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  1. Article ; Online: Response by Egbe to Letter Regarding Article, "Right Heart Dysfunction in Adults With Coarctation of Aorta: Prevalence and Prognostic Implications".

    Egbe, Alexander C

    Circulation. Cardiovascular imaging

    2022  Volume 15, Issue 3, Page(s) e014007

    MeSH term(s) Adult ; Aorta/physiopathology ; Aortic Coarctation/diagnostic imaging ; Aortic Coarctation/epidemiology ; Aortic Coarctation/physiopathology ; Cardiomyopathies ; Heart/physiopathology ; Humans ; Prevalence ; Prognosis
    Language English
    Publishing date 2022-02-23
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2435045-X
    ISSN 1942-0080 ; 1941-9651
    ISSN (online) 1942-0080
    ISSN 1941-9651
    DOI 10.1161/CIRCIMAGING.122.014007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6743: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: Heart Failure Staging and Indications for Advanced Therapies in Adults with Congenital Heart Disease.

    Egbe, Alexander C / Connolly, Heidi M

    Heart failure clinics

    2024  Volume 20, Issue 2, Page(s) 147–154

    Abstract: Heart failure (HF) is common in adults with congenital heart disease (CHD), and it is the leading cause of death in this population. Adults with CHD presenting with stage D HF have a poor prognosis, and early recognition of signs of advanced HF and ... ...

    Abstract Heart failure (HF) is common in adults with congenital heart disease (CHD), and it is the leading cause of death in this population. Adults with CHD presenting with stage D HF have a poor prognosis, and early recognition of signs of advanced HF and referral for advanced therapies for HF offer the best survival as compared with other therapies. The indications for advanced therapies for HF outlined in this article should serve as a guide for clinicians to determine the optimal time for referral. Palliative care should be part of the multidisciplinary care model for HF in patients with CHD.
    MeSH term(s) Adult ; Humans ; Heart Failure/diagnosis ; Heart Defects, Congenital/complications ; Palliative Care
    Language English
    Publishing date 2024-01-17
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2212019-1
    ISSN 1551-7136
    ISSN 1551-7136
    DOI 10.1016/j.hfc.2023.12.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6554: Show issues Location:
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  3. Article ; Online: Response by Egbe to Letter Regarding Article "Doppler-Derived Arterial Load Indices Better Reflect Left Ventricular Afterload Than Systolic Blood Pressure in Coarctation of Aorta".

    Egbe, Alexander C

    Circulation. Cardiovascular imaging

    2020  Volume 13, Issue 4, Page(s) e010704

    MeSH term(s) Aorta/diagnostic imaging ; Aortic Coarctation/diagnostic imaging ; Arteries ; Blood Pressure ; Heart Ventricles ; Humans
    Language English
    Publishing date 2020-04-16
    Publishing country United States
    Document type Letter ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 2435045-X
    ISSN 1942-0080 ; 1941-9651
    ISSN (online) 1942-0080
    ISSN 1941-9651
    DOI 10.1161/CIRCIMAGING.120.010704
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6743: Show issues Location:
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  4. Article ; Online: Abnormal Right Ventricular-Pulmonary Arterial Coupling in Patients With Coarctation of Aorta Presenting With Aortic Stenosis.

    Egbe, Alexander C / Pellikka, Patricia A / Connolly, Heidi M / Borlaug, Barry A

    JACC. Cardiovascular imaging

    2024  Volume 17, Issue 5, Page(s) 571–572

    MeSH term(s) Humans ; Aortic Coarctation/diagnostic imaging ; Aortic Coarctation/physiopathology ; Aortic Coarctation/complications ; Pulmonary Artery/diagnostic imaging ; Pulmonary Artery/physiopathology ; Pulmonary Artery/abnormalities ; Aortic Valve Stenosis/diagnostic imaging ; Aortic Valve Stenosis/physiopathology ; Aortic Valve Stenosis/surgery ; Aortic Valve Stenosis/complications ; Male ; Ventricular Function, Right ; Female ; Hemodynamics ; Pulmonary Circulation ; Adult ; Predictive Value of Tests ; Young Adult ; Adolescent
    Language English
    Publishing date 2024-02-07
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 2491503-8
    ISSN 1876-7591 ; 1936-878X
    ISSN (online) 1876-7591
    ISSN 1936-878X
    DOI 10.1016/j.jcmg.2023.12.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6846: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Reply: Abnormal Pulmonary Vascular Reserve in Fontan: Pulmonary Vascular Disease Versus Diastolic Dysfunction.

