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  1. AU="Eeg-Olofsson, Karin Edebol"
  2. AU="Hosokawa, Yuri"
  3. AU="Christophi, Christopher"
  4. AU="Ren, Zhiyun"
  5. AU="Sabari, Benjamin R"
  6. AU="Sellal, Nabila"
  7. AU="Kamei, Yoshiki"
  8. AU="Htun Nyunt, Oo"
  9. AU="Lalonde, Donald H"
  10. AU=Olliaro Piero L AU=Olliaro Piero L
  11. AU="Fortney, J J"

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  1. Buch: Pediatric clinical neurophysiology

    Eeg-Olofsson, Karin Edebol

    (International review of child n neurology series)

    2006  

    Körperschaft International Child Neurology Association
    Verfasserangabe ed. by Karin Edebol Eeg-Olofsson. International Child Neurology Association
    Serientitel International review of child n neurology series
    Sprache Englisch
    Umfang VI, 254 S. : Ill., graph. Darst.
    Verlag Mac Keith
    Erscheinungsort London
    Erscheinungsland Vereinigtes Königreich
    Dokumenttyp Buch
    HBZ-ID HT014833578
    ISBN 1-898-68348-4 ; 978-1-898-68348-3
    Datenquelle Katalog ZB MED Medizin, Gesundheit

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    2007 A 2018 bestellbar zur Ausleihe Magazin

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  2. Buch: Paediatric clinical neurophysiology

    Eeg-Olofsson, Karin Edebol

    (International review of child neurology series)

    2006  

    Titelvarianten Pediatric clinical neurophysiology
    Körperschaft International Child Neurology Association
    Verfasserangabe edited by Karin Edebol Eeg-Olofsson
    Serientitel International review of child neurology series
    Mesh-Begriff(e) Nervous System Diseases/physiopathology ; Neurophysiology/methods ; Diagnostic Techniques, Neurological ; Child
    Sprache Englisch
    Umfang vi, 254 p. :, ill. ;, 24 cm.
    Verlag Mac Keith Press for the International Child Neurology Association
    Erscheinungsort London
    Dokumenttyp Buch
    ISBN 9781898683483 ; 1898683484
    Datenquelle Katalog der US National Library of Medicine (NLM)

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  3. Artikel: Techniques in pediatric neurophysiology.

    Eeg-Olofsson, Karin Edebol

    Supplements to Clinical neurophysiology

    2005  Band 57, Seite(n) 137–144

    Mesh-Begriff(e) Child ; Electric Stimulation/methods ; Electromyography/methods ; Humans ; Muscle, Skeletal/physiology ; Nerve Fibers/physiology ; Nervous System Diseases/diagnosis ; Nervous System Diseases/physiopathology ; Neural Conduction/physiology ; Neurophysiology/methods
    Sprache Englisch
    Erscheinungsdatum 2005-08-08
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article ; Review
    ISSN 1567-424X
    ISSN 1567-424X
    DOI 10.1016/s1567-424x(09)70351-4
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Physiological and structural anorectal abnormalities in patients with systemic sclerosis and fecal incontinence.

    Franck-Larsson, Karin / Graf, Wilhelm / Eeg-Olofsson, Karin Edebol / Axelson, Hans W / Rönnblom, Anders

    Scandinavian journal of gastroenterology

    2014  Band 49, Heft 9, Seite(n) 1076–1083

    Abstract: Objective: Fecal incontinence is common in systemic sclerosis (SSc), but the underlying mechanisms are not fully understood. The objectives of this study were to characterize anorectal physiological and morphological defects in SSc patients and to ... ...

