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  1. Article ; Online: Prevalence of HIV in slums area: a systematic review and meta-analysis.

    Behzadifar, Meysam / Ehsanzadeh, Seyed Jafar / Darvishi Teli, Banafshe / Azari, Samad / Bakhtiari, Ahad / Behzadifar, Masoud

    BMC infectious diseases

    2024  Volume 24, Issue 1, Page(s) 52

    Abstract: Background: Human Immunodeficiency Virus (HIV) remains a significant global health burden, particularly affecting vulnerable populations residing in slum areas which is characterized by overcrowding, poverty, and limited access to healthcare services, ... ...

    Abstract Background: Human Immunodeficiency Virus (HIV) remains a significant global health burden, particularly affecting vulnerable populations residing in slum areas which is characterized by overcrowding, poverty, and limited access to healthcare services, create an environment conducive to the transmission and spread of HIV. Despite the recognition of this issue, there is a lack of comprehensive understanding regarding the prevalence of HIV in slums. The aim of this study was to systematically synthesize the existing global evidence on HIV prevalence in slum populations.
    Methods: A rigorous systematic literature review was conducted by searching multiple electronic databases, including Medline via PubMed, Scopus, Embase, Web of Sciences, and Directory of Open Access Journals (DOAJ), covering the period from January 1, 1990, to March 31, 2023. The quality and risk of bias for each included study were assessed using the Newcastle-Ottawa Scale. The pooled prevalence with its corresponding 95% confidence interval (CI) was calculated using a random-effects model with the Freeman-Tukey double arcsine transformation. The degree of heterogeneity among the studies was evaluated using the I
    Results: A systematic examination of the relevant literature resulted in the inclusion of a total of 22 studies for the purpose of this meta-analysis. These studies collectively assessed a sizable cohort consisting of 52,802 participants. Utilizing a random-effects model, an estimation of the overall prevalence of HIV in the slum area was determined to be 10% (95% CI: 7-13%). Further delineation through subgroup analysis based on the gender revealed a higher prevalence of HIV among women, standing at 13% (95% CI: 8-19%, 18 studies: I
    Conclusion: The current study elucidates the troublingly high prevalence of HIV infection within slums area. Also, this finding underscores the urgent necessity for targeted and tailored interventions specifically aimed at curtailing the spread of HIV within slums. Policymakers must take cognizance of these results and devote their efforts towards the implementation of effective strategies to mitigate gender disparities, address poverty alleviation, and empower the inhabitants of these marginalized areas.
    MeSH term(s) Female ; Humans ; Male ; HIV/isolation & purification ; HIV Infections/epidemiology ; Poverty ; Poverty Areas ; Prevalence
    Language English
    Publishing date 2024-01-05
    Publishing country England
    Document type Meta-Analysis ; Systematic Review ; Journal Article
    ZDB-ID 2041550-3
    ISSN 1471-2334 ; 1471-2334
    ISSN (online) 1471-2334
    ISSN 1471-2334
    DOI 10.1186/s12879-023-08877-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Exploring the landscape of health technology assessment in Iran: perspectives from stakeholders on needs, demand and supply.

    Aryankhesal, Aidin / Behzadifar, Meysam / Bakhtiari, Ahad / Shahabi, Saeed / Azari, Samad / Darvishi Teli, Banafshe / Rezapour, Aziz / Ehsanzadeh, Seyed Jafar / Behzadifar, Masoud

    Health research policy and systems

    2024  Volume 22, Issue 1, Page(s) 11

    Abstract: Background: The evaluation of health technologies plays a crucial role in the allocation of resources and the promotion of equitable healthcare access, known as health technology assessment (HTA). This study focuses on Iran's efforts to integrate HTA ... ...

