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  1. Article ; Online: Mild airways obstruction: spirometric diagnostic pitfalls and solutions.

    Alotaibi, Nawaf M / Eddy, Rachel L / Sin, Don D

    Current opinion in pulmonary medicine

    2023  Volume 30, Issue 2, Page(s) 121–128

    Abstract: Purpose of review: Spirometry is a validated tool in the diagnosis of obstructive airways disease. However, it may be insufficiently sensitive in detecting airflow limitation in the small airways. This review highlights common clinical scenarios wherein ...

    Abstract Purpose of review: Spirometry is a validated tool in the diagnosis of obstructive airways disease. However, it may be insufficiently sensitive in detecting airflow limitation in the small airways. This review highlights common clinical scenarios wherein airflow limitation may be missed or overlooked.
    Recent findings: This article covers recent literature on the interpretation of lung function test, focusing on detection of mild obstructive airways disease. It also sheds light on the contextual difficulties of defining mild airflow limitation on spirometry.
    Summary: We highlight the consensus definition of mild obstructive airways disease and emphasize that this definition does not necessarily mean mild in certain disease-specific contexts. Several spirometric findings outside of a reduced forced expiratory volume in one second/forced vital capacity ratio should raise suspicion of mild obstruction.
    MeSH term(s) Humans ; Spirometry ; Airway Obstruction ; Lung Diseases, Obstructive ; Forced Expiratory Volume
    Language English
    Publishing date 2023-10-19
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 1285505-4
    ISSN 1531-6971 ; 1070-5287 ; 1078-1641
    ISSN (online) 1531-6971
    ISSN 1070-5287 ; 1078-1641
    DOI 10.1097/MCP.0000000000001023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Regional Airway Heterogeneity in Asthma: Histopathology, MRI, and CT Imaging.

    Eddy, Rachel L / Parraga, Grace

    Chest

    2021  Volume 159, Issue 2, Page(s) 876–877

    MeSH term(s) Asthma/diagnostic imaging ; Humans ; Magnetic Resonance Imaging ; Tomography, X-Ray Computed
    Language English
    Publishing date 2021-02-10
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1016/j.chest.2020.09.090
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  3. Article ; Online: Editorial for "Flow Volume Loop and Regional Ventilation Assessment Using Phase Resolved Functional Lung (PREFUL) MRI: Comparison With 129Xenon Ventilation MRI and Lung Function Testing".

    Eddy, Rachel L / Rayment, Jonathan H

    Journal of magnetic resonance imaging : JMRI

    2020  Volume 53, Issue 4, Page(s) 1106–1107

    MeSH term(s) Humans ; Lung/diagnostic imaging ; Magnetic Resonance Imaging ; Respiration ; Respiratory Function Tests ; Xenon
    Chemical Substances Xenon (3H3U766W84)
    Language English
    Publishing date 2020-12-11
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 1146614-5
    ISSN 1522-2586 ; 1053-1807
    ISSN (online) 1522-2586
    ISSN 1053-1807
    DOI 10.1002/jmri.27462
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    Zs.MO 236: Show issues

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  4. Article ; Online: Pulmonary xenon-129 MRI: new opportunities to unravel enigmas in respiratory medicine.

    Eddy, Rachel L / Parraga, Grace

    The European respiratory journal

    2020  Volume 55, Issue 2

    MeSH term(s) Humans ; Lung/diagnostic imaging ; Magnetic Resonance Imaging ; Pulmonary Medicine ; Xenon Isotopes
    Chemical Substances Xenon Isotopes ; Xenon-129
    Language English
    Publishing date 2020-02-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.01987-2019
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    Zs.MO 292: Show issues

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  5. Article ; Online: Computed Tomography Vascular Tree-in-Bud: A Novel Prognostic Imaging Biomarker in COVID-19?

    Eddy, Rachel L / Sin, Don D

    American journal of respiratory and critical care medicine

    2020  Volume 202, Issue 5, Page(s) 642–644

    MeSH term(s) Betacoronavirus ; Biomarkers ; COVID-19 ; Coronavirus Infections ; Humans ; Lung ; Pandemics ; Pneumonia, Viral ; Prognosis ; SARS-CoV-2
    Chemical Substances Biomarkers
    Keywords covid19
    Language English
    Publishing date 2020-07-20
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202007-2833ED
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  6. Article ; Online: Reply to Miller

    Eddy, Rachel L / Parraga, Grace

    American journal of respiratory and critical care medicine

    2020  Volume 202, Issue 8, Page(s) 1195–1197

    MeSH term(s) Asthma ; Humans ; Respiration Disorders ; Respiratory System ; Tomography, X-Ray Computed
    Language English
    Publishing date 2020-07-09
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202005-2034LE
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  7. Article ; Online: Measuring Regional Pulmonary Function Using Noncontrast CT: More Reasons to Join the FAN Bandwagon.

