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Article ; Online: Patient and clinician priorities for information on treatment outcomes for advanced ovarian cancer: a Delphi exercise.

Baxter, Kathryn / Agnew, Heather / Morgan, Jennie / Holland, Cathrine / Flynn, Darren / Edmondson, Richard

2024

Abstract: Objective: Patients with advanced ovarian cancer face a range of treatment options, and there is unwarranted variation in treatment decision-making between UK providers. Decision support tools that produce data on treatment outcomes as a function of ... ...

Abstract	Objective: Patients with advanced ovarian cancer face a range of treatment options, and there is unwarranted variation in treatment decision-making between UK providers. Decision support tools that produce data on treatment outcomes as a function of individual patient characteristics, would help both patients and clinicians to make informed, preference- and values-based choices. However, data on treatment outcomes to include in such tools are lacking. Methods: Following a literature review, a questionnaire was designed for use in a Delphi process to establish which treatment outcomes are important to both patients and clinicians in decision-making for treatment for advanced ovarian cancer. Patient and clinician panels were established. Results: Following 2 Delphi rounds, consensus was achieved for 7/11 items in the patient panel and 8/11 items in the clinician panel. Consensus across both panels was achieved for inclusion of both overall survival and progression free survival as important items in the decision-making process, although there remained differences of opinion as to whether these should be presented as relative or absolute values. Conclusion: Information needs for treatment decision-making in ovarian cancer differ between and within patient and clinician groups. Whilst overall survival and progression free survival are universally accepted as important data items, decision support tools will need to be nuanced to allow presentation of a range of outcomes and associated probabilities, and in a range of formats, that can be tailored to the preferences of clinician and patients.
Language	English
Publishing date	2024-03-21
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2478405-9
ISSN	2005-0399 ; 2005-0380
ISSN (online)	2005-0399
ISSN	2005-0380
DOI	10.3802/jgo.2024.35.e63
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Article ; Online: Engineering strategies to optimise adoptive cell therapy in ovarian cancer.

Guerra, Catarina / Kalaitsidou, Milena / Kueberuwa, Gray / Hawkins, Robert / Edmondson, Richard

Cancer treatment reviews

2023 Volume 121, Page(s) 102632

Abstract: Ovarian cancer is amongst the ten most common cancer types in women, and it is one of the leading causes of death. Despite the promising results of targeted therapies, including anti-angiogenic agents and poly (ADP-ribose) polymerase inhibitors (PARPi), ... ...

Abstract	Ovarian cancer is amongst the ten most common cancer types in women, and it is one of the leading causes of death. Despite the promising results of targeted therapies, including anti-angiogenic agents and poly (ADP-ribose) polymerase inhibitors (PARPi), the majority of patients will relapse and develop treatment resistance, implying that novel therapeutic strategies are required. Adoptive cell therapy (ACT) refers to the process by which autologous immune cells are used to eliminate cancer. Examples include tumour infiltrating lymphocytes (TILs), T cells genetically engineered with T cell receptors (TCR), or chimeric antigen receptor (CAR)-T cells. Recently, ACT has revealed promising results in the treatment of haematological malignancies, however, its application to solid tumours is still limited due to lack of functionality and persistence of T cells, prevalence of an exhausted phenotype and impaired trafficking towards the tumour microenvironment (TME). In this review we explore the potential of ACT for the treatment of ovarian cancer and strategies to overcome its principal limitations.
MeSH term(s)	Humans ; Female ; Immunotherapy, Adoptive/methods ; Neoplasm Recurrence, Local ; Ovarian Neoplasms/therapy ; Neoplasms/therapy ; T-Lymphocytes ; Receptors, Antigen, T-Cell ; Tumor Microenvironment
Chemical Substances	Receptors, Antigen, T-Cell
Language	English
Publishing date	2023-10-05
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	125102-8
ISSN	1532-1967 ; 0305-7372
ISSN (online)	1532-1967
ISSN	0305-7372
DOI	10.1016/j.ctrv.2023.102632
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Article ; Online: Population-based testing of non-mucinous epithelial ovarian cancer in Scotland.

