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  1. Book: Krankheit, Krankheitsursachen und -bilder

    Eferl, Robert

    (MCW-Block ; 8)

    2018  

    Author's details Robert Eferl (Hg.)
    Series title MCW-Block ; 8
    Collection
    Keywords Gefäßbiologie ; Genetik ; Histopathologie ; Immunologie ; Krankheitsentstehung ; Krebsforschung ; Psychologie ; Krankheit ; Ätiologie ; Krankheitsbild
    Subject Krankheitsursache ; Krankheit ; Erkrankung ; Krankheitszustand ; Krankheiten ; Morbus ; Nosos ; Pathos
    Subject code 616.071
    Language German
    Size 540 Seiten, Illustrationen, 28 cm, 1310 g
    Edition 11., aktualisierte Auflage
    Publisher Facultas
    Publishing place Wien
    Publishing country Austria
    Document type Book
    Old title Vorangegangen ist
    HBZ-ID HT019893238
    ISBN 978-3-7089-1694-1 ; 3-7089-1694-8
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2019 A 185 available for loan (reading room) Lesesaal EG

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  2. Book: Mouse models of cancer

    Eferl, Robert / Casanova, Emilio

    methods and protocols

    (Methods in molecular biology ; 1267 ; Springer protocols)

    2015  

    Author's details ed. by Robert Eferl ; Emilio Casanova
    Series title Methods in molecular biology ; 1267
    Springer protocols
    Collection
    Language English
    Size XI, 463 S., Ill., graph. Darst.
    Publisher Humana Press
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT018592019
    ISBN 978-1-4939-2296-3 ; 9781493922970 ; 1-4939-2296-3 ; 1493922971
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 7042 -1267- verfügbar in Königswinter Königswinter

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  3. Article ; Online: Type I and II interferon signaling in colorectal cancer liver metastasis.

    Mödl, Bernadette / Moritsch, Stefan / Zwolanek, Daniela / Eferl, Robert

    Cytokine

    2022  Volume 161, Page(s) 156075

    Abstract: Metastatic colorectal cancer is one of the leading causes of cancer-related deaths worldwide. Traditional chemotherapy extended the lifespan of cancer patients by only a few months, but targeted therapies and immunotherapy prolonged survival and led to ... ...

    Abstract Metastatic colorectal cancer is one of the leading causes of cancer-related deaths worldwide. Traditional chemotherapy extended the lifespan of cancer patients by only a few months, but targeted therapies and immunotherapy prolonged survival and led to long-term remissions in some cases. Type I and II interferons have direct pro-apoptotic and anti-proliferative effects on cancer cells and stimulate anti-cancer immunity. As a result, interferon production by cells in the tumor microenvironment is in the spotlight of immunotherapies as it affects the responses of anti-cancer immune cells. However, promoting effects of interferons on colorectal cancer metastasis have also been reported. Here we summarize our knowledge about pro- and anti-metastatic effects of type I and II interferons in colorectal cancer liver metastasis and discuss possible therapeutic implications.
    MeSH term(s) Humans ; Colorectal Neoplasms/pathology ; Immunotherapy ; Interferons ; Liver Neoplasms/secondary ; Tumor Microenvironment
    Chemical Substances Interferons (9008-11-1)
    Language English
    Publishing date 2022-10-30
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1018055-2
    ISSN 1096-0023 ; 1043-4666
    ISSN (online) 1096-0023
    ISSN 1043-4666
    DOI 10.1016/j.cyto.2022.156075
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  4. Article: CCL2 at the crossroad of cancer metastasis.

    Eferl, Robert

    JAK-STAT

    2013  Volume 2, Issue 2, Page(s) e23816

    Abstract: Primary tumors can affect organ functions, either mechanically when they grow to a considerable size or via production of hormones. However, mortality of cancer patients is in most cases due to formation of secondary growths.(1) (,) (2) Consequently, ... ...

