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Article ; Online: Molecular architectures of iron complexes for oxygen reduction catalysis-Activity enhancement by hydroxide ions coupling.

Ei Phyu Win, Poe / Yang, Jiahui / Ning, Shuwang / Huang, Xiang / Fu, Gengtao / Sun, Qiming / Xia, Xing-Hua / Wang, Jiong

Proceedings of the National Academy of Sciences of the United States of America

2024 Volume 121, Issue 11, Page(s) e2316553121

Abstract: Developing cost-effective and high-performance electrocatalysts for oxygen reduction reaction (ORR) is critical for clean energy generation. Here, we propose an approach to the synthesis of iron phthalocyanine nanotubes (FePc NTs) as a highly active and ... ...

Abstract	Developing cost-effective and high-performance electrocatalysts for oxygen reduction reaction (ORR) is critical for clean energy generation. Here, we propose an approach to the synthesis of iron phthalocyanine nanotubes (FePc NTs) as a highly active and selective electrocatalyst for ORR. The performance is significantly superior to FePc in randomly aggregated and molecularly dispersed states, as well as the commercial Pt/C catalyst. When FePc NTs are anchored on graphene, the resulting architecture shifts the ORR potentials above the redox potentials of Fe
Language	English
Publishing date	2024-03-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.2316553121
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Article ; Online: Correction

Ei Phyu Win / Kyaw Kyaw Win / Sonoko D Bellingrath-Kimura / Aung Zaw Oo

PLoS ONE, Vol 17, Iss 1, p e

Influence of rice varieties, organic manure and water management on greenhouse gas emissions from paddy rice soils.

2022 Volume 0263554

Abstract: This corrects the article DOI:10.1371/journal.pone.0253755.]. ...

Abstract	[This corrects the article DOI:10.1371/journal.pone.0253755.].
Keywords	Medicine ; R ; Science ; Q
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Correction

Ei Phyu Win / Kyaw Kyaw Win / Sonoko D. Bellingrath-Kimura / Aung Zaw Oo

PLoS ONE, Vol 17, Iss

Influence of rice varieties, organic manure and water management on greenhouse gas emissions from paddy rice soils

2022 Volume 1

Keywords	Medicine ; R ; Science ; Q
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Influence of rice varieties, organic manure and water management on greenhouse gas emissions from paddy rice soils.

Ei Phyu Win / Kyaw Kyaw Win / Sonoko D Bellingrath-Kimura / Aung Zaw Oo

PLoS ONE, Vol 16, Iss 6, p e

2021 Volume 0253755

Abstract: The study is focused on impact of manure application, rice varieties and water management on greenhouse gas (GHG) emissions from paddy rice soil in pot experiment. The objectives of this study were a) to assess the effect of different types of manure ... ...

Abstract	The study is focused on impact of manure application, rice varieties and water management on greenhouse gas (GHG) emissions from paddy rice soil in pot experiment. The objectives of this study were a) to assess the effect of different types of manure amendments and rice varieties on greenhouse gas emissions and b) to determine the optimum manure application rate to increase rice yield while mitigating GHG emissions under alternate wetting and drying irrigation in paddy rice production. The first pot experiment was conducted at the Department of Agronomy, Yezin Agricultural University, Myanmar, in the wet season from June to October 2016. Two different organic manures (compost and cow dung) and control (no manure), and two rice varieties; Manawthukha (135 days) and IR-50 (115 days), were tested. The results showed that cumulative CH4 emission from Manawthukha (1.084 g CH4 kg-1 soil) was significantly higher than that from IR-50 (0.683 g CH4 kg-1 soil) (P<0.0046) with yield increase (P<0.0164) because of the longer growth duration of the former. In contrast, higher cumulative nitrous oxide emissions were found for IR-50 (2.644 mg N2O kg-1 soil) than for Manawthukha (2.585 mg N2O kg-1 soil). However, IR-50 showed less global warming potential (GWP) than Manawthukha (P<0.0050). Although not significant, the numerically lowest CH4 and N2O emissions were observed in the cow dung manure treatment (0.808 g CH4 kg-1 soil, 2.135 mg N2O kg-1 soil) compared to those of the control and compost. To determine the effect of water management and organic manures on greenhouse gas emissions, second pot experiments were conducted in Madaya township during the dry and wet seasons from February to October 2017. Two water management practices {continuous flooding (CF) and alternate wetting and drying (AWD)} and four cow dung manure rates {(1) 0 (2) 2.5 t ha-1 (3) 5 t ha-1 (4) 7.5 t ha-1} were tested. The different cow dung manure rates did not significantly affect grain yield or greenhouse gas emissions in this experiment. ...
Keywords	Medicine ; R ; Science ; Q
Subject code	571
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
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Article ; Online: First Detection of Mycobacterium tuberculosis Clinical Isolates Harboring I491F Borderline Resistance

