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  1. Article: RESPIRATORY AND CIRCULATORY FACTORS IN UPTAKE AND DISTRIBUTION OF VOLATILE ANAESTHETIC AGENTS.

    EGER, E I

    British journal of anaesthesia

    2003  Volume 36, Page(s) 155–171

    MeSH term(s) Adipose Tissue ; Anesthesia ; Anesthesia, Inhalation ; Anesthetics ; Biophysical Phenomena ; Biophysics ; Blood Chemical Analysis ; Blood Circulation ; Brain ; Cyclopropanes ; Ether ; Halothane ; Metabolism ; Nitrous Oxide ; Pharmacology ; Physical Phenomena ; Physics ; Physiology ; Respiration
    Chemical Substances Anesthetics ; Cyclopropanes ; Ether (0F5N573A2Y) ; cyclopropane (99TB643425) ; Nitrous Oxide (K50XQU1029) ; Halothane (UQT9G45D1P)
    Language English
    Publishing date 2003-09-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 80074-0
    ISSN 1471-6771 ; 0007-0912
    ISSN (online) 1471-6771
    ISSN 0007-0912
    DOI 10.1093/bja/36.3.155
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Factors affecting the rapidity of alteration of nitrous oxide concentration in a circle cystem.

    EGER, E I

    Anesthesiology

    2003  Volume 21, Page(s) 348–355

    MeSH term(s) Nitrous Oxide/metabolism
    Chemical Substances Nitrous Oxide (K50XQU1029)
    Language English
    Publishing date 2003-04-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 269-0
    ISSN 0003-3022
    ISSN 0003-3022
    DOI 10.1097/00000542-196007000-00002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Conflicts of interest: are they a problem for anaesthesia journals?

    Eger, E I

    British journal of anaesthesia

    2001  Volume 86, Issue 5, Page(s) 734

    MeSH term(s) Anesthesiology/standards ; Anesthetics, Inhalation ; Conflict of Interest ; Humans ; Methyl Ethers ; Periodicals as Topic/standards
    Chemical Substances Anesthetics, Inhalation ; Methyl Ethers ; sevoflurane (38LVP0K73A)
    Language English
    Publishing date 2001-08-29
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 80074-0
    ISSN 1471-6771 ; 0007-0912
    ISSN (online) 1471-6771
    ISSN 0007-0912
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  4. Article: Compound A: does it matter?

    Eger, E I

    Canadian journal of anaesthesia = Journal canadien d'anesthesie

    2001  Volume 48, Issue 5, Page(s) 427–430

    MeSH term(s) Adsorption ; Anesthetics, Inhalation/chemistry ; Canada ; Carbon Dioxide/chemistry ; Ethers/chemistry ; Ethers/toxicity ; Humans ; Hydrocarbons, Fluorinated/chemistry ; Hydrocarbons, Fluorinated/toxicity ; Kidney Diseases/chemically induced ; Methyl Ethers/chemistry
    Chemical Substances Anesthetics, Inhalation ; Ethers ; Hydrocarbons, Fluorinated ; Methyl Ethers ; Carbon Dioxide (142M471B3J) ; sevoflurane (38LVP0K73A) ; fluoromethyl 2,2-difluoro-1-(trifluoromethyl)vinyl ether (58109-34-5)
    Language English
    Publishing date 2001-05-02
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 91002-8
    ISSN 1496-8975 ; 0832-610X
    ISSN (online) 1496-8975
    ISSN 0832-610X
    DOI 10.1007/BF03028302
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Age, minimum alveolar anesthetic concentration, and minimum alveolar anesthetic concentration-awake.

    Eger, E I

    Anesthesia and analgesia

    2001  Volume 93, Issue 4, Page(s) 947–953

    Abstract: Unlabelled: Two defining effects of inhaled anesthetics (immobility in the face of noxious stimulation, and absence of memory) correlate with the end-tidal concentrations of the anesthetics. Such defining effects are characterized as MAC (the ... ...

    Abstract Unlabelled: Two defining effects of inhaled anesthetics (immobility in the face of noxious stimulation, and absence of memory) correlate with the end-tidal concentrations of the anesthetics. Such defining effects are characterized as MAC (the concentration producing immobility in 50% of patients subjected to a noxious stimulus) and MAC-Awake (the concentration suppressing appropriate response to command in 50% of patients; memory is usually lost at MAC-Awake). If the concentrations are monitored and corrected for the effects of age and temperature, the concentrations may be displayed as multiples of MAC for a standard age, usually 40 yr. This article provides an algorithm that might be used to produce such a display, including provision of an estimate of the effect of nitrous oxide.
    Implications: Two defining effects of inhaled anesthetics (immobility in the face of noxious stimulation, and absence of memory) correlate with the end-tidal concentrations of the anesthetics. Thus, these defining effects may be monitored and the results displayed if the concentrations are known and corrected for the effects of age and temperature.
    MeSH term(s) Aging/physiology ; Anesthesia, Inhalation ; Anesthetics, Inhalation/pharmacokinetics ; Humans ; Pulmonary Alveoli/metabolism
    Chemical Substances Anesthetics, Inhalation
    Language English
    Publishing date 2001-10
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, P.H.S. ; Review
    ZDB-ID 80032-6
    ISSN 1526-7598 ; 0003-2999
    ISSN (online) 1526-7598
    ISSN 0003-2999
    DOI 10.1097/00000539-200110000-00029
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 149: Show issues

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  6. Article: General versus regional anaesthesia for hip fracture surgery.

