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  1. Article ; Online: Clearance of Pneumococcal Colonization in Infants Is Delayed through Altered Macrophage Trafficking.

    Steven J Siegel / Edwin Tamashiro / Jeffrey N Weiser

    PLoS Pathogens, Vol 11, Iss 6, p e

    2015  Volume 1005004

    Abstract: Infections are a common cause of infant mortality worldwide, especially due to Streptococcus pneumoniae. Colonization is the prerequisite to invasive pneumococcal disease, and is particularly frequent and prolonged in children, though the mechanisms ... ...

    Abstract Infections are a common cause of infant mortality worldwide, especially due to Streptococcus pneumoniae. Colonization is the prerequisite to invasive pneumococcal disease, and is particularly frequent and prolonged in children, though the mechanisms underlying this susceptibility are unknown. We find that infant mice exhibit prolonged pneumococcal carriage, and are delayed in recruiting macrophages, the effector cells of clearance, into the nasopharyngeal lumen. This lack of macrophage recruitment is paralleled by a failure to upregulate chemokine (C-C) motif ligand 2 (Ccl2 or Mcp-1), a macrophage chemoattractant that is required in adult mice to promote clearance. Baseline expression of Ccl2 and the related chemokine Ccl7 is higher in the infant compared to the adult upper respiratory tract, and this effect requires the infant microbiota. These results demonstrate that signals governing macrophage recruitment are altered at baseline in infant mice, which prevents the development of appropriate innate cell infiltration in response to pneumococcal colonization, delaying clearance of pneumococcal carriage.
    Keywords Immunologic diseases. Allergy ; RC581-607 ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2015-06-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Lemierre's syndrome

    Pedro Ernesto Barbosa Pinheiro / Priscilla Durante Miotto / Natalia Quinhone Shigematsu / Edwin Tamashiro / Fabiana Cardoso Pereira Valera / Wilma Teresinha Anselmo-Lima

    Brazilian Journal of Otorhinolaryngology , Vol 81, Iss 1, Pp 115-

    a pharyngotonsillitis complication

    2015  Volume 116

    Keywords Otorhinolaryngology ; RF1-547 ; Medicine ; R
    Language Portuguese
    Publishing date 2015-02-01T00:00:00Z
    Publisher Associação Brasileira de Otorrinolaringologia e Cirurgia Cervicofacial
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Pólipo antrocoanal bilateral

    Henrique Augusto Cantareira Sabino / Francesca Maia Faria / Edwin Tamashiro / Wilma Terezinha Anselmo Lima / Fabiana Cardoso Pereira Valera

    Brazilian Journal of Otorhinolaryngology , Vol 80, Iss 2, Pp 182-

    relato de caso

    2014  Volume 183

    Keywords Otorhinolaryngology ; RF1-547 ; Medicine ; R
    Language Portuguese
    Publishing date 2014-04-01T00:00:00Z
    Publisher Associação Brasileira de Otorrinolaringologia e Cirurgia Cervicofacial
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: O impacto da septoplastia Metzembaum sobre o crescimento nasal e facial em crianças

    Denise Barreiro Costa / Wilma Terezinha Anselmo-Lima / Edwin Tamashiro / Carla Enoki / Fabiana Cardoso Pereira Valera

    Brazilian Journal of Otorhinolaryngology , Vol 79, Iss 4, Pp 454-

    2013  Volume 459

    Abstract: Há vários estudos que investigaram os efeitos da septoplastia no crescimento facial em crianças, com resultados conflitantes. No entanto, poucos empregaram medidas objetivas ou avaliaram os pacientes após o término do crescimento facial. OBJETIVO: Este ... ...