    Abstract Background: The evaluation of health technologies plays a crucial role in the allocation of resources and the promotion of equitable healthcare access, known as health technology assessment (HTA). This study focuses on Iran's efforts to integrate HTA and aims to gain insights into stakeholder perspectives regarding capacity needs, demand and implementation.
    Methods: In this study, we employed the HTA introduction status analysis questionnaire developed by the International Decision Support Initiative (iDSI), which has been utilized in various countries. The questionnaire consisted of 12 questions divided into three sections: HTA need, demand and supply. To identify key informants, we conducted a literature review and consulted with the Ministry of Health and Medical Education (MOHME), as well we experts in policy-making, health service provision and HTA. We selected stakeholders who held decision-making positions in the healthcare domain. A modified Persian version of the questionnaire was administered online from September 2022 to January 2023 and was pretested for clarity. The analysis of the collected data involved quantitative methods for descriptive analysis and qualitative methods for thematic analysis.
    Results: In this study, a total of 103 questionnaires were distributed, resulting in a favourable response rate of 61% from 63 participants, of whom 68% identified as male. The participants, when assessing the needs of HTA, rated allocative efficiency as the highest priority, with a mean rating of 8.53, thereby highlighting its crucial role in optimizing resource allocation. Furthermore, healthcare quality, with a mean rating of 8.17, and transparent decision-making, with a mean rating of 7.92, were highly valued for their impact on treatment outcomes and accountability. The importance of budget control (mean rating 7.58) and equity (mean rating 7.25) were also acknowledged, as they contribute to maintaining sustainability and promoting social justice. In terms of HTA demand, safety concerns were identified as the top priority, closely followed by effectiveness and cost-effectiveness, with an expanded perspective on the economy. However, limited access to local data was reported, which arose from various factors including data collection practices, system fragmentation and privacy concerns. The priorities of HTA users encompassed coverage, payment reform, benefits design, guidelines, service delivery and technology registration. Evidence generation involved the participation of medical universities, research centres and government bodies, albeit with ongoing challenges in research quality, data access and funding. The study highlights government support and medical education as notable strengths in this context.
    Conclusions: This study provides a comprehensive evaluation of Iran's HTA landscape, considering its capacity, demand and implementation aspects. It underlines the vital role of HTA in optimizing resources, improving healthcare quality and promoting equity. The study also sheds light on the strengths of evidence generation in the country, while simultaneously identifying challenges related to data access and system fragmentation. In terms of policy priorities, evidence-based decision-making emerges as crucial for enhancing healthcare access and integrating technology. The study stresses the need for evidence-based practices, a robust HTA infrastructure and collaboration among stakeholders to achieve better healthcare outcomes in Iran.
    MeSH term(s) Humans ; Male ; Delivery of Health Care ; Iran ; Policy Making ; Resource Allocation ; Technology Assessment, Biomedical ; Female
    Language English
    Publishing date 2024-01-15
    Publishing country England
    Document type Review ; Journal Article
    ZDB-ID 2101196-5
    ISSN 1478-4505 ; 1478-4505
    ISSN (online) 1478-4505
    ISSN 1478-4505
    DOI 10.1186/s12961-023-01097-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Features of teleoncology in lung cancer: A scoping review.

    Garavand, Ali / Aslani, Nasim / Behmanesh, Ali / Khara, Rouhallah / Ehsanzadeh, Seyed Jafar / Khodaveisi, Taleb

    Patient education and counseling

    2023  Volume 114, Page(s) 107831

    Abstract: Objectives: There are several challenges in providing healthcare services for lung cancer patients. Using teleoncology is an effective solution to meet such challenges. Given this, we in this study aimed to identify the features of teleoncology in lung ... ...

    Abstract Objectives: There are several challenges in providing healthcare services for lung cancer patients. Using teleoncology is an effective solution to meet such challenges. Given this, we in this study aimed to identify the features of teleoncology in lung cancer.
    Methods: We conducted this scoping review in 2023. We first searched scientific databases including PubMed, Scopus, ISI Web of Sciences, and Science Direct by combining related keywords for the past 12 years (2012-2023).
    Results: After reviewing 860 articles, we selected 39 studies for the purpose of this study. The interventions of teleoncology for lung cancer patients have four main categories, namely: monitoring of symptoms, monitoring the process of treatment and rehabilitation of patients, self-management and patient empowerment, and providing consultation for patients.
    Conclusion: The appropriate implementation of teleoncology systems improves the patient's condition and reduces lung cancer complications by improving the availability of different health services.
    Practice implications: More attention should be paid to the evaluation of telemedicine systems from the perspective of patients and health service providers. Also, the latest platforms, including mobile phone-based software, should be used to implement such systems.
    MeSH term(s) Humans ; Telemedicine ; Health Services ; Self-Management ; Lung Neoplasms/therapy
    Language English
    Publishing date 2023-05-29
    Publishing country Ireland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 605590-4
    ISSN 1873-5134 ; 0738-3991
    ISSN (online) 1873-5134
    ISSN 0738-3991
    DOI 10.1016/j.pec.2023.107831
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  4. Article ; Online: History of primary health care in Iran.

