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Article: The Association Between Fibromyalgia and Cardiovascular Morbidity: Emerging Concern.

Hertz, Adi / Ehrenberg, Scott / Amital, Howard

The Israel Medical Association journal : IMAJ

2023 Volume 25, Issue 9, Page(s) 637–638

MeSH term(s)	Humans ; Fibromyalgia/epidemiology ; Disease Progression ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/etiology
Language	English
Publishing date	2023-10-02
Publishing country	Israel
Document type	Journal Article
ZDB-ID	2008291-5
ISSN	1565-1088 ; 0021-2180
ISSN	1565-1088 ; 0021-2180
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Zs.A 5470: Show issues

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Article ; Online: The existence of a bidirectional link between ischemic heart disease and fibromyalgia.

Mansour, Mahmoud / Ehrenberg, Scott / Mahroum, Naim / Tsur, Avishai M / Fisher, Lior / Amital, Howard

Coronary artery disease

2024 Volume 35, Issue 2, Page(s) 99–104

Abstract: Study objectives: Fibromyalgia (FM) is one of the most common causes of chronic widespread musculoskeletal pain, but also sleep disturbances, cognitive and psychological disorders. It has been suggested that FM may have a correlation with cardiovascular ...

Abstract	Study objectives: Fibromyalgia (FM) is one of the most common causes of chronic widespread musculoskeletal pain, but also sleep disturbances, cognitive and psychological disorders. It has been suggested that FM may have a correlation with cardiovascular events. In this study, we aimed to assess the association between FM and ischemic heart disease (IHD). Methods: A population-based cross-sectional study was conducted utilizing data retrieved from the largest medical records database in Israel, Clalit Health Services. Patients were defined as having FM or IHD when there were at least two such documented diagnoses in their medical records. The occurrence of IHD was compared between FM and age- and sex-frequency-matched healthy controls. A logistic regression model was used to estimate this association following an adjustment for conventional cardiovascular risk factors and depression. Results: An overall population of 18 598 FM patients and 36 985 age- and gender-matched controls were included in the study. The proportion of IHD amongst FM patients was increased in comparison to controls (9.2% and 6.2%, respectively; P < 0.001). Furthermore, FM demonstrated an independent association with IHD on multivariate analysis (odds ratio [OR], 1.43; 95% confidence intervals [CI], 1.33-1.54; P < 0.0001). Finally, IHD was also found to be independently associated with the diagnosis of FM (OR, 1.40; CI, 1.31-1.51; P < 0.0001). Conclusion: Our data suggest a bidirectional link between FM and IHD even after the adjustment for conventional cardiovascular risk factors. These findings should be considered when treating patients with either FM or IHD, and their routine interactional screening may be of clinical importance.
MeSH term(s)	Humans ; Fibromyalgia/diagnosis ; Fibromyalgia/epidemiology ; Fibromyalgia/complications ; Risk Factors ; Cross-Sectional Studies ; Myocardial Ischemia/diagnosis ; Myocardial Ischemia/epidemiology ; Myocardial Ischemia/complications ; Heart Disease Risk Factors
Language	English
Publishing date	2024-01-12
Publishing country	England
Document type	Journal Article
ZDB-ID	1047268-x
ISSN	1473-5830 ; 0954-6928
ISSN (online)	1473-5830
ISSN	0954-6928
DOI	10.1097/MCA.0000000000001329
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Zs.A 3039: Show issues

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Article: Coronary artery ectasia: prevalence, angiographic characteristics and clinical outcome.

Willner, Nadav Asher / Ehrenberg, Scott / Musallam, Anees / Roguin, Ariel

Open heart

2020 Volume 7, Issue 1

Abstract: Objective: Determine coronary artery ectasia (CAE) prevalence and clinical outcome in a large cohort of patients underwent coronary angiography.: Methods: In an 11-year period, between 2006 and 2017, 20 455 coronary angiography studies were performed ...