    Abstract Há vários estudos que investigaram os efeitos da septoplastia no crescimento facial em crianças, com resultados conflitantes. No entanto, poucos empregaram medidas objetivas ou avaliaram os pacientes após o término do crescimento facial. OBJETIVO: Este estudo avalia os efeitos da septoplastia Metzenbaum, que preserva o pericôndrio e áreas relacionadas com o crescimento, sobre o crescimento nasal e facial em crianças. MÉTODO: Crianças que foram operadas antes dos 14 anos e que apresentavam 16 anos ou mais na avaliação foram incluídas. Dezesseis pacientes foram selecionados. Os seguintes parâmetros foram avaliados: satisfação clínica (patência e estética nasal); medidas antropométricas; cefalometria. Desenho científico: estudo de coorte histórica com corte transversal. RESULTADOS: A idade média na cirurgia foi de 13 anos; as crianças foram avaliadas em média 4,3 anos após a cirurgia. Apenas um paciente apresentou medidas antropométricas e cefalométricas abaixo da normalidade, porém, sem queixas quanto à estética ou à patência. Outros quatro pacientes apresentaram queixa quanto à estética nasal e três quanto à patência nasal. CONCLUSÃO: A septoplastia Metzenbaum parece ser uma técnica segura na correção de desvios caudais. Esta técnica não apresentou impacto significativo no crescimento facial dos pacientes avaliados.
    Keywords antropometria ; crescimento ; desenvolvimento maxilofacial ; ossos faciais ; septo nasal ; Otorhinolaryngology ; RF1-547 ; Medicine ; R
    Language Portuguese
    Publishing date 2013-08-01T00:00:00Z
    Publisher Associação Brasileira de Otorrinolaringologia e Cirurgia Cervicofacial
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Efeitos do cigarro sobre o epitélio respiratório e sua participação na rinossinusite crônica Effects of cigarette smoking on the respiratory epithelium and its role in the pathogenesis of chronic rhinosinusitis

    Edwin Tamashiro / Noam A Cohen / James N Palmer / Wilma Terezinha Anselmo Lima

    Brazilian Journal of Otorhinolaryngology , Vol 75, Iss 6, Pp 903-

    2009  Volume 907

    Abstract: O crescente consumo de cigarro tem despertado preocupações com o desenvolvimento e agravamento de doenças, em especial às relacionadas ao trato respiratório. OBJETIVO: Neste artigo revisamos as evidências que apontam os efeitos da fumaça de cigarro sobre ...

    Abstract O crescente consumo de cigarro tem despertado preocupações com o desenvolvimento e agravamento de doenças, em especial às relacionadas ao trato respiratório. OBJETIVO: Neste artigo revisamos as evidências que apontam os efeitos da fumaça de cigarro sobre o epitélio respiratório bem como o seu papel na fisiopatogenia na rinossinusite crônica. CONCLUSÃO: Embora existam dados que fortaleçam um vínculo entre o hábito de fumar e a RSC, em seu conjunto, os estudos demonstram que deve haver grande dependência da susceptibilidade individual na resposta à fumaça de cigarro para o desenvolvimento ou manutenção da RSC. Uma adequada orientação a esses pacientes para interrupção do consumo de cigarro, assim como o reforço de campanhas de combate ao tabagismo, são de extrema importância para o controle dessa doença de grande impacto sócio-econômico. The increasing consumption of cigarettes has aroused concerns about the development and worsening of diseases, particularly those related to the respiratory tract. AIM: In this paper we review the evidence suggesting the effects of cigarette smoking on the respiratory epithelium and its role in the pathogenesis in chronic rhinosinusitis. CONCLUSIONS: Although there is evidence supporting a link between smoking and CRS, studies suggest that there might be individual susceptibility to cigarette smoking causing the development and/or maintenance of CRS. Proper patient educations to quit smoking as well as reinforcement of antismoking campaigns are extremely important to control this disease of major socio-economic impact.
    Keywords mucosa respiratória ; sinusite ; tabaco ; respiratory mucosa ; sinusitis ; tobacco ; Otorhinolaryngology ; RF1-547 ; Medicine ; R ; DOAJ:Otorhinolaryngology ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
    Language Portuguese
    Publishing date 2009-12-01T00:00:00Z
    Publisher Associação Brasileira de Otorrinolaringologia e Cirurgia Cervicofacial
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Respiratory DNA viruses are undetectable in nasopharyngeal secretions from adenotonsillectomized children.

