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  1. Book ; Online: Evidence in Action between Science and Society

    Ehlers, Sarah / Esselborn, Stefan

    Constructing, Validating, and Contesting Knowledge

    2023  

    Keywords Humanities ; Historiography ; General & world history ; legal domain, knowledge, science, political domain
    Language English
    Size 1 Online-Ressource
    Publisher Taylor and Francis
    Document type Book ; Online
    Note English
    HBZ-ID HT030383305
    ISBN 9781032037059 ; 1032037059
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online: Wissen und Begründen

    Zachmann, Karin / Ehlers, Sarah

    2019  

    Abstract: Evidenz ist in der Wissensgesellschaft zu einer zentralen Ressource geworden. Gleichzeitig sind Aushandlungen um die Gültigkeit von Wissen ein im Laufe des 20. Jahrhunderts politisch brisanter werdendes Phänomen, das multiple Bereiche der Wissenschaft, ... ...

    Abstract Evidenz ist in der Wissensgesellschaft zu einer zentralen Ressource geworden. Gleichzeitig sind Aushandlungen um die Gültigkeit von Wissen ein im Laufe des 20. Jahrhunderts politisch brisanter werdendes Phänomen, das multiple Bereiche der Wissenschaft, der Technik, der Politik, der Medizin und der Gesellschaft prägt. Nicht erst die Diagnose eines "postfaktischen Zeitalters" zeigt: Wissen wird in modernen Gesellschaften nicht per se akzeptiert, sondern Wissensakteure und -akteurinnen müssen überzeugen, um ihren Befunden Evidenz zu verleihen. Doch welche Praktiken wenden sie dazu an, wie wird die Gültigkeit von Wissen in verschiedenen Öffentlichkeiten ausgehandelt? Der Sammelband untersucht diese hier als Evidenzpraktiken verstandenen Dynamiken in interdisziplinärer Perspektive.-

    Die Autoren und Autorinnen widmen sich dazu Beispielen aus der Medizin-, Kommunikations-, Wirtschafts-, Wissenschafts-, Technik- und Umweltweltforschung und sie verbinden dabei die Analyse der jüngsten Geschichte mit aktuellen Phänomenen. Mit Beiträgen von Helena Bilandzic, Tommaso Bruni, Sarah Ehlers, Stefan Esselborn, Sascha Dickel, Kay Felder, Mariacarla Gadebusch Bondio, Christine Haßauer, Susanne Kinnebrock, Magdalena Klingler, Emilia Lehmann, Sabine Maasen, Ruth Müller, Jutta Roosen, Helmuth Trischler, Andreas Wenninger, Fabienne Will, Karin ZachmannEvidence has become a key resource within our knowledge society. At the same time, during the course of the 20th century, negotiations on the validity of knowledge became a political and controversial phenomenon which has since shaped the multiple fields of science, technology, politics, medicine and society.-

    As the diagnosis of a 'post-factual age' makes clear: knowledge will not be accepted in modern society per se; instead knowledge operators have to satisfy demands to give validity to their findings. But which practices should they apply for this purpose? How is the validity of knowledge negotiated in different public spheres? Using an interdisciplinary perspective, this anthology examines the dynamics of evidence practices. The authors cover examples from research in the fields of medicine, communication, the economy, science, technology and environmental studies. At the same time, they connect analysis from recent history with current phenomena. With contributions by Helena Bilandzic, Tommaso Bruni, Sarah Ehlers, Stefan Esselborn, Sascha Dickel, Kay Felder, Mariacarla Gadebusch Bondio, Christine Haßauer, Susanne Kinnebrock, Magdalena Klingler, Emilia Lehmann, Sabine Maasen, Ruth Müller, Jutta Roosen, Helmuth Trischler, Andreas Wenninger, Fabienne Will, Karin Zachmann
    Keywords Sociology (General)
    Size 1 electronic resource (170 pages)
    Publisher Nomos Verlagsgesellschaft mbH and Company KG
    Document type Book ; Online
    Note de ; Open Access
    HBZ-ID HT020394824
    ISBN 9783748903383 ; 3748903383
    DOI https://doi.org/10.5771/9783748903383
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Book ; Thesis: Europa und die Schlafkrankheit

    Ehlers, Sarah / Budde, Gunilla / Gosewinkel, Dieter / Nützenadel, Alexander / Nolte, Paul / Ullmann, Hans-Peter

    Koloniale Seuchenbekämpfung, europäische Identitäten und moderne Medizin 1890–1950

    (Kritische Studien zur Geschichtswissenschaft ; 232)

    2019  

    Abstract: Zu Beginn des 20. Jahrhunderts verwüsteten Epidemien der Schlafkrankheit weite Teile der europäischen Kolonialgebiete in Afrika. Diese akute Krise in den Krankheitsgebieten setzte eine ganze Reihe von Entwicklungen in Gang, deren Reichweite sich ... ...