Abstract	Objective: Determine coronary artery ectasia (CAE) prevalence and clinical outcome in a large cohort of patients underwent coronary angiography. Methods: In an 11-year period, between 2006 and 2017, 20 455 coronary angiography studies were performed at a large university centre. Patients diagnosed with CAE based on procedure report were included in the final analysis. Results: CAE was diagnosed in 174 out of 20 455 studies (0.85% per total angiograms, 161 patients). Patients' average age was 59.6±11.2 years old with male predominance (90.7%). Diffuse ectasia morphology was most common (78.9%), followed by fusiform (16.1%) and saccular (5%). Mixed CAE and atherosclerotic heart disease (ASHD) was present in 75.2% of the patients and isolated CAE in 24.8%. The most common coronary artery involved was the right coronary artery (RCA) (79%). Following index angiography, all the isolated CAE group was managed conservatively, while 67% of the mixed CAE-ASHD group underwent coronary intervention. In an average follow-up of 6±3.6 years, adverse clinical event (a composite endpoint of any death, cerebrovascular accident, myocardial infarction, thromboembolic event, bleeding and stent thrombosis) occurred in 48.8% of the mixed CAE-ASHD group compared with 25% in the isolated CAE group (p<0.05). Conclusions: CAE is a rare phenomenon. The most common artery involved was the RCA, and the diffused type of CAE was the most frequent. Most patients with CAE have also concomitant ASHD, and those patients have higher mortality and complications rate, compared with isolated CAE disease.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Conservative Treatment ; Coronary Aneurysm/diagnostic imaging ; Coronary Aneurysm/mortality ; Coronary Aneurysm/therapy ; Coronary Angiography ; Coronary Vessels/diagnostic imaging ; Dilatation, Pathologic ; Female ; Humans ; Israel/epidemiology ; Male ; Middle Aged ; Predictive Value of Tests ; Prevalence ; Retrospective Studies ; Time Factors ; Treatment Outcome
Language	English
Publishing date	2020-12-04
Publishing country	England
Document type	Journal Article
ZDB-ID	2747269-3
ISSN	2053-3624 ; 2044-6055
ISSN	2053-3624 ; 2044-6055
DOI	10.1136/openhrt-2019-001096
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Article ; Online: Regression of Systolic Anterior Motion in Progressive Hypertrophic Cardiomyopathy.

Koren, Ofir / Ehrenberg, Scott / Bloch, Lev / Rozner, Ehud / Turgeman, Yoav / Naddaf, Sari

The American journal of case reports

2021 Volume 22, Page(s) e931359

Abstract: BACKGROUND Systolic anterior motion (SAM) is the dynamic anteriorly directed movement of the anterior mitral valve leaflet during systole toward the left ventricular outflow tract (LVOT). The history of SAM in progressive hypertrophic cardiomyopathy (HCM) ...

Abstract	BACKGROUND Systolic anterior motion (SAM) is the dynamic anteriorly directed movement of the anterior mitral valve leaflet during systole toward the left ventricular outflow tract (LVOT). The history of SAM in progressive hypertrophic cardiomyopathy (HCM) is unclear. It is believed that SAM is an irreversible process that progresses as the gradient over the LVOT increases. We present a case where SAM regressed after extensive left atrial (LA) and left ventricle (LV) remodeling in a patient with progressive HCM. CASE REPORT A 78-year-old woman presented with effort dyspnea. Echocardiogram revealed HCM with an interventricular septal (IVS) thickness of 20 mm, significant pressure gradient over LVOT, and prominent SAM. The LV chamber dimensions were within normal range. The patient was prescribed medications against heart failure and discharged. Six years later, she was admitted with an acute respiratory infection. She underwent transthoracic and transesophageal echocardiograms, which showed no systolic function change. The IVS thickness was lower, LV and LA were significantly enlarged, and there was a significant mitral regurgitation with an anteriorly directed jet and no SAM. The transesophageal echocardiogram revealed a posterior leaflet's prolapse with a flail P2 segment, which required percutaneous edge-to-edge mitral repair. CONCLUSIONS Our case highlights the multiple theories behind the mechanism of SAM in HCM. The long-standing pressure gradient over the LVOT lead to extensive left side remodeling, which then altered the geometric, kinetic, and structural forces and, consequently, the Venturi effect. At the end stage of HCM, IVS lost its thickness, pressure gradient declined, and SAM regressed.
MeSH term(s)	Aged ; Cardiomyopathy, Hypertrophic/diagnostic imaging ; Echocardiography ; Female ; Humans ; Mitral Valve/diagnostic imaging ; Mitral Valve Insufficiency ; Systole
Language	English
Publishing date	2021-04-29
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	2517183-5
ISSN	1941-5923 ; 1941-5923
ISSN (online)	1941-5923
ISSN	1941-5923
DOI	10.12659/AJCR.931359
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Article ; Online: Sinus Node Dysfunction due to Occlusion of the Sinus Node Artery during Percutaneous Coronary Intervention.

