LIVIVO - Search results -

Search results

Result 1 - 10 of total 11

Search options

Article ; Online: Influence of growth hormone replacement on neurological and psychomotor development. Case report.

Motta, Felipe / Eisencraft, Adriana Pasmanik / Crisostomo, Lindiane Gomes

2018 Volume 16, Issue 2, Page(s) eRC3961

Abstract: The height response to the use of growth hormone in short height cases has already been confirmed in the literature. The influence of the insulin-like growth factor 1 (GH-IGF1) axis components on development, function, regeneration, neuroprotection, ... ...

Abstract	The height response to the use of growth hormone in short height cases has already been confirmed in the literature. The influence of the insulin-like growth factor 1 (GH-IGF1) axis components on development, function, regeneration, neuroprotection, cognition, and motor functions has been evaluated in experimental studies and in adults with central nervous system lesions. However, there is still little research on the clinical impact of hormone replacement on neurological and psychomotor development. This report presents the case of a patient with excellent weight-height recovery and, even more surprisingly, neurological and psychomotor development in response to use of growth hormone. The result strengthens the correlation between experimental and clinical findings related to cerebral plasticity response to growth hormone in children. A preterm male patient with multiple health problems during the neonatal and young infancy period, who for six years presented with a relevant deficit in growth, bone maturation, and neurological and psychomotor development. At six years of age, he had low stature (z-score -6.89), low growth rate, and low weight (z-score -7.91). He was incapable of sustaining his axial weight, had not developed fine motor skills or sphincter control, and presented with dysfunctional swallowing and language. Supplementary tests showed low IGF-11 levels, with no changes on the image of the hypothalamus-pituitary region, and bone age consistent with three-year-old children - for a chronological age of six years and one month. Growth hormone replacement therapy had a strong impact on the weight-height recovery as well as on the neurological and psychomotor development of this child.
MeSH term(s)	Body Height/drug effects ; Body Height/physiology ; Body Weight/drug effects ; Body Weight/physiology ; Child ; Child Development/drug effects ; Child Development/physiology ; Hormone Replacement Therapy/methods ; Human Growth Hormone/deficiency ; Human Growth Hormone/therapeutic use ; Humans ; Male ; Nervous System Diseases/drug therapy ; Psychomotor Disorders/drug therapy ; Time Factors ; Treatment Outcome
Chemical Substances	Human Growth Hormone (12629-01-5)
Language	Portuguese
Publishing date	2018-05-14
Publishing country	Brazil
Document type	Case Reports
ZDB-ID	2418293-X
ISSN	2317-6385 ; 1679-4508
ISSN (online)	2317-6385
ISSN	1679-4508
DOI	10.1590/S1679-45082018RC3961
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article ; Online: Multisystem inflammatory syndrome associated with COVID-19 from the pediatric emergency physician's point of view.

Simon Junior, Hany / Sakano, Tania Miyuki Shimoda / Rodrigues, Regina Maria / Eisencraft, Adriana Pasmanik / Carvalho, Vitor Emanoel Lemos de / Schvartsman, Claudio / Reis, Amelia Gorete Afonso da Costa

Jornal de pediatria

2020 Volume 97, Issue 2, Page(s) 140–159

Abstract: Objective: Multisystem inflammatory syndrome in children (MIS-C) associated with coronavirus disease (COVID-19) is a rare and challenging diagnosis requiring early treatment. The diagnostic criteria involve clinical, laboratory, and complementary tests. ...

Abstract	Objective: Multisystem inflammatory syndrome in children (MIS-C) associated with coronavirus disease (COVID-19) is a rare and challenging diagnosis requiring early treatment. The diagnostic criteria involve clinical, laboratory, and complementary tests. This review aims to draw pediatrician attention to this diagnosis, suggesting early treatment strategies, and proposing a pediatric emergency care flowchart. Sources: The PubMed/MEDLINE/WHO COVID-19 databases were reviewed for original and review articles, systematic reviews, meta-analyses, case series, and recommendations from medical societies and health organizations published through July 3, 2020. The reference lists of the selected articles were manually searched to identify any additional articles. Summary of the findings: COVID-19 infection is less severe in children than in adults, but can present as MIS-C, even in patients without comorbidities. There is evidence of an exacerbated inflammatory response with potential systemic injury, and it may present with aspects similar to those of Kawasaki disease, toxic shock syndrome, and macrophage activation syndrome. MIS-C can develop weeks after COVID-19 infection, suggesting an immunomediated cause. The most frequent clinical manifestations include fever, gastrointestinal symptoms, rash, mucous membrane changes, and cardiac dysfunction. Elevated inflammatory markers, lymphopenia, and coagulopathy are common laboratory findings. Supportive treatment and early immunomodulation can control the intense inflammatory response and reduce complications and mortality. Conclusions: MIS-C associated with COVID-19 is serious, rare, and potentially fatal. The emergency department pediatrician must recognize and treat it early using immunomodulatory strategies to reduce systemic injury. Further studies are needed to identify the disease pathogenesis and establish the most appropriate treatment.
MeSH term(s)	Adult ; COVID-19 ; Child ; Coronavirus ; Emergency Service, Hospital ; Humans ; Physicians ; SARS-CoV-2 ; Systemic Inflammatory Response Syndrome
Keywords	covid19
Language	English
Publishing date	2020-09-11
Publishing country	Brazil
Document type	Journal Article ; Review
ZDB-ID	731324-x
ISSN	1678-4782 ; 0021-7557
ISSN (online)	1678-4782
ISSN	0021-7557
DOI	10.1016/j.jped.2020.08.004
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 1265: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Perception of usefulness of laboratory tests ordering by internal medicine residents in ambulatory setting: A single-center prospective cohort study.