    Aboutorabi, Ali / Darvishi Teli, Banafshe / Rezapour, Aziz / Ehsanzadeh, Seyed Jafar / Martini, Mariano / Behzadifar, Masoud

    Journal of preventive medicine and hygiene

    2023  Volume 64, Issue 3, Page(s) E367–E374

    Abstract: Background: The history of the primary healthcare system in Iran portrays a journey of strategic development and implementation that has resulted in significant advancements in healthcare access and overall population well-being. Starting in the early ... ...

    Abstract Background: The history of the primary healthcare system in Iran portrays a journey of strategic development and implementation that has resulted in significant advancements in healthcare access and overall population well-being. Starting in the early 1980s, Iran embarked on a comprehensive approach to health care delivery prioritizing universal access, equity, and community participation.
    Introduction: The foundation of this system was established during the Alma-Ata Conference in 1978, which placed a strong emphasis on the role of primary health care in attaining health for all.Iran's unwavering commitment to this approach led to the creation of an extensive network of rural and urban health centers designed to offer essential health services and preventive care to all citizens.
    Discussion: Over the years, the expansion of Iran's primary healthcare system has yielded noteworthy accomplishments. Maternal and child mortality rates have seen substantial declines, attributed to improved access to maternal care and immunization services. The effectiveness of the system in reaching diverse populations has been enhanced through community engagement and the integration of traditional medicine. Furthermore, Iran's focus on health education and disease prevention has resulted in heightened public awareness and the adoption of healthier lifestyles. Despite these achievements, challenges continue to persist. Disparities in the quality and accessibility of services between urban and rural areas remain a concern. Moreover, the ongoing necessity for infrastructure development, training of the health workforce, and efficient resource allocation underscore the continuous efforts required to strengthen the primary healthcare system.
    Conclusions: The history of Iran's primary health care system is marked by progress and achievements, underscored by an unwavering commitment to providing comprehensive, community-based care. Iran's journey serves as an exemplary model, highlighting the positive impact of prioritizing primary health care in achieving better health outcomes for its population. As Iran continues to evolve its health system, addressing challenges and building upon successes, the history of its primary health care system serves as a valuable lesson in the pursuit of accessible and equitable health care for all.
    MeSH term(s) Child ; Humans ; Iran/epidemiology ; Health Services Accessibility ; Community Participation ; Rural Population ; Primary Health Care
    Language English
    Publishing date 2023-11-01
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 1102926-2
    ISSN 2421-4248 ; 1121-2233
    ISSN (online) 2421-4248
    ISSN 1121-2233
    DOI 10.15167/2421-4248/jpmh2023.64.3.3081
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  5. Article: Challenges of Budgeting and Public Financial Management in Iran's Health System: A Qualitative Study.

    Moradi, Tayebeh / Kabir, Mohammad Javad / Pourasghari, Hamid / Ehsanzadeh, Seyed Jafar / Aryankhesal, Aidin

    Medical journal of the Islamic Republic of Iran

    2023  Volume 37, Page(s) 80

    Abstract: Background: Efficient and effective management of budgets and financial resources is critical for health systems to achieve their goals; in this regard, countries may face budgetary and financial challenges owing to the weak prediction of resources and ... ...

