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  1. Article: Identifying high-risk stage IIIA cutaneous melanoma patients who might benefit from adjuvant therapy: the importance of micrometastatic tumor burden.

    Egger, Michael E

    Annals of translational medicine

    2023  Volume 11, Issue 10, Page(s) 371

    Language English
    Publishing date 2023-03-03
    Publishing country China
    Document type Editorial ; Comment
    ZDB-ID 2893931-1
    ISSN 2305-5847 ; 2305-5839
    ISSN (online) 2305-5847
    ISSN 2305-5839
    DOI 10.21037/atm-23-597
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Incremental Improvements in the Ability to Distinguish High-Risk Intraductal Papillary Mucinous Neoplasms.

    Egger, Michael E

    Annals of surgical oncology

    2023  Volume 30, Issue 6, Page(s) 3186–3187

    MeSH term(s) Humans ; Pancreatic Neoplasms/diagnosis ; Carcinoma, Pancreatic Ductal/diagnosis ; Neoplasms, Cystic, Mucinous, and Serous
    Language English
    Publishing date 2023-02-03
    Publishing country United States
    Document type Editorial
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-023-13202-2
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4042: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: The Role of Clinical Prediction Tools to Risk Stratify Patients with Melanoma After a Positive Sentinel Lymph Node Biopsy.

    Egger, Michael E

    Annals of surgical oncology

    2021  Volume 28, Issue 8, Page(s) 4082–4083

    MeSH term(s) Humans ; Lymph Nodes ; Melanoma/surgery ; Sentinel Lymph Node/surgery ; Sentinel Lymph Node Biopsy ; Skin Neoplasms/surgery
    Language English
    Publishing date 2021-05-28
    Publishing country United States
    Document type Editorial
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-018-07099-5
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4042: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Sentinel Lymph Node Biopsy for Thin Melanoma-Some Need It, Some Don't. So Now What?

    Egger, Michael E

    Annals of surgical oncology

    2021  Volume 28, Issue 7, Page(s) 3449–3451

    MeSH term(s) Humans ; Lymph Nodes ; Melanoma/surgery ; Sentinel Lymph Node/surgery ; Sentinel Lymph Node Biopsy ; Skin Neoplasms/surgery
    Language English
    Publishing date 2021-04-22
    Publishing country United States
    Document type Editorial
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-021-10038-6
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4042: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Prognosis in Thin Melanoma Patients: Is Slightly Less Than Excellent Still Okay?

    Egger, Michael E

    Annals of surgical oncology

    2021  Volume 28, Issue 12, Page(s) 6911–6914

    MeSH term(s) Humans ; Melanoma ; Prognosis ; Skin Neoplasms
    Language English
    Publishing date 2021-09-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-021-10772-x
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4042: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Improved Access to Healthcare is Good for Everyone.

    Scoggins, Charles R / Egger, Michael E

    Annals of surgical oncology

    2021  Volume 29, Issue 1, Page(s) 17–19

    MeSH term(s) Health Services Accessibility ; Humans
    Language English
    Publishing date 2021-09-17
    Publishing country United States
    Document type Editorial
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-021-10793-6
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  7. Article: Corresponding ctDNA and tumor burden dynamics in metastatic melanoma patients on systemic treatment.

    Egger, Michael E / Alexander, Evan / Van Meter, Tracy / Kong, Maiying / Maung, Aye Aye / Valdes, Roland / Hall, Melissa Barousse / Linder, Mark W

    Translational oncology

    2024  Volume 42, Page(s) 101883

    Abstract: Radiographic imaging is the current standard for monitoring progression of tumor-burden and therapeutic resistance in patients with metastatic melanoma. Plasma circulating tumor DNA (ctDNA) has shown promise as a survelience tool, but longitudinal data ... ...

