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  1. Article: Évaluation des connaissances de l’échinococcose alvéolaire réalisée auprès des médecins généralistes de la Province de Liège : impact d’une intervention formative.

    Boulanger, Maxime / Léonard, Philippe / Egrek, Sabrina / Detry, Olivier / Hayette, Marie-Pierre

    Revue medicale de Liege

    2023  Volume 78, Issue 3, Page(s) 153–159

    Abstract: Alveolar echinococcosis is an indigenouszoonosis caused by the growth of the larval stage of a small tapeworm, Echinococcus multilocularis. Despite a low incidence in Belgium, with about 10 cases on average recorded per year, this parasitosis poses a ... ...

    Title translation Evaluation of the knowledge on alveolar echinococcosis among general practitioners in the province of Liege : impact of a formative intervention.
    Abstract Alveolar echinococcosis is an indigenouszoonosis caused by the growth of the larval stage of a small tapeworm, Echinococcus multilocularis. Despite a low incidence in Belgium, with about 10 cases on average recorded per year, this parasitosis poses a real public health problem because it often remains difficult to diagnose and is potentially fatal in the absence of treatment. General practitioners are on the frontline, but they do not always know enough about the disease, which causes a delay in the diagnosis and impacts the prognosis. The present study aims to assess the level of knowledge of alveolar echinococcosis among general practitioners in the province of Liège via a questionnaire, on the one hand, and to increase their level of knowledge via a formative intervention using a video capsule, on the other hand. We have performed a randomized controlled experimental study, which showed that general practitioners in the province of Liège have limited knowledge on alveolar echinococcosis. This mainly concerns symptomatology, diagnostic tools and treatment. The formative intervention carried out allowed increasing their level of knowledge about this disease.
    MeSH term(s) Animals ; Humans ; General Practitioners ; Echinococcosis/diagnosis ; Echinococcosis/epidemiology ; Echinococcosis/therapy ; Echinococcus multilocularis ; Belgium/epidemiology
    Language French
    Publishing date 2023-03-15
    Publishing country Belgium
    Document type Randomized Controlled Trial ; English Abstract ; Journal Article
    ZDB-ID 414001-1
    ISSN 0370-629X ; 0035-3663
    ISSN 0370-629X ; 0035-3663
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Development and optimization of a one step process for the production and sterilization of liposomes using supercritical CO

    Penoy, Noémie / Delma, Kouka Luc / Homkar, Nirmayi / Karim Sakira, Abdoul / Egrek, Sabrina / Sacheli, Rosalie / Sacré, Pierre-Yves / Grignard, Bruno / Hayette, Marie-Pierre / Somé, Touridomon Issa / Semdé, Rasmané / Evrard, Brigitte / Piel, Géraldine

    International journal of pharmaceutics

    2024  Volume 651, Page(s) 123769

    Abstract: Liposomes are very interesting drug delivery systems for pharmaceutical and therapeutic purposes. However, liposome sterilization as well as their industrial manufacturing remain challenging. Supercritical carbon dioxide is an innovative technology that ... ...

    Abstract Liposomes are very interesting drug delivery systems for pharmaceutical and therapeutic purposes. However, liposome sterilization as well as their industrial manufacturing remain challenging. Supercritical carbon dioxide is an innovative technology that can potentially overcome these limitations. The aim of this study was to optimize a one-step process for producing and sterilizing liposomes using supercritical CO
    MeSH term(s) Humans ; Liposomes/chemistry ; Carbon Dioxide/chemistry ; Drug Delivery Systems ; Sterilization ; Infertility
    Chemical Substances Liposomes ; Carbon Dioxide (142M471B3J)
    Language English
    Publishing date 2024-01-04
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 428962-6
    ISSN 1873-3476 ; 0378-5173
    ISSN (online) 1873-3476
    ISSN 0378-5173
    DOI 10.1016/j.ijpharm.2024.123769
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Use of supercritical CO

    Delma, Kouka Luc / Penoy, Noémie / Sakira, Abdoul Karim / Egrek, Sabrina / Sacheli, Rosalie / Grignard, Bruno / Hayette, Marie-Pierre / Issa Somé, Touridomon / Evrard, Brigitte / Semdé, Rasmané / Piel, Géraldine

    European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V

    2023  Volume 183, Page(s) 112–118

    Abstract: The effects of four potential supercritical carbon dioxide ( ... ...