    Eger, E I

    British journal of anaesthesia

    2000  Volume 85, Issue 3, Page(s) 492

    MeSH term(s) Anesthesia, Conduction ; Anesthesia, General ; Hip Fractures/surgery ; Humans
    Language English
    Publishing date 2000-09
    Publishing country England
    Document type Comment ; Letter
    ZDB-ID 80074-0
    ISSN 1471-6771 ; 0007-0912
    ISSN (online) 1471-6771
    ISSN 0007-0912
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  7. Article ; Online: Inhaled anesthesia: the original closed-loop drug administration paradigm.

    Gupta, D K / Eger, E I

    Clinical pharmacology and therapeutics

    2008  Volume 84, Issue 1, Page(s) 15–18

    Abstract: We administer anesthetics to obtain therapeutic effects and minimize untoward side effects. Anesthetists can precisely control inhaled anesthetic concentrations by controlling end-tidal volatile anesthetic concentrations. This degree of control ... ...

    Abstract We administer anesthetics to obtain therapeutic effects and minimize untoward side effects. Anesthetists can precisely control inhaled anesthetic concentrations by controlling end-tidal volatile anesthetic concentrations. This degree of control eliminates the need for closed-loop inhaled anesthetic systems. The low solubility of modern inhaled anesthetics adds to the stability and control of the anesthetic state; the effective inhaled concentration varies little during maintenance of anesthesia unless altered by the anesthetist. A less precise closed-loop system applies a processed electroencephalogram (EEG) to assess depth of anesthesia and enable accurate delivery of volatile and intravenous anesthetics to maintain a stable state of anesthesia.
    MeSH term(s) Anesthesia, Closed-Circuit/instrumentation ; Anesthesia, Closed-Circuit/methods ; Anesthesia, Inhalation/instrumentation ; Anesthesia, Inhalation/methods ; Humans
    Language English
    Publishing date 2008-07
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 123793-7
    ISSN 1532-6535 ; 0009-9236
    ISSN (online) 1532-6535
    ISSN 0009-9236
    DOI 10.1038/clpt.2008.85
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  8. Article: Intraoperative therapeutic suggestions.

    Eger, E I

    British journal of anaesthesia

    1999  Volume 83, Issue 5, Page(s) 825–826

    MeSH term(s) Humans ; Intraoperative Care/methods ; Postoperative Nausea and Vomiting/prevention & control ; Research Design ; Suggestion
    Language English
    Publishing date 1999-11
    Publishing country England
    Document type Comment ; Letter
    ZDB-ID 80074-0
    ISSN 1471-6771 ; 0007-0912
    ISSN (online) 1471-6771
    ISSN 0007-0912
    DOI 10.1093/bja/83.5.825
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  9. Article: Is there a responsibility to disclose data used as the basis for a publication?

    Eger, E I

    Anesthesia and analgesia

    1999  Volume 88, Issue 3, Page(s) 693–694

    MeSH term(s) Data Interpretation, Statistical ; Ethics, Medical ; Humans ; Publications ; Reproducibility of Results ; Research Design
    Language English
    Publishing date 1999-03
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 80032-6
    ISSN 1526-7598 ; 0003-2999
    ISSN (online) 1526-7598
    ISSN 0003-2999
    DOI 10.1097/00000539-199903000-00051
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    Zs.MO 149: Show issues

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  10. Article: Current and future perspectives on inhaled anesthetics.

    Eger, E I

    Pharmacotherapy

    1998  Volume 18, Issue 5, Page(s) 895–910

    Abstract: The discovery of ether anesthesia made modern surgery possible. Successive improvements produced today's inhaled anesthetics, compounds that allow precise control over the anesthetic state without compromising safety. Such control extends to induction ... ...

    Abstract The discovery of ether anesthesia made modern surgery possible. Successive improvements produced today's inhaled anesthetics, compounds that allow precise control over the anesthetic state without compromising safety. Such control extends to induction and maintenance of, and recovery from, anesthesia. The greatest emphasis is on the last, particularly the rapid recovery obtained with anesthetics with low solubility in blood and tissues. The lowest solubility is produced by halogenation with fluoride to the exclusion of other halogens. The safety of anesthesia has many components. Important among these is molecular stability that permits elimination of the unchanged anesthetic molecule in expired air and provides resistance to degradation by metabolism and by carbon dioxide absorbents. Halogenation with fluorine produces more stable, safer anesthetics. Greater stability, lower solubility, and rapid recovery can decrease direct and indirect costs.
    MeSH term(s) Anesthetics, Inhalation/pharmacokinetics ; Anesthetics, Inhalation/pharmacology ; Cardiovascular System/drug effects ; Central Nervous System/drug effects ; Humans ; Respiration/drug effects
    Chemical Substances Anesthetics, Inhalation
    Language English
    Publishing date 1998-09
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 603158-4
    ISSN 1875-9114 ; 0277-0008
    ISSN (online) 1875-9114
    ISSN 0277-0008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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