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  1. Article ; Online: Enlarging 18 F-FDG-Avid Solitary Pulmonary Nodule: A Distinctly Unusual Presentation of Cytomegalovirus Infection in a Patient Receiving Chemotherapy.

    Zamora, Edgar / Edema, Ukuemi / Zuckier, Lionel S

    Clinical nuclear medicine

    2023  Volume 48, Issue 10, Page(s) 917–918

    Abstract: Abstract: Rapidly growing lung lesions, particularly in immunocompromised patients, invoke consideration of an infectious etiology. Aspergillomas, for example, can appear as round nodules with soft tissue attenuation, often associated with cavitation, ... ...

    Abstract Abstract: Rapidly growing lung lesions, particularly in immunocompromised patients, invoke consideration of an infectious etiology. Aspergillomas, for example, can appear as round nodules with soft tissue attenuation, often associated with cavitation, and are variably 18 F-FDG avid. In contrast, cytomegalovirus, which may also evidence 18 F-FDG uptake, typically manifests as ground-glass opacities, symmetrically distributed small pulmonary nodules, or confluent consolidations, with lower lobe predilection. We describe a patient treated for lymphoma presenting with a solitary enlarging FDG-avid lung nodule, which was determined on resection to be focal cytomegalovirus infection, a distinctly uncommon presentation of this pathogen, more typical of fungal or mycobacterial disease.
    MeSH term(s) Humans ; Solitary Pulmonary Nodule/diagnostic imaging ; Fluorodeoxyglucose F18 ; Cytomegalovirus Infections/complications ; Cytomegalovirus Infections/diagnostic imaging ; Biological Transport
    Chemical Substances Fluorodeoxyglucose F18 (0Z5B2CJX4D) ; abamectin (5U8924T11H)
    Language English
    Publishing date 2023-08-30
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 197628-x
    ISSN 1536-0229 ; 0363-9762
    ISSN (online) 1536-0229
    ISSN 0363-9762
    DOI 10.1097/RLU.0000000000004794
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Cardiothoracic operating room blood gas workflow performance improvement initiative.

    Forest, Stefanie K / Kuan, Kevin / Edema, Ukuemi / Forest, Stephen J / Leff, Jonathan D

    American journal of clinical pathology

    2024  

    Abstract: Objectives: To evaluate the current workflow of blood gas ordering and testing in a cardiothoracic operating room to identify opportunities to streamline the process, using performance improvement methodologies.: Methods: Issues with specimen ... ...

    Abstract Objectives: To evaluate the current workflow of blood gas ordering and testing in a cardiothoracic operating room to identify opportunities to streamline the process, using performance improvement methodologies.
    Methods: Issues with specimen relabeling were identified that lead to delayed results and potential patient safety concerns. Blood gas specimen relabeling was evaluated for operating room cases from August 2018 to December 2022. An OpTime Epic Sidebar button for arterial blood gas and venous blood gas orders was created in January 2019 to streamline the ordering process so that laboratory barcode labels were then printed in the operating room and attached to the specimen, eliminating the need for relabeling by the technologists.
    Results: This Epic Sidebar intervention led to a drastic improvement of appropriate labeling, which has been sustained. From March 2019 to January 2023, with our new workflow, over 95% of blood gas specimens arrived barcode labeled compared to less than 1% in the preintervention era.
    Conclusions: A multidisciplinary team with key stakeholders is important to address complex care issues. Performance improvement methodology is critical to develop interventions that hardwire the process. This intervention led to a sustained reduction in secondary relabeling of patient samples and improved timeliness of reporting of blood gas results.
    Language English
    Publishing date 2024-03-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 2944-0
    ISSN 1943-7722 ; 0002-9173
    ISSN (online) 1943-7722
    ISSN 0002-9173
    DOI 10.1093/ajcp/aqae014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Localized Metastatic Recurrence of HCC following Distal Extremity Trauma: Bone Scintigraphy and Anatomicopathological Correlation.

    Zamora, Edgar / Rivera Valladares, Louisiana / Edema, Ukuemi / Freeman, Leonard M

    World journal of nuclear medicine

    2022  Volume 21, Issue 3, Page(s) 244–247

    Abstract: Hepatocellular carcinoma (HCC) is the most common type of liver cancer, with a poor median survival when left untreated. Extrahepatic metastases involving musculoskeletal tissues typically present with concomitant nonosseous metastases at the time of ... ...