Doi, Dimitria / Vale, Romulo Ribeiro do / Monteiro, Jean Michell Correia / Plens, Glauco Cabral Marinho / Ferreira Junior, Mario / Fonseca, Luiz Augusto Marcondes / Perazzio, Sandro Félix / Besen, Bruno Adler Maccagnan Pinheiro / Lichtenstein, Arnaldo / Taniguchi, Leandro Utino / Sumita, Nairo Massakazu / Corá, Aline Pivetta / Eisencraft, Adriana Pasmanik / Duarte, Alberto José da Silva

PloS one

2021 Volume 16, Issue 5, Page(s) e0250769

Abstract: The demand for high value health care uncovered a steady trend in laboratory tests ordering and inappropriate testing practices. Residents' training in laboratory ordering practice provides an opportunity for quality improvement. We collected information ...

Abstract	The demand for high value health care uncovered a steady trend in laboratory tests ordering and inappropriate testing practices. Residents' training in laboratory ordering practice provides an opportunity for quality improvement. We collected information on demographics, the main reason for the appointment, preexisting medical conditions and presence of co-morbidities from first-visit patients to the internal medicine outpatient service of our university general hospital. We also collected information on all laboratory tests ordered by the attending medical residents. At a follow-up visit, we recorded residents' subjective perception on the usefulness of each ordered laboratory test for the purposes of diagnosis, prognosis, treatment or screening. We observed that 17.3% of all ordered tests had no perceived utility by the attending resident. Tests were usually ordered to exclude differential diagnoses (26.7%) and to help prognosis estimation (19.1%). Age and co-morbidity influenced the chosen category to legitimate usefulness of tests ordering. This study suggests that clinical objectives (diagnosis, prognosis, treatment or prevention) as well as personalization to age and previous health conditions should be considered before test ordering to allow a more appropriate laboratory tests ordering, but further studies are necessary to examine this framework beyond this medical training scenario.
MeSH term(s)	Adult ; Ambulatory Care Facilities/statistics & numerical data ; Attitude of Health Personnel ; Clinical Laboratory Techniques ; Cohort Studies ; Female ; Humans ; Internal Medicine/education ; Internship and Residency/statistics & numerical data ; Male
Language	English
Publishing date	2021-05-11
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0250769
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article: Multisystem inflammatory syndrome associated with COVID-19 from the pediatric emergency physician's point of view

Abstract: OBJECTIVE: Multisystem inflammatory syndrome in children (MIS-C) associated with coronavirus disease (COVID-19) is a rare and challenging diagnosis requiring early treatment. The diagnostic criteria involve clinical, laboratory, and complementary tests. ... ...

Abstract	OBJECTIVE: Multisystem inflammatory syndrome in children (MIS-C) associated with coronavirus disease (COVID-19) is a rare and challenging diagnosis requiring early treatment. The diagnostic criteria involve clinical, laboratory, and complementary tests. This review aims to draw pediatrician attention to this diagnosis, suggesting early treatment strategies, and proposing a pediatric emergency care flowchart. SOURCES: The PubMed/MEDLINE/WHO COVID-19 databases were reviewed for original and review articles, systematic reviews, meta-analyses, case series, and recommendations from medical societies and health organizations published through July 3, 2020. The reference lists of the selected articles were manually searched to identify any additional articles. SUMMARY OF THE FINDINGS: COVID-19 infection is less severe in children than in adults, but can present as MIS-C, even in patients without comorbidities. There is evidence of an exacerbated inflammatory response with potential systemic injury, and it may present with aspects similar to those of Kawasaki disease, toxic shock syndrome, and macrophage activation syndrome. MIS-C can develop weeks after COVID-19 infection, suggesting an immunomediated cause. The most frequent clinical manifestations include fever, gastrointestinal symptoms, rash, mucous membrane changes, and cardiac dysfunction. Elevated inflammatory markers, lymphopenia, and coagulopathy are common laboratory findings. Supportive treatment and early immunomodulation can control the intense inflammatory response and reduce complications and mortality. CONCLUSIONS: MIS-C associated with COVID-19 is serious, rare, and potentially fatal. The emergency department pediatrician must recognize and treat it early using immunomodulatory strategies to reduce systemic injury. Further studies are needed to identify the disease pathogenesis and establish the most appropriate treatment.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #753227
Database	COVID19

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾

Article ; Online: Multisystem inflammatory syndrome associated with COVID-19 from the pediatric emergency physician's point of view

Jornal de Pediatria ; ISSN 0021-7557

2020

Keywords	Pediatrics, Perinatology, and Child Health ; covid19
Language	English
Publisher	Elsevier BV
Publishing country	us
Document type	Article ; Online
DOI	10.1016/j.jped.2020.08.004
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: SARS-CoV-2 and rhinovirus infections: are there differences in clinical presentation, laboratory abnormalities, and outcomes in the pediatric population?

