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  1. Article ; Online: Soap Bubble Pollination

    Xi Yang / Eijiro Miyako

    iScience, Vol 23, Iss 6, Pp 101188- (2020)

    2020  

    Abstract: Summary: Natural and artificial flower pollination are critical processes in the life cycle of flowering plants. Declines in the number of global pollinator insects, the heavy labor of conducting artificial pollination manually, and the rising cost of ... ...

    Abstract Summary: Natural and artificial flower pollination are critical processes in the life cycle of flowering plants. Declines in the number of global pollinator insects, the heavy labor of conducting artificial pollination manually, and the rising cost of pollen grains are considered to be significant worldwide problems. Here we show that chemically functionalized soap bubbles exhibit effective and convenient delivery of pollen grains to the targeted flowers thanks to their stickiness, softness, high flexibility, and enhancement of pollen activity. By exploring the physicochemical properties of functional soap bubbles, we could prepare mechanically stabilized soap bubbles capable of withstanding the windmills produced by robotic pollination. An unmanned aerial vehicle equipped with a soap bubble maker was autonomously controlled to pollinate flowers. Such technology of automatic intelligent robotic pollination with functional soft materials would lead to innovative agricultural systems that can tackle the global issues of pollination.
    Keywords Surface Chemistry ; Agricultural Science ; Engineering ; Robotics ; Science ; Q
    Subject code 580
    Language English
    Publishing date 2020-06-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Alternating-Magnetic-Field-Mediated Wireless Manipulations of a Liquid Metal for Therapeutic Bioengineering

    Yue Yu / Eijiro Miyako

    iScience, Vol 3, Iss , Pp 134-

    2018  Volume 148

    Abstract: Summary: As emergent multifunctional materials, room temperature liquid metals (LMs) display many unique properties. Here we show that applying an external alternating magnetic field (AMF) to an LM induces various physical phenomena, such as exothermic ... ...

    Abstract Summary: As emergent multifunctional materials, room temperature liquid metals (LMs) display many unique properties. Here we show that applying an external alternating magnetic field (AMF) to an LM induces various physical phenomena, such as exothermic behavior, controlled locomotion, electromagnetic levitation, and transformations of the LMs between different morphologies and configurations, in a non-contact manner. Additional interesting therapeutic bioengineering applications of LMs demonstrated herein include in vitro and in vivo effective cancer magnetic hyperthermia via wireless AMF, remote manipulation of a pill-shaped microdevice based on an LM/hydrogel composite, and spatiotemporal controlled release of drug molecules from the microdevice. Overall, as an innovative therapeutic bioengineering technology, this platform and the described performance traits of LMs enable the development of biocompatible smart devices with a wide range of dynamic components that can be wirelessly controlled in a manner that solves issues related to the powering of devices and biocompatibility. : Bioengineering; Biomaterials; Biomedical Materials Subject Areas: Bioengineering, Biomaterials, Biomedical Materials
    Keywords Science ; Q
    Subject code 621
    Language English
    Publishing date 2018-05-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: The VIPR2-selective antagonist KS-133 changes macrophage polarization and exerts potent anti-tumor effects as a single agent and in combination with an anti-PD-1 antibody.

    Kotaro Sakamoto / Wararat Kittikulsuth / Eijiro Miyako / Akumwami Steeve / Rika Ishimura / Shinsaku Nakagawa / Yukio Ago / Akira Nishiyama

    PLoS ONE, Vol 18, Iss 7, p e

    2023  Volume 0286651

    Abstract: We have previously demonstrated that KS-133 is a specific and potent antagonist of vasoactive intestinal peptide receptor 2 (VIPR2). We have also shown that vasoactive intestinal peptide-VIPR2 signaling affects the polarity and activation of tumor- ... ...