    Abstract Hepatocellular carcinoma (HCC) is the most common type of liver cancer, with a poor median survival when left untreated. Extrahepatic metastases involving musculoskeletal tissues typically present with concomitant nonosseous metastases at the time of diagnosis. A 61-year-old male on 1-year remission, following transarterial chemoembolization of a 2.3-cm hepatic HCC 1 year before, presented with a 2-month history of left wrist pain and swelling after falling on an outstretched hand. Computed tomographic scan revealed diffuse osteolytic lesions localized in left hand and distal forearm, associated with equivocal diffuse activity on bone scan. Subsequent surgical debridement revealed metastatic hepatocellular carcinoma.
    Language English
    Publishing date 2022-08-16
    Publishing country Germany
    Document type Case Reports
    ZDB-ID 2911903-0
    ISSN 1607-3312 ; 1450-1147
    ISSN (online) 1607-3312
    ISSN 1450-1147
    DOI 10.1055/s-0042-1750439
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 7137: Show issues Location:
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  4. Article ; Online: Clinicopathologic characterization of cutaneous adult T-cell leukemia/lymphoma: A single tertiary care center experience in the United States.

    Modi, Mitul B / Kiszluk, Alexandra / Chai, Jiani N / Edema, Ukuemi / Ma, Maxwell Y / Sica, R Alejandro / Wang, Yanhua / Shi, Yang

    American journal of clinical pathology

    2023  Volume 161, Issue 2, Page(s) 140–148

    Abstract: Objectives: Adult T-cell leukemia/lymphoma (ATLL) is a rare aggressive T-cell leukemia/lymphoma associated with human T lymphotropic virus type 1 infection. The patients might present with skin rash before, at, or after the diagnosis. The ... ...

    Abstract Objectives: Adult T-cell leukemia/lymphoma (ATLL) is a rare aggressive T-cell leukemia/lymphoma associated with human T lymphotropic virus type 1 infection. The patients might present with skin rash before, at, or after the diagnosis. The dermatopathologic finding might be diagnostically very challenging.
    Methods: We retrospectively identified 110 patients with ATLL at a single institution in a 19-year period, with 19 patients having skin biopsies. Clinical, dermatopathologic, immunophenotypic, and molecular findings were studied.
    Results: The cohort included 13 skin-first (5 acute, 5 lymphomatous, 2 chronic, 1 smoldering), 6 skin-second (4 acute, 1 lymphomatous, 1 smoldering), and 91 patients without skin biopsy. Some nonphotoprotected areas of body such as the forearm and lower lip were also seen. Skin manifestations included papular (5), erythroderma (1), nodulotumoral (3), plaques (1), patches (1), and a combination of skin rashes (2). Histopathologic findings included large pleomorphic cells, angiocentrism, epidermal infiltration with large Pautrier-like microabscesses, and folliculotropism. Fifteen (78.9%) cases showed CD4+/CD7-/CD25+. Next-generation sequencing study was conducted on 5 patients using either blood or bone marrow samples, revealing multiple genetic mutations across multiple signaling pathways.
    Conclusions: Pleomorphic large, atypical cells with CD4+/CD25+/CD7- immunophenotype from a non-"bathing trunk" location, especially in a patient from endemic regions, raise suspicion for ATLL. T-cell receptor gene rearrangement is almost always positive, and the neoplasm usually demonstrates multiple mutations by next-generation sequencing study.
    MeSH term(s) Adult ; Humans ; United States ; Leukemia-Lymphoma, Adult T-Cell/pathology ; Retrospective Studies ; Tertiary Care Centers ; Skin Neoplasms/diagnosis ; Skin Neoplasms/genetics ; Lymphoma
    Language English
    Publishing date 2023-10-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 2944-0
    ISSN 1943-7722 ; 0002-9173
    ISSN (online) 1943-7722
    ISSN 0002-9173
    DOI 10.1093/ajcp/aqad120
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: PIK3CA-related overgrowth spectrum (PROS) presenting as isolated macrodactyly.

    Krishnamurthy, Kritika / Edema, Ukuemi / Ustun, Berrin / Villanueva-Siles, Esperanza / Koehler, Steven M / Naeem, Rizwan / Wang, Yanhua / Goldstein, Doctor Y

    Journal of surgical case reports

    2023  Volume 2023, Issue 10, Page(s) rjad549

    Abstract: PIK3CA-related overgrowth spectrum (PROS) is a heterogeneous group of diseases, with varied clinical presentations ranging from isolated segmental overgrowths to megalencephaly and vascular malformations, all resulting from post-zygotic activating ... ...