    Ronaldo Bragança Martins / Lucas Penna Rocha / Mirela Moreira Prates / Talita Bianca Gagliardi / Balduino Biasoli / Marcelo Junqueira Leite / Guilherme Buzatto / Miguel Angelo Hyppolito / Davi Casale Aragon / Edwin Tamashiro / Fabiana Cardoso Pereira Valera / Eurico Arruda / Wilma Terezinha Anselmo-Lima

    PLoS ONE, Vol 12, Iss 3, p e

    2017  Volume 0174188

    Abstract: Respiratory viruses are frequently detected in association with chronic tonsillar hypertrophy in the absence of symptoms of acute respiratory infection (ARI). The present analysis was done in follow-up to a previous clinical study done by this same group. ...

    Abstract Respiratory viruses are frequently detected in association with chronic tonsillar hypertrophy in the absence of symptoms of acute respiratory infection (ARI). The present analysis was done in follow-up to a previous clinical study done by this same group. Nasopharyngeal washes (NPWs) were obtained from 83 of 120 individuals at variable times post adenotonsillectomy, in the absence of ARI symptoms. A look back at virus detection results in NPWs from the same 83 individuals at the time of tonsillectomy revealed that 73.5% (61/83) were positive for one or more viruses. The overall frequency of respiratory virus detection in post-tonsillectomy NPWs was 58.8%. Rhinovirus (RV) was the agent most frequently detected, in 38 of 83 subjects (45.8%), followed by enterovirus in 7 (8.4%), human metapneumovirus in 6 (7.2%), human respiratory syncytial virus in 3 (3.6%) and human coronavirus in 1 (1.2%). Remarkably, there was no detection of adenovirus (HAdV) or human bocavirus (HBoV) in asymptomatic individuals in follow-up of adenotonsillectomy. In keeping with persistence of respiratory DNA viruses in human tonsils, tonsillectomy significantly reduces asymptomatic shedding of HAdV and HBoV in NPWs.
    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2017-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Review of experimental models

    André Coura Perez / Guilherme Pietrucci Buzatto / Ivan de Picole Dantas / João Vicente Dorgam / Fabiana Cardoso Pereira Valera / Edwin Tamashiro / Wilma Terezinha Anselmo Lima

    Brazilian Journal of Otorhinolaryngology , Vol 80, Iss 5, Pp 435-

    sinusitis in rabbits

    2014  Volume 440

    Abstract: INTRODUCTION: In order to better understand the pathophysiology of rhinosinusitis, several attempts have been made to create the disease in an animal model. Among the studied rodents each has its advantages and disadvantages. Rabbits are considered more ... ...

    Abstract INTRODUCTION: In order to better understand the pathophysiology of rhinosinusitis, several attempts have been made to create the disease in an animal model. Among the studied rodents each has its advantages and disadvantages. Rabbits are considered more appropriate for studies that require surgical manipulation or invasive procedures. OBJECTIVES: To evaluate the most viable experimental model of rhinosinusitis in rabbits to be adopted in future studies. METHODS: An electronic search for studies with experimental models of rhinosinusitis in rabbits published in English and Portuguese between July of 1967 and January of 2013 was conducted in Medline, Pub Med, Cochrane, and CAPES databases, using the keywords "sinusitis", "rabbits", and "polyps". RESULTS: A total of 256 studies were retrieved, but in accordance with the inclusion and exclusion criteria, only ten studies were selected. Many different methods of response assessment were used in these studies. CONCLUSION: To date, there is no ideal experimental model for induction of acute or chronic rhinosinusitis in rabbits, but the rhinogenic model appears to be the most viable option for the continuity of studies of the disease.
    Keywords Sinusite ; Coelhos ; Pólipos ; Otorhinolaryngology ; RF1-547 ; Medicine ; R
    Subject code 001
    Language Portuguese
    Publishing date 2014-10-01T00:00:00Z
    Publisher Associação Brasileira de Otorrinolaringologia e Cirurgia Cervicofacial
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Análise microbiológica em secreção de seio maxilar nos pacientes com rinossinusite crônica Maxillary sinuses microbiology from patients with chronic rhinosinusitis

    Karina Mantovani / Andréia Alessandra Bisanha / Ricardo Cassiano Demarco / Edwin Tamashiro / Roberto Martinez / Wilma Terezinha Anselmo-Lima

    Brazilian Journal of Otorhinolaryngology , Vol 76, Iss 5, Pp 548-

    2010  Volume 551

    Abstract: Não existem dados definitivos e consistentes sobre a real distribuição dos microorganismos presentes em pacientes com Rinossinusite Crônica (RSC). A variabilidade dos resultados de estudos em RSC deve-se às diferentes técnicas utilizadas como método de ... ...

