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Article: Cholesterol Pleural Effusion - "Pseudochylothorax" in a Smoker.

Kooblal, M / Cadogan, S / Egan, J J

2020 Volume 113, Issue 7, Page(s) 135

Language	English
Publishing date	2020-07-30
Publishing country	Ireland
Document type	Letter
ZDB-ID	193134-9
ISSN	0332-3102 ; 0021-129X
ISSN	0332-3102 ; 0021-129X
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Article ; Online: Follow-up and nonpharmacological management of the idiopathic pulmonary fibrosis patient.

Egan, J J

European respiratory review : an official journal of the European Respiratory Society

2010 Volume 20, Issue 120, Page(s) 114–117

Abstract: Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, fatal form of diffuse interstitial lung disease. Management of IPF requires an orderly approach, with regular evaluations and implementation of both pharmacological and nonpharmacological ... ...

Abstract	Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, fatal form of diffuse interstitial lung disease. Management of IPF requires an orderly approach, with regular evaluations and implementation of both pharmacological and nonpharmacological treatments. Pulmonary rehabilitation can relieve patients from the distressing symptoms of IPF and improve quality of life. Oxygen therapy is central to treatment of all patients. Lung transplantation enhances survival in selected patients. Mechanical ventilation may be used in patients with acute exacerbations, but the prognosis is poor in these cases. Palliative care focuses on symptom management, advance directives and end-of-life planning. Patient support groups may also play an important role.
MeSH term(s)	Disease Progression ; Humans ; Idiopathic Pulmonary Fibrosis/diagnosis ; Idiopathic Pulmonary Fibrosis/therapy ; Lung Transplantation ; Oxygen Inhalation Therapy ; Palliative Care ; Respiration, Artificial ; Time Factors ; Treatment Outcome
Language	English
Publishing date	2010-11-08
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1077620-5
ISSN	1600-0617 ; 0905-9180
ISSN (online)	1600-0617
ISSN	0905-9180
DOI	10.1183/09059180.00001811
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Zs.A 3265: Show issues

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Article: Acute Respiratory Failure Post Single Lung Transplantation: An Unusual Cause.

Daly, A / Egan, J J / Redmond, K C

Irish medical journal

2017 Volume 110, Issue 9, Page(s) 637

Abstract: Vascular complications of pulmonary vessels post-transplant are rare but are associated with high morbidity and mortality. We describe the first published case of surgical management of pulmonary vein stenosis complicated by early thrombosis post single ... ...

Abstract	Vascular complications of pulmonary vessels post-transplant are rare but are associated with high morbidity and mortality. We describe the first published case of surgical management of pulmonary vein stenosis complicated by early thrombosis post single lung transplantation. This report describes early diagnostic techniques and subsequent management options in such patients where pulmonary vascular complications are a potential.
MeSH term(s)	Acute Disease ; Humans ; Lung Transplantation/adverse effects ; Postoperative Complications/etiology ; Pulmonary Embolism/etiology ; Respiratory Distress Syndrome, Adult ; Respiratory Insufficiency/etiology ; Stenosis, Pulmonary Vein/etiology ; Time Factors
Language	English
Publishing date	2017-10-10
Publishing country	Ireland
Document type	Case Reports ; Journal Article
ZDB-ID	193134-9
ISSN	0332-3102 ; 0021-129X
ISSN	0332-3102 ; 0021-129X
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Zs.B 148: Show issues

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Article: The Efficacy of Bronchial Thermoplasty for Severe Persistent Asthma: The First National Experience.

Watchorn, D C / Sahadevan, A / Egan, J J / Lane, S J

Irish medical journal

2016 Volume 109, Issue 5, Page(s) 406

Abstract: There is an unmet need for new therapies in severe persistent asthma. Bronchial thermoplasty is a bronchoscopic procedure which employs radiofrequency energy to reduce airway smooth muscle and has been demonstrated to improve symptomatic control in ... ...

Abstract	There is an unmet need for new therapies in severe persistent asthma. Bronchial thermoplasty is a bronchoscopic procedure which employs radiofrequency energy to reduce airway smooth muscle and has been demonstrated to improve symptomatic control in severe persistent asthma in other populations. Seven patients have completed bronchial thermoplasty at a tertiary referral centre in Ireland. Asthma Control Test scores and data on hospitalisations, exacerbations, maintenance corticosteroid requirements, rescue bronchodilator use and peak expiratory flow rate (PEFR) were compared one year before and one year post treatment. Significant improvements were demonstrated in mean Asthma Control Test scores, from 8.9 to 14.7 (p = 0.036). Trends towards improvement were seen in mean hospitalisations (respective values for total in 12 month period 5.0, 0.9; p = 0.059) and PEFR (181.4 l/min, 280 l/min respectively; p = 0.059). These data support the use of bronchial thermoplasty in severe persistent asthma in the Irish population.
Language	English
Publishing date	2016-05-10
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	193134-9
ISSN	0332-3102 ; 0021-129X
ISSN	0332-3102 ; 0021-129X
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Article ; Online: A multidisciplinary evaluation of suspected, non-confirmed cases of COVID-19 including chest CT, as compared to World Health Organization recommendations.