Mon, Aye Su / Ei, Phyu Win / Htwe, Mi Mi / Nyunt, Myat Htut / Win, Su Mon / Nyunt, Wint Wint / Myint, Zaw / Aung, Wah Wah

Antimicrobial agents and chemotherapy

2022 Volume 66, Issue 12, Page(s) e0092522

MeSH term(s)	Mycobacterium tuberculosis ; Myanmar ; Mutation ; Antitubercular Agents/pharmacology ; DNA-Directed RNA Polymerases/genetics ; Drug Resistance, Bacterial/genetics ; Bacterial Proteins/genetics ; Antibiotics, Antitubercular/pharmacology
Chemical Substances	Antitubercular Agents ; DNA-Directed RNA Polymerases (EC 2.7.7.6) ; Bacterial Proteins ; Antibiotics, Antitubercular
Language	English
Publishing date	2022-11-07
Publishing country	United States
Document type	Letter ; Research Support, Non-U.S. Gov't
ZDB-ID	217602-6
ISSN	1098-6596 ; 0066-4804
ISSN (online)	1098-6596
ISSN	0066-4804
DOI	10.1128/aac.00925-22
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Article ; Online: Evaluation of the QuantaMatrix Multiplexed Assay Platform for Molecular Diagnosis of Multidrug- and Extensively Drug-Resistant Tuberculosis Using Clinical Strains Isolated in Myanmar.

Chang, Yunhee / Kim, Seoyong / Kim, Yeun / Ei, Phyu Win / Hwang, Dasom / Lee, Jongseok / Chang, Chulhun L / Lee, Hyeyoung

Annals of laboratory medicine

2019 Volume 40, Issue 2, Page(s) 142–147

Abstract: Background: Although the incidence of tuberculosis (TB) is decreasing, cases of multidrug-resistant (MDR) TB and extensively drug-resistant (XDR) TB continue to increase. As conventional phenotype drug susceptibility testing (pDST) takes six to eight ... ...

Abstract	Background: Although the incidence of tuberculosis (TB) is decreasing, cases of multidrug-resistant (MDR) TB and extensively drug-resistant (XDR) TB continue to increase. As conventional phenotype drug susceptibility testing (pDST) takes six to eight weeks, molecular assays are widely used to determine drug resistance. we developed QuantaMatrix Multiplexed Assay Platform (QMAP) MDR/XDR assay (QuantaMatrix Inc., Seoul, Korea) that can simultaneously detect mutations related to both first- and second-line drug resistance (rifampin, isoniazid, ethambutol, fluoroquinolones, second-line injectable drugs, and streptomycin). Methods: We used 190 clinical Results: QMAP results were 87.9% (167/190) concordant with pDST results. In the 23 isolates with discordant results, the QMAP and DNA sequencing results completely matched. Conclusions: The QMAP MDR/XDR assay can detect all known DNA mutations associated with drug resistance for both MDR- and XDR-MTB strains. It can be used for molecular diagnosis of MDR- and XDR-TB to rapidly initiate appropriate anti-TB drug therapy.
MeSH term(s)	Antitubercular Agents/pharmacology ; Antitubercular Agents/therapeutic use ; DNA, Bacterial/genetics ; DNA, Bacterial/metabolism ; Drug Resistance, Multiple, Bacterial/genetics ; Extensively Drug-Resistant Tuberculosis/diagnosis ; Extensively Drug-Resistant Tuberculosis/drug therapy ; Humans ; Microbial Sensitivity Tests ; Multiplex Polymerase Chain Reaction/methods ; Mutation ; Myanmar ; Mycobacterium tuberculosis/genetics ; Mycobacterium tuberculosis/isolation & purification ; Phenotype ; Sequence Analysis, DNA ; Tuberculosis, Multidrug-Resistant/diagnosis ; Tuberculosis, Multidrug-Resistant/drug therapy
Chemical Substances	Antitubercular Agents ; DNA, Bacterial
Language	English
Publishing date	2019-10-24
Publishing country	Korea (South)
Document type	Evaluation Study ; Journal Article
ZDB-ID	2677441-0
ISSN	2234-3814 ; 2234-3806
ISSN (online)	2234-3814
ISSN	2234-3806
DOI	10.3343/alm.2020.40.2.142
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Article ; Online: Molecular Strain Typing of Mycobacterium tuberculosis: a Review of Frequently Used Methods.