    Abstract PIK3CA-related overgrowth spectrum (PROS) is a heterogeneous group of diseases, with varied clinical presentations ranging from isolated segmental overgrowths to megalencephaly and vascular malformations, all resulting from post-zygotic activating mutations in PIK3CA. Isolated macrodactyly of upper limb is extremely rare, accounting only for 0.9%-1% of all congenital anomalies of the upper limb. This report describes a case of congenital, isolated, nonprogressive macrodactyly of the right index finger and thumb, in an adult patient that was treated with debulking surgery. The microscopic features were compatible with lipomatosis of nerve. Due to the prompt and pertinent molecular testing, which identified a somatic PIK3CA variant, c.3140A > G, p.H1047R., the case was classified as a PROS. The availability of mTOR inhibitors offers additional treatment possibilities in cases with progressive disease. This case report highlights the importance of molecular testing to identify PROS, to further the knowledge of this continually expanding entity.
    Language English
    Publishing date 2023-10-14
    Publishing country England
    Document type Case Reports
    ZDB-ID 2580919-2
    ISSN 2042-8812
    ISSN 2042-8812
    DOI 10.1093/jscr/rjad549
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  6. Article: Localized Metastatic Recurrence of HCC following Distal Extremity Trauma: Bone Scintigraphy and Anatomicopathological Correlation

    Zamora, Edgar / Rivera Valladares, Louisiana / Edema, Ukuemi / Freeman, Leonard M.

    World Journal of Nuclear Medicine

    2022  Volume 21, Issue 03, Page(s) 244–247

    Abstract: Hepatocellular carcinoma (HCC) is the most common type of liver cancer, with a poor median survival when left untreated. Extrahepatic metastases involving musculoskeletal tissues typically present with concomitant nonosseous metastases at the time of ... ...

    Abstract Hepatocellular carcinoma (HCC) is the most common type of liver cancer, with a poor median survival when left untreated. Extrahepatic metastases involving musculoskeletal tissues typically present with concomitant nonosseous metastases at the time of diagnosis. A 61-year-old male on 1-year remission, following transarterial chemoembolization of a 2.3-cm hepatic HCC 1 year before, presented with a 2-month history of left wrist pain and swelling after falling on an outstretched hand. Computed tomographic scan revealed diffuse osteolytic lesions localized in left hand and distal forearm, associated with equivocal diffuse activity on bone scan. Subsequent surgical debridement revealed metastatic hepatocellular carcinoma.
    Keywords distal metastases ; posttraumatic ; HCC ; osseous
    Language English
    Publishing date 2022-08-16
    Publisher Thieme Medical and Scientific Publishers Pvt. Ltd.
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2911903-0
    ISSN 1607-3312 ; 1450-1147
    ISSN (online) 1607-3312
    ISSN 1450-1147
    DOI 10.1055/s-0042-1750439
    Database Thieme publisher's database

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  7. Article ; Online: TMEM106B Puncta Is Increased in Multiple Sclerosis Plaques, and Reduced Protein in Mice Results in Delayed Lipid Clearance Following CNS Injury.

    Shafit-Zagardo, Bridget / Sidoli, Simone / Goldman, James E / DuBois, Juwen C / Corboy, John R / Strittmatter, Stephen M / Guzik, Hillary / Edema, Ukuemi / Arackal, Anita G / Botbol, Yair M / Merheb, Emilio / Nagra, Rashed M / Graff, Sarah

    Cells

    2023  Volume 12, Issue 13

    Abstract: During inflammatory, demyelinating diseases such as multiple sclerosis (MS), inflammation and axonal damage are prevalent early in the course. Axonal damage includes swelling, defects in transport, and failure to clear damaged intracellular proteins, all ...