    Author's details Dr. Gunilla Budde ist Professorin für Deutsche und Europäische Geschichte des 19. und 20. Jahrhunderts und Vizepräsidentin an der Carl von Ossietzky Universität Oldenburg
    Series title Kritische Studien zur Geschichtswissenschaft ; 232
    Abstract Zu Beginn des 20. Jahrhunderts verwüsteten Epidemien der Schlafkrankheit weite Teile der europäischen Kolonialgebiete in Afrika. Diese akute Krise in den Krankheitsgebieten setzte eine ganze Reihe von Entwicklungen in Gang, deren Reichweite sich keineswegs auf den afrikanischen Kontinent beschränkte. Während in den Kolonien Zwangsuntersuchungen und -behandlungen der afrikanischen Bevölkerung eingeführt, Verkehrswege kontrolliert und ganze Landstriche evakuiert und umgestaltet wurden, formiert...
    Keywords MHMA100 ; HHIB050 ; HHIWE ; HHIWSB ; Medizingeschichte ; Geschichte/Neuzeit ; Imperialismus ; Kolonialmedizin ; Kolonialismus ; Afrika ; Europa ; Biomedizin
    Language German
    Size 377 p.
    Edition 1
    Publisher Vandenhoeck & Ruprecht
    Document type Book ; Thesis
    Note PDA Manuell_2
    Format 160 x 237 x 30
    ISBN 9783525310687 ; 3525310684
    Database PDA

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  4. Article ; Online: Large abdominal mechanoreceptive sense organs in small plant-dwelling insects.

    Ehlers, Sarah / Baum, Daniel / Mühlethaler, Roland / Hoch, Hannelore / Bräunig, Peter

    Biology letters

    2022  Volume 18, Issue 4, Page(s) 20220078

    Abstract: The Hemiptera, with approximately 98 000 species, is one of the largest insect orders. Most species feed by sucking sap from plant tissues and are thus often vectors for economically important phytopathogens. Well known within this group are the large ... ...

    Abstract The Hemiptera, with approximately 98 000 species, is one of the largest insect orders. Most species feed by sucking sap from plant tissues and are thus often vectors for economically important phytopathogens. Well known within this group are the large cicadas (Cicadomorpha: Cicadoidea: Cicadidae) because they produce extremely loud airborne sounds. Less well known are their mostly tiny relatives, the leafhoppers, spittlebugs, treehoppers and planthoppers that communicate by silent vibrational signals. While the generation of these signals has been extensively investigated, the mechanisms of their perception are poorly understood. This study provides a complete description and three-dimensional reconstruction of a large and complex array of mechanoreceptors in the first abdominal segments of the Rhododendron leafhopper
    MeSH term(s) Animals ; Hemiptera ; Sense Organs
    Language English
    Publishing date 2022-04-13
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2135022-X
    ISSN 1744-957X ; 1744-9561
    ISSN (online) 1744-957X
    ISSN 1744-9561
    DOI 10.1098/rsbl.2022.0078
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Process optimization and transfer of freeze-drying in nested vial systems.

    Ehlers, Sarah / Schroeder, Rudolf / Friess, Wolfgang

    European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V

    2021  Volume 159, Page(s) 143–150

    Abstract: Scale-up and transfer of freeze-drying processes is a crucial challenge in biopharma industry. With the success of small batch processing lines utilizing rack vial holding systems, further detailed knowledge about freeze-drying cycles and their scale-up ... ...