    Parraga, Grace / Eddy, Rachel L

    Radiology

    2020  Volume 298, Issue 1, Page(s) 210–211

    MeSH term(s) Humans ; Pulmonary Disease, Chronic Obstructive ; Respiration ; Tomography, X-Ray Computed ; Xenon
    Chemical Substances Xenon (3H3U766W84)
    Language English
    Publishing date 2020-11-24
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 80324-8
    ISSN 1527-1315 ; 0033-8419
    ISSN (online) 1527-1315
    ISSN 0033-8419
    DOI 10.1148/radiol.2020203983
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  8. Article: Disease activity in COPD: time to make imaging biomarkers a PET project?

    Milne, Stephen / Eddy, Rachel L / Sin, Don D

    ERJ open research

    2021  Volume 7, Issue 3

    Abstract: FDG uptake on PET/CT is a potential biomarker of pulmonary inflammation in COPD and may reflect disease activity, but does it have the characteristics of a "good" biomarker? ...

    Abstract FDG uptake on PET/CT is a potential biomarker of pulmonary inflammation in COPD and may reflect disease activity, but does it have the characteristics of a "good" biomarker?
    Language English
    Publishing date 2021-08-31
    Publishing country England
    Document type Editorial
    ZDB-ID 2827830-6
    ISSN 2312-0541
    ISSN 2312-0541
    DOI 10.1183/23120541.00445-2021
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  9. Article ; Online: Post-COVID-19 dyspnoea and pulmonary imaging: a systematic review and meta-analysis.

    Guinto, Elizabeth / Gerayeli, Firoozeh V / Eddy, Rachel L / Lee, Hyun / Milne, Stephen / Sin, Don D

    European respiratory review : an official journal of the European Respiratory Society

    2023  Volume 32, Issue 169

    Abstract: Background: A proportion of coronavirus disease 2019 (COVID-19) survivors experience persistent dyspnoea without measurable impairments in lung function. We performed a systematic review and meta-analysis to determine relationships between dyspnoea and ... ...

    Abstract Background: A proportion of coronavirus disease 2019 (COVID-19) survivors experience persistent dyspnoea without measurable impairments in lung function. We performed a systematic review and meta-analysis to determine relationships between dyspnoea and imaging abnormalities over time in post-COVID-19 patients.
    Methods: Using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, we analysed studies published prior to 15 September 2022 and indexed by Google Scholar, PubMed and LitCOVID which assessed chest imaging in adults ≥3 months after COVID-19. Demographic, chest imaging, spirometric and post-COVID-19 symptom data were extracted. The relationships between imaging abnormalities and dyspnoea, sex and age were determined using a random effects model and meta-regression.
    Results: 47 studies were included in the meta-analysis (n=3557). The most prevalent computed tomography (CT) imaging abnormality was ground-glass opacities (GGOs) (44.9% (95% CI 37.0-52.9%) at any follow-up time-point). Occurrence of reticulations significantly decreased between early and late follow-up (p=0.01). The prevalence of imaging abnormalities was related to the proportion of patients with dyspnoea (p=0.012). The proportion of females was negatively correlated with the presence of reticulations (p=0.001), bronchiectasis (p=0.001) and consolidations (p=0.025). Age was positively correlated with imaging abnormalities across all modalities (p=0.002) and imaging abnormalities present only on CT (p=0.001) (GGOs (p=0.004) and reticulations (p=0.001)). Spirometric values improved during follow-up but remained within the normal range at all time-points.
    Conclusions: Imaging abnormalities were common 3 months after COVID-19 and their occurrence was significantly related to the presence of dyspnoea. This suggests that CT imaging is a sensitive tool for detecting pulmonary abnormalities in patients with dyspnoea, even in the presence of normal spirometric measurements.
    MeSH term(s) Adult ; Female ; Humans ; COVID-19 ; SARS-CoV-2 ; Lung/diagnostic imaging ; Dyspnea/diagnostic imaging ; Dyspnea/etiology ; Lung Diseases
    Language English
    Publishing date 2023-08-09
    Publishing country England
    Document type Meta-Analysis ; Systematic Review ; Journal Article ; Review
    ZDB-ID 1077620-5
    ISSN 1600-0617 ; 0905-9180
    ISSN (online) 1600-0617
    ISSN 0905-9180
    DOI 10.1183/16000617.0253-2022
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