McGrath, J / Kenny, C / Smyth, H / McGinty, T / Sheehan, G / Gaine, S / McCullagh, B / MacMahon, P / Egan, J J / Cotter, A

Clinical radiology

2021 Volume 76, Issue 5, Page(s) 384–390

Abstract: Aim: To report an audit of the evaluation of suspected, unconfirmed cases of COVID-19 including chest computed tomography (CT), as compared to World Health Organization recommendations.: Methods: A clinical audit was undertaken examining the ... ...

Abstract	Aim: To report an audit of the evaluation of suspected, unconfirmed cases of COVID-19 including chest computed tomography (CT), as compared to World Health Organization recommendations. Methods: A clinical audit was undertaken examining the evaluation of patients with suspected COVID-19 with negative SARS-CoV-2 reverse transcriptase polymerase chain reaction (RT-PCR) results, with comparison to WHO recommendations. A retrospective chart review was undertaken for 90 patients examining investigations, in particular CT, used to clarify the diagnosis. Results: Ninety patients underwent additional investigation. Seventy-five per cent adherence to WHO recommendations was observed. Fifty-two men (57.78%) and 38 (42.22%) women were investigated, with a median age of 69 years (range 20-96 years). Seventy-nine chest CT examinations demonstrated positive, indeterminate, and negative rates for COVID-19 of 3.79%, 24.1%, and 72.15% respectively. Three patients had discordant swab results with initially negative and subsequently positive results for SARS-CoV-2, resulting in false-negative rates of 5.1% for those retested. Combining discordant RT-PCR swab results, positive radiology, and patients treated as COVID-19-positive due to indeterminate radiology and highly consistent symptoms, resulted in a false-negative rate for initial SARS-CoV-2 RT-PCR swabs of 16.67%. Conclusion: Seventy-five per cent compliance with relevant WHO guidance and a false-negative rate for initial swabs of 16.67% was demonstrated. Further evidence is needed to fully determine the utility of chest CT in the diagnosis of COVID-19 in the context of initial false-negative RT-PCR results.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; COVID-19/diagnostic imaging ; COVID-19 Nucleic Acid Testing ; Critical Pathways ; False Negative Reactions ; Female ; Guideline Adherence ; Humans ; Lung/diagnostic imaging ; Male ; Medical Audit ; Middle Aged ; Patient Care Team ; Practice Guidelines as Topic ; Retrospective Studies ; SARS-CoV-2 ; Tomography, X-Ray Computed ; World Health Organization ; Young Adult
Language	English
Publishing date	2021-02-23
Publishing country	England
Document type	Journal Article
ZDB-ID	391227-9
ISSN	1365-229X ; 0009-9260
ISSN (online)	1365-229X
ISSN	0009-9260
DOI	10.1016/j.crad.2021.02.006
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Article ; Online: The efficacy and safety of bronchial thermoplasty in severe persistent asthma on extended follow-up.

O'Reilly, A / Browne, I / Watchorn, D / Egan, J J / Lane, S

QJM : monthly journal of the Association of Physicians

2017 Volume 111, Issue 3, Page(s) 155–159

Abstract: Background: Asthma is a common condition and there remains a subset of patients who are poorly controlled on maximal therapy. Bronchial thermoplasty (BT) is a bronchoscopic therapy using radiofrequency energy to reduce airway smooth muscle, which has ... ...

