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Article: Esophageal Stricture Caused by CMV in a Non-HIV-Infected Renal Transplant Patient.

Tennant, Tamera C / Pandey, Samiksha / Edhi, Ahmed I / Batke, Mihaela

2022 Volume 9, Issue 8, Page(s) e00836

Abstract: Esophageal stricture due to cytomegalovirus (CMV) infection is an uncommon pathology, with most reported cases occurring in patients infected with human immunodeficiency virus. We report a renal transplant patient who presented with progressive dysphagia ...

Abstract	Esophageal stricture due to cytomegalovirus (CMV) infection is an uncommon pathology, with most reported cases occurring in patients infected with human immunodeficiency virus. We report a renal transplant patient who presented with progressive dysphagia and weight loss for 2 years. Endoscopic examination revealed a long esophageal stricture with a necrotic lesion but no typical CMV esophageal ulcers; immunostains were positive for CMV. Dysphagia resolved after treatment with ganciclovir and serial esophageal dilations. We are presenting the first case of esophageal stricture due to CMV esophagitis in a renal transplant patient without human immunodeficiency virus infection and are reviewing current literature.
Language	English
Publishing date	2022-08-31
Publishing country	United States
Document type	Case Reports
ZDB-ID	2814825-3
ISSN	2326-3253
ISSN	2326-3253
DOI	10.14309/crj.0000000000000836
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Eradicating H. pylori.

Desai, Tusar / Edhi, Ahmed I / Hakim, Seifeldin

The American journal of gastroenterology

2019 Volume 114, Issue 12, Page(s) 1827–1828

MeSH term(s)	Adenocarcinoma/prevention & control ; Anti-Bacterial Agents/adverse effects ; Anti-Bacterial Agents/therapeutic use ; Arrhythmias, Cardiac/chemically induced ; Clarithromycin/adverse effects ; Clarithromycin/therapeutic use ; Drug Therapy, Combination ; Esophageal Neoplasms/prevention & control ; Helicobacter Infections/drug therapy ; Helicobacter pylori ; Humans ; Mortality ; Myocardial Infarction/chemically induced ; Patient Selection ; Practice Guidelines as Topic ; Quinolones/adverse effects ; Quinolones/therapeutic use ; Risk ; Risk Assessment ; Stomach Neoplasms/prevention & control ; United States
Chemical Substances	Anti-Bacterial Agents ; Quinolones ; Clarithromycin (H1250JIK0A)
Language	English
Publishing date	2019-10-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	390122-1
ISSN	1572-0241 ; 0002-9270
ISSN (online)	1572-0241
ISSN	0002-9270
DOI	10.14309/ajg.0000000000000424
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Article ; Online: Esophagopericardial fistula from thermal injury after local abnormal ventricular activity arrhythmia ablation therapy: endoscopic findings and therapy.

Edhi, Ahmed I / Gjeorgjievski, Mihajlo / Kulesza, Gregory / Cappell, Mitchell S

Gastrointestinal endoscopy

2019 Volume 91, Issue 3, Page(s) 709–711

MeSH term(s)	Arrhythmias, Cardiac/therapy ; Burns/etiology ; Catheter Ablation/adverse effects ; Esophageal Fistula/diagnostic imaging ; Esophageal Fistula/etiology ; Esophageal Fistula/therapy ; Esophagus/diagnostic imaging ; Esophagus/injuries ; Esophagus/surgery ; Heart Diseases/diagnostic imaging ; Heart Diseases/etiology ; Heart Diseases/surgery ; Humans ; Male ; Middle Aged ; Pericardial Effusion/etiology ; Pericardial Effusion/microbiology ; Pericardial Effusion/surgery ; Pericardium/diagnostic imaging ; Pericardium/injuries ; Pericardium/surgery ; Prosthesis Implantation ; Self Expandable Metallic Stents ; Staphylococcal Infections/etiology ; Staphylococcal Infections/microbiology ; Staphylococcal Infections/therapy ; Staphylococcus epidermidis/isolation & purification
Language	English
Publishing date	2019-09-24
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	391583-9
ISSN	1097-6779 ; 0016-5107
ISSN (online)	1097-6779
ISSN	0016-5107
DOI	10.1016/j.gie.2019.09.023
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Article: Clarithromycin-Associated Acute Liver Failure Leading to Fatal, Massive Upper Gastrointestinal Hemorrhage from Profound Coagulopathy: Case Report and Systematic Literature Review.