    Abstract Scale-up and transfer of freeze-drying processes is a crucial challenge in biopharma industry. With the success of small batch processing lines utilizing rack vial holding systems, further detailed knowledge about freeze-drying cycles and their scale-up for vials in a rack is required. Therefore, product temperature (T
    MeSH term(s) Drug Compounding/instrumentation ; Drug Compounding/methods ; Drug Packaging/instrumentation ; Drug Packaging/methods ; Freeze Drying/instrumentation ; Freeze Drying/methods ; Temperature
    Language English
    Publishing date 2021-01-09
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1065368-5
    ISSN 1873-3441 ; 0939-6411
    ISSN (online) 1873-3441
    ISSN 0939-6411
    DOI 10.1016/j.ejpb.2021.01.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: In-situ investigation of solid phase evolution during lyophilization of mannitol-based antibody formulations using an XRPD climate chamber.

    Seiler, Vanessa K / Weber, Stefan / Börner, Markus / Witting, Madeleine / Ehlers, Sarah / Nagel, Norbert

    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

    2023  Volume 184, Page(s) 106407

    Abstract: Crystalline mannitol is commonly used as bulking agent in antibody formulations to provide structure to the lyophilized cake and prevent collapse. Depending on the lyophilization process conditions mannitol can either crystallize as α-, β-, δ-mannitol, ... ...

    Abstract Crystalline mannitol is commonly used as bulking agent in antibody formulations to provide structure to the lyophilized cake and prevent collapse. Depending on the lyophilization process conditions mannitol can either crystallize as α-, β-, δ-mannitol, mannitol-hemihydrate, or transition to its amorphous state. While crystalline mannitol helps to create a firmer cake structure this is not true for amorphous mannitol. The hemihydrate is also an undesired physical form as it may reduce the drug product stability by releasing bound water molecules into the cake. Our aim was to simulate lyophilization processes in an X-ray powder diffraction (XRPD) climate chamber. In the climate chamber, the process can be carried out fast with low sample quantities to determine optimal process conditions. Insights on the emergence of desired anhydrous mannitol forms helps to adjust the process parameters in larger scale freeze-dryers. In our study we have identified the critical process steps for our formulations and then varied relevant process parameters, which were the annealing temperature, annealing time and temperature ramp rate of the freeze-drying process. Furthermore, the effect of the presence of antibodies on excipient crystallization was investigated by performing the studies on placebo solutions versus two respective antibody formulations. A comparison of the products obtained in a freeze-dryer and the simulated process in the climate chamber showed good accordance demonstrating the method as suitable tool to identify ideal process conditions on a laboratory scale.
    MeSH term(s) Mannitol/chemistry ; Drug Compounding/methods ; X-Ray Diffraction ; Freeze Drying/methods ; Antibodies ; Excipients/chemistry ; Calorimetry, Differential Scanning
    Chemical Substances Mannitol (3OWL53L36A) ; Antibodies ; Excipients
    Language English
    Publishing date 2023-02-19
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1154366-8
    ISSN 1879-0720 ; 0928-0987
    ISSN (online) 1879-0720
    ISSN 0928-0987
    DOI 10.1016/j.ejps.2023.106407
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Secondary Syphilis.

    Ehlers, Sarah / Sergent, Shane / Ashurst, John

    Clinical practice and cases in emergency medicine

    2020  Volume 4, Issue 4, Page(s) 675–676

    Abstract: Case presentation: A 40-year-old male presented the the emergency department (ED) due to a diffuse body rash after a sexual encounter. Examination revealed a maculopapular rash that included the palms and soles of the feet bilaterally. A rapid plasma ... ...

    Abstract Case presentation: A 40-year-old male presented the the emergency department (ED) due to a diffuse body rash after a sexual encounter. Examination revealed a maculopapular rash that included the palms and soles of the feet bilaterally. A rapid plasma reagin was positive, and the patient was treated with 2.4 million units of benzathine benzylpenicillin intramuscularly.
    Diagnosis: Secondary syphilis can mimic many disease processes but classically presents as a painless macular rash on the palms of the hands and soles of the feet. Diagnosis is based upon clinical examination coupled with serological testing. Emergency department management should include 2.4 million units of benzathine benzylpenicillin intramuscularly and mitigation strategies.
    Language English
    Publishing date 2020-11-20
    Publishing country United States
    Document type Journal Article
    ISSN 2474-252X
    ISSN (online) 2474-252X
    DOI 10.5811/cpcem.2020.7.48515
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Trouble With the Neighbor During Freeze-Drying: Rivalry About Energy.

