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  1. Book ; Online: Medicinal Plants for Cardiovascular and Neurodegenerative Aging-related Diseases: From Bench to Bedside

    Liu, Yue / Echeverria Moran, Valentina / Xu, Youhua

    2020  

    Keywords Science: general issues ; Pharmacology ; medicinal plants ; aging ; age-related diseases ; cardiovascular disease ; neurodegenerative diseases
    Size 1 electronic resource (294 pages)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021230427
    ISBN 9782889661602 ; 2889661601
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article: Brain effects of nicotine and derived compounds.

    Echeverria Moran, Valentina

    Frontiers in pharmacology

    2013  Volume 4, Page(s) 60

    Language English
    Publishing date 2013-05-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2013.00060
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Editorial: Insights in ethnopharmacology: 2021.

    Kim, Cheorl-Ho / Echeverria Moran, Valentina / Hohmann, Judit / Echeverria, Javier / Yen, Hung-Rong / Lu, Aiping / Heinrich, Michael

    Frontiers in pharmacology

    2022  Volume 13, Page(s) 997577

    Language English
    Publishing date 2022-09-20
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2022.997577
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Cotinine halts the advance of Alzheimer's disease-like pathology and associated depressive-like behavior in Tg6799 mice.

    Patel, Sagar / Grizzell, J Alex / Holmes, Rosalee / Zeitlin, Ross / Solomon, Rosalynn / Sutton, Thomas L / Rohani, Adeeb / Charry, Laura C / Iarkov, Alexandre / Mori, Takashi / Echeverria Moran, Valentina

    Frontiers in aging neuroscience

    2014  Volume 6, Page(s) 162

    Abstract: Alzheimer's disease (AD) is associated with cognitive and non-cognitive symptoms for which there are currently no effective therapies. We have previously reported that cotinine, a natural product obtained from tobacco leaves, prevented memory loss and ... ...

    Abstract Alzheimer's disease (AD) is associated with cognitive and non-cognitive symptoms for which there are currently no effective therapies. We have previously reported that cotinine, a natural product obtained from tobacco leaves, prevented memory loss and diminished amyloid-β (Aβ) plaque pathology in transgenic 6799 mice (Tg6799 mice) when treated prior to the development of the pathology. We have also shown that cotinine reduces depressive-like behavior in normal and chronically stressed C57BL/6 mice. Here, we extend our previous studies by investigating the effects of cotinine on the progression of AD-like pathology, depressive-like behavior, and the mechanisms underlying its beneficial effects in Tg6799 mice when left untreated until after a more advanced stage of the disease's development. The results show that vehicle-treated Tg6799 mice displayed an accentuated loss of working memory and an abundant Aβ plaque pathology that were accompanied by higher levels of depressive-like behavior as compared to control littermates. By contrast, prolonged daily cotinine treatment to Tg6799 mice, withheld until after a mid-level progression of AD-like pathology, reduced Aβ levels/plaques and depressive-like behavior. Moreover, this treatment paradigm dramatically improved working memory as compared to control littermates. The beneficial effects of cotinine were accompanied by an increase in the expression of the active form of protein kinase B and the postsynaptic density protein 95 in the hippocampi and frontal cortices of Tg6799 mice. This suggests that cotinine halts the progression of AD-like pathology while reducing depressive-like behavior by stimulating signaling pathways supporting synaptic plasticity in Tg6799 mice. The potential use of cotinine to treat cognitive and non-cognitive symptoms of AD is discussed.
    Language English
    Publishing date 2014-07-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2558898-9
    ISSN 1663-4365
    ISSN 1663-4365
    DOI 10.3389/fnagi.2014.00162
    Database MEDical Literature Analysis and Retrieval System OnLINE

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