Abstract	Background: Asthma is a common condition and there remains a subset of patients who are poorly controlled on maximal therapy. Bronchial thermoplasty (BT) is a bronchoscopic therapy using radiofrequency energy to reduce airway smooth muscle, which has been shown to improve asthma control although further evidence regarding long-term efficacy and safety is required. Aim: We aimed to demonstrate safety and efficacy of BT on extended follow-up. Our initial experience with this group was previously reported in 2016, where patients were shown to have a significant improvement in asthma control test (ACT) scores 1-year post-treatment. Design: We carried out a retrospective observational study of seven patients who underwent BT between 2012 and 2013 in an Irish severe asthma centre. The primary endpoint was change in ACT scores from baseline to present. Methods: Seven patients underwent BT at a tertiary referral centre in Ireland. ACT scores and data on hospital admissions, exacerbations, maintenance corticosteroid requirements, rescue bronchodilator use and forced expiratory volume for 1 s (FEV1) prior to the procedure and on extended follow-up were collected. Mean follow-up was 49.42 months. Results: A trend towards improvement was seen in median hospitalisations (respective values for median over 12 months 3, 1 P = 0.059) and ACT scores, from 9 to 13 (P = 0.249). Mean FEV1 was 1.68 l prior to treatment and 1.46 l 4 years post-treatment (P = 0.237). There was no mortality among the group. Conclusions: These data support the safety of BT and suggest extended efficacy.
MeSH term(s)	Adult ; Aged ; Asthma/drug therapy ; Asthma/physiopathology ; Asthma/surgery ; Bronchial Thermoplasty/adverse effects ; Bronchial Thermoplasty/methods ; Bronchodilator Agents/administration & dosage ; Drug Administration Schedule ; Female ; Follow-Up Studies ; Forced Expiratory Volume/physiology ; Glucocorticoids/administration & dosage ; Hospitalization/statistics & numerical data ; Humans ; Male ; Middle Aged ; Retrospective Studies ; Severity of Illness Index ; Treatment Outcome
Chemical Substances	Bronchodilator Agents ; Glucocorticoids
Language	English
Publishing date	2017-11-16
Publishing country	England
Document type	Journal Article ; Observational Study
ZDB-ID	1199985-8
ISSN	1460-2393 ; 0033-5622 ; 1460-2725
ISSN (online)	1460-2393
ISSN	0033-5622 ; 1460-2725
DOI	10.1093/qjmed/hcx221
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Article ; Online: Successful pregnancy outcome in a patient following heart, lung and renal transplant.

Dhonnchu, Tara Ni / Regan, Carmen / Egan, J J

Transplant international : official journal of the European Society for Organ Transplantation

2012 Volume 25, Issue 3, Page(s) e43–4

MeSH term(s)	Adult ; Cesarean Section ; Cystic Fibrosis/surgery ; Female ; Heart Transplantation ; Humans ; Infant, Newborn ; Kidney Transplantation ; Live Birth ; Lung Transplantation ; Pregnancy ; Pregnancy Complications
Language	English
Publishing date	2012-03
Publishing country	England
Document type	Case Reports ; Letter
ZDB-ID	639435-8
ISSN	1432-2277 ; 0934-0874
ISSN (online)	1432-2277
ISSN	0934-0874
DOI	10.1111/j.1432-2277.2011.01414.x
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Article: New treatments for pulmonary fibrosis?

Egan, J J

Lancet (London, England)

1999 Volume 354, Issue 9193, Page(s) 1839–1840

MeSH term(s)	Antihypertensive Agents/therapeutic use ; Antineoplastic Agents/therapeutic use ; Epoprostenol/therapeutic use ; Humans ; Iloprost/therapeutic use ; Interferon-gamma/therapeutic use ; Pulmonary Fibrosis/drug therapy ; Pulmonary Fibrosis/pathology ; Recombinant Proteins ; Vasodilator Agents/therapeutic use
Chemical Substances	Antihypertensive Agents ; Antineoplastic Agents ; Recombinant Proteins ; Vasodilator Agents ; Interferon-gamma (82115-62-6) ; Epoprostenol (DCR9Z582X0) ; Iloprost (JED5K35YGL)
Language	English
Publishing date	1999-11-27
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	3306-6
ISSN	1474-547X ; 0140-6736 ; 0023-7507
ISSN (online)	1474-547X
ISSN	0140-6736 ; 0023-7507
DOI	10.1016/S0140-6736(99)00347-5
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Article ; Online: Renal transplantation outcomes following heart and heart-lung transplantation.

Wong, L / Chee, Y R / Healy, D G / Egan, J J / Sadlier, D M / O'Meara, Y M

Irish journal of medical science

2017 Volume 186, Issue 4, Page(s) 1027–1032

Abstract: Background: Chronic kidney disease is a frequent complication following heart and combined heart-lung transplantation. The aim of this study was to analyse the outcome of a subsequent renal transplant in heart, lung and heart-lung transplantation ... ...

Abstract	Background: Chronic kidney disease is a frequent complication following heart and combined heart-lung transplantation. The aim of this study was to analyse the outcome of a subsequent renal transplant in heart, lung and heart-lung transplantation recipients. Methods: All heart, lung and heart-lung transplant recipients who received a subsequent renal transplant over a 27-year period in a national heart and lung transplant centre were included in this study. Results: A total of 18 patients who had previously undergone heart (n = 6), lung (n = 7) and heart-lung (n = 5) transplantation received a renal transplant. The mean duration to development of end-stage kidney disease (ESKD) was 115 ± 45.9 months. The most common contributor to ESKD was calcineurin inhibitor nephrotoxicity. The 5-year patient survival and graft survival rates were 91.7 and 85.6%, respectively. The median creatinine level at the most recent follow-up was 123 μmol/L, IQR 90.8-147.5. Conclusions: The overall outcome of renal transplantation following previous non-renal solid organ transplantation is excellent considering the medical complexity and co-morbidities of this patient population. Renal transplantation represents an important treatment option for ESKD in non-renal solid organ transplant recipients.
Language	English
Publishing date	2017-11
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	390895-1
ISSN	1863-4362 ; 0021-1265
ISSN (online)	1863-4362
ISSN	0021-1265
DOI	10.1007/s11845-016-1550-3
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Article ; Online: Declining incidence of keratinocyte carcinoma in organ transplant recipients.