Koren, Ofir / Antonelli, Dante / Khamaise, Ranya / Ehrenberg, Scott / Rozner, Ehud / Turgeman, Yoav

Journal of interventional cardiology

2021 Volume 2021, Page(s) 8810484

Abstract: Background: Sinus node artery occlusion (SNO) is a rare complication of percutaneous coronary intervention (PCI). We analyze both the short- and long-term consequences of SNO.: Methods: We retrospectively reviewed 1379 consecutive PCI's involving RCA ...

Abstract	Background: Sinus node artery occlusion (SNO) is a rare complication of percutaneous coronary intervention (PCI). We analyze both the short- and long-term consequences of SNO. Methods: We retrospectively reviewed 1379 consecutive PCI's involving RCA and Cx arteries performed in our heart institute from 2016 to 2019. Median follow-up was 44 ± 5 months. Results: Among the 4844 PCIs performed during the study period, 284 involved the RCA and the circumflex's proximal segment. Periprocedural SNO was estimated by angiography observed in 15 patients (5.3%), all originated from RCA. The majority of SNO occurred during urgent and primary PCIs following acute coronary syndrome (ACS). Sinus node dysfunction (SND) appeared in 12 (80%) of patients. Four (26.6%) patients had sinus bradycardia, which resolved spontaneously, and 8 (53.3%) patients had sinus arrest with an escaped nodal rhythm, which mostly responded to medical treatment during the first 24 hours. There was no association between PCI technique and outcome. Three patients (20%) required urgent temporary ventricular pacing. One patient had permanent pacemaker implantation. Pacemaker interrogation during follow-up revealed a recovery of the sinus node function after one month. Conclusion: SNO is rare and seen mostly during angioplasty to the proximal segment of the RCA during ACS. The risk of developing sinus node dysfunction following SNO is high. SND usually appears during the first 24 h of PCI. The majority of SND patients responded to medical treatment, and only in rare cases were permanent pacemakers required.
MeSH term(s)	Acute Coronary Syndrome/therapy ; Adult ; Aged ; Aged, 80 and over ; Coronary Vessels/injuries ; Female ; Humans ; Male ; Middle Aged ; Pacemaker, Artificial ; Percutaneous Coronary Intervention/adverse effects ; Percutaneous Coronary Intervention/methods ; Retrospective Studies ; Sick Sinus Syndrome/drug therapy ; Sick Sinus Syndrome/etiology ; Sick Sinus Syndrome/therapy ; Sinoatrial Node/injuries
Language	English
Publishing date	2021-03-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	1036325-7
ISSN	1540-8183 ; 0896-4327
ISSN (online)	1540-8183
ISSN	0896-4327
DOI	10.1155/2021/8810484
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Zs.A 2719: Show issues

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Article ; Online: Sex-Differences in Atrial Fibrillation Patients: Bias or Proper Management?

Israeli, Asaf / Gal, Danna / Younis, Autba / Ehrenberg, Scott / Rozner, Ehud / Turgeman, Yoav / Naami, Edmund / Naami, Robert / Koren, Ofir

Vascular health and risk management

2022 Volume 18, Page(s) 347–358

Abstract: Background: Studies analyze the degree to which gender-based differences are affected by age and comorbidities show mixed results.: Methods: Using a retrospective cohort study, we analyzed 327 consecutive patients who presented to the emergency ... ...