Evans, D G / Edmondson, R / Crosbie, E J

BJOG : an international journal of obstetrics and gynaecology

2018 Volume 125, Issue 11, Page(s) 1459

MeSH term(s)	BRCA2 Protein ; Carcinoma, Ovarian Epithelial ; Female ; Germ Cells ; Humans ; Neoplasms, Glandular and Epithelial ; Ovarian Neoplasms ; Scotland
Chemical Substances	BRCA2 Protein ; BRCA2 protein, human
Language	English
Publishing date	2018-05-10
Publishing country	England
Document type	Journal Article ; Comment
ZDB-ID	2000931-8
ISSN	1471-0528 ; 0306-5456 ; 1470-0328
ISSN (online)	1471-0528
ISSN	0306-5456 ; 1470-0328
DOI	10.1111/1471-0528.15174
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Article ; Online: A three protein signature fails to externally validate as a biomarker to predict surgical outcome in high-grade epithelial ovarian cancer.

Hawarden, Amy / Price, Marcus / Russell, Bryn / Wilson, Godfrey / Farrelly, Laura / Embleton-Thirsk, Andrew / Parmar, Mahesh / Edmondson, Richard

PloS one

2023 Volume 18, Issue 3, Page(s) e0281798

Abstract: Introduction: For patients with advanced epithelial ovarian cancer, complete surgical cytoreduction remains the strongest predictor of outcome. However, identifying patients who are likely to benefit from such surgery remains elusive and to date few ... ...

Abstract	Introduction: For patients with advanced epithelial ovarian cancer, complete surgical cytoreduction remains the strongest predictor of outcome. However, identifying patients who are likely to benefit from such surgery remains elusive and to date few surgical outcome prediction tools have been validated. Here we attempted to externally validate a promising three protein signature, which had previously shown strong association with suboptimal surgical debulking (AUC 0.89, accuracy 92.8%), (Riester, M., et al., (2014)). Methods: 238 high-grade epithelial ovarian cancer samples were collected from patients who participated in a large multicentre trial (ICON5). Samples were collected at the time of initial surgery and before randomisation. Surgical outcome data were collated from prospectively collected study records. Immunohistochemical scores were generated by two independent observers for the three proteins in the original signature (POSTN, CXCL14 and pSmad2/3). Predictive values were generated for individual and combination protein signatures. Results: When assessed individually, none of the proteins showed any evidence of predictive affinity for suboptimal surgical outcome in our cohort (AUC POSTN 0.55, pSmad 2/3 0.53, CXCL 14 0.62). The combined signature again showed poor predictive ability with an AUC 0.58. Conclusions: Despite showing original promise, when this protein signature is applied to a large external cohort, it is unable to accurately predict surgical outcomes. This could be attributed to overfitting of the original model, or differences in surgical practice between cohorts.
MeSH term(s)	Humans ; Female ; Carcinoma, Ovarian Epithelial/surgery ; Ovarian Neoplasms/surgery ; Biomarkers ; Prognosis ; Proteins ; Cytoreduction Surgical Procedures ; Treatment Outcome
Chemical Substances	Biomarkers ; Proteins
Language	English
Publishing date	2023-03-23
Publishing country	United States
Document type	Multicenter Study ; Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0281798
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Article ; Online: Optimization of polygenic risk scores in BRCA1/2 pathogenic variant heterozygotes in epithelial ovarian cancer.

Flaum, Nicola / Bowes, John / Smith, Miriam J / Crosbie, Emma J / Edmondson, Richard / Lophatananon, Artitaya / Evans, D Gareth

Genetics in medicine : official journal of the American College of Medical Genetics

2023 Volume 25, Issue 9, Page(s) 100898

Abstract: Purpose: A third of familial epithelial ovarian cancer (EOC) is explained by BRCA1/2 pathogenic variants. Polygenic risk scores (PRSs) for BRCA1/2 heterozygotes associated with EOC have been created, but impact of combination with clinical and hormonal ... ...