    Abstract Primary tumors can affect organ functions, either mechanically when they grow to a considerable size or via production of hormones. However, mortality of cancer patients is in most cases due to formation of secondary growths.(1) (,) (2) Consequently, various drugs are currently employed in clinical trials to impair specific steps of cancer metastasis such as mesenchymal or amoeboid cell migration, intravasation and/or colonization.(2) From the clinical point of view, targeting late metastatic processes such as extravasation or colonization might be required for cancer patients that bear already dormant micrometastases in their capillaries which have left behind earlier metastatic steps. Development of such drugs needs characterization of molecular targets implicated in distinct steps of cancer metastasis.
    Language English
    Publishing date 2013-08-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2682221-0
    ISSN 2162-3996 ; 2162-3988
    ISSN (online) 2162-3996
    ISSN 2162-3988
    DOI 10.4161/jkst.23816
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: A dual role for interferon γ signalling in hepatocellular carcinoma.

    Eferl, Robert

    Journal of hepatology

    2012  Volume 57, Issue 5, Page(s) 940–942

    MeSH term(s) Animals ; Carcinoma, Hepatocellular/epidemiology ; Carcinoma, Hepatocellular/genetics ; Gene Deletion ; Interferon-gamma/genetics ; Liver Neoplasms/epidemiology ; Liver Neoplasms/genetics ; Receptors, Cytoplasmic and Nuclear/genetics
    Chemical Substances Receptors, Cytoplasmic and Nuclear ; farnesoid X-activated receptor ; Interferon-gamma (82115-62-6)
    Language English
    Publishing date 2012-11
    Publishing country Netherlands
    Document type Comment ; Editorial
    ZDB-ID 605953-3
    ISSN 1600-0641 ; 0168-8278
    ISSN (online) 1600-0641
    ISSN 0168-8278
    DOI 10.1016/j.jhep.2012.07.040
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2027: Show issues Location:
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  6. Book: Mouse models of cancer

    Eferl, Robert / Casanova, Emilio

    methods and protocols

    (Methods in Molecular Biology, ; 1267 ; Springer protocols,)

    2015  

    Abstract: This volume is essential for geneticists, molecular biologists, biochemists, and medical doctors interested in the use of mouse models in cancer research. Recent genome studies, together with refined genetic engineering techniques, have greatly increased ...

    Author's details edited by Robert Eferl, Emilio Casanova
    Series title Methods in Molecular Biology, ; 1267
    Springer protocols,
    Abstract This volume is essential for geneticists, molecular biologists, biochemists, and medical doctors interested in the use of mouse models in cancer research. Recent genome studies, together with refined genetic engineering techniques, have greatly increased the value of using mice for research on cancer and other human disorders. The chapters of this book will support scientists in choosing the most suitable mouse models for their research questions. The book provides detailed methodological information for genetic or chemical induction of different types of cancer, histomorphometric cancer analysis, and "in vivo" imaging, as well as protocols to investigate oncogene addiction, immune surveillance, and hallmarks of cancer such as angiogenesis or metastasis. Four review-like articles provide background information on mouse technologies and histopathologic differences between mouse and human cancers. The mouse models described in individual chapters will fuel the understanding of cancer initiation, immune system roles, tumor angiogenesis, invasion, metastasis, and the relevance of molecular diversity observed among human cancers. Written in the highly successful "Methods in Molecular Biology" series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Cutting-edge and resourceful, "Mouse Models of Cancers: Methods and Protocols, " is a valuable laboratory resource for all researchers, from the graduate level upwards, who study cancer and new possibilities for its treatment."
    MeSH term(s) Neoplasms, Experimental ; Mice ; Neoplasm Metastasis ; Neoplasm Invasiveness
    Language English
    Size xi, 463 pages :, illustrations (some color) ;, 26 cm.
    Document type Book
    ISBN 9781493922963 ; 1493922963 ; 9781493922970 ; 1493922971
    Database Catalogue of the US National Library of Medicine (NLM)

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  7. Article ; Online: CDK4/6 inhibition and sorafenib: a ménage à deux in HCC therapy?