Edhi, Ahmed I / Hakim, Seifeldin / Shams, Christienne / Bedi, Damanpreet / Amin, Mitual / Cappell, Mitchell S

Case reports in hepatology

2020 Volume 2020, Page(s) 2135239

Abstract: While erythromycin has caused numerous cases of acute liver failure (ALF), clarithromycin, a similar macrolide antibiotic, has caused only six reported cases of ALF. A new case of clarithromycin-associated ALF is reported with hepatic histopathology and ... ...

Abstract	While erythromycin has caused numerous cases of acute liver failure (ALF), clarithromycin, a similar macrolide antibiotic, has caused only six reported cases of ALF. A new case of clarithromycin-associated ALF is reported with hepatic histopathology and exclusion of other etiologies by extensive workup, and the syndrome of clarithromycin-associated ALF is better characterized by systematic review. A 60-year-old nonalcoholic man, with normal baseline liver function tests, was admitted with diffuse abdominal pain and AST = 499 U/L and ALT = 539 U/L, six days after completing a 7-day course of clarithromycin 500 mg twice daily for suspected upper respiratory infection. AST and ALT each rose to about 1,000 U/L on day-2 of admission, and rose to ≥6,000 U/L on day-3, with development of severe hepatic encephalopathy and severe coagulopathy. Planned liver biopsy was cancelled due to coagulopathies. Extensive evaluation for infectious, immunologic, and metabolic causes of liver disease was negative. Abdominal computerized tomography and abdominal ultrasound with Doppler were unremarkable. The patient developed massive, acute upper gastrointestinal bleeding associated with coagulopathies. Esophagogastroduodenoscopy was planned after massive blood product transfusions, but the patient rapidly expired from hemorrhagic shock. Autopsy revealed a golden-brown heavy liver with massive hepatic necrosis and sinusoidal congestion. Rise of AST/ALT to about 1,000 U/L each was temporally incompatible with shock liver because this rise preceded the hemorrhagic shock, but the subsequent AST/ALT rise to ≥6,000 U/L each may have had a component of shock liver. The six previously reported cases were limited by failure to exclude hepatitis E (4), lack of liver biopsy (2), and uninterpretable liver biopsy (1) and by confounding potential etiologies including disulfiram, israpidine, or recent acetaminophen use (3), clarithromycin overdose (1), active alcohol use (1), and severe heart failure (1). Review of 6 previously reported and current case of clarithromycin-associated ALF revealed that patients had AST and ALT values in the thousands. Five patients died and 2 survived.
Language	English
Publishing date	2020-02-18
Publishing country	United States
Document type	Case Reports
ISSN	2090-6587
ISSN	2090-6587
DOI	10.1155/2020/2135239
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Article: One Oral Dose of Sodium Polystyrene Sulfonate Associated with Ischemic Colitis and Crystal Deposition in Colonic Mucosa.

Edhi, Ahmed I / Cappell, Mitchell S / Sharma, Nisha / Amin, Mitual / Patel, Atulkumar

ACG case reports journal

2018 Volume 5, Page(s) e74

Language	English
Publishing date	2018-10-17
Publishing country	United States
Document type	Case Reports
ZDB-ID	2814825-3
ISSN	2326-3253
ISSN	2326-3253
DOI	10.14309/crj.2018.74
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Article ; Online: S1738 Novel Finding of Protein-Losing Enteropathy in a Patient With Collagenous Duodenitis and Colitis Complicated by COVID-19 Infection

Gill, Inayat / Shaheen, Aciel A. / Edhi, Ahmed I. / Amin, Mitual B. / Rana, Ketan / Cappell, Mitchell S.