    Abstract Background: Efficient and effective management of budgets and financial resources is critical for health systems to achieve their goals; in this regard, countries may face budgetary and financial challenges owing to the weak prediction of resources and consumptions, and lack of prioritization for their budget. This study aims to identify the most critical policies and events that have affected public financial management and health budgeting and existing challenges in Iran.
    Methods: We conducted the present study in 2022 using a 2-stage qualitative method. First, by reviewing upstream documents and laws, we identified evidence related to health budgeting. Then, we conducted 13 semi-structured interviews with informed people in the health budgeting field that led us toward the main challenges through thematic content analysis.
    Results: After reviewing 48 upstream documents related to health budgeting, we identified 85 policies. After reviewing the articles, we achieved 11 themes and 71 subthemes. The most critical challenges of the budgeting cycle were as follows: (I) budget formulation, including inappropriate budget structure, conflicts of interest and infringement, lack of financial sustainability, and transparency; (II) budget execution, including a nonexecutable approved budget, complicated allocation process, and ineffective allocations; and (III) monitoring, reporting, and evaluation (MR&E), including fragmentation of MR&E processes, ineffective monitoring and evaluation, weak evaluation of platforms, and inadequate transparency.
    Conclusion: Most challenges in the health budgeting system are related to the budget formulation and approval stage that have their roots in implementation, monitoring, and reporting. In addition, Iran's macroeconomic and financial issues have also damaged the budgeting of the health sector. Budget problems affect the goals and outcomes of this sector, especially the health system.
    Language English
    Publishing date 2023-07-17
    Publishing country Iran
    Document type Journal Article
    ZDB-ID 1095990-7
    ISSN 1016-1430
    ISSN 1016-1430
    DOI 10.47176/mjiri.37.80
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    Zs.A 3383: Show issues Location:
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  6. Article ; Online: Cost-effectiveness of brentuximab vedotin in Hodgkin lymphoma: a systematic review.

    Arabloo, Jalal / Azari, Samad / Gorji, Hasan Abolghasem / Rezapour, Aziz / Alipour, Vahid / Ehsanzadeh, Seyed Jafar

    European journal of clinical pharmacology

    2023  Volume 79, Issue 11, Page(s) 1443–1452

    Abstract: Purpose: This study aimed to systematically review and critically appraise cost-effectiveness studies on Brentuximab vedotin (BV) in patients with Hodgkin lymphoma (HL).: Methods: The PubMed, Scopus, Web of Science core collection, and Embase ... ...

    Abstract Purpose: This study aimed to systematically review and critically appraise cost-effectiveness studies on Brentuximab vedotin (BV) in patients with Hodgkin lymphoma (HL).
    Methods: The PubMed, Scopus, Web of Science core collection, and Embase databases were searched until July 3, 2022. We included published full economic evaluation studies on BV for treating patients with HL. The methodological quality of the studies was assessed using the Quality of Health Economic Studies (QHES) checklist. Meanwhile, we used qualitative synthesis to analyze the findings. We converted the incremental cost-effectiveness ratios (ICERs) to the value of the US dollar in 2022.
    Results: Eight economic evaluations met the study's inclusion criteria. The results of three studies that compared BV plus doxorubicin, vinblastine, and dacarbazine (BV + AVD) front-line therapy with doxorubicin, bleomycin, vincristine, and dacarbazine (ABVD) showed that BV is unlikely to be cost-effective as a front-line treatment in patients advanced stage (III or IV) HL. Four studies investigated the cost-effectiveness of BV in patients with relapsed or refractory (R/R) HL after autologous stem cell transplantation (ASCT). BV was not cost-effective in the reviewed studies at accepted thresholds. In addition, the adjusted ICERs ranged from $65,382 to $374,896 per quality-adjusted life-year (QALY). The key drivers of cost-effectiveness were medication costs, hazard ratio for BV, and utilities.
    Conclusion: Available economic evaluations show that using BV as front-line treatment or consolidation therapy is not cost-effective based on specific ICER thresholds for patients with HL or R/R HL. To decide on this orphan drug, we should consider other factors such as existence of alternative treatment options, clinical benefits, and disease burden.
    MeSH term(s) Humans ; Hodgkin Disease/drug therapy ; Hodgkin Disease/etiology ; Brentuximab Vedotin/therapeutic use ; Cost-Benefit Analysis ; Hematopoietic Stem Cell Transplantation ; Doxorubicin ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Bleomycin/therapeutic use ; Vinblastine/therapeutic use ; Vinblastine/adverse effects ; Dacarbazine/therapeutic use ; Dacarbazine/adverse effects ; Transplantation, Autologous
    Chemical Substances Brentuximab Vedotin (7XL5ISS668) ; Doxorubicin (80168379AG) ; Bleomycin (11056-06-7) ; Vinblastine (5V9KLZ54CY) ; Dacarbazine (7GR28W0FJI)
    Language English
    Publishing date 2023-09-01
    Publishing country Germany
    Document type Systematic Review ; Journal Article ; Review
    ZDB-ID 121960-1
    ISSN 1432-1041 ; 0031-6970
    ISSN (online) 1432-1041
    ISSN 0031-6970
    DOI 10.1007/s00228-023-03557-6
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    Zs.A 672: Show issues Location:
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  7. Article ; Online: Safety and Effectiveness of Endodermal Radiofrequency for Skin Rejuvenation: A Systematic Review.