Ei, Phyu Win / Aung, Wah Wah / Lee, Jong Seok / Choi, Go Eun / Chang, Chulhun L

Journal of Korean medical science

2016 Volume 31, Issue 11, Page(s) 1673–1683

Abstract: Tuberculosis, caused by the bacterium Mycobacterium tuberculosis, remains one of the most serious global health problems. Molecular typing of M. tuberculosis has been used for various epidemiologic purposes as well as for clinical management. Currently, ... ...

Abstract	Tuberculosis, caused by the bacterium Mycobacterium tuberculosis, remains one of the most serious global health problems. Molecular typing of M. tuberculosis has been used for various epidemiologic purposes as well as for clinical management. Currently, many techniques are available to type M. tuberculosis. Choosing the most appropriate technique in accordance with the existing laboratory conditions and the specific features of the geographic region is important. Insertion sequence IS6110-based restriction fragment length polymorphism (RFLP) analysis is considered the gold standard for the molecular epidemiologic investigations of tuberculosis. However, other polymerase chain reaction-based methods such as spacer oligonucleotide typing (spoligotyping), which detects 43 spacer sequence-interspersing direct repeats (DRs) in the genomic DR region; mycobacterial interspersed repetitive units-variable number tandem repeats, (MIRU-VNTR), which determines the number and size of tandem repetitive DNA sequences; repetitive-sequence-based PCR (rep-PCR), which provides high-throughput genotypic fingerprinting of multiple Mycobacterium species; and the recently developed genome-based whole genome sequencing methods demonstrate similar discriminatory power and greater convenience. This review focuses on techniques frequently used for the molecular typing of M. tuberculosis and discusses their general aspects and applications.
MeSH term(s)	DNA Transposable Elements/genetics ; High-Throughput Nucleotide Sequencing ; Humans ; Molecular Typing/methods ; Mycobacterium tuberculosis/genetics ; Mycobacterium tuberculosis/isolation & purification ; Mycobacterium tuberculosis/metabolism ; Nucleic Acid Hybridization ; Polymerase Chain Reaction ; Polymorphism, Restriction Fragment Length ; Tandem Repeat Sequences/genetics ; Tuberculosis/microbiology
Chemical Substances	DNA Transposable Elements
Language	English
Publishing date	2016-10-05
Publishing country	Korea (South)
Document type	Journal Article ; Review
ZDB-ID	639262-3
ISSN	1598-6357 ; 1011-8934
ISSN (online)	1598-6357
ISSN	1011-8934
DOI	10.3346/jkms.2016.31.11.1673
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Article ; Online: Pyrazinamide resistance and pncA mutations in drug resistant Mycobacterium tuberculosis clinical isolates from Myanmar.