    Ehlers, Sarah / Schroeder, Rudolf / Friess, Wolfgang

    Journal of pharmaceutical sciences

    2020  Volume 110, Issue 3, Page(s) 1219–1226

    Abstract: Batch homogeneity during lyophilization is crucial to ensure products with high quality. Known as edge-vial-effect, vials at the corners and edges tend to run warmer than center vials during primary drying. This is associated with risk of collapse or ... ...

    Abstract Batch homogeneity during lyophilization is crucial to ensure products with high quality. Known as edge-vial-effect, vials at the corners and edges tend to run warmer than center vials during primary drying. This is associated with risk of collapse or increased costs due to use of more conservative, longer drying conditions resulting in lower product temperature. The edge-vial-effect has been attributed to radiation coming from the chamber wall. We could show that the neighbor vial has a dominant impact on product temperature during lyophilization. Depending on the number of neighbors as well as the distance to a neighbor vial, the neighbor vial exerts a remarkable cooling effect. Energy transfer by gas conduction enables the cooling effect of a neighboring vial over a distance up to 10 mm. This not only leads to prolonged primary drying but also impacts cake appearance. Thus, to avoid trouble during lyophilization you have to watch out for the neighborhood.
    MeSH term(s) Desiccation ; Energy Transfer ; Freeze Drying ; Technology, Pharmaceutical ; Temperature
    Keywords covid19
    Language English
    Publishing date 2020-10-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3151-3
    ISSN 1520-6017 ; 0022-3549
    ISSN (online) 1520-6017
    ISSN 0022-3549
    DOI 10.1016/j.xphs.2020.10.024
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Impact of chamber wall temperature on energy transfer during freeze-drying.

    Ehlers, Sarah / Friess, Wolfgang / Schroeder, Rudolf

    International journal of pharmaceutics

    2020  Volume 592, Page(s) 120025

    Abstract: Minimization of radiation coming from the chamber wall during lyophilization has the potential to reduce the edge-vial-effect. The edge-vial-effect is a phenomenon in which vials positioned at the shelf edges and corners tend to run warmer compared to ... ...

    Abstract Minimization of radiation coming from the chamber wall during lyophilization has the potential to reduce the edge-vial-effect. The edge-vial-effect is a phenomenon in which vials positioned at the shelf edges and corners tend to run warmer compared to center vials. A higher product temperature may result in product collapse in these vials. Consequently, more conservative and time-consuming freeze-drying cycles with lower shelf temperatures and pressures are chosen to ensure a product temperature below the collapse temperature in all vials. The edge-vial-effect is of even higher impact in small batches, where the ratio of corner and edge to center vials is higher compared to large scale manufacturing. The chamber wall is often discussed as the primary source of radiation impacting corner and edge vials. A radiation cage was set at different low temperatures to determine the impact of chamber wall temperatures below 0 °C on product temperature. At the end of primary drying, product temperature of corner vials could be reduced by 6 °C through the radiation cage but primary drying was elongated. Compared to vials in a tray, the chamber wall temperature had less impact on vials nested in a rack system due to a shielding effect of the rack itself. Corner and center vials ran more homogeneous with radiation cage since the edge and corner vials were slowed down. The difference in primary drying time between corner and center vials in the tray could be significantly reduced by 18% by means of 7 h when the radiation cage was controlled at product temperature and combined with a higher shelf temperature. In summary, the radiation cage is a useful tool for a more homogeneous batch with the potential to reduce primary drying time. Nevertheless, the drying difference between corner and center vials could only be reduced and was not completely eliminated.
    MeSH term(s) Desiccation ; Energy Transfer ; Freeze Drying ; Hot Temperature ; Technology, Pharmaceutical ; Temperature
    Language English
    Publishing date 2020-11-01
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 428962-6
    ISSN 1873-3476 ; 0378-5173
    ISSN (online) 1873-3476
    ISSN 0378-5173
    DOI 10.1016/j.ijpharm.2020.120025
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Book ; Online ; Thesis: Nests and chamber wall temperature control as tools in pharmaceutical freeze-drying

    Ehlers, Sarah [Verfasser] / Frieß, Wolfgang [Akademischer Betreuer]

    evaluation of heat transfer, edge-vial-effect and drying kinetics

    2020  

    Author's details Sarah Ehlers ; Betreuer: Wolfgang Frieß
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language English
    Publisher Universitätsbibliothek der Ludwig-Maximilians-Universität
    Publishing place München
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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