    Rezapour, Aziz / Arabloo, Jalal / Moradi, Najmeh / Ehsanzadeh, Seyed Jafar / Hourzad, Maryam / Alipour, Vahid

    Aesthetic plastic surgery

    2022  Volume 47, Issue 1, Page(s) 378–386

    Abstract: Background: With the advent of new technologies, the demand for non-invasive and effective procedures to treat skin laxity has increased. In this research, we aimed to review studies conducted on the safety and effectiveness of endodermal radiofrequency ...

    Abstract Background: With the advent of new technologies, the demand for non-invasive and effective procedures to treat skin laxity has increased. In this research, we aimed to review studies conducted on the safety and effectiveness of endodermal radiofrequency (ER) for skin rejuvenation.
    Methods: We searched the databases of Embase, PubMed, Scopus, and Google Scholar from 2000 to 2020 to conduct a systematic review based on the PRISMA statement. Screening of titles, abstracts, and full-text articles was performed independently by two reviewers according to inclusion and exclusion criteria.
    Results: This study showed that ER resulted in improvement in wrinkles and sagging, reduction of fat, tightening of skin of the face, neck, and jawline, improvement in skin elasticity, pigmentation, contouring of the body, and epidermal thickness decrease. ER technology leads to a significant and satisfactory improvement in skin rejuvenation, lower contouring of skin of the face and neck, as well as patients' satisfaction. Side effects of ER are temporary, and usually disappear spontaneously after a few days to one month.
    Conclusion: Cosmetic services providers can use this effective and safe technology to treat skin laxity and skin rejuvenation as a substitute for surgery. Level of evidence III This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .
    MeSH term(s) Humans ; Rejuvenation ; Patient Satisfaction ; Skin ; Plastic Surgery Procedures ; Neck/surgery ; Skin Aging ; Treatment Outcome
    Language English
    Publishing date 2022-09-30
    Publishing country United States
    Document type Systematic Review ; Journal Article ; Review
    ZDB-ID 532791-x
    ISSN 1432-5241 ; 0364-216X
    ISSN (online) 1432-5241
    ISSN 0364-216X
    DOI 10.1007/s00266-022-03097-x
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  8. Article ; Online: A SWOT analysis of the development of health technology assessment in Iran.

    Behzadifar, Masoud / Ghanbari, Mahboubeh Khaton / Azari, Samad / Bakhtiari, Ahad / Rahimi, Sara / Ehsanzadeh, Seyed Jafar / Sharafkhani, Naser / Moridi, Salman / Bragazzi, Nicola Luigi

    PloS one

    2023  Volume 18, Issue 3, Page(s) e0283663

    Abstract: Background: Health systems need to prioritize their services, ensuring efficiency and equitable health provision allocation and access. Alongside, health technology assessment (HTA) seeks to systematically evaluate various aspects of health technologies ...