    Abstract We have previously demonstrated that KS-133 is a specific and potent antagonist of vasoactive intestinal peptide receptor 2 (VIPR2). We have also shown that vasoactive intestinal peptide-VIPR2 signaling affects the polarity and activation of tumor-associated macrophages, which is another strategy for cancer immunotherapy apart from the activation of effector T cells. In this study, we aimed to examine whether the selective blockade of VIPR2 by KS-133 changes the polarization of macrophages and induces anti-tumor effects. In the presence of KS-133, genetic markers indicative of tumor-aggressive M1-type macrophages were upregulated, and conversely, those of tumor-supportive M2-type macrophages were downregulated. Daily subcutaneous administration of KS-133 tended to suppress the growth of CT26 tumors (murine colorectal cancer-derived cells) implanted subcutaneously in Balb/c mice. To improve the pharmacological efficacy and reduce the number of doses, we examined a nanoformulation of KS-133 using the US Food and Drug Administration-approved pharmaceutical additive surfactant Cremophor® EL. KS-133 nanoparticles (NPs) were approximately 15 nm in size and stable at 4°C after preparation. Meanwhile, KS-133 was gradually released from the NPs as the temperature was increased. Subcutaneous administration of KS-133 NPs once every 3 days had stronger anti-tumor effects than daily subcutaneous administration of KS-133. Furthermore, KS-133 NPs significantly enhanced the pharmacological efficacy of an immune checkpoint-inhibiting anti-PD-1 antibody. A pharmacokinetic study suggested that the enhancement of anti-tumor activity was associated with improvement of the pharmacokinetic profile of KS-133 upon nanoformulation. Our data have revealed that specific blockade of VIPR2 by KS-133 has therapeutic potential for cancer both alone and in combination with immune checkpoint inhibitors.
    Keywords Medicine ; R ; Science ; Q
    Subject code 610
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Photothermogenetic inhibition of cancer stemness by near-infrared-light-activatable nanocomplexes

    Yue Yu / Xi Yang / Sheethal Reghu / Sunil C. Kaul / Renu Wadhwa / Eijiro Miyako

    Nature Communications, Vol 11, Iss 1, Pp 1-

    2020  Volume 14

    Abstract: Cancer stem cells (CSCs) are known to induce chemotherapy resistance, and cause tumour relapse and metastasis. Here, the authors develop photoactive nanocarbon complexes with second near-infrared photothermal ability to target cancer cells overexpressing ...

    Abstract Cancer stem cells (CSCs) are known to induce chemotherapy resistance, and cause tumour relapse and metastasis. Here, the authors develop photoactive nanocarbon complexes with second near-infrared photothermal ability to target cancer cells overexpressing the receptor TRPV2 and show it to suppress CSCs through dysregulation of the Wnt/β-catenin signalling pathway.
    Keywords Science ; Q
    Language English
    Publishing date 2020-08-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Species-Specific Biodegradation of Sporopollenin-Based Microcapsules

    Teng-Fei Fan / Michael G. Potroz / Ee-Lin Tan / Mohammed Shahrudin Ibrahim / Eijiro Miyako / Nam-Joon Cho

    Scientific Reports, Vol 9, Iss 1, Pp 1-

    2019  Volume 13

    Abstract: Abstract Sporoderms, the outer layers of plant spores and pollen grains, are some of the most robust biomaterials in nature. In order to evaluate the potential of sporoderms in biomedical applications, we studied the biodegradation in simulated ... ...

    Abstract Abstract Sporoderms, the outer layers of plant spores and pollen grains, are some of the most robust biomaterials in nature. In order to evaluate the potential of sporoderms in biomedical applications, we studied the biodegradation in simulated gastrointestinal fluid of sporoderm microcapsules (SDMCs) derived from four different plant species: lycopodium (Lycopodium clavatum L.), camellia (Camellia sinensis L.), cattail (Typha angustifolia L.), and dandelion (Taraxacum officinale L.). Dynamic image particle analysis (DIPA) and field-emission scanning electron microscopy (FE-SEM) were used to investigate the morphological characteristics of the capsules, and Fourier-transform infrared (FTIR) spectroscopy was used to evaluate their chemical properties. We found that SDMCs undergo bulk degradation in a species-dependent manner, with camellia SDMCs undergoing the most extensive degradation, and dandelion and lycopodium SDMCs being the most robust.
    Keywords Medicine ; R ; Science ; Q
    Subject code 580
    Language English
    Publishing date 2019-07-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Human blood plasma catalyses the degradation of Lycopodium plant sporoderm microcapsules

    Teng-Fei Fan / Michael G. Potroz / Ee-Lin Tan / Jae H. Park / Eijiro Miyako / Nam-Joon Cho

    Scientific Reports, Vol 9, Iss 1, Pp 1-

    2019  Volume 7

    Abstract: Abstract Plant sporoderm are among the most robust biomaterials in nature. We investigate the erosion of Lycopodium sporoderm microcapsules (SDMCs) triggered by human blood plasma. Dynamic image particle analysis (DIPA), field emission scanning electron ... ...