    Abstract Não existem dados definitivos e consistentes sobre a real distribuição dos microorganismos presentes em pacientes com Rinossinusite Crônica (RSC). A variabilidade dos resultados de estudos em RSC deve-se às diferentes técnicas utilizadas como método de coleta, variações nos métodos de cultura, uso prévio de antibiótico, dificuldade de se distinguir agentes colonizadores e patogênicos. FORMA DE ESTUDO: Clínico-prospectivo. OBJETIVO: Estudar a incidência dos microrganismos presentes nos pacientes com RSC na nossa região, através da cultura da secreção do seio maxilar, coletada sob visão endoscópica. MATERIAIS E MÉTODOS: Estudo transversal em 62 pacientes com RSC, submetidos à coleta de secreção de seio maxilar por via endoscópica, com material enviado para cultura para diagnóstico microbiológico. RESULTADOS: Das 62 amostras estudadas, em 33 (53,2%) não houve crescimento de microrganismos; 29 (45,2%) apresentaram isolamento de aeróbios; um caso (1,6%) mostrou crescimento de fungo; não houve o isolamento de microrganismos anaeróbios. Pseudomonas aeruginosa foi isolada com maior frequência - em 8 amostras (27,6%), Staphylococcus aureus e Staphylococcus epidermidis em 4 amostras cada um (13,9%), Streptococcus pneumoniae em 3 amostras (10,4%), outros Gram-negativos em 17 amostras (31%). CONCLUSÃO: Pseudomonas aeruginosa, outras bactérias Gram-negativas e Staphylococcus spp constituíram a microbiota predominante nos seios paranasais de pacientes com RSC. There isn't definitive and consistent data concerning the distribution of bacterial species in patients with Chronic Sinusitis (CS). The variability of the results from studies in CS may be due to the different techniques used as collection method, variations in culture methods, previous antibiotic use, and difficulty in distinguishing bacterial flora from pathogenic agents. STUDY DESIGN: Clinical prospective. AIM: To identify the incidence of microorganisms in patients with CRS by growing bacteria from the secretion of the maxillary sinus. PATIENTS AND METHODS: Cross-sectional study in 62 patients that had undergone FESS for treatment of chronic sinusitis; cultures from the maxillary sinus were obtained. RESULTS: 62 samples, 33 (53.2%) had no growth; 29 (45.2%) counts of aerobic bacteria; one case (1.6%) of fungus growth; we did not find anaerobic bacteria. Pseudomonas aeruginosa was the one more frequently found - 8 samples (27.6%), Staphylococcus aureus and Staphylococcus epidermidis in 4 samples each; Streptococcus pneumoniae in 3 samples (10.4%); other Gram negative agents in 17 samples (31%). CONCLUSION: In the present study we concluded that Pseudomonas aeruginosa, other Gram negatives bacteria and Staphylococcus spp were the representatives of the bacterial flora found in the paranasal sinuses of patients with CS.
    Keywords microbiologia ; sinusite ; microbiology ; sinusitis ; Otorhinolaryngology ; RF1-547 ; Medicine ; R ; DOAJ:Otorhinolaryngology ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
    Language Portuguese
    Publishing date 2010-10-01T00:00:00Z
    Publisher Associação Brasileira de Otorrinolaringologia e Cirurgia Cervicofacial
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Implications of bacterial biofilms in chronic rhinosinusitis

    Edwin Tamashiro / Marcelo B. Antunes / James N. Palmer / Noam A. Cohen / Wilma T. Anselmo-Lima

    Brazilian Journal of Infectious Diseases, Vol 13, Iss 3, Pp 232-

    2009  Volume 235

    Abstract: The recognition of sessile form of bacteria with particular features, known as biofilm, has given new insights to the understanding of pathogenesis of several chronic diseases, including Chronic Rhinosinusitis (CRS). In this article we review the main ... ...