    Abstract Background: Health systems need to prioritize their services, ensuring efficiency and equitable health provision allocation and access. Alongside, health technology assessment (HTA) seeks to systematically evaluate various aspects of health technologies to be used by policy- and decision-makers. In the present study, we aim to identify strengths, weaknesses, opportunities, and threats in developing an HTA in Iran.
    Method: This qualitative study was conducted using 45 semi-structured interviews from September 2020 to March 2021. Participants were selected from key individuals involved in health and other health-related sectors. Based on the objectives of the study, we used purposive sampling (snowball sampling) to select individuals. The range of length of the interviews was between 45 to 75 minutes. Four authors of the present study carefully reviewed the transcripts of interviews. Meanwhile, the data were coded on the four domains of strengths, weaknesses, opportunities, and threats (SWOT). Transcribed interviews were then entered into the software and analyzed. Data management was performed using MAXQDA software, and also analyzed using directed content analysis.
    Results: Participants identified eleven strengths for HTA in Iran, namely the establishment of an administrative unit for HTA within the Ministry of Health and Medical Education (MOHME); university-level courses and degrees for HTA; adapted approach of HTA models to the Iranian context; HTA is mentioned as a priority on the agenda in upstream documents and government strategic plans. On the other hand, sixteen weaknesses in developing HTA in Iran were identified: unavailability of a well-defined organizational position for using HTA graduates; HTA advantages and its basic concept are unfamiliar to many managers and decision-makers; weak inter-sectoral collaboration in HTA-related research and key stakeholders; and, failure to use HTA in primary health care. Also, participants identified opportunities for HTA development in Iran: support from the political side for reducing national health expenditures; commitment and planning to achieve universal health coverage (on behalf of the government and parliament); improved communication among all stakeholders engaged in the health system; decentralization and regionalization of decisions; and capacity building to use HTA in organizations outside the MOHME. High inflation and bad economic situation; poor transparency in decisions; lack of support from insurance companies; lack of sufficient data to conduct HTA research; rapid change of managers in the health system; and economic sanctions against Iran are threats to the developmental path of HTA in Iran.
    Conclusion: HTA can be properly developed in Iran if we use its strengths and opportunities, and address its weaknesses and threats.
    MeSH term(s) Humans ; Iran ; Technology Assessment, Biomedical ; Health Policy ; Government Programs ; Communication
    Language English
    Publishing date 2023-03-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0283663
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  9. Article: Helicobacter pylori Infection Mediates Inflammation and Tumorigenesis-Associated Genes Through miR-155-5p: An Integrative Omics and Bioinformatics-Based Investigation

    Mahbobi, Ramina / Fallah, Fatemeh / Behmanesh, Ali / Yadegar, Abbas / Hakemi-Vala, Mojdeh / Ehsanzadeh, Seyed Jafar / Shams, Roshanak

    Current microbiology. 2022 July, v. 79, no. 7

    2022  

    Abstract: Helicobacter pylori (H. pylori) is a major human pathogenic bacterium that survives in the gastric mucosa. The aim of this study is to evaluate the expression of the target gene network of miR-155-5p in H. pylori-related gastritis using a combination of ... ...

