Article ; Online: Analyzing Criteria Affecting the Functionality of G-Quadruplex-Based DNA Aptazymes as Colorimetric Biosensors and Development of Quinine-Binding Aptazymes.
2021 Volume 93, Issue 12, Page(s) 5161–5169
Abstract: A DNA aptazyme consists of an aptamer domain and a DNAzyme module, in which the DNAzyme activity can be regulated by the aptamer-target interaction. The complex of G-quadruplex (GQ) and hemin is a peroxidase-mimicking DNAzyme and has become increasingly ... ...
| Abstract | A DNA aptazyme consists of an aptamer domain and a DNAzyme module, in which the DNAzyme activity can be regulated by the aptamer-target interaction. The complex of G-quadruplex (GQ) and hemin is a peroxidase-mimicking DNAzyme and has become increasingly popular as a reporter system for biosensing applications. The development of GQ-based aptazymes is of high interest as they can be used as label-free biosensors for the real-time detection of pathogens. Herein, we rationally designed ca. 200 GQ-based aptazyme candidates and evaluated the suitability of 14 aptamers targeting quinine, Protein A, |
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| MeSH term(s) | Aptamers, Nucleotide ; Biosensing Techniques ; Colorimetry ; DNA ; DNA, Catalytic/metabolism ; G-Quadruplexes ; Hemin ; Quinine |
| Chemical Substances | Aptamers, Nucleotide ; DNA, Catalytic ; Hemin (743LRP9S7N) ; DNA (9007-49-2) ; Quinine (A7V27PHC7A) |
| Language | English |
| Publishing date | 2021-03-16 |
| Publishing country | United States |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 1508-8 |
| ISSN | 1520-6882 ; 0003-2700 |
| ISSN (online) | 1520-6882 |
| ISSN | 0003-2700 |
| DOI | 10.1021/acs.analchem.0c05052 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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