    Abstract Objective: Fecal incontinence is common in systemic sclerosis (SSc), but the underlying mechanisms are not fully understood. The objectives of this study were to characterize anorectal physiological and morphological defects in SSc patients and to correlate the results with incontinence symptoms.
    Materials and methods: Twenty-five SSc patients underwent anorectal neurophysiological investigations, anal manometry, and ultrasound.
    Results: Eleven patients (44%) reported incontinence to solid or liquid feces, but no patient reported diarrhea. Increased fiber density (FD) was recorded in 78% of patients with and in 86% of patients without fecal incontinence not significant (NS). Incontinent patients had lower squeeze pressure (SP; median 49.5 mm Hg) in the high-pressure zone (HPZ) than continent patients (median 72 mm Hg; p = 0.01). In two of the incontinent patients, sonographic abnormalities of the internal anal sphincter (IAS) and the external anal sphincter (EAS) were present, whereas in another two patients isolated IAS abnormalities were seen. These four individuals had lower resting pressure at 1 cm and in the HPZ, and lower SP at 2 cm than patients with normal anorectal sonographic findings (p < 0.05).
    Conclusion: Lower voluntary SP in incontinent patients and EAS sonographic abnormalities only in patients with incontinence suggest that the EAS is more important in maintaining fecal continence in SSc patients than has previously been reported. The finding of increased FD in most patients further supports involvement of the EAS function in SSc and could indicate previous nerve injury with consequent incomplete reinnervation.
    Mesh-Begriff(e) Adult ; Aged ; Anal Canal/diagnostic imaging ; Anal Canal/physiopathology ; Electromyography ; Fecal Incontinence/diagnostic imaging ; Fecal Incontinence/etiology ; Fecal Incontinence/physiopathology ; Female ; Humans ; Male ; Manometry ; Middle Aged ; Pressure ; Proctoscopy ; Quality of Life ; Scleroderma, Systemic/complications ; Scleroderma, Systemic/diagnostic imaging ; Scleroderma, Systemic/physiopathology ; Ultrasonography
    Sprache Englisch
    Erscheinungsdatum 2014-09
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 82042-8
    ISSN 1502-7708 ; 0036-5521
    ISSN (online) 1502-7708
    ISSN 0036-5521
    DOI 10.3109/00365521.2014.913188
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel: Evaluation of the paradoxical sphincter contraction by a strain/squeeze index in constipated patients.

    Karlbom, Urban / Eeg-Olofsson, Karin Edebol / Graf, Wilhelm / Påhlman, Lars

    Diseases of the colon and rectum

    2005  Band 48, Heft 10, Seite(n) 1923–1929

    Abstract: Purpose: One finding in patients with constipation is the paradoxical puborectalis contraction, i.e. , activation of the sphincter muscles during straining instead of relaxation. The aims of this study were to evaluate the importance of needle placement ...

    Abstract Purpose: One finding in patients with constipation is the paradoxical puborectalis contraction, i.e. , activation of the sphincter muscles during straining instead of relaxation. The aims of this study were to evaluate the importance of needle placement in sphincter-electromyography and to evaluate a strain/squeeze index in constipated patients and control subjects.
    Methods: We investigated consecutively 194 constipated patients and 16 control subjects with integrated electromyography during straining and squeezing and calculated a strain/squeeze index. The examination was performed in the puborectalis and in the external anal sphincter muscle through hook-electrodes.
    Results: There was a strong correlation between indices in the puborectalis muscle and in the external anal sphincter muscle (r = 0.70-0.80, P < 0.001). Forty-seven patients (24 percent) had a mean index of greater than 50 compared with none in the control group (P = 0.01). Mean overall index in patients was 24 (range, 0-306) vs. 18 (range, 0-45) in controls (P = 0.12). Patients with an index greater than 50 had impaired rectal evacuation (P < 0.001), increased threshold for urge (P < 0.05), and tended to have fewer stools (P = 0.06).
    Conclusion: Quantification of paradoxical contraction in the puborectalis and external anal sphincter with a strain/squeeze index differentiates patients in whom paradoxical activity may be a cause of constipation. An index above 50 may be of pathologic significance. Correlations between activity in the puborectalis and external anal sphincter muscle were strong which suggests that investigation in one of them is sufficient.
    Mesh-Begriff(e) Adult ; Aged ; Aged, 80 and over ; Anal Canal/physiopathology ; Constipation/physiopathology ; Electromyography ; Female ; Humans ; Male ; Middle Aged ; Muscle Contraction/physiology ; Muscle Relaxation/physiology
    Sprache Englisch
    Erscheinungsdatum 2005-10
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 212581-x
    ISSN 1530-0358 ; 0012-3706
    ISSN (online) 1530-0358
    ISSN 0012-3706
    DOI 10.1007/s10350-005-0148-z
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel: Duchenne muscular dystrophy and idiopathic hyperCKemia in the same family.