Ei, Phyu Win / Mon, Aye Su / Htwe, Mi Mi / Win, Su Mon / Aye, Kay Thi / San, Lai Lai / Zaw, Ni Ni / Nyunt, Wint Wint / Myint, Zaw / Lee, Jong Seok / Aung, Wah Wah

Tuberculosis (Edinburgh, Scotland)

2020 Volume 125, Page(s) 102013

Abstract: Pyrazinamide (PZA) is an important anti-tuberculosis drug, which is active against semi-dormant bacilli and used as a component of first-line drugs and drug-resistant tuberculosis regimens. Mutations in pncA and its promoter region are main cause of PZA ... ...

Abstract	Pyrazinamide (PZA) is an important anti-tuberculosis drug, which is active against semi-dormant bacilli and used as a component of first-line drugs and drug-resistant tuberculosis regimens. Mutations in pncA and its promoter region are main cause of PZA resistance. There are limited PZA susceptibility data as there is no routine drug susceptibility testing (DST) for PZA. This study was aimed to determine the proportion of PZA resistance among rifampicin-resistant tuberculosis patients and to identify mutations which are responsible for PZA resistance in pncA and its promoter region. Liquid-based DST was performed to detect PZA susceptibility on 192 culture positive rifampicin-resistant isolates collected from National Tuberculosis Reference Laboratory. Sequencing on pncA including its promoter region was performed and analysis was done on 157 isolates. Phenotypic PZA resistance was detected in 58.9% of isolates. Sixty-five different mutations were distributed in pncA or promoter region of 82 isolates. Sensitivity and specificity of pncA sequencing in detection of PZA resistance showed 89.8% and 95.6% respectively. High proportion of PZA resistance among rifampicin-resistant cases highlighted the need for effective treatment regimen development for PZA-resistant MDR-TB. It is also suggested that routine PZA susceptibility test should be incorporated to treatment monitoring regimen and National Drug Resistance surveys.
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; Antitubercular Agents/pharmacology ; DNA Mutational Analysis ; DNA, Bacterial/genetics ; Drug Resistance, Multiple, Bacterial/genetics ; Female ; Genotype ; Humans ; Incidence ; Male ; Middle Aged ; Mutation ; Myanmar/epidemiology ; Mycobacterium tuberculosis/genetics ; Mycobacterium tuberculosis/isolation & purification ; Pyrazinamide/pharmacology ; Retrospective Studies ; Tuberculosis, Multidrug-Resistant/drug therapy ; Tuberculosis, Multidrug-Resistant/epidemiology ; Tuberculosis, Multidrug-Resistant/microbiology ; Young Adult
Chemical Substances	Antitubercular Agents ; DNA, Bacterial ; Pyrazinamide (2KNI5N06TI)
Language	English
Publishing date	2020-10-27
Publishing country	Scotland
Document type	Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
ZDB-ID	2046804-0
ISSN	1873-281X ; 1472-9792
ISSN (online)	1873-281X
ISSN	1472-9792
DOI	10.1016/j.tube.2020.102013
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Article: Genotypes and genetic characters of Mycobacterium tuberculosis from Myanmar using three typing methods

Ei, Phyu Win / Lee, Jong Seok / Aung, Wah Wah / Yeun, Kim / Korma, Workneh / Nyunt, Wint Wint / Swe, Thyn Lei / Htwe, Mi Mi / Win, Su Mon / Aung, Si Thu / Chang, Chulhun L / Lee, Hyeyoung

Infection, genetics, and evolution. 2019 Nov., v. 75

2019

Abstract: Knowledge on basic characteristics of Mycobacterium tuberculosis (MTB) is helpful to understand the disease epidemiology and support the prediction of clinical outcome of the disease. The aim of this study was to detect the genotypes and genotypic ... ...