American Journal of Gastroenterology

2020 Volume 115, Issue 1, Page(s) S897–S898

Keywords	Hepatology ; Gastroenterology ; covid19
Language	English
Publisher	Ovid Technologies (Wolters Kluwer Health)
Publishing country	us
Document type	Article ; Online
ZDB-ID	390122-1
ISSN	1572-0241 ; 0002-9270
ISSN (online)	1572-0241
ISSN	0002-9270
DOI	10.14309/01.ajg.0000709000.06042.7d
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Article ; Online: Digestive Manifestations in Patients Hospitalized With Coronavirus Disease 2019.

Elmunzer, B Joseph / Spitzer, Rebecca L / Foster, Lydia D / Merchant, Ambreen A / Howard, Eric F / Patel, Vaishali A / West, Mary K / Qayed, Emad / Nustas, Rosemary / Zakaria, Ali / Piper, Marc S / Taylor, Jason R / Jaza, Lujain / Forbes, Nauzer / Chau, Millie / Lara, Luis F / Papachristou, Georgios I / Volk, Michael L / Hilson, Liam G /

Zhou, Selena / Kushnir, Vladimir M / Lenyo, Alexandria M / McLeod, Caroline G / Amin, Sunil / Kuftinec, Gabriela N / Yadav, Dhiraj / Fox, Charlie / Kolb, Jennifer M / Pawa, Swati / Pawa, Rishi / Canakis, Andrew / Huang, Christopher / Jamil, Laith H / Aneese, Andrew M / Glamour, Benita K / Smith, Zachary L / Hanley, Katherine A / Wood, Jordan / Patel, Harsh K / Shah, Janak N / Agarunov, Emil / Sethi, Amrita / Fogel, Evan L / McNulty, Gail / Haseeb, Abdul / Trieu, Judy A / Dixon, Rebekah E / Yang, Jeong Yun / Mendelsohn, Robin B / Calo, Delia / Aroniadis, Olga C / LaComb, Joseph F / Scheiman, James M / Sauer, Bryan G / Dang, Duyen T / Piraka, Cyrus R / Shah, Eric D / Pohl, Heiko / Tierney, William M / Mitchell, Stephanie / Condon, Ashwinee / Lenhart, Adrienne / Dua, Kulwinder S / Kanagala, Vikram S / Kamal, Ayesha / Singh, Vikesh K / Pinto-Sanchez, Maria Ines / Hutchinson, Joy M / Kwon, Richard S / Korsnes, Sheryl J / Singh, Harminder / Solati, Zahra / Willingham, Field F / Yachimski, Patrick S / Conwell, Darwin L / Mosier, Evan / Azab, Mohamed / Patel, Anish / Buxbaum, James / Wani, Sachin / Chak, Amitabh / Hosmer, Amy E / Keswani, Rajesh N / DiMaio, Christopher J / Bronze, Michael S / Muthusamy, Raman / Canto, Marcia I / Gjeorgjievski, V Mihajlo / Imam, Zaid / Odish, Fadi / Edhi, Ahmed I / Orosey, Molly / Tiwari, Abhinav / Patwardhan, Soumil / Brown, Nicholas G / Patel, Anish A / Ordiah, Collins O / Sloan, Ian P / Cruz, Lilian / Koza, Casey L / Okafor, Uchechi / Hollander, Thomas / Furey, Nancy / Reykhart, Olga / Zbib, Natalia H / Damianos, John A / Esteban, James / Hajidiacos, Nick / Saul, Melissa / Mays, Melanie / Anderson, Gulsum / Wood, Kelley / Mathews, Laura / Diakova, Galina / Caisse, Molly / Wakefield, Lauren / Nitchie, Haley / Waljee, Akbar K / Tang, Weijing / Zhang, Yueyang / Zhu, Ji / Deshpande, Amar R / Rockey, Don C / Alford, Teldon B / Durkalski, Valerie

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

2020 Volume 19, Issue 7, Page(s) 1355–1365.e4

Abstract: Background & aims: The prevalence and significance of digestive manifestations in coronavirus disease 2019 (COVID-19) remain uncertain. We aimed to assess the prevalence, spectrum, severity, and significance of digestive manifestations in patients ... ...