Menzies, S / O'Leary, E / Callaghan, G / Galligan, M / Deady, S / Gadallah, B / Lenane, P / Lally, A / Houlihan, D D / Morris, P G / Sexton, D J / McCormick, P A / Egan, J J / O'Neill, J P / Conlon, P J / Moloney, F J

The British journal of dermatology

2019 Volume 181, Issue 5, Page(s) 983–991

Abstract: Background: All organ transplant populations are predisposed to increased rates of keratinocyte carcinoma (KC). Since this increased risk was first appreciated, immunosuppressive regimens have changed and organ transplant recipients (OTRs) have been ... ...

Abstract	Background: All organ transplant populations are predisposed to increased rates of keratinocyte carcinoma (KC). Since this increased risk was first appreciated, immunosuppressive regimens have changed and organ transplant recipients (OTRs) have been aggressively screened for KC. There is a perception that these measures have impacted on KC incidence but there is a paucity of population-based studies on post-transplant rates of basal cell carcinoma (BCC). Objectives: To identify trends in incidence rates for KC following solid organ transplantation over the past two decades. Methods: This nationwide, population-based study included all solid OTRs transplanted between 1994 and 2014. Patient data were matched to national cancer registry data to determine the standardized incidence ratio (SIR) of KC in solid OTRs compared with the general population. Results: In total 3580 solid OTRs were included. The total follow-up time was 28 407 person-years (median follow-up 7·11 years). The overall SIRs for squamous cell carcinoma (SCC) and BCC were 19·7 and 7·0, respectively. Our study documents a progressive fall in the SIRs for SCC and BCC from peak SIRs (95% confidence intervals) in 1994-1996 of 26·4 (21·5-32·4) and 9·1 (7·4-11·3) to 6·3 (2·3-16·7) and 3·2 (1·4-7·1) in 2012-2014, respectively. The ratio of SCC to BCC has remained at 3 to 1 over the last two decades. Conclusions: Our study is the first to demonstrate a significant reduction over the past two decades in the incidences of both SCC and BCC following solid organ transplantation. The SCC-to-BCC ratio was maintained, demonstrating that both are reducing equally. This trend coincided with temporal changes in immunosuppressive protocols and the introduction of skin cancer prevention programmes. What's already known about this topic? Prior studies have shown that the risk of cutaneous squamous cell carcinoma (SCC) has declined over recent decades following solid organ transplantation. It is not known whether the risk of basal cell carcinoma (BCC) has reduced in line with this. What does this study add? Our study documents a progressive fall in the risk of SCC and BCC following solid organ transplantation over the last two decades. The SCC-to-BCC ratio was maintained, demonstrating that both are reducing equally. The trends observed in our study coincided with temporal changes in immunosuppressive protocols and the introduction of cancer prevention programmes, suggesting that these factors have positively impacted on the risk of keratinocyte carcinoma in this cohort.
MeSH term(s)	Adolescent ; Adult ; Aged ; Carcinoma, Basal Cell/epidemiology ; Carcinoma, Basal Cell/etiology ; Carcinoma, Basal Cell/prevention & control ; Carcinoma, Squamous Cell/epidemiology ; Carcinoma, Squamous Cell/etiology ; Carcinoma, Squamous Cell/prevention & control ; Child ; Child, Preschool ; Female ; Follow-Up Studies ; Graft Rejection/immunology ; Graft Rejection/prevention & control ; Humans ; Immunosuppression/adverse effects ; Immunosuppression/methods ; Incidence ; Infant ; Ireland/epidemiology ; Male ; Middle Aged ; Organ Transplantation/adverse effects ; Registries/statistics & numerical data ; Skin Neoplasms/epidemiology ; Skin Neoplasms/etiology ; Skin Neoplasms/prevention & control ; Transplant Recipients/statistics & numerical data ; Young Adult
Language	English
Publishing date	2019-05-02
Publishing country	England
Document type	Journal Article
ZDB-ID	80076-4
ISSN	1365-2133 ; 0007-0963
ISSN (online)	1365-2133
ISSN	0007-0963
DOI	10.1111/bjd.18094
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