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  1. Article: The Role of Climate Change in Asthma.

    Goshua, Anna / Sampath, Vanitha / Efobi, Jo Ann / Nadeau, Kari

    Advances in experimental medicine and biology

    2023  Volume 1426, Page(s) 25–41

    Abstract: Human activity and increased use of fossil fuels have led to climate change. These changes are adversely affecting human health, including increasing the risk of developing asthma. Global temperatures are predicted to increase in the future. In 2019, ... ...

    Abstract Human activity and increased use of fossil fuels have led to climate change. These changes are adversely affecting human health, including increasing the risk of developing asthma. Global temperatures are predicted to increase in the future. In 2019, asthma affected an estimated 262 million people and caused 455,000 deaths. These rates are expected to increase. Climate change by intensifying climate events such as drought, flooding, wildfires, sand storms, and thunderstorms has led to increases in air pollution, pollen season length, pollen and mold concentration, and allergenicity of pollen. These effects bear implications for the onset, exacerbation, and management of childhood asthma and are increasing health inequities. Global efforts to mitigate the effects of climate change are urgently needed with the goal of limiting global warming to between 1.5 and 2.0 °C of preindustrial times as per the 2015 Paris Agreement. Clinicians need to take an active role in these efforts in order to prevent further increases in asthma prevalence. There is a role for clinician advocacy in both the clinical setting as well as in local, regional, and national settings to install measures to control and curb the escalating disease burden of childhood asthma in the setting of climate change.
    MeSH term(s) Humans ; Climate Change ; Asthma/epidemiology ; Allergens/adverse effects ; Air Pollution/adverse effects ; Pollen/adverse effects
    Chemical Substances Allergens
    Language English
    Publishing date 2023-07-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 410187-X
    ISSN 0065-2598
    ISSN 0065-2598
    DOI 10.1007/978-3-031-32259-4_2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Acute and chronic impacts of heat stress on planetary health.

    Sampath, Vanitha / Shalakhti, Omar / Veidis, Erika / Efobi, Jo Ann Ifeoma / Shamji, Mohamed H / Agache, Ioana / Skevaki, Chrysanthi / Renz, Harald / Nadeau, Kari C

    Allergy

    2023  Volume 78, Issue 8, Page(s) 2109–2120

    Abstract: Heat waves are increasing in intensity, frequency, and duration causing significant heat stress in all living organisms. Heat stress has multiple negative effects on plants affecting photosynthesis, respiration, growth, development, and reproduction. It ... ...

    Abstract Heat waves are increasing in intensity, frequency, and duration causing significant heat stress in all living organisms. Heat stress has multiple negative effects on plants affecting photosynthesis, respiration, growth, development, and reproduction. It also impacts animals leading to physiological and behavioral alterations, such as reduced caloric intake, increased water intake, and decreased reproduction and growth. In humans, epidemiological studies have shown that heat waves are associated with increased morbidity and mortality. There are many biological effects of heat stress (structural changes, enzyme function disruption, damage through reactive oxygen or nitrogen species). While plants and animals can mitigate some of these effects through adaptive mechanisms such as the generation of heat shock proteins, antioxidants, stress granules, and others, these mechanisms may likely be inadequate with further global warming. This review summarizes the effects of heat stress on plants and animals and the adaptative mechanisms that have evolved to counteract this stress.
    MeSH term(s) Humans ; Animals ; Heat-Shock Response ; Photosynthesis ; Antioxidants ; Stress, Physiological
    Chemical Substances Antioxidants
    Language English
    Publishing date 2023-04-09
    Publishing country Denmark
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 391933-x
    ISSN 1398-9995 ; 0105-4538
    ISSN (online) 1398-9995
    ISSN 0105-4538
    DOI 10.1111/all.15702
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Acute and chronic impacts of heat stress on planetary health

    Sampath, Vanitha / Shalakhti, Omar / Veidis, Erika / Efobi, Jo Ann Ifeoma / Shamji, Mohamed H. / Agache, Ioana / Skevaki, Chrysanthi / Renz, H. / Nadeau, Kari C.

    Allergy. 2023 Aug., v. 78, no. 8, p. 2109-2120

    2023  , Page(s) 2109–2120

    Abstract: Heat waves are increasing in intensity, frequency, and duration causing significant heat stress in all living organisms. Heat stress has multiple negative effects on plants affecting photosynthesis, respiration, growth, development, and reproduction. It ... ...

    Abstract Heat waves are increasing in intensity, frequency, and duration causing significant heat stress in all living organisms. Heat stress has multiple negative effects on plants affecting photosynthesis, respiration, growth, development, and reproduction. It also impacts animals leading to physiological and behavioral alterations, such as reduced caloric intake, increased water intake, and decreased reproduction and growth. In humans, epidemiological studies have shown that heat waves are associated with increased morbidity and mortality. There are many biological effects of heat stress (structural changes, enzyme function disruption, damage through reactive oxygen or nitrogen species). While plants and animals can mitigate some of these effects through adaptive mechanisms such as the generation of heat shock proteins, antioxidants, stress granules, and others, these mechanisms may likely be inadequate with further global warming. This review summarizes the effects of heat stress on plants and animals and the adaptative mechanisms that have evolved to counteract this stress.
    Keywords energy intake ; enzymes ; heat ; heat stress ; hypersensitivity ; morbidity ; mortality ; nitrogen ; oxygen ; photosynthesis ; reproduction
    Language English
    Dates of publication 2023-08
    Size p. 2109-2120
    Publishing place John Wiley & Sons, Ltd
    Document type Article ; Online
    Note REVIEW
    ZDB-ID 391933-x
    ISSN 1398-9995 ; 0105-4538
    ISSN (online) 1398-9995
    ISSN 0105-4538
    DOI 10.1111/all.15702
    Database NAL-Catalogue (AGRICOLA)

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  4. Article ; Online: Climate change and public health: The effects of global warming on the risk of allergies and autoimmune diseases: The effects of global warming on the risk of allergies and autoimmune diseases.

    Lee, Alexandra S / Aguilera, Juan / Efobi, Jo Ann / Jung, Youn Soo / Seastedt, Hana / Shah, Mihir M / Yang, Emily / Konvinse, Katherine / Utz, Paul J / Sampath, Vanitha / Nadeau, Kari C

    EMBO reports

    2023  Volume 24, Issue 4, Page(s) e56821

    Abstract: Global climate change and extreme weather events are associated with epigenetic modifications in immune cells, leading to the possible increased risk and prevalence of allergies and autoimmune diseases. ...

    Abstract Global climate change and extreme weather events are associated with epigenetic modifications in immune cells, leading to the possible increased risk and prevalence of allergies and autoimmune diseases.
    MeSH term(s) Humans ; Climate Change ; Global Warming ; Public Health ; Hypersensitivity/epidemiology ; Hypersensitivity/etiology ; Autoimmune Diseases/epidemiology ; Autoimmune Diseases/etiology
    Language English
    Publishing date 2023-02-27
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2020896-0
    ISSN 1469-3178 ; 1469-221X
    ISSN (online) 1469-3178
    ISSN 1469-221X
    DOI 10.15252/embr.202356821
    Database MEDical Literature Analysis and Retrieval System OnLINE

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