    Egbe, Alexander C / Borlaug, Barry A

    Journal of the American College of Cardiology

    2021  Volume 77, Issue 12, Page(s) 1596–1597

    MeSH term(s) Fontan Procedure/adverse effects ; Humans ; Lung ; Pulmonary Circulation ; Vascular Diseases/diagnosis
    Language English
    Publishing date 2021-03-26
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 605507-2
    ISSN 1558-3597 ; 0735-1097
    ISSN (online) 1558-3597
    ISSN 0735-1097
    DOI 10.1016/j.jacc.2021.01.037
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1846: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 196: Show issues

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  6. Article ; Online: Prophylactic anticoagulation for the prevention of bioprosthetic valve thrombosis: to be or not to be?

    Egbe, Alexander C / Miranda, William R / Connolly, Heidi M / Pislaru, Sorin V

    European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery

    2023  Volume 63, Issue 1

    MeSH term(s) Swine ; Animals ; Aortic Valve/surgery ; Bioprosthesis/adverse effects ; Heart Valve Prosthesis/adverse effects ; Anticoagulants/therapeutic use ; Thrombosis/etiology ; Thrombosis/prevention & control
    Chemical Substances Anticoagulants
    Language English
    Publishing date 2023-01-02
    Publishing country Germany
    Document type Editorial ; Comment
    ZDB-ID 639293-3
    ISSN 1873-734X ; 1010-7940 ; 1567-4258
    ISSN (online) 1873-734X
    ISSN 1010-7940 ; 1567-4258
    DOI 10.1093/ejcts/ezac584
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2303: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Prognostic Implications of Right Atrial Dysfunction in Adults With Pulmonary Atresia and Intact Ventricular Septum.

    Egbe, Alexander C / Miranda, William R / Connolly, Heidi M

    CJC pediatric and congenital heart disease

    2022  Volume 1, Issue 1, Page(s) 23–29

    Abstract: Background: Pulmonary atresia with intact ventricular septum is associated with significant morbidity and mortality, but there are limited data to guide risk stratification in this population. The purpose of this study was to assess the role right ... ...

    Abstract Background: Pulmonary atresia with intact ventricular septum is associated with significant morbidity and mortality, but there are limited data to guide risk stratification in this population. The purpose of this study was to assess the role right atrial (RA) strain indices for prognostication in this population.
    Methods: This is a retrospective study of adults (aged ≥18 years) with pulmonary atresia with intact ventricular septum and biventricular repair who underwent echocardiogram (2003-2019). RA reservoir strain was used as the primary metric of RA function, and RA dysfunction was defined as RA reservoir strain <31%. Clinical outcomes were assessed using 4 different indices: (1) functional impairment (New York Heart Association II-IV); (2) hepatorenal dysfunction (model for end-stage liver disease excluding international normalized ratio score >11); (3) incident atrial arrhythmias/heart failure hospitalization; (4) heart transplant/cardiovascular death.
    Results: Of the 43 patients in the study, RA strain imaging was feasible in 95%, and RA dysfunction was present in 95%. Of the 43 patients, 67% and 49% had functional impairment and hepatorenal dysfunction, respectively; 44% developed incident atrial arrhythmia/heart failure hospitalization and 14% died during follow-up. RA reservoir strain was independently associated with all indices of clinical outcomes.
    Conclusion: Collectively, these data suggest that RA strain imaging was feasible in almost all patients and can be used for risk stratification in this population. There was a high prevalence of comorbidities including hepatorenal dysfunction. Further studies are needed to determine the prognostic implications of hepatorenal dysfunction (a previously unrecognized complication), and whether using RA function indices for clinical decision making will lead to improved outcomes in this population.
    Language English
    Publishing date 2022-02-02
    Publishing country United States
    Document type Journal Article
    ISSN 2772-8129
    ISSN (online) 2772-8129
    DOI 10.1016/j.cjcpc.2021.11.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: On-Treatment Blood Pressure and Progressive Cardiac Remodeling in Adults With Repaired Coarctation of Aorta.

    Egbe, Alexander C / Miranda, William R / Connolly, Heidi M

    JACC. Cardiovascular imaging

    2022  Volume 15, Issue 11, Page(s) 2012–2014

    MeSH term(s) Adult ; Humans ; Aortic Coarctation/diagnostic imaging ; Aortic Coarctation/surgery ; Blood Pressure/physiology ; Ventricular Remodeling ; Predictive Value of Tests ; Aorta
    Language English
    Publishing date 2022-08-17
    Publishing country United States
    Document type Letter ; Research Support, N.I.H., Extramural
    ZDB-ID 2491503-8
    ISSN 1876-7591 ; 1936-878X
    ISSN (online) 1876-7591
    ISSN 1936-878X
    DOI 10.1016/j.jcmg.2022.06.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6846: Show issues Location:
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  9. Article ; Online: Prognostic Role of Tricuspid Annular Plane Systolic Excursion/Right Ventricular Systolic Pressure Ratio in Coarctation of Aorta.

