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  1. AU="Edward S. Debnam"
  2. AU="Freeston, Sarah L"
  3. AU="Bertolucci, S."
  4. AU="de Barros, Rosires M B"
  5. AU="Carr, Crystal C"
  6. AU="Davies, Mark Lloyd"
  7. AU=St Gelais Corine
  8. AU=Engstrom Malitta
  9. AU="Hongo, Akane"
  10. AU="Krykorková, I"
  11. AU=Yan Bing
  12. AU="Nakos, Konstantinos"
  13. AU="Schreiner, Ryan"
  14. AU=Pltz T
  15. AU="Akhmanova, Anna" AU="Akhmanova, Anna"
  16. AU="Goretsky, Anton"
  17. AU="Cordoza, Makayla L"
  18. AU=Midoux Patrick AU=Midoux Patrick
  19. AU="Mundt, H M"
  20. AU=Tsivitse Susan

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  1. Artikel: Nrf2 transcriptional derepression from Keap1 by dietary polyphenols

    Bayele, Henry K / Edward S. Debnam / Kaila S. Srai

    Biochemical and biophysical research communications. 2016 Jan. 15, v. 469

    2016  

    Abstract: The liver expresses batteries of cytoprotective genes that confer cellular resistance to oxidative stress and xenobiotic toxins, and protection against cancer and other stress-related diseases. These genes are mainly regulated by Nrf2, making this ... ...

    Abstract The liver expresses batteries of cytoprotective genes that confer cellular resistance to oxidative stress and xenobiotic toxins, and protection against cancer and other stress-related diseases. These genes are mainly regulated by Nrf2, making this transcription factor a target for small molecule discovery to treat such diseases. In this report, we identified dietary polyphenolic antioxidants that not only activated these genes but also relieved Nrf2 repression by Keap1, a Cul3-dependent ubiquitin ligase adaptor protein that mediates its degradation. Analysis of postprandial liver RNA revealed a marked activation of both genes by all test polyphenols compared with controls. Nrf2 inhibition by RNA interference reduced polyphenol effects on its target gene expression. Our data suggest that polyphenols may induce cellular defense genes by derepressing Nrf2 inhibition by Keap1. We posit that this ability to derepress Nrf2 and reactivate its target genes may underlie the protection conferred by polyphenols against oxidative stress-related diseases.
    Schlagwörter RNA ; RNA interference ; antioxidants ; gene expression ; genes ; liver ; neoplasms ; oxidative stress ; polyphenols ; toxins ; transcription (genetics) ; transcription factors ; ubiquitin-protein ligase ; Antioxidant ; Antioxidant response element ; Detoxification ; Dietary polyphenols ; Cytoprotection ; ARE ; hQR1 ; GST-Ya ; Nrf2 ; Keap1 ; t-BHQ ; DMSO
    Sprache Englisch
    Erscheinungsverlauf 2016-0115
    Umfang p. 521-528.
    Erscheinungsort Elsevier Inc.
    Dokumenttyp Artikel
    ZDB-ID 205723-2
    ISSN 0006-291X ; 0006-291X
    ISSN (online) 0006-291X
    ISSN 0006-291X
    DOI 10.1016/j.bbrc.2015.11.103
    Datenquelle NAL Katalog (AGRICOLA)

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  2. Artikel ; Online: Quercetin inhibits intestinal iron absorption and ferroportin transporter expression in vivo and in vitro.

    Marija Lesjak / Rukshana Hoque / Sara Balesaria / Vernon Skinner / Edward S Debnam / Surjit K S Srai / Paul A Sharp

    PLoS ONE, Vol 9, Iss 7, p e

    2014  Band 102900

    Abstract: Balancing systemic iron levels within narrow limits is critical for maintaining human health. There are no known pathways to eliminate excess iron from the body and therefore iron homeostasis is maintained by modifying dietary absorption so that it ... ...

    Abstract Balancing systemic iron levels within narrow limits is critical for maintaining human health. There are no known pathways to eliminate excess iron from the body and therefore iron homeostasis is maintained by modifying dietary absorption so that it matches daily obligatory losses. Several dietary factors can modify iron absorption. Polyphenols are plentiful in human diet and many compounds, including quercetin--the most abundant dietary polyphenol--are potent iron chelators. The aim of this study was to investigate the acute and longer-term effects of quercetin on intestinal iron metabolism. Acute exposure of rat duodenal mucosa to quercetin increased apical iron uptake but decreased subsequent basolateral iron efflux into the circulation. Quercetin binds iron between its 3-hydroxyl and 4-carbonyl groups and methylation of the 3-hydroxyl group negated both the increase in apical uptake and the inhibition of basolateral iron release, suggesting that the acute effects of quercetin on iron transport were due to iron chelation. In longer-term studies, rats were administered quercetin by a single gavage and iron transporter expression measured 18 h later. Duodenal FPN expression was decreased in quercetin-treated rats. This effect was recapitulated in Caco-2 cells exposed to quercetin for 18 h. Reporter assays in Caco-2 cells indicated that repression of FPN by quercetin was not a transcriptional event but might be mediated by miRNA interaction with the FPN 3'UTR. Our study highlights a novel mechanism for the regulation of iron bioavailability by dietary polyphenols. Potentially, diets rich in polyphenols might be beneficial for patients groups at risk of iron loading by limiting the rate of intestinal iron absorption.
    Schlagwörter Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 570
    Sprache Englisch
    Erscheinungsdatum 2014-01-01T00:00:00Z
    Verlag Public Library of Science (PLoS)
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel: Nrf2 transcriptional derepression from Keap1 by dietary polyphenols

    Bayele, Henry K. / Edward S. Debnam / Kaila S. Srai

    Biochemical and biophysical research communications

    Band v. 469

    Abstract: The liver expresses batteries of cytoprotective genes that confer cellular resistance to oxidative stress and xenobiotic toxins, and protection against cancer and other stress-related diseases. These genes are mainly regulated by Nrf2, making this ... ...

    Abstract The liver expresses batteries of cytoprotective genes that confer cellular resistance to oxidative stress and xenobiotic toxins, and protection against cancer and other stress-related diseases. These genes are mainly regulated by Nrf2, making this transcription factor a target for small molecule discovery to treat such diseases. In this report, we identified dietary polyphenolic antioxidants that not only activated these genes but also relieved Nrf2 repression by Keap1, a Cul3-dependent ubiquitin ligase adaptor protein that mediates its degradation. Analysis of postprandial liver RNA revealed a marked activation of both genes by all test polyphenols compared with controls. Nrf2 inhibition by RNA interference reduced polyphenol effects on its target gene expression. Our data suggest that polyphenols may induce cellular defense genes by derepressing Nrf2 inhibition by Keap1. We posit that this ability to derepress Nrf2 and reactivate its target genes may underlie the protection conferred by polyphenols against oxidative stress-related diseases.
    Sprache Englisch
    Dokumenttyp Artikel
    ISSN 0006-291X
    Datenquelle AGRIS - International Information System for the Agricultural Sciences and Technology

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    Kategorien

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

    Fernleihe an ZB MED

    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

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