    Abstract Radiographic imaging is the current standard for monitoring progression of tumor-burden and therapeutic resistance in patients with metastatic melanoma. Plasma circulating tumor DNA (ctDNA) has shown promise as a survelience tool, but longitudinal data on the dynamics between plasma ctDNA concentrations and radiographic imaging is lacking. We evaluated the relationship between longitudinal radiographic measures of tumor burden and ctDNA concentrations in plasma on 30 patients with metastatic melanoma on systemic treatment. In 9 patients with no radiographic evidence of disease over a total of 15 time points, ctDNA concentrations were undetectable. In 21 patients with radiographic tumor burden, ctDNA was detected in 81 % of 58 time points. Plasma ctDNA concentrations demonstrated a modest positive correlation with total tumor burden (TTB) measurements (R
    Language English
    Publishing date 2024-02-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2443840-6
    ISSN 1936-5233
    ISSN 1936-5233
    DOI 10.1016/j.tranon.2024.101883
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  8. Article ; Online: Developing sarcopenia during neoadjuvant therapy is associated with worse survival in esophageal adenocarcinoma patients.

    Pierce, Katherine / Philips, Prejesh / Egger, Michael E / Scoggins, Charles R / Martin, Robert Cg

    Surgery

    2023  Volume 175, Issue 3, Page(s) 718–725

    Abstract: Background: Sarcopenia in cancer patients has been associated with mixed postoperative outcomes. The aim of this study was to evaluate whether the development of sarcopenia during the neoadjuvant period is predictive of postoperative mortality in ... ...

    Abstract Background: Sarcopenia in cancer patients has been associated with mixed postoperative outcomes. The aim of this study was to evaluate whether the development of sarcopenia during the neoadjuvant period is predictive of postoperative mortality in esophageal adenocarcinoma patients.
    Methods: We queried a prospective database to retrieve the sarcopenic status of patients with esophageal adenocarcinoma who underwent cross-sectional imaging of the third lumbar vertebra at diagnosis and within 2 months of undergoing an esophagogastrectomy between 2014 and 2022.
    Results: Of the 71 patients included in the study, 36 (50.7%) presented with sarcopenia at diagnosis. Of the 35 non-sarcopenic patients, 14 (40%) developed sarcopenia during the neo-adjuvant period. Patients who were not sarcopenic at diagnosis but developed sarcopenia preoperatively had significantly worse overall survival than patients sarcopenic at diagnosis and not sarcopenic preoperatively and patients experiencing no change in sarcopenic status (median 18 vs 47 vs 31 months; P = .02). Diagnostic and preoperative sarcopenic status alone were not significantly associated with overall survival (P = .48 and P = .56, respectively). Although 37 (52.1%) patients died, the cause of death was often not cancer-related (54.1%) and included acute respiratory failure, pneumonia, and cardiac arrest. No significant survival difference was observed when stratified by >10% weight loss (P = .9) or large loss in body mass index (P = .8).
    Conclusion: Developing sarcopenia during the neo-adjuvant period may be associated with worse overall survival in patients requiring esophagogastrectomy.
    MeSH term(s) Humans ; Sarcopenia/diagnosis ; Sarcopenia/diagnostic imaging ; Neoadjuvant Therapy/adverse effects ; Esophageal Neoplasms/complications ; Esophageal Neoplasms/surgery ; Adenocarcinoma/complications ; Adenocarcinoma/surgery ; Retrospective Studies ; Prognosis
    Language English
    Publishing date 2023-10-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 202467-6
    ISSN 1532-7361 ; 0039-6060
    ISSN (online) 1532-7361
    ISSN 0039-6060
    DOI 10.1016/j.surg.2023.09.017
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    Uk I Zs.129: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Does Stage Migration Occur as a Consequence of Omitting Completion Lymph Node Dissection for Melanoma?

    Senders, Zachary J / Bartlett, Edmund K / Mouw, Tyler J / McMasters, Kelly M / Egger, Michael E

    Annals of surgical oncology

    2023  Volume 30, Issue 6, Page(s) 3648–3654

    Abstract: Introduction: Completion lymph node dissection (CLND) is no longer recommended routinely in the treatment of melanoma. CLND omission may understage patients for whom the distinction between stage IIIA and IIIB-C could alter adjuvant therapy ... ...