Abstract	Background & aims: The prevalence and significance of digestive manifestations in coronavirus disease 2019 (COVID-19) remain uncertain. We aimed to assess the prevalence, spectrum, severity, and significance of digestive manifestations in patients hospitalized with COVID-19. Methods: Consecutive patients hospitalized with COVID-19 were identified across a geographically diverse alliance of medical centers in North America. Data pertaining to baseline characteristics, symptomatology, laboratory assessment, imaging, and endoscopic findings from the time of symptom onset until discharge or death were abstracted manually from electronic health records to characterize the prevalence, spectrum, and severity of digestive manifestations. Regression analyses were performed to evaluate the association between digestive manifestations and severe outcomes related to COVID-19. Results: A total of 1992 patients across 36 centers met eligibility criteria and were included. Overall, 53% of patients experienced at least 1 gastrointestinal symptom at any time during their illness, most commonly diarrhea (34%), nausea (27%), vomiting (16%), and abdominal pain (11%). In 74% of cases, gastrointestinal symptoms were judged to be mild. In total, 35% of patients developed an abnormal alanine aminotransferase or total bilirubin level; these were increased to less than 5 times the upper limit of normal in 77% of cases. After adjusting for potential confounders, the presence of gastrointestinal symptoms at any time (odds ratio, 0.93; 95% CI, 0.76-1.15) or liver test abnormalities on admission (odds ratio, 1.31; 95% CI, 0.80-2.12) were not associated independently with mechanical ventilation or death. Conclusions: Among patients hospitalized with COVID-19, gastrointestinal symptoms and liver test abnormalities were common, but the majority were mild and their presence was not associated with a more severe clinical course.
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; COVID-19/complications ; Female ; Gastrointestinal Diseases/virology ; Humans ; Male ; Middle Aged ; North America ; Young Adult
Keywords	covid19
Language	English
Publishing date	2020-10-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	2119789-1
ISSN	1542-7714 ; 1542-3565
ISSN (online)	1542-7714
ISSN	1542-3565
DOI	10.1016/j.cgh.2020.09.041
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Article ; Online: Digestive Manifestations in Patients Hospitalized with COVID-19

Elmunzer, B. Joseph / Spitzer, Rebecca L. / Foster, Lydia D. / Merchant, Ambreen A. / Howard, Eric F. / Patel, Vaishali A. / West, Mary K. / Qayad, Emad / Nustas, Rosemary / Zakaria, Ali / Piper, Marc S. / Taylor, Jason R. / Jaza, Lujain / Forbes, Nauzer / Chau, Millie / Lara, Luis F. / Papachristou, Georgios I. / Volk, Michael L. / Hilson, Liam G. /