Abstract	Background: Studies analyze the degree to which gender-based differences are affected by age and comorbidities show mixed results. Methods: Using a retrospective cohort study, we analyzed 327 consecutive patients who presented to the emergency department (ED) due to Atrial Fibrillation (AF) from 2014 to 2017 with follow-up at one year. Results: Females with AF were older (p < 0.001), with higher Body Mass Indexes (BMI) (p < 0.001), and a higher rate of hypertension (p < 0.001), hyperlipidemia (p = 0.01), diabetes mellitus (p = 0.05), valvular heart disease (p = 0.05), and thyroid dysfunction (18.3% vs 1.8%, p < 0.001). AF males had higher rate of coronary artery disease (p < 0.001) and heart failure with reduced ejection fraction (p < 0.001). Females were managed with rate control medications more frequently than with antiarrhythmic (p < 0.001). After adjusting gender to age and comorbidities, females continued to have higher rates of heart failure hospitalization (Odds Ratio (OR) 2.73 95% Confidence Interval (CI) 1.04-5.89, P-value <0.001) and recurrent AF (OR 3.86, P-value=0.02). Thyroid dysfunction and the lack of antiarrhythmic treatments significantly increased the risk of AF (OR 5.95 95% CI 3.15-9.73, OR 3.42, respectively, P-value <0.001 for both) regardless of gender. The mortality rate differs only in a sub-group of females ≥75 years of age (OR 1.60, P < 0.001). Conclusion: AF males and females differ significantly in baseline characteristics and tend to be treated unnecessarily differently for AF. Heart failure hospitalizations and recurrent AF continued to be associated with female AF patients, even after adjusting gender to age and comorbidities. Thyroid dysfunction and AF treatment may explain the higher rates of recurrent AF in female patients.
MeSH term(s)	Anti-Arrhythmia Agents/adverse effects ; Atrial Fibrillation/diagnosis ; Atrial Fibrillation/drug therapy ; Atrial Fibrillation/epidemiology ; Comorbidity ; Female ; Heart Failure/diagnosis ; Heart Failure/epidemiology ; Heart Failure/therapy ; Humans ; Male ; Retrospective Studies
Chemical Substances	Anti-Arrhythmia Agents
Language	English
Publishing date	2022-05-05
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2186568-1
ISSN	1178-2048 ; 1176-6344
ISSN (online)	1178-2048
ISSN	1176-6344
DOI	10.2147/VHRM.S366285
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Article ; Online: Epinephrine soaked tampons induced transient acute dilated cardiomyopathy during FESS procedure.

Naddaf, Sari / Ehrenberg, Scott / Hakim, Rony / Mahamid, Muhamad / Turgeman, Yoav / Koren, Ofir

BMC cardiovascular disorders

2020 Volume 20, Issue 1, Page(s) 452

Abstract: Background: Epinephrine, in all modes of use, may pose a wide range of cardiotoxic events, ranging from sinus tachycardia to heart failure, life threatening arrhythmias, and even death. Because of daily and extensive use of epinephrine, these unusual ... ...

Abstract	Background: Epinephrine, in all modes of use, may pose a wide range of cardiotoxic events, ranging from sinus tachycardia to heart failure, life threatening arrhythmias, and even death. Because of daily and extensive use of epinephrine, these unusual and rare events tend to be forgotten by physicians. We present a case of dilated cardiomyopathy that developed following routine use of epinephrine-impregnated tampons during function endoscopic sinus (FESS) surgery. Case presentation: A healthy, 24-year-old man with no family history of heart disease has undergone elective surgery under general anesthesia to repair the paranasal sinuses using endoscopic approach. During surgery, soon after being treated with 1: 1000 diluted epinephrine-soaked tampons, an hypertensive crisis was noticed followed by pulseless electrical activity. An extensive examination led to the diagnosis of non-ischemic dilated cardiomyopathy. After several days of heart failure medical therapy, complete resolution of all structural and functional changes was achieved. Conclusion: In our case, we present an unusual and rare event of acute dilated cardiomyopathy following the use of epinephrine-soaked tampons during elective FESS surgery. A prompt response was observed after several days of heart failure treatment. Awareness of the epinephrine cardiotoxic potential even in the form of soaked tampons is essential for proper diagnosis and prompt treatment.
MeSH term(s)	Acute Disease ; Adrenergic Agonists/administration & dosage ; Adrenergic Agonists/adverse effects ; Cardiomyopathy, Dilated/chemically induced ; Cardiomyopathy, Dilated/diagnostic imaging ; Cardiomyopathy, Dilated/drug therapy ; Cardiotoxicity ; Endoscopy ; Epinephrine/administration & dosage ; Epinephrine/adverse effects ; Humans ; Male ; Nasal Surgical Procedures ; Paranasal Sinuses/surgery ; Tampons, Surgical ; Treatment Outcome ; Young Adult
Chemical Substances	Adrenergic Agonists ; Epinephrine (YKH834O4BH)
Language	English
Publishing date	2020-10-16
Publishing country	England
Document type	Case Reports
ZDB-ID	2059859-2
ISSN	1471-2261 ; 1471-2261
ISSN (online)	1471-2261
ISSN	1471-2261
DOI	10.1186/s12872-020-01706-8
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Article ; Online: The possible onset of fibromyalgia following acute COVID-19 infection.