    Abstract The effects of four potential supercritical carbon dioxide (ScCO
    MeSH term(s) Liposomes ; Phospholipids ; Carbon Dioxide/pharmacology ; Hydrogen Peroxide ; Sterilization/methods
    Chemical Substances Liposomes ; Phospholipids ; Carbon Dioxide (142M471B3J) ; Hydrogen Peroxide (BBX060AN9V)
    Language English
    Publishing date 2023-01-11
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1065368-5
    ISSN 1873-3441 ; 0939-6411
    ISSN (online) 1873-3441
    ISSN 0939-6411
    DOI 10.1016/j.ejpb.2023.01.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Genetic diversity of Echinococcus multilocularis specimens isolated from Belgian patients with alveolar echinococcosis using EmsB microsatellites analysis.

    Sacheli, Rosalie / Knapp, Jenny / Pholien, Caroline / Egrek, Sabrina / Léonard, Philippe / Giot, Jean-Baptiste / Delaere, Bénédicte / Blétard, Noella / Gofflot, Stéphanie / Nollevaux, Marie-Cécile / Meunier, Paul / Lovinfosse, Pierre / Pirotte, Benoit / Truyens, Carine / Millon, Laurence / Detry, Olivier / Hayette, Marie-Pierre

    Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases

    2023  Volume 116, Page(s) 105531

    Abstract: The genetic diversity of Echinococcus multilocularis (E. multilocularis) specimens isolated from patients with alveolar echinococcosis (AE), is a major field of investigation to correlate with sources of infection, clinical manifestations and prognosis ... ...

    Abstract The genetic diversity of Echinococcus multilocularis (E. multilocularis) specimens isolated from patients with alveolar echinococcosis (AE), is a major field of investigation to correlate with sources of infection, clinical manifestations and prognosis of the disease. Molecular markers able to distinguish samples are commonly used worldwide, including the EmsB microsatellite. Here, we report the use of the EmsB microsatellite polymorphism data mining for the retrospective typing of Belgian specimens of E. multilocularis infecting humans. A total of 18 samples from 16 AE patients treated between 2006 and 2021 were analyzed through the EmsB polymorphism. Classification of specimens was performed through a dendrogram construction in order to compare the similarity among Belgian samples, some human referenced specimens on the EWET database (EmsB Website for the Echinococcus Typing) and previously published EmsB profiles from red foxes circulating in/near Belgium. According to a comparison with human European specimens previously genotyped in profiles, the 18 Belgian ones were classified into three EmsB profiles. Four specimens could not be assigned to an already known profile but some are near to EWET referenced samples. This study also highlights that some specimens share the same EmsB profile with profiles characterized in red foxes from north Belgium, the Netherlands, Luxembourg and French department near to the Belgian border. Furthermore, Belgian specimens present a genetic diversity and include one profile that don't share similarities with the ones referenced in the EWET database. However, at this geographical scale, there is no clear correlation between EmsB profiles and geographical location. Further studies including additional clinical samples and isolates from foxes and rodents of south Belgium are necessary to better understand the spatial and temporal circumstances of human infections but also a potential correlation between EmsB profiles and parasite virulence.
    MeSH term(s) Animals ; Humans ; Belgium/epidemiology ; Echinococcus multilocularis/genetics ; Foxes/parasitology ; Retrospective Studies ; Genetic Variation ; Microsatellite Repeats
    Language English
    Publishing date 2023-11-20
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2037068-4
    ISSN 1567-7257 ; 1567-1348
    ISSN (online) 1567-7257
    ISSN 1567-1348
    DOI 10.1016/j.meegid.2023.105531
    Database MEDical Literature Analysis and Retrieval System OnLINE

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