    Calvisi, Diego / Eferl, Robert

    Gut

    2017  Volume 66, Issue 7, Page(s) 1179–1180

    MeSH term(s) Antineoplastic Agents ; Apoptosis/drug effects ; Carcinoma, Hepatocellular ; Cell Line, Tumor ; Humans ; Liver Neoplasms ; Niacinamide/analogs & derivatives ; Phenylurea Compounds ; Sorafenib
    Chemical Substances Antineoplastic Agents ; Phenylurea Compounds ; Niacinamide (25X51I8RD4) ; Sorafenib (9ZOQ3TZI87)
    Language English
    Publishing date 2017-01-05
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 80128-8
    ISSN 1468-3288 ; 0017-5749
    ISSN (online) 1468-3288
    ISSN 0017-5749
    DOI 10.1136/gutjnl-2016-313547
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 160: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  8. Article ; Online: Chromosomal instability in HCC: a key function for checkpoint kinase 2.

    Eferl, Robert / Trauner, Michael

    Gut

    2017  

    Language English
    Publishing date 2017-05-05
    Publishing country England
    Document type Editorial
    ZDB-ID 80128-8
    ISSN 1468-3288 ; 0017-5749
    ISSN (online) 1468-3288
    ISSN 0017-5749
    DOI 10.1136/gutjnl-2017-314101
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 160: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  9. Article ; Online: p21Waf1/Cip1 revisited: oncogenic function in hepatocellular carcinoma.

    Goldenberg, Daniel / Eferl, Robert

    Gut

    2013  Volume 63, Issue 9, Page(s) 1372–1373

    MeSH term(s) Animals ; Carcinogenesis/metabolism ; Carcinoma, Hepatocellular/etiology ; Cholestasis, Intrahepatic/complications ; Cyclin-Dependent Kinase Inhibitor p21/metabolism ; Female ; Hepatic Insufficiency/physiopathology ; Humans ; Liver Neoplasms/etiology ; Liver Regeneration/physiology ; Male
    Chemical Substances Cyclin-Dependent Kinase Inhibitor p21
    Language English
    Publishing date 2013-11-12
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 80128-8
    ISSN 1468-3288 ; 0017-5749
    ISSN (online) 1468-3288
    ISSN 0017-5749
    DOI 10.1136/gutjnl-2013-306343
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Defects in microvillus crosslinking sensitize to colitis and inflammatory bowel disease.

    Mödl, Bernadette / Awad, Monira / Zwolanek, Daniela / Scharf, Irene / Schwertner, Katharina / Milovanovic, Danijela / Moser, Doris / Schmidt, Katy / Pjevac, Petra / Hausmann, Bela / Krauß, Dana / Mohr, Thomas / Svinka, Jasmin / Kenner, Lukas / Casanova, Emilio / Timelthaler, Gerald / Sibilia, Maria / Krieger, Sigurd / Eferl, Robert

    EMBO reports

    2023  Volume 24, Issue 10, Page(s) e57084

    Abstract: Intestinal epithelial cells are covered by the brush border, which consists of densely packed microvilli. The Intermicrovillar Adhesion Complex (IMAC) links the microvilli and is required for proper brush border organization. Whether microvillus ... ...

    Abstract Intestinal epithelial cells are covered by the brush border, which consists of densely packed microvilli. The Intermicrovillar Adhesion Complex (IMAC) links the microvilli and is required for proper brush border organization. Whether microvillus crosslinking is involved in the intestinal barrier function or colitis is currently unknown. We investigate the role of microvillus crosslinking in colitis in mice with deletion of the IMAC component CDHR5. Electron microscopy shows pronounced brush border defects in CDHR5-deficient mice. The defects result in severe mucosal damage after exposure to the colitis-inducing agent DSS. DSS increases the permeability of the mucus layer and brings bacteria in direct contact with the disorganized brush border of CDHR5-deficient mice. This correlates with bacterial invasion into the epithelial cell layer which precedes epithelial apoptosis and inflammation. Single-cell RNA sequencing data of patients with ulcerative colitis reveals downregulation of CDHR5 in enterocytes of diseased areas. Our results provide experimental evidence that a combination of microvillus crosslinking defects with increased permeability of the mucus layer sensitizes to inflammatory bowel disease.
    Language English
    Publishing date 2023-09-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 2020896-0
    ISSN 1469-3178 ; 1469-221X
    ISSN (online) 1469-3178
    ISSN 1469-221X
    DOI 10.15252/embr.202357084
    Database MEDical Literature Analysis and Retrieval System OnLINE

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