Tokiko / Tomiyama, Hirofumi / Vai, Benedetta / Veer, Ilya M / Venkatasubramanian, Ganesan / Vetter, Nora C / Vriend, Chris / Walitza, Susanne / Waller, Lea / Wang, Zhen / Watanabe, Anri / Wolff, Nicole / Yun, Je-Yeon / Zhao, Qing / van Leeuwen, Wieke A / van Marle, Hein J F / van de Mortel, Laurens A / van der Straten, Anouk / van der Werf, Ysbrand D / Thompson, Paul M / Stein, Dan J / van den Heuvel, Odile A / van Wingen, Guido A

    Molecular psychiatry

    2023  Volume 28, Issue 10, Page(s) 4320

    Language English
    Publishing date 2023-08-16
    Publishing country England
    Document type Published Erratum
    ZDB-ID 1330655-8
    ISSN 1476-5578 ; 1359-4184
    ISSN (online) 1476-5578
    ISSN 1359-4184
    DOI 10.1038/s41380-023-02211-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: The functional connectome in obsessive-compulsive disorder: resting-state mega-analysis and machine learning classification for the ENIGMA-OCD consortium.

    Bruin, Willem B / Abe, Yoshinari / Alonso, Pino / Anticevic, Alan / Backhausen, Lea L / Balachander, Srinivas / Bargallo, Nuria / Batistuzzo, Marcelo C / Benedetti, Francesco / Bertolin Triquell, Sara / Brem, Silvia / Calesella, Federico / Couto, Beatriz / Denys, Damiaan A J P / Echevarria, Marco A N / Eng, Goi Khia / Ferreira, Sónia / Feusner, Jamie D / Grazioplene, Rachael G /
    Gruner, Patricia / Guo, Joyce Y / Hagen, Kristen / Hansen, Bjarne / Hirano, Yoshiyuki / Hoexter, Marcelo Q / Jahanshad, Neda / Jaspers-Fayer, Fern / Kasprzak, Selina / Kim, Minah / Koch, Kathrin / Bin Kwak, Yoo / Kwon, Jun Soo / Lazaro, Luisa / Li, Chiang-Shan R / Lochner, Christine / Marsh, Rachel / Martínez-Zalacaín, Ignacio / Menchon, Jose M / Moreira, Pedro S / Morgado, Pedro / Nakagawa, Akiko / Nakao, Tomohiro / Narayanaswamy, Janardhanan C / Nurmi, Erika L / Zorrilla, Jose C Pariente / Piacentini, John / Picó-Pérez, Maria / Piras, Fabrizio / Piras, Federica / Pittenger, Christopher / Reddy, Janardhan Y C / Rodriguez-Manrique, Daniela / Sakai, Yuki / Shimizu, Eiji / Shivakumar, Venkataram / Simpson, Blair H / Soriano-Mas, Carles / Sousa, Nuno / Spalletta, Gianfranco / Stern, Emily R / Evelyn Stewart, S / Szeszko, Philip R / Tang, Jinsong / Thomopoulos, Sophia I / Thorsen, Anders L / Yoshida, Tokiko / Tomiyama, Hirofumi / Vai, Benedetta / Veer, Ilya M / Venkatasubramanian, Ganesan / Vetter, Nora C / Vriend, Chris / Walitza, Susanne / Waller, Lea / Wang, Zhen / Watanabe, Anri / Wolff, Nicole / Yun, Je-Yeon / Zhao, Qing / van Leeuwen, Wieke A / van Marle, Hein J F / van de Mortel, Laurens A / van der Straten, Anouk / van der Werf, Ysbrand D / Thompson, Paul M / Stein, Dan J / van den Heuvel, Odile A / van Wingen, Guido A

    Molecular psychiatry

    2023  Volume 28, Issue 10, Page(s) 4307–4319

    Abstract: Current knowledge about functional connectivity in obsessive-compulsive disorder (OCD) is based on small-scale studies, limiting the generalizability of results. Moreover, the majority of studies have focused only on predefined regions or functional ... ...

    Abstract Current knowledge about functional connectivity in obsessive-compulsive disorder (OCD) is based on small-scale studies, limiting the generalizability of results. Moreover, the majority of studies have focused only on predefined regions or functional networks rather than connectivity throughout the entire brain. Here, we investigated differences in resting-state functional connectivity between OCD patients and healthy controls (HC) using mega-analysis of data from 1024 OCD patients and 1028 HC from 28 independent samples of the ENIGMA-OCD consortium. We assessed group differences in whole-brain functional connectivity at both the regional and network level, and investigated whether functional connectivity could serve as biomarker to identify patient status at the individual level using machine learning analysis. The mega-analyses revealed widespread abnormalities in functional connectivity in OCD, with global hypo-connectivity (Cohen's d: -0.27 to -0.13) and few hyper-connections, mainly with the thalamus (Cohen's d: 0.19 to 0.22). Most hypo-connections were located within the sensorimotor network and no fronto-striatal abnormalities were found. Overall, classification performances were poor, with area-under-the-receiver-operating-characteristic curve (AUC) scores ranging between 0.567 and 0.673, with better classification for medicated (AUC = 0.702) than unmedicated (AUC = 0.608) patients versus healthy controls. These findings provide partial support for existing pathophysiological models of OCD and highlight the important role of the sensorimotor network in OCD. However, resting-state connectivity does not so far provide an accurate biomarker for identifying patients at the individual level.
    MeSH term(s) Humans ; Connectome/methods ; Brain Mapping/methods ; Magnetic Resonance Imaging/methods ; Brain ; Obsessive-Compulsive Disorder ; Biomarkers ; Neural Pathways
    Chemical Substances Biomarkers
    Language English
    Publishing date 2023-05-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 1330655-8
    ISSN 1476-5578 ; 1359-4184
    ISSN (online) 1476-5578
    ISSN 1359-4184
    DOI 10.1038/s41380-023-02077-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4812: Show issues Location:
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