Zhou, Selena / Kushnir, Vladimir M. / Lenyo, Alexandria M. / McLeod, Caroline G. / Amin, Sunil / Kuftinec, Gabriela N. / Yadav, Dhiraj / Fox, Charlie / Kolb, Jennifer M. / Pawa, Swati / Pawa, Rishi / Canakis, Andrew / Huang, Christopher / Jamil, Laith H. / Aneese, Andrew M. / Glamour, Benita K. / Smith, Zachary L. / Hanley, Katherine A. / Wood, Jordan / Patel, Harsh K. / Shah, Janak N. / Agarunov, Emil / Sethi, Amrita / Fogel, Evan L. / McNulty, Gail / Haseeb, Abdul / Trieu, Judy A. / Dixon, Rebekah E. / Yang, Jeong Yun / Mendelsohn, Robin B. / Calo, Delia / Aroniadis, Olga C. / LaComb, Joseph F. / Scheiman, James M. / Sauer, Bryan G. / Dang, Duyen T. / Piraka, Cyrus R. / Shah, Eric D. / Pohl, Heiko / Tierney, William M. / Mitchell, Stephanie / Condon, Ashwinee / Lenhart, Adrienne / Dua, Kulwinder S. / Kanagala, Vikram S. / Kamal, Ayesha / Singh, Vikesh K. / Pinto-Sanchez, Maria Ines / Hutchinson, Joy M. / Kwon, Richard S. / Korsnes, Sheryl J. / Singh, Harminder / Solati, Zahra / Deshpande, Amar R. / Rockey, Don C. / Alford, Teldon B. / Durkalski, Valerie / Willingham, Field F. / Yachimski, Patrick S. / Conwell, Darwin L. / Mosier, Evan / Azab, Mohamed / Patel, Anish / Buxbaum, James / Wani, Sachin / Chak, Amitabh / Hosmer, Amy E. / Keswani, Rajesh N. / DiMaio, Christopher J. / Bronze, Michael S. / Muthusamy, Raman / Canto, Marcia I. / Gjeorgjievski, V. Mihajlo / Imam, Zaid / Odish, Fadi / Edhi, Ahmed I. / Orosey, Molly / Tiwari, Abhinav / Patwardhan, Soumil / Brown, Nicholas G. / Patel, Anish A. / Ordiah, Collins O. / Sloan, Ian P. / Cruz, Lilian / Koza, Casey L. / Okafor, Uchechi / Hollander, Thomas / Furey, Nancy / Reykhart, Olga / Zbib, Natalia H. / Damianos, John A. / Esteban, James / Hajidiacos, Nick / Saul, Melissa / Mays, Melanie / Anderson, Gulsum / Wood, Kelley / Mathews, Laura / Diakova, Galina / Caisse, Molly / Wakefield, Lauren / Nitchie, Haley

medRxiv

Abstract: Background: The prevalence and significance of digestive manifestations in COVID-19 remain uncertain. Methods: Consecutive patients hospitalized with COVID-19 were identified across a geographically diverse alliance of medical centers in North America. ... ...

Abstract	Background: The prevalence and significance of digestive manifestations in COVID-19 remain uncertain. Methods: Consecutive patients hospitalized with COVID-19 were identified across a geographically diverse alliance of medical centers in North America. Data pertaining to baseline characteristics, symptomatology, laboratory assessment, imaging, and endoscopic findings from the time of symptom onset until discharge or death were manually abstracted from electronic health records to characterize the prevalence, spectrum, and severity of digestive manifestations. Regression analyses were performed to evaluate the association between digestive manifestations and severe outcomes related to COVID-19. Results: A total of 1992 patients across 36 centers met eligibility criteria and were included. Overall, 53% of patients experienced at least one gastrointestinal symptom at any time during their illness, most commonly diarrhea (34%), nausea (27%), vomiting (16%), and abdominal pain (11%). In 74% of cases, gastrointestinal symptoms were judged to be mild. In total, 35% of patients developed an abnormal alanine aminotransferase or total bilirubin level; these were elevated to less than 5 times the upper limit of normal in 77% of cases. After adjusting for potential confounders, the presence of gastrointestinal symptoms at any time (odds ratio 0.93, 95% confidence interval 0.76-1.15) or liver test abnormalities on admission (odds ratio 1.31, 95% confidence interval 0.80-2.12) were not independently associated with mechanical ventilation or death. Conclusions: Among patients hospitalized with COVID-19, gastrointestinal symptoms and liver test abnormalities were common but the majority were mild and their presence was not associated with a more severe clinical course.
Keywords	covid19
Language	English
Publishing date	2020-07-09
Publisher	Cold Spring Harbor Laboratory Press
Document type	Article ; Online
DOI	10.1101/2020.07.07.20143024
Database	COVID19