    Abstract The recognition of sessile form of bacteria with particular features, known as biofilm, has given new insights to the understanding of pathogenesis of several chronic diseases, including Chronic Rhinosinusitis (CRS). In this article we review the main characteristics of biofilms, describe the current methods used to demonstrate biofilms in chronic rhinosinusitis and discuss the future directions of research in the field.
    Keywords Chronic rhinosinusitis ; biofilm ; planktonic bacteria ; Infectious and parasitic diseases ; RC109-216 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Internal medicine ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
    Language English
    Publishing date 2009-06-01T00:00:00Z
    Publisher Brazilian Society of Infectious Diseases
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Expression of RANTES, eotaxin-2, ICAM-1, LFA-1 and CCR-3 in chronic rhinosinusitis patients with nasal polyposis Expressão de RANTES, eotaxina-2, ICAM-1, LFA-1 e CCR-3 em pacientes com rinossinusite crônica associada à polipose nasossinusal

    Fransérgio Emílio Cavallari / Fabiana Cardoso Pereira Valera / Aline Jorge Gallego / Rafael Rossell Malinsky / Daniel Salgado Küpper / Cristiane Milanezi / João Santana da Silva / Edwin Tamashiro / Wilma Terezinha Anselmo-Lima

    Acta Cirurgica Brasileira, Vol 27, Iss 9, Pp 645-

    2012  Volume 649

    Abstract: PURPOSE: To compare gene expression of the chemokines RANTES and eotaxin-2, its receptor, CCR-3, adhesion molecule ICAM-1 and its receptor LFA-1 in eosinophilic polyps and in control normal nasal mucosa. METHODS: Gene expression was quantified by Real ... ...

    Abstract PURPOSE: To compare gene expression of the chemokines RANTES and eotaxin-2, its receptor, CCR-3, adhesion molecule ICAM-1 and its receptor LFA-1 in eosinophilic polyps and in control normal nasal mucosa. METHODS: Gene expression was quantified by Real Time PCR in polyps (n=35) and in healthy nasal mucosa (n=15). RESULTS: Eosinophilic polyps showed a higher expression of eotaxin-2 and RANTES, but not of CCR-3, ICAM-1 or LFA-1 compared to control nasal mucosa. CONCLUSION: Eosinophilic polyps present greater expression of eotaxin-2 and RANTES, but not of CCR-3, ICAM-1 or LFA-1 compared to control nasal mucosa. OBJETIVO: Comparar a expressão gênica das quimiocinas RANTES e eotaxina-2, do seu receptor CCR-3, da molécula de adesão ICAM-1 e do seu receptor LFA-1 entre pólipos nasais eosinofílicos (PE) (n=35) e mucosa nasal controle (n=15). MÉTODOS: Quantificou-se a expressão gênica dos mediadores citados pela técnica de PCR em tempo real em PEs e em mucosas de concha média de pacientes sem doenças nasais ou alteração endoscópica. RESULTADOS: Pólipos eosinofílicos apresentam maior expressão de eotaxina-2 e RANTES, mas não de CCR-3, ICAM-1 e LFA-1, quando comparados as mucosas nasais controles. CONCLUSÃO: Pólipos eosinofícios apresentaram maior expressão de eotaxin-2 and RANTES, mas não de CCR-3, ICAM-1 ou LFA-1,comparada à mucosa nasal controle.
    Keywords Pólipos Nasais ; Quimiocinas ; Molécula 1 de Adesão Intercelular ; Sinusite ; Nasal Polyps ; Chemokines ; Intercellular Adhesion Molecule-1 ; Sinusitis ; Surgery ; RD1-811 ; Medicine ; R ; DOAJ:Surgery ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
    Language English
    Publishing date 2012-09-01T00:00:00Z
    Publisher Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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