    Abstract Abstract Plant sporoderm are among the most robust biomaterials in nature. We investigate the erosion of Lycopodium sporoderm microcapsules (SDMCs) triggered by human blood plasma. Dynamic image particle analysis (DIPA), field emission scanning electron microscopy (FESEM) and Fourier transform infrared (FTIR) spectroscopy demonstrate the degradation events, suggesting bulk erosion as the dominant mechanism for SDMCs fragmentation in human blood. These results should prove valuable in discerning the behaviour of SDMCs in potential biological applications.
    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2019-02-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Light-driven liquid metal nanotransformers for biomedical theranostics

    Svetlana A. Chechetka / Yue Yu / Xu Zhen / Manojit Pramanik / Kanyi Pu / Eijiro Miyako

    Nature Communications, Vol 8, Iss 1, Pp 1-

    2017  Volume 19

    Abstract: Liquid metals are excellent candidate materials for biomedicine, owing to their intriguing optical properties and chemical stability. Here, the authors design multifunctional theranostic liquid metal nanocapsules that, upon irradiation, generate heat and ...

    Abstract Liquid metals are excellent candidate materials for biomedicine, owing to their intriguing optical properties and chemical stability. Here, the authors design multifunctional theranostic liquid metal nanocapsules that, upon irradiation, generate heat and reactive oxygen species and change shape to release drugs.
    Keywords Science ; Q
    Language English
    Publishing date 2017-05-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article: Physicochemically functionalized carbon nanohorns for multi-dimensional cancer elimination

    Chechetka, Svetlana A / Eijiro Miyako / Masako Yudasaka / Minfang Zhang

    Carbon. 2016 Feb., v. 97

    2016  

    Abstract: We have developed multi-componential nanomaterials that are based on folic acid (FA) and polyethylenimine-functionalized carbon nanohorn conjugates that encapsulate magnetite nanoparticles. The nanoconjugates were characterized using a variety of ... ...

    Abstract We have developed multi-componential nanomaterials that are based on folic acid (FA) and polyethylenimine-functionalized carbon nanohorn conjugates that encapsulate magnetite nanoparticles. The nanoconjugates were characterized using a variety of experimental setups, including dynamic light scattering, thermogravimetric analysis, Fourier transform infrared spectrometry, and ultraviolet–visible–near-infrared (UV–Vis–NIR) spectroscopy. An NIR laser and a radio frequency-induction heating system were used to evaluate the heat-generating capability of the nanoconjugates. Aqueous solutions containing the nanoconjugates exhibited a significant increase in temperature after laser irradiation and/or radio frequency induction compared with controls. The intercellular distribution of the nanoconjugates was quantitatively analyzed using UV–Vis–NIR spectroscopy with two cell lines: human epidermal carcinoma (KB) and human embryonic (FHs173We) cells. The interaction between the FA-modified nanoconjugates and KB cells was enhanced through overexpression of FA receptors on the surface of the KB cells. A stronger interaction between the nanoconjugates and KB cells was observed in the presence of a magnet. Furthermore, laser- and/or radio frequency-induced nanoconjugates in combination with external magnetic application reduced the viability of KB cells. Therefore, the present study will open a new direction for the development of multi-dimensional cancer therapy.
    Keywords aqueous solutions ; carbon ; carcinoma ; cell lines ; folic acid ; Fourier transform infrared spectroscopy ; heating systems ; humans ; irradiation ; light scattering ; magnetic materials ; magnetism ; magnetite ; nanoparticles ; quantitative analysis ; radio ; radio waves ; receptors ; temperature ; therapeutics ; thermogravimetry ; viability
    Language English
    Dates of publication 2016-02
    Size p. 45-53.
    Publishing place Elsevier Ltd
    Document type Article
    ISSN 0008-6223
    DOI 10.1016/j.carbon.2015.05.077
    Database NAL-Catalogue (AGRICOLA)

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