Abstract	Purpose: A third of familial epithelial ovarian cancer (EOC) is explained by BRCA1/2 pathogenic variants. Polygenic risk scores (PRSs) for BRCA1/2 heterozygotes associated with EOC have been created, but impact of combination with clinical and hormonal risk factors is unclear. Methods: We genotyped 300 cases and 355 controls and constructed modified PRSs based on those validated by Barnes et al. Model discrimination and EOC risk was assessed by area under the curve (AUC) values and difference between lowest and highest quintile odds ratios (ORs). We investigated model optimization using logistic regression to combine models with clinical and hormonal data. Results: Unadjusted AUC values ranged from 0.526 to 0.551 with 2.2- to 2.3-fold increase in OR between lowest and highest quintiles (BRCA1 heterozygotes) and 0.574 to 0.585 AUC values with a 6.3- to 7.7-fold increase (BRCA2 heterozygotes). The optimized model (parity, age at menarche, menopause, and first full-term pregnancy) estimated AUC values of 0.872 to 0.876 and 21- to 23-fold increase in OR (BRCA1 heterozygotes) and AUC values of 0.857 to 0.867 and 40- to 41-fold increase (BRCA2 heterozygotes). Conclusion: The combination of PRS with age, family history, and hormonal factors significantly improved the EOC risk discrimination ability. However, the contribution of the PRS was small. Larger prospective studies are needed to assess if combined-PRS models could provide information to inform risk-reducing decisions.
MeSH term(s)	Pregnancy ; Humans ; Female ; BRCA1 Protein/genetics ; Heterozygote ; Carcinoma, Ovarian Epithelial/genetics ; Genetic Predisposition to Disease ; BRCA2 Protein/genetics ; Risk Factors ; Ovarian Neoplasms/genetics ; Breast Neoplasms
Chemical Substances	BRCA1 protein, human ; BRCA1 Protein ; BRCA2 protein, human ; BRCA2 Protein
Language	English
Publishing date	2023-05-19
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1455352-1
ISSN	1530-0366 ; 1098-3600
ISSN (online)	1530-0366
ISSN	1098-3600
DOI	10.1016/j.gim.2023.100898
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Article ; Online: MDT practice determines treatment pathway for patients with advanced ovarian cancer: A multi-centre observational study.

Khassan, T / Smitten, E / Wood, N / Fotopoulou, C / Morrison, J / MacDonald, M / Baxter, K / Edmondson, R J

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

2023 Volume 49, Issue 8, Page(s) 1504–1510

Abstract: Objective: To investigate decision making for patients with advanced ovarian cancer as a possible explanation of geographical variation in treatment patterns.: Methods: We carried out a multi-centre observational study in multidisciplinary teams ... ...

Abstract	Objective: To investigate decision making for patients with advanced ovarian cancer as a possible explanation of geographical variation in treatment patterns. Methods: We carried out a multi-centre observational study in multidisciplinary teams meetings for five major UK cancer centres. All patients presenting to five cancer centres with advanced ovarian cancer over a six-week period. The GO-MDT-MODe tool was used to provide a measure of participation and quality of case discussion for all cases of advanced ovarian cancer. MDT scores were correlated with surgical data extracted from national audit data. Data were recorded for overall MDT performance. Results: A total of 870 case discussions, including 145 cases of advanced ovarian cancer, were observed. MDTs varied in structure, format and time allocation between centres. Cluster analysis showed significant variation in quality and participation of discussion between centres (p < 0.0025) and this correlated with the proportion of patients in the wider cancer alliance undergoing surgery. Conclusions: We have shown that at least part of the variation in practice seen in the UK correlates with different behaviours within MDTs. Increasing time for discussion and encouraging participation from all staff groups may increase proportions of patients undergoing optimal treatment regimens.
MeSH term(s)	Male ; Humans ; Female ; Patient Care Team ; Genital Neoplasms, Male ; Carcinoma, Ovarian Epithelial ; Ovarian Neoplasms/surgery
Language	English
Publishing date	2023-03-16
Publishing country	England
Document type	Observational Study ; Multicenter Study ; Journal Article
ZDB-ID	632519-1
ISSN	1532-2157 ; 0748-7983
ISSN (online)	1532-2157
ISSN	0748-7983
DOI	10.1016/j.ejso.2023.03.210
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Book ; Online: The Political Context of Collective Action

Edmondson, Ricca

(Routledge / ECPR Studies in European Political Science)

2013

Abstract: The study of social and popular movements continues to attract great interest, but little is known of political activity which takes place outside of traditional political structures. Tnis volume looks at informal political action which arises when ... ...