Savin, Einat / Rosenn, Gali / Tsur, Avishai M / Hen, Or / Ehrenberg, Scott / Gendelman, Omer / Buskila, Dan / Halpert, Gilad / Amital, Daniela / Amital, Howard

PloS one

2023 Volume 18, Issue 2, Page(s) e0281593

Abstract: Introduction: The exact pathogenesis of fibromyalgia (FM) syndrome is unclear. However, various infectious have been implicated with the development of FM after their acute phase. We aimed to investigate the incidence of FM syndrome among convalesced ... ...

Abstract	Introduction: The exact pathogenesis of fibromyalgia (FM) syndrome is unclear. However, various infectious have been implicated with the development of FM after their acute phase. We aimed to investigate the incidence of FM syndrome among convalesced individuals following hospitalization for Acute Coronavirus Disease-2019 (COVID-19). Methods: We performed a cross-sectional study on patients who were discharged after COVID-19 hospitalization from the Sheba Medical Center, Israel, between July 2020 to November 2020. A phone interview was performed consisting of the following questionnaires: the Fibromyalgia Survey Diagnostic Criteria Questionnaire, Sense of Coherence Questionnaire to evaluate resilience, and the Subjective Traumatic Outlook Questionnaire to assess the associated psychological aspects of the trauma. The incidence of post-COVID FM was calculated and regression models were performed to identify predictors. Results: The study population consisted of 198 eligible patients who completed the phone interview. The median age was 64 (52-72) and 37% were women. The median follow-up was 5.2 months (IQR 4.4-5.8). The incidence of FM was 15% (30 patients) and 87% (172 patients) had at least one FM-related symptom. Female gender was significantly associated with post-COVID FM (OR 3.65, p = 0.002). In addition, high median Subjective Traumatic Outlook scores and low median Sense of Coherence scores were both significantly associated with post-COVID FM (OR 1.19, p<0.001 and OR 0.92, p<0.001, respectively). Conclusions: FM is highly prevalent among COVID-19 convalescent patients. Our finding suggests that a significant subjective traumatic experience and a low resilience are highly associated with post-COVID FM.
MeSH term(s)	Humans ; Female ; Middle Aged ; Male ; Fibromyalgia/complications ; Fibromyalgia/epidemiology ; Fibromyalgia/diagnosis ; Cross-Sectional Studies ; COVID-19/complications ; COVID-19/epidemiology ; Surveys and Questionnaires ; Israel/epidemiology
Language	English
Publishing date	2023-02-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0281593
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Article ; Online: Murine fundus fluorescein angiography: An alternative approach using a handheld camera.

Ehrenberg, Moshe / Ehrenberg, Scott / Schwob, Ouri / Benny, Ofra

Experimental eye research

2016 Volume 148, Page(s) 74–78

Abstract: In today's modern pharmacologic approach to treating sight-threatening retinal vascular disorders, there is an increasing demand for a compact, mobile, lightweight and cost-effective fluorescein fundus camera to document the effects of antiangiogenic ... ...

