Article ; Online: speedingCARs
Nature Communications, Vol 13, Iss 1, Pp 1-
accelerating the engineering of CAR T cells by signaling domain shuffling and single-cell sequencing
2022 Volume 16
Abstract: Chimeric antigen receptors (CAR) are a promising option for cell-based immunotherapy for cancer and other immune diseases. Here the authors develop speedingCARs, an integrated CAR design and screening platform based on modular signaling domain shuffling ... ...
| Abstract | Chimeric antigen receptors (CAR) are a promising option for cell-based immunotherapy for cancer and other immune diseases. Here the authors develop speedingCARs, an integrated CAR design and screening platform based on modular signaling domain shuffling and single cell transcriptomic analyses, and test its potential for identifying and validating novel CAR designs. |
|---|---|
| Keywords | Science ; Q |
| Language | English |
| Publishing date | 2022-11-01T00:00:00Z |
| Publisher | Nature Portfolio |
| Document type | Article ; Online |
| Database | BASE - Bielefeld Academic Search Engine (life sciences selection) |
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