    Abstract During inflammatory, demyelinating diseases such as multiple sclerosis (MS), inflammation and axonal damage are prevalent early in the course. Axonal damage includes swelling, defects in transport, and failure to clear damaged intracellular proteins, all of which affect recovery and compromise neuronal integrity. The clearance of damaged cell components is important to maintain normal turnover and restore homeostasis. In this study, we used mass spectrometry to identify insoluble proteins within high-speed/mercaptoethanol/sarcosyl-insoluble pellets from purified white matter plaques isolated from the brains of individuals with relapsing-remitting MS (RRMS). We determined that the transmembrane protein 106B (TMEM106B), normally lysosome-associated, is insoluble in RRMS plaques relative to normal-appearing white matter from individuals with Alzheimer's disease and non-neurologic controls. Relative to wild-type mice, hypomorphic mice with a reduction in TMEM106B have increased axonal damage and lipid droplet accumulation in the spinal cord following myelin-oligodendrocyte-glycoprotein-induced experimental autoimmune encephalomyelitis. Additionally, the corpora callosa from cuprizone-challenged hypomorphic mice fail to clear lipid droplets efficiently during remyelination, suggesting that when TMEM106B is compromised, protein and lipid clearance by the lysosome is delayed. As TMEM106B contains putative lipid- and LC3-binding sites, further exploration of these sites is warranted.
    MeSH term(s) Mice ; Animals ; Multiple Sclerosis ; Encephalomyelitis, Autoimmune, Experimental ; Spinal Cord/metabolism ; Myelin-Oligodendrocyte Glycoprotein/metabolism ; Lipids/adverse effects
    Chemical Substances Myelin-Oligodendrocyte Glycoprotein ; Lipids
    Language English
    Publishing date 2023-06-27
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells12131734
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Identification of Glandular (Acinar)/Tubule Formation in Invasive Carcinoma of the Breast: A Study to Determine Concordance Using the World Health Organization Definition.

    Lo, Yungtai / Lester, Susan C / Ellis, Ian O / Lanjewar, Sonali / Laurini, Javier / Patel, Ami / Bhattarai, Ava / Ustun, Berrin / Harmon, Bryan / Kleer, Celina G / Ross, Dara / Amin, Ali / Wang, Yihong / Bradley, Robert / Turashvili, Gulisa / Zeng, Jennifer / Baum, Jordan / Singh, Kamaljeet / Hakima, Laleh /
    Harigopal, Malini / Komforti, Miglena / Shin, Sandra J / Abbott, Sara E / Jaffer, Shabnam / Badve, Sunil Shankar / Khoury, Thaer / D'Alfonso, Timothy M / Ginter, Paula S / Collins, Victoria / Towne, William / Gan, Yujun / Nassar, Aziza / Sahin, Aysegul A / Flieder, Andrea / Aldrees, Rana / Ngo, Marie-Helene / Edema, Ukuemi / Sapna, Fnu / Schnitt, Stuart J / Fineberg, Susan A

    Archives of pathology & laboratory medicine

    2024  

    Abstract: Context.—: The Nottingham Grading System (NGS) developed by Elston and Ellis is used to grade invasive breast cancer (IBC). Glandular (acinar)/tubule formation is a component of NGS.: Objective.—: To investigate the ability of pathologists to ... ...

    Abstract Context.—: The Nottingham Grading System (NGS) developed by Elston and Ellis is used to grade invasive breast cancer (IBC). Glandular (acinar)/tubule formation is a component of NGS.
    Objective.—: To investigate the ability of pathologists to identify individual structures that should be classified as glandular (acinar)/tubule formation.
    Design.—: A total of 58 hematoxylin-eosin photographic images of IBC with 1 structure circled were classified as tubules (41 cases) or nontubules (17 cases) by Professor Ellis. Images were sent as a PowerPoint (Microsoft) file to breast pathologists, who were provided with the World Health Organization definition of a tubule and asked to determine if a circled structure represented a tubule.
    Results.—: Among 35 pathologists, the κ statistic for assessing agreement in evaluating the 58 images was 0.324 (95% CI, 0.314-0.335). The median concordance rate between a participating pathologist and Professor Ellis was 94.1% for evaluating 17 nontubule cases and 53.7% for 41 tubule cases. A total of 41% of the tubule cases were classified correctly by less than 50% of pathologists. Structures classified as tubules by Professor Ellis but often not recognized as tubules by pathologists included glands with complex architecture, mucinous carcinoma, and the "inverted tubule" pattern of micropapillary carcinoma. A total of 80% of participants reported that they did not have clarity on what represented a tubule.
    Conclusions.—: We identified structures that should be included as tubules but that were not readily identified by pathologists. Greater concordance for identification of tubules might be obtained by providing more detailed images and descriptions of the types of structures included as tubules.
    Language English
    Publishing date 2024-01-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 194119-7
    ISSN 1543-2165 ; 0363-0153 ; 0096-8528 ; 0003-9985
    ISSN (online) 1543-2165
    ISSN 0363-0153 ; 0096-8528 ; 0003-9985
    DOI 10.5858/arpa.2023-0163-OA
    Database MEDical Literature Analysis and Retrieval System OnLINE

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