Article ; Online: Hepatic steatosis as an independent risk factor for severe disease in patients with COVID-19: A computed tomography study.
JGH open : an open access journal of gastroenterology and hepatology
2020 Volume 4, Issue 6, Page(s) 1102–1107
Abstract: Background and aim: Hepatic steatosis (HS) is associated with diabetes, hypertension, and obesity, comorbidities recently related to COVID-19 severity. Here, we assessed if tomographic HS is also a risk factor for severe COVID-19 pneumonia.: Methods: ...
| Abstract | Background and aim: Hepatic steatosis (HS) is associated with diabetes, hypertension, and obesity, comorbidities recently related to COVID-19 severity. Here, we assessed if tomographic HS is also a risk factor for severe COVID-19 pneumonia. Methods: We included 213 patients with a positive real time polymerase chain reaction (RT-PCR) test and chest computed tomography (CT) from an out-hospital facility and a hospital. We obtained information on demographics; weight; height; smoking history; diabetes; hypertension; and cardiovascular, lung, and renal disease. Two radiologists scored the CO-RADs system (COVID-19 Reporting and Data System) (1 = normal, 2 = inconsistent, 3-4 = indeterminate, and 5 = typical findings) and the chest CT severity index (≥20 of 40 was considered severe disease). They evaluated the liver-to-spleen ratio (CT Results: Of the patients, 61% were men, with a mean age of 51.2 years, 48.3% were CO-RADs 1 and 51.7% CO-RADs 2-5. Severe tomographic disease was present in 103 patients (48.4%), all CO-RADs 5. This group was older; mostly men; and with a higher prevalence of obesity, hypertension, diabetes, and HS (69.9 Conclusion: HS was independently associated with severe COVID pneumonia. The physiopathological explanation of this finding remains to be elucidated. CT |
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| Keywords | covid19 |
| Language | English |
| Publishing date | 2020-08-04 |
| Publishing country | Australia |
| Document type | Journal Article |
| ISSN | 2397-9070 |
| ISSN (online) | 2397-9070 |
| DOI | 10.1002/jgh3.12395 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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