    Eeg-Olofsson, Orvar / Kalimo, Hannu / Eeg-Olofsson, Karin Edebol / Jagell, Sten / Marklund, Lena / Simonsson, Linda / Dahl, Niklas

    European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society

    2008  Band 12, Heft 5, Seite(n) 404–407

    Abstract: Familial hyperCKemia is a rare condition, and a combination with Duchenne muscular dystrophy (DMD) is extremely rare. A boy showed muscle weakness from the age of 10 months and presented typical signs of DMD at the age of 18 months. The diagnosis was ... ...

    Abstract Familial hyperCKemia is a rare condition, and a combination with Duchenne muscular dystrophy (DMD) is extremely rare. A boy showed muscle weakness from the age of 10 months and presented typical signs of DMD at the age of 18 months. The diagnosis was supported by markedly elevated serum creatine kinase (CK) value as well as by neurophysiological and muscle biopsy findings at the age of 23 months. The diagnosis was confirmed by identification of a stop codon in exon 43 (p.2095Arg>X) of the dystrophin gene. Interestingly, the father and his near relatives had increased serum CK values without any clinical symptoms or signs, nor a defect in caveolin-3 gene. We suggest that the occurrence of familial hyperCKemia may have triggered the early onset of symptoms in our patient.
    Mesh-Begriff(e) Biopsy ; Child ; Child, Preschool ; Codon, Terminator/genetics ; Creatine Kinase/blood ; DNA Mutational Analysis ; Disease Progression ; Dystrophin/genetics ; Genetic Markers/genetics ; Genetic Predisposition to Disease/genetics ; Humans ; Infant ; Male ; Metabolic Diseases/enzymology ; Metabolic Diseases/genetics ; Metabolic Diseases/physiopathology ; Muscle Weakness/enzymology ; Muscle Weakness/genetics ; Muscle Weakness/physiopathology ; Muscle, Skeletal/enzymology ; Muscle, Skeletal/pathology ; Muscle, Skeletal/physiopathology ; Muscular Dystrophy, Duchenne/enzymology ; Muscular Dystrophy, Duchenne/genetics ; Muscular Dystrophy, Duchenne/physiopathology ; Mutation/genetics ; Up-Regulation/genetics
    Chemische Substanzen Codon, Terminator ; Dystrophin ; Genetic Markers ; Creatine Kinase (EC 2.7.3.2)
    Sprache Englisch
    Erscheinungsdatum 2008-10-02
    Erscheinungsland England
    Dokumenttyp Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1397146-3
    ISSN 1090-3798
    ISSN 1090-3798
    DOI 10.1016/j.ejpn.2007.10.014
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  7. Artikel: Analysis of motor pathway involvement in konzo using transcranial electrical and magnetic stimulation.

    Tshala-Katumbay, Desire / Eeg-Olofsson, Karin Edebol / Kazadi-Kayembe, Theodore / Tylleskär, Thorkild / Fällmar, Peo

    Muscle & nerve

    2002  Band 25, Heft 2, Seite(n) 230–235

    Abstract: To elucidate the involvement of motor pathways in konzo, 21 konzo subjects (mean age 22 years) underwent transcranial electrical stimulation (TES) in 1998. Fourteen konzo subjects (mean age 21 years) underwent transcranial magnetic stimulation (TMS) in ... ...