    Abstract Helicobacter pylori (H. pylori) is a major human pathogenic bacterium that survives in the gastric mucosa. The aim of this study is to evaluate the expression of the target gene network of miR-155-5p in H. pylori-related gastritis using a combination of public gene expression datasets and web-based platforms. To evaluate the expression of genes related to gastritis, we used two datasets from Gene Expression Omnibus (GEO) database. Then, we determined the overlaps between the predicted miR-155-5p target genes and gastritis-dysregulated GEO datasets genes; in the next step, we identified the possible miR-155-5p target-DEGs (Target-Differentially Expressed Genes). Also, we performed multiple bioinformatics analyses to identify the most important targets and downstream pathways associated with this miRNA. Using the UCSC cancer genomic browser analysis tool, we investigated the expression of hub genes in relation to gastric cancer and H. pylori infection, as well as the potential role of hub genes in gastritis, inflammation, and cancer. In this regard, 28 differentially expressed target genes of miR-155-5p were identified. Most of the captured target genes were correlated with the host immune response and inflammation. Based on the specific patterns of expression in gastritis and cancer, CD9, MST1R, and ADAM10 were candidates for the most probable targets of miR-155-5p. Although the focus of this study is primarily on bioinformatics, we think that our findings should be experimentally validated before they can be used as potential therapeutic and diagnostic tools.
    Keywords Helicobacter pylori ; Internet ; animal pathogenic bacteria ; data collection ; databases ; gastric mucosa ; gastritis ; gene expression ; gene expression regulation ; genes ; genomics ; immune response ; inflammation ; microRNA ; multiomics ; stomach neoplasms ; therapeutics
    Language English
    Dates of publication 2022-07
    Size p. 192.
    Publishing place Springer US
    Document type Article
    ZDB-ID 134238-1
    ISSN 1432-0991 ; 0343-8651
    ISSN (online) 1432-0991
    ISSN 0343-8651
    DOI 10.1007/s00284-022-02880-y
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  10. Article ; Online: The effects of clinical decision support system for prescribing medication on patient outcomes and physician practice performance: a systematic review and meta-analysis.

    Taheri Moghadam, Sharare / Sadoughi, Farahnaz / Velayati, Farnia / Ehsanzadeh, Seyed Jafar / Poursharif, Shayan

    BMC medical informatics and decision making

    2021  Volume 21, Issue 1, Page(s) 98

    Abstract: Background: Clinical Decision Support Systems (CDSSs) for Prescribing are one of the innovations designed to improve physician practice performance and patient outcomes by reducing prescription errors. This study was therefore conducted to examine the ... ...

    Abstract Background: Clinical Decision Support Systems (CDSSs) for Prescribing are one of the innovations designed to improve physician practice performance and patient outcomes by reducing prescription errors. This study was therefore conducted to examine the effects of various CDSSs on physician practice performance and patient outcomes.
    Methods: This systematic review was carried out by searching PubMed, Embase, Web of Science, Scopus, and Cochrane Library from 2005 to 2019. The studies were independently reviewed by two researchers. Any discrepancies in the eligibility of the studies between the two researchers were then resolved by consulting the third researcher. In the next step, we performed a meta-analysis based on medication subgroups, CDSS-type subgroups, and outcome categories. Also, we provided the narrative style of the findings. In the meantime, we used a random-effects model to estimate the effects of CDSS on patient outcomes and physician practice performance with a 95% confidence interval. Q statistics and I
    Results: On the basis of the inclusion criteria, 45 studies were qualified for analysis in this study. CDSS for prescription drugs/COPE has been used for various diseases such as cardiovascular diseases, hypertension, diabetes, gastrointestinal and respiratory diseases, AIDS, appendicitis, kidney disease, malaria, high blood potassium, and mental diseases. In the meantime, other cases such as concurrent prescribing of multiple medications for patients and their effects on the above-mentioned results have been analyzed. The study shows that in some cases the use of CDSS has beneficial effects on patient outcomes and physician practice performance (std diff in means = 0.084, 95% CI 0.067 to 0.102). It was also statistically significant for outcome categories such as those demonstrating better results for physician practice performance and patient outcomes or both. However, there was no significant difference between some other cases and traditional approaches. We assume that this may be due to the disease type, the quantity, and the type of CDSS criteria that affected the comparison. Overall, the results of this study show positive effects on performance for all forms of CDSSs.
    Conclusions: Our results indicate that the positive effects of the CDSS can be due to factors such as user-friendliness, compliance with clinical guidelines, patient and physician cooperation, integration of electronic health records, CDSS, and pharmaceutical systems, consideration of the views of physicians in assessing the importance of CDSS alerts, and the real-time alerts in the prescription.
    MeSH term(s) Decision Support Systems, Clinical ; Electronic Health Records ; Humans ; Physicians ; Prescriptions
    Language English
    Publishing date 2021-03-10
    Publishing country England
    Document type Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't ; Systematic Review
    ISSN 1472-6947
    ISSN (online) 1472-6947
    DOI 10.1186/s12911-020-01376-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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