    Ahmed, Marwan / Karnakoti, Snigdha / Abozied, Omar / Kandlakunta, Sriharsha / Younis, Ahmed / Egbe, Alexander C

    CJC pediatric and congenital heart disease

    2023  Volume 2, Issue 4, Page(s) 167–173

    Abstract: Background: Right ventricular (RV) systolic dysfunction and pulmonary hypertension are associated with mortality in adults with coarctation of aorta (COA). The tricuspid annular plane systolic excursion/RV systolic pressure (TAPSE/RVSP) ratio is a ... ...

    Abstract Background: Right ventricular (RV) systolic dysfunction and pulmonary hypertension are associated with mortality in adults with coarctation of aorta (COA). The tricuspid annular plane systolic excursion/RV systolic pressure (TAPSE/RVSP) ratio is a validated noninvasive tool for the assessment of RV-pulmonary arterial (RV-PA) coupling in patients with PA hypertension, but similar data are lacking in adults with COA. The purpose of this study was to assess the relationship between the TAPSE/RVSP ratio and outcomes in this population.
    Methods: A retrospective cohort study of adults with repaired COA was performed. RV systolic dysfunction was defined as RV free wall strain ≥-24% at baseline, whereas new-onset RV systolic dysfunction was defined RV free wall strain ≥-24% during follow-up.
    Results: Of 661 patients, TAPSE, RVSP, and TAPSE/pulmonary artery systolic pressure ratio were 22 ± 6 mm, 34 ± 12 mm Hg, and 0.71 (0.48-0.89) mm/mm Hg, respectively. Of 661 patients, 152 (23%) had RV systolic dysfunction at baseline, and TAPSE/RVSP <0.43 mm/mm Hg was the optimal threshold to detect RV systolic dysfunction. TAPSE/RVSP <0.43 mm Hg was associated with RV systolic dysfunction (adjusted odds ratio: 3.11 [1.83-6.19],
    Conclusions: The TAPSE/RVSP ratio can potentially be used to identify patients at risk for new-onset RV systolic dysfunction and right heart failure and provide opportunity for proactive interventions to prevent adverse outcomes.
    Language English
    Publishing date 2023-05-05
    Publishing country United States
    Document type Journal Article
    ISSN 2772-8129
    ISSN (online) 2772-8129
    DOI 10.1016/j.cjcpc.2023.05.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Relationship between left atrial myopathy and atrial fibrillation in adults with coarctation of aorta.

    Egbe, Alexander C / Abozied, Omar / Miranda, William R / Connolly, Heidi M / Deshmukh, Abhishek J

    American heart journal plus : cardiology research and practice

    2023  Volume 27, Page(s) 100284

    Abstract: Background: Although patients with coarctation of aorta (COA) have clinical risk factors for atrial fibrillation (AF), there are limited data about AF prevalence, and role of left atrial (LA) indices for risk stratification in this population. We ... ...

    Abstract Background: Although patients with coarctation of aorta (COA) have clinical risk factors for atrial fibrillation (AF), there are limited data about AF prevalence, and role of left atrial (LA) indices for risk stratification in this population. We hypothesized that LA indices (LA reservoir strain and LA volume index) were associated with AF, and would identify patients at risk for AF progression.
    Methods: We analyzed electrocardiograms/Holters, and echocardiograms of adult COA patients at Mayo Clinic (2000-2018).
    Results: Of 776 patients, 726(94 %), 46(5.9 %) and 4(0.5 %) had no history of AF, paroxysmal AF, and persistent AF respectively; yielding AF prevalence of 6.4 %. LA reservoir strain (AUC 0.782 [0.751-0.808]) had more robust association with AF as compared to LA volume index (AUC difference -0.115, p < 0.001).Among 726 patients without prior AF, 25(3.4 %) had new-onset AF during follow-up. LA reservoir strain <25 % and LA volume index >34 ml/m
    Conclusions: Collectively, these data suggest that LA strain can potentially be used for AF risk stratification. Further studies are required to determine whether LA strain can proactively identify patients that will respond favorably to different antiarrhythmic therapies, and whether interventions to reduce LV pressure overload will improve LA function and reduce AF progression.
    Language English
    Publishing date 2023-02-25
    Publishing country United States
    Document type Journal Article
    ISSN 2666-6022
    ISSN (online) 2666-6022
    DOI 10.1016/j.ahjo.2023.100284
    Database MEDical Literature Analysis and Retrieval System OnLINE

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