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Article ; Online: Digestive Manifestations in Patients Hospitalized with COVID-19

Elmunzer, B. Joseph / Spitzer, Rebecca L. / Foster, Lydia D. / Merchant, Ambreen A. / Howard, Eric F. / Patel, Vaishali A. / West, Mary K. / Qayed, Emad / Nustas, Rosemary / Zakaria, Ali / Piper, Marc S. / Taylor, Jason R. / Jaza, Lujain / Forbes, Nauzer / Chau, Millie / Lara, Luis F. / Papachristou, Georgios I. / Volk, Michael L. / Hilson, Liam G. /

Zhou, Selena / Kushnir, Vladimir M. / Lenyo, Alexandria M. / McLeod, Caroline G. / Amin, Sunil / Kuftinec, Gabriela N. / Yadav, Dhiraj / Fox, Charlie / Kolb, Jennifer M. / Pawa, Swati / Pawa, Rishi / Canakis, Andrew / Huang, Christopher / Jamil, Laith H. / Aneese, Andrew M. / Glamour, Benita K. / Smith, Zachary L. / Hanley, Katherine A. / Wood, Jordan / Patel, Harsh K. / Shah, Janak N. / Agarunov, Emil / Sethi, Amrita / Fogel, Evan L. / McNulty, Gail / Haseeb, Abdul / Trieu, Judy A. / Dixon, Rebekah E. / Yang, Jeong Yun / Mendelsohn, Robin B. / Calo, Delia / Aroniadis, Olga C. / LaComb, Joseph F. / Scheiman, James M. / Sauer, Bryan G. / Dang, Duyen T. / Piraka, Cyrus R. / Shah, Eric D. / Pohl, Heiko / Tierney, William M. / Mitchell, Stephanie / Condon, Ashwinee / Lenhart, Adrienne / Dua, Kulwinder S. / Kanagala, Vikram S. / Kamal, Ayesha / Singh, Vikesh K. / Pinto-Sanchez, Maria Ines / Hutchinson, Joy M. / Kwon, Richard S. / Korsnes, Sheryl J. / Singh, Harminder / Solati, Zahra / Willingham, Field F. / Yamchimski, Patrick S. / Conwell, Darwin L. / Mosier, Evan / Azab, Mohamed / Patel, Anish / Buxbaum, James / Wani, Sachin / Chak, Amitabh / Hosmer, Amy E. / Keswani, Rajesh N. / DiMaio, Christopher J. / Bronze, Michael S. / Muthusamy, Raman / Canto, Marcia I. / Gjeorgjievski, V. Mihajlo / Imam, Zaid / Odish, Fadi / Edhi, Ahmed I. / Orosey, Molly / Tiwari, Abhinav / Patwardhan, Soumil / Brown, Nicholas G. / Patel, Anish A. / Ordiah, Collins O. / Sloan, Ian P. / Cruz, Lilian / Koza, Casey L. / Okafor, Uchechi / Hollander, Thomas / Furey, Nancy / Reykhart, Olga / Zbib, Natalia H. / Damianos, John A. / Esteban, James / Hajidiacos, Nick / Saul, Melissa / Mays, Melanie / Anderson, Gulsum / Wood, Kelley / Mathews, Laura / Diakova, Galina / Caisse, Molly / Wakefield, Lauren / Nitchie, Haley / Waljee, Akbar K. / Tang, Weijing / Zhang, Yueyang / Zhu, Ji / Deshpande, Amar R. / Rockey, Don C. / Alford, Teldon B. / Durkalski, Valerie

Clinical Gastroenterology and Hepatology ; ISSN 1542-3565

2020

Keywords	Hepatology ; Gastroenterology ; covid19
Language	English
Publisher	Elsevier BV
Publishing country	us
Document type	Article ; Online
DOI	10.1016/j.cgh.2020.09.041
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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