Series title	Routledge / ECPR Studies in European Political Science
Abstract	The study of social and popular movements continues to attract great interest, but little is known of political activity which takes place outside of traditional political structures. Tnis volume looks at informal political action which arises when conventional frameworks, such as those provided by welfare states, are in crisis or decline. At such times the usual expectations about politcal action may not apply, so what actually goes on?Greatly expanding the scope for research into collective action, this volume will be of great interest to students and researchers of politics and sociolog
Language	English
Size	Online-Ressource (261 p)
Publisher	Taylor and Francis
Publishing place	Hoboken
Document type	Book ; Online
Note	Description based upon print version of record
ISBN	9780415169417 ; 0415169410
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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Article ; Online: Propensity score matching confirms that primary surgery or neoadjuvant chemotherapy result in equivalent survival within a comprehensive cohort of patients with high-grade serous ovarian cancer.

Russell, B / Hawarden, A / Gee, M / Edmondson, R J

Gynecologic oncology

2020 Volume 160, Issue 1, Page(s) 24–31

Abstract: Objective: Our objective was to investigate whether trial evidence showing that neoadjuvant chemotherapy is non inferior to primary surgery for the primary treatment of advanced ovarian cancer could be extrapolated to groups of patients that were not ... ...

Abstract	Objective: Our objective was to investigate whether trial evidence showing that neoadjuvant chemotherapy is non inferior to primary surgery for the primary treatment of advanced ovarian cancer could be extrapolated to groups of patients that were not included in the trials. Methods: Using a detailed retrospective cohort of all patients managed through a single tertiary hospital we carried out a propensity score analysis, principal component analysis, and cox proportional hazard analysis to compare survival in matched cohorts. Results: A propensity score analysis showed that for at least 41% of all patients with advanced high-grade serous cancer neoadjuvant chemotherapy is non inferior to primary surgery (median survival primary surgery: 38 months, neoadjuvant chemotherapy: 35 months. P = 0.39). However, principal component analysis, supported by cox modelling, suggests that for some subgroups, including patients with subdiaphragmatic nodal disease, primary surgery may be associated with improved survival (HR 0.11, CI 0.026-0.48). Conclusions: We have shown that the findings of previous trials can be extrapolated to a wider population and that statistical modelling can be used to identify groups or patients who benefit from specific modalities of treatment.
MeSH term(s)	Aged ; Carcinoma, Ovarian Epithelial/drug therapy ; Carcinoma, Ovarian Epithelial/mortality ; Carcinoma, Ovarian Epithelial/surgery ; Carcinoma, Ovarian Epithelial/therapy ; Cohort Studies ; England/epidemiology ; Female ; Humans ; Middle Aged ; Neoadjuvant Therapy ; Ovarian Neoplasms/drug therapy ; Ovarian Neoplasms/mortality ; Ovarian Neoplasms/surgery ; Ovarian Neoplasms/therapy ; Principal Component Analysis ; Propensity Score ; Proportional Hazards Models ; Retrospective Studies
Language	English
Publishing date	2020-11-05
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	801461-9
ISSN	1095-6859 ; 0090-8258
ISSN (online)	1095-6859
ISSN	0090-8258
DOI	10.1016/j.ygyno.2020.10.035
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Article ; Online: Should we worry about obesity in our ovarian cancer patients, too?

Sawan, S / Edmondson, R J

BJOG : an international journal of obstetrics and gynaecology

2016 Volume 123, Issue 2, Page(s) 309

MeSH term(s)	Female ; Humans ; Obesity/surgery ; Ovarian Neoplasms/surgery ; Postoperative Complications/surgery
Language	English
Publishing date	2016-01
Publishing country	England
Document type	Comment ; Journal Article
ZDB-ID	2000931-8
ISSN	1471-0528 ; 0306-5456 ; 1470-0328
ISSN (online)	1471-0528
ISSN	0306-5456 ; 1470-0328
DOI	10.1111/1471-0528.13773
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Article: Values of educational visits in obstetrics. Staff changes will have affected ventouse rates.

Edmondson, R

BMJ (Clinical research ed.)

1999 Volume 318, Issue 7191, Page(s) 1144

MeSH term(s)	Data Collection ; Humans ; Obstetrics/education ; Vacuum Extraction, Obstetrical
Language	English
Publishing date	1999-04-24
Publishing country	England
Document type	Comment ; Letter
ZDB-ID	1362901-3
ISSN	1756-1833 ; 0959-8138 ; 0959-8154 ; 0959-8146 ; 0959-535X ; 1759-2151
ISSN (online)	1756-1833
ISSN	0959-8138 ; 0959-8154 ; 0959-8146 ; 0959-535X ; 1759-2151
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