    Abstract To elucidate the involvement of motor pathways in konzo, 21 konzo subjects (mean age 22 years) underwent transcranial electrical stimulation (TES) in 1998. Fourteen konzo subjects (mean age 21 years) underwent transcranial magnetic stimulation (TMS) in 2000. Three subjects underwent both TES and TMS. Motor evoked potentials (MEPs) were recorded in the abductor pollicis brevis (APB) muscle with TES, and in the abductor digiti minimi (ADM) and tibialis anterior (TA) muscles with TMS. APB-MEPs were normal in 2 of 21 subjects and absent in 9; central conduction time (CCT) was prolonged in 10. Resting ADM-MEPs were absent in 9 of 14 subjects with clinically preserved upper limbs. Among these nine, seven subjects responded after facilitation. Most subjects (13 of 14) failed to show TA-MEPs. Of the subjects who underwent both types of stimulation, one had normal TES-MEP but abnormal ADM-MEP with TMS. These findings suggest involvement of both corticomotoneurons and motor descending pathways in konzo.
    Mesh-Begriff(e) Adolescent ; Adult ; Brain/physiopathology ; Child ; Electric Stimulation ; Evoked Potentials, Motor/physiology ; Female ; Humans ; Magnetics ; Male ; Middle Aged ; Motor Neurons/physiology ; Movement Disorders/physiopathology ; Neural Conduction/physiology ; Neural Pathways/physiopathology ; Reaction Time/physiology
    Sprache Englisch
    Erscheinungsdatum 2002-01-28
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 438353-9
    ISSN 1097-4598 ; 0148-639X
    ISSN (online) 1097-4598
    ISSN 0148-639X
    DOI 10.1002/mus.10029
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  8. Artikel ; Online: Frontotemporal dementia-amyotrophic lateral sclerosis complex is simulated by neurodegeneration with brain iron accumulation.

    Santillo, Alexander Frizell / Skoglund, Lena / Lindau, Maria / Eeg-Olofsson, Karin Edebol / Tovi, Metin / Engler, Henry / Brundin, Rose-Marie / Ingvast, Sofie / Lannfelt, Lars / Glaser, Anna / Kilander, Lena

    Alzheimer disease and associated disorders

    2009  Band 23, Heft 3, Seite(n) 298–300

    Abstract: We describe a case of late onset neurodegeneration with brain iron accumulation (NBIA) presenting as frontotemporal dementia (FTD) with amyotrophic lateral sclerosis (ALS). A male patient presented at age 66 with change of personality: disinhibition, ... ...

    Abstract We describe a case of late onset neurodegeneration with brain iron accumulation (NBIA) presenting as frontotemporal dementia (FTD) with amyotrophic lateral sclerosis (ALS). A male patient presented at age 66 with change of personality: disinhibition, emotional blunting, and socially inappropriate behavior, coupled with dysarthria, dystonia, and corticospinal tract involvement. Magnetic resonance imaging showed general cortical atrophy, iron deposits in the globus pallidus, and the "eye of the tiger" sign. Neuropsychologic performance was globally reduced, especially executive functions. Fluorodeoxyglucose positron emission tomography showed hypometabolism predominantly in frontal and temporal areas. Repeated neurophysiologic examinations showed signs of chronic denervation. The patient was diagnosed with NBIA but fulfilled consensus criteria for FTD and had a clinical picture of ALS, without neurophysiologic confirmation. Our finding introduces NBIA as a possible cause of FTD and as a differential diagnosis of the FTD-ALS complex.
    Mesh-Begriff(e) Aged ; Amyotrophic Lateral Sclerosis/physiopathology ; Brain/metabolism ; Brain/pathology ; Diagnosis, Differential ; Electromyography ; Frontotemporal Dementia/physiopathology ; Humans ; Iron/metabolism ; Magnetic Resonance Imaging ; Male ; Neuropsychological Tests ; Pantothenate Kinase-Associated Neurodegeneration/diagnosis ; Pantothenate Kinase-Associated Neurodegeneration/pathology ; Pantothenate Kinase-Associated Neurodegeneration/physiopathology ; Pedigree ; Positron-Emission Tomography
    Chemische Substanzen Iron (E1UOL152H7)
    Sprache Englisch
    Erscheinungsdatum 2009-07
    Erscheinungsland United States
    Dokumenttyp Case Reports ; Journal Article
    ZDB-ID 1002700-2
    ISSN 1546-4156 ; 0893-0341
    ISSN (online) 1546-4156
    ISSN 0893-0341
    DOI 10.1097/WAD.0b013e3181a2b76b
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