Abstract	Knowledge on basic characteristics of Mycobacterium tuberculosis (MTB) is helpful to understand the disease epidemiology and support the prediction of clinical outcome of the disease. The aim of this study was to detect the genotypes and genotypic characters of clinical Mycobacterium tuberculosis (MTB) isolates from new and retreatment rifampicin-resistant patients using three different genotyping methods. Mycobacterial interspersed repetitive units-variable number tandem repeat (MIRU-VNTR) typing was used to determine the diversity of 222 clinical isolates. Spoligotyping and IS6110-restriction fragment length polymorphism (RFLP) typing were also used to investigate the genetic characters of 105 MTB strains. Among the 15 genotypes detected by MIRU-VNTR, Beijing strains were the most prevalent of all strains (54.8%); new cases (40.5%) and retreatment cases (69.4%), followed by EAI strain. Spoligotyping categorized the strains into 11 lineages and 13 orphans whereas 96 different IS6110 patterns were identified using RFLP method. The mode number of IS6110 was 18 and 20. Higher band numbers were found in Beijing genotype (p < 0.001). Clustering rates by spoligotyping, MIRU-VNTR and IS6110-RFLP typing were 0.714, 0.004 and 0.085, respectively. Discriminatory powers of spoligotyping, MIRU-VNTR typing and IS6110-RFLP typing were 0.637, 1.000 and 0.997, respectively. Dominant Beijing genotype in both new and retreatment cases denoting that prevailing tuberculosis in Myanmar changed from EAI to Beijing lineage.
Keywords	Mycobacterium tuberculosis ; epidemiology ; evolution ; genotype ; genotyping ; infection ; prediction ; tuberculosis ; China ; Myanmar
Language	English
Dates of publication	2019-11
Publishing place	Elsevier B.V.
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	2037068-4
ISSN	1567-1348
ISSN	1567-1348
DOI	10.1016/j.meegid.2019.104005
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Genotypes and genetic characters of Mycobacterium tuberculosis from Myanmar using three typing methods.

Ei, Phyu Win / Lee, Jong Seok / Aung, Wah Wah / Yeun, Kim / Korma, Workneh / Nyunt, Wint Wint / Swe, Thyn Lei / Htwe, Mi Mi / Win, Su Mon / Aung, Si Thu / Chang, Chulhun L / Lee, Hyeyoung

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases

2019 Volume 75, Page(s) 104005

Abstract	Knowledge on basic characteristics of Mycobacterium tuberculosis (MTB) is helpful to understand the disease epidemiology and support the prediction of clinical outcome of the disease. The aim of this study was to detect the genotypes and genotypic characters of clinical Mycobacterium tuberculosis (MTB) isolates from new and retreatment rifampicin-resistant patients using three different genotyping methods. Mycobacterial interspersed repetitive units-variable number tandem repeat (MIRU-VNTR) typing was used to determine the diversity of 222 clinical isolates. Spoligotyping and IS6110-restriction fragment length polymorphism (RFLP) typing were also used to investigate the genetic characters of 105 MTB strains. Among the 15 genotypes detected by MIRU-VNTR, Beijing strains were the most prevalent of all strains (54.8%); new cases (40.5%) and retreatment cases (69.4%), followed by EAI strain. Spoligotyping categorized the strains into 11 lineages and 13 orphans whereas 96 different IS6110 patterns were identified using RFLP method. The mode number of IS6110 was 18 and 20. Higher band numbers were found in Beijing genotype (p < 0.001). Clustering rates by spoligotyping, MIRU-VNTR and IS6110-RFLP typing were 0.714, 0.004 and 0.085, respectively. Discriminatory powers of spoligotyping, MIRU-VNTR typing and IS6110-RFLP typing were 0.637, 1.000 and 0.997, respectively. Dominant Beijing genotype in both new and retreatment cases denoting that prevailing tuberculosis in Myanmar changed from EAI to Beijing lineage.
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; Female ; Genetic Variation ; Genotype ; Geography ; Humans ; Male ; Middle Aged ; Minisatellite Repeats ; Molecular Epidemiology ; Molecular Typing ; Myanmar/epidemiology ; Mycobacterium tuberculosis/classification ; Mycobacterium tuberculosis/genetics ; Phylogeny ; Polymorphism, Restriction Fragment Length ; Tuberculosis/epidemiology ; Tuberculosis/microbiology ; Young Adult
Language	English
Publishing date	2019-08-19
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2037068-4
ISSN	1567-7257 ; 1567-1348
ISSN (online)	1567-7257
ISSN	1567-1348
DOI	10.1016/j.meegid.2019.104005
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