    Abstract Introduction: Completion lymph node dissection (CLND) is no longer recommended routinely in the treatment of melanoma. CLND omission may understage patients for whom the distinction between stage IIIA and IIIB-C could alter adjuvant therapy recommendations. The aim of this study is to determine if stage migration has occurred with the declining use of CLND.
    Methods: Patients with clinically node-negative ≥ T1b cutaneous melanoma were identified from the National Cancer Database (NCDB) from 2012 to 2018. CLND utilization and changes in AJCC staging were analyzed. Patients undergoing sentinel lymph node biopsy (SLNB) alone were compared with those undergoing SLNB + CLND.
    Results: Overall, 68,933 patients met inclusion criteria and 60,536 underwent SLNB, of which 9031 (14.9%) were tumor positive. CLND was performed in 3776 (41.8%). Patients undergoing CLND were younger (58 versus 62 years, p < 0.0001) and more likely male (61.5% versus 57.9%, p = 0.0005). Patients were more likely to have an N classification >N1a if they received SLNB + CLND (36.8%) versus SLNB alone (19.3%), p < 0.0001. This translated to a small difference in stage IIIA patients between groups (SLNB alone 34.0%, SLNB + CLND 31.8%, p < 0.0001). Of the patients with T1b/T2a tumors who would be upstaged from IIIA to IIIC with identification of additional positive nodes, IIIC incidence was only slightly higher after SLNB + CLND compared with SLNB alone (4.4% versus 1.1%, p < 0.0001). CLND utilization dramatically decreased from 59% in 2012 to 12.6% in 2018, p < 0.0001. However, the incidence of stage IIIA disease for all patients remained stable over the 7-year study period.
    Conclusions: While the utilization of CLND after positive SLNB has declined dramatically in the last 7 years, stage migration that may affect adjuvant therapy decisions has not occurred to a clinically meaningful degree.
    MeSH term(s) Humans ; Male ; Melanoma/surgery ; Melanoma/pathology ; Skin Neoplasms/surgery ; Skin Neoplasms/pathology ; Lymph Node Excision ; Sentinel Lymph Node Biopsy ; Combined Modality Therapy ; Syndrome ; Retrospective Studies ; Sentinel Lymph Node/pathology
    Language English
    Publishing date 2023-03-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-023-13342-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4042: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  10. Article: Patient Selection and Outcomes of Laparoscopic Microwave Ablation of Hepatocellular Carcinoma.

    Martin, Robert C G / Woeste, Matthew / Egger, Michael E / Scoggins, Charles R / McMasters, Kelly M / Philips, Prejesh

    Cancers

    2023  Volume 15, Issue 7

    Abstract: Background: Laparoscopic microwave ablation (MWA) of hepatocellular carcinoma is underutilized and predictors of survival in this setting are not well characterized.: Methods: The prognostic value of clinicopathologic variables was evaluated on ... ...

    Abstract Background: Laparoscopic microwave ablation (MWA) of hepatocellular carcinoma is underutilized and predictors of survival in this setting are not well characterized.
    Methods: The prognostic value of clinicopathologic variables was evaluated on progression-free survival (PFS) and overall survival (OS) by univariate and multivariate analyses. The aim of this study was to evaluate a preferred laparoscopic MWA approach in HCC patients that are not candidates for percutaneous ablation and further classify clinicopathologic factors that may predict survival outcomes following operative MWA in the setting of primary HCC.
    Results: 184 patients with HCC (median age 66, (33-86), 70% male) underwent laparoscopic MWA (N = 162, 88% laparoscopic) compared to 12% undergoing open MWA (N = 22). Median PFS was 29.3 months (0.2-170) and OS was 44.2 months (2.8-170). Ablation success was confirmed in 100% of patients. Ablation recurrence occurred in 3% (6/184), and local/hepatic recurrence occurred in 34%, at a median time of 19 months (9-18). Distant progression was noted in 8%. Median follow up was 34.1 months (6.4-170). Procedure-related complications were recorded in six (9%) patients with one 90-day mortality. Further, >1 lesion, AFP levels ≥ 80 ng/mL, and an "invader" on pre-operative radiology were associated with increased risk of progression (>1 lesion HR 2.92, 95% CI 1.06 -7.99,
    Conclusions: Preoperative lesion number, AFP ≥ 80 ng/mL, and an aggressive imaging characteristic (Invader) independently predict PFS and OS following laparoscopic operative MWA.
    Language English
    Publishing date 2023-03-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15071965
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