Abstract	In today's modern pharmacologic approach to treating sight-threatening retinal vascular disorders, there is an increasing demand for a compact, mobile, lightweight and cost-effective fluorescein fundus camera to document the effects of antiangiogenic drugs on laser-induced choroidal neovascularization (CNV) in mice and other experimental animals. We have adapted the use of the Kowa Genesis Df Camera to perform Fundus Fluorescein Angiography (FFA) in mice. The 1 kg, 28 cm high camera has built-in barrier and exciter filters to allow digital FFA recording to a Compact Flash memory card. Furthermore, this handheld unit has a steady Indirect Lens Holder that firmly attaches to the main unit, that securely holds a 90 diopter lens in position, in order to facilitate appropriate focus and stability, for photographing the delicate central murine fundus. This easily portable fundus fluorescein camera can effectively record exceptional central retinal vascular detail in murine laser-induced CNV, while readily allowing the investigator to adjust the camera's position according to the variable head and eye movements that can randomly occur while the mouse is optimally anesthetized. This movable image recording device, with efficiencies of space, time, cost, energy and personnel, has enabled us to accurately document the alterations in the central choroidal and retinal vasculature following induction of CNV, implemented by argon-green laser photocoagulation and disruption of Bruch's Membrane, in the experimental murine model of exudative macular degeneration.
MeSH term(s)	Angiogenesis Inhibitors/therapeutic use ; Animals ; Choroid/blood supply ; Choroidal Neovascularization/diagnostic imaging ; Choroidal Neovascularization/drug therapy ; Disease Models, Animal ; Fluorescein Angiography/instrumentation ; Fluorescein Angiography/methods ; Image Processing, Computer-Assisted/methods ; Mice ; Photography/methods
Chemical Substances	Angiogenesis Inhibitors
Language	English
Publishing date	2016-07
Publishing country	England
Document type	Journal Article
ZDB-ID	80122-7
ISSN	1096-0007 ; 0014-4835
ISSN (online)	1096-0007
ISSN	0014-4835
DOI	10.1016/j.exer.2016.05.024
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Article ; Online: Association of anti-Ro seropositivity with cardiac rhythm and conduction disturbances.

Akuka, Aviram / Ben-Shabat, Niv / Watad, Abdulla / Tsur, Avishai M / Ehrenberg, Scott / McGonagle, Dennis / Comaneshter, Doron / Beinart, Roy / Cohen, Arnon D / Amital, Howard

European heart journal

2022

Abstract: Aims: Anti-Ro/La autoantibodies are especially prevalent in autoimmune diseases but are also relatively frequent in healthy adults. Their arrhythmogenic effect on the immature cardiac conductive system is well established, with substantial evidence ... ...

Abstract	Aims: Anti-Ro/La autoantibodies are especially prevalent in autoimmune diseases but are also relatively frequent in healthy adults. Their arrhythmogenic effect on the immature cardiac conductive system is well established, with substantial evidence demonstrating an increased risk for congenital atrioventricular block in neonates of seropositive mothers. Despite their wide distribution and their arrhythmogenic potential effect, there are no large population studies conducted in seropositive adults. Thus, this is the first large population-based study to examine the association of anti-Ro/La seropositivity with cardiac rhythm and conduction disturbances. Methods and results: This cross-sectional designed study involved the electronic health records of the largest health maintenance organization in Israel. All subjects that were tested positive for anti-Ro/anti-La antibodies between the years 2002 and 2019 were included and were matched by age, gender, and place of residence, with controls. Rates of different cardiac rhythm and conduction disturbances were compared between groups. Sensitivity analyses were performed using propensity score matching. The study population included 17 231 anti-Ro/La seropositive subjects and 84 368 controls. Anti-Ro seropositive patients had higher rates of conduction disturbances (3.0 vs. 1.7%, P < 0.001) and rhythm disturbances (10.5 vs. 7.0%, P < 0.001). Patients who tested positive for anti-La alone did not demonstrate a significant association with arrhythmias. Multivariate logistic regression analysis, controlling for possible confounders, showed an increased risk for cardiac conduction disturbances [odds ratio (OR) 1.44, 95% confidence interval (CI) 1.25-1.66, P < 0.001], as well as for cardiac rhythm disturbances (OR 1.21, 95% CI 1.11-1.31, P < 0.001) among anti-Ro seropositive patients. However, the association with rhythm disturbances was more robust in certain subgroup analyses. Conclusions: Anti-Ro seropositivity is positively associated with adult cardiac conduction disturbances and, to a lesser extent, cardiac rhythm disturbances, regardless of the presence of concurrent autoimmune disease.
Language	English
Publishing date	2022-09-23
Publishing country	England
Document type	Journal Article
ZDB-ID	603098-1
ISSN	1522-9645 ; 0195-668X
ISSN (online)	1522-9645
ISSN	0195-668X
DOI	10.1093/eurheartj/ehac516
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