Pereira, Maria Fernanda Bádue / Suguita, Priscila / Litvinov, Nadia / Farhat, Sylvia Costa Lima / Paula, Camila Sanson Yoshino de / Lázari, Carolina Dos Santos / Bedê, Pedro Vale / Framil, Juliana Valeria de Souza / Bueno, Catarina / Branas, Priscila Cristina Abduch Adas / Guimarães, Irina Monteiro da Costa / Leite, Marcia Marques / Navega, Ana Carolina Barsaglini / Nanbu, Danilo Yamamoto / Schvartsman, Claudio / Pinho, João Renato Rebello / Silva, Clovis Artur Almeida / Marques, Heloisa Helena de Sousa / Eisencraft, Adriana Pasmanik /

Rossi, Alfio / Delgado, Artur Figueiredo / Leal, Gabriela Nunes / Gibelli, Maria Augusta Cicaroni / Palmeira, Patricia / Sakita, Neusa Keico / Santos, Emilly Henrique Dos / Rocha, Mussya Cisotto / Kanunfre, Kelly Aparecida / Okay, Thelma Suely / Carneiro-Sampaio, Magda / Carvalho, Werther Brunow de

Revista do Instituto de Medicina Tropical de Sao Paulo

2022 Volume 64, Page(s) e34

Abstract: This study aims to assess COVID-19 and other respiratory viruses in pediatric patients. Between April 17 and September 30, 2020, we collected 1,566 respiratory samples from 1,044 symptomatic patients who were younger than 18 years old to assess SARS-CoV- ... ...

Abstract	This study aims to assess COVID-19 and other respiratory viruses in pediatric patients. Between April 17 and September 30, 2020, we collected 1,566 respiratory samples from 1,044 symptomatic patients who were younger than 18 years old to assess SARS-CoV-2 infection. Of these, 919 were analyzed for other respiratory pathogens (ORP). Patients with laboratory-confirmed COVID-19 or ORP were included. We evaluated 76 pediatric COVID-19 infections and 157 other respiratory virus infections. Rhinovirus occurred in 132/157 (84%). COVID-19 patients who were significantly older, had more fevers, headaches and pneumonia than those with ORP. The median white blood cell count was lower in patients with SARS-CoV-2 than in those with ORP (6,470 versus 8,170; p=0.02). COVID-19 patients had significantly worse symptoms than those with ORP.
MeSH term(s)	Adolescent ; COVID-19/diagnosis ; Child ; Communicable Diseases ; Humans ; Rhinovirus ; SARS-CoV-2
Language	English
Publishing date	2022-05-25
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	128928-7
ISSN	1678-9946 ; 0036-4665
ISSN (online)	1678-9946
ISSN	0036-4665
DOI	10.1590/S1678-9946202264034
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 292: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Severe clinical spectrum with high mortality in pediatric patients with COVID-19 and multisystem inflammatory syndrome.

Pereira, Maria Fernanda Badue / Litvinov, Nadia / Farhat, Sylvia Costa Lima / Eisencraft, Adriana Pasmanik / Gibelli, Maria Augusta Bento Cicaroni / Carvalho, Werther Brunow de / Fernandes, Vinicius Rodrigues / Fink, Thais de Toledo / Framil, Juliana Valéria de Souza / Galleti, Karine Vusberg / Fante, Alice Lima / Fonseca, Maria Fernanda Mota / Watanabe, Andreia / Paula, Camila Sanson Yoshino de / Palandri, Giovanna Gavros / Leal, Gabriela Nunes / Diniz, Maria de Fatima Rodrigues / Pinho, João Renato Rebello / Silva, Clovis Artur /

Marques, Heloisa Helena de Sousa / Rossi Junior, Alfio / Delgado, Artur Figueiredo / Andrade, Anarella Penha Meirelles de / Schvartsman, Claudio / Sabino, Ester Cerdeira / Rocha, Mussya Cisotto / Kanunfre, Kelly Aparecida / Okay, Thelma Suely / Carneiro-Sampaio, Magda Maria Sales / Jorge, Patricia Palmeira Daenekas

Clinics (Sao Paulo, Brazil)

2020 Volume 75, Page(s) e2209

Abstract: Objectives: To assess the outcomes of pediatric patients with laboratory-confirmed coronavirus disease (COVID-19) with or without multisystem inflammatory syndrome in children (MIS-C).: Methods: This cross-sectional study included 471 samples ... ...

Abstract	Objectives: To assess the outcomes of pediatric patients with laboratory-confirmed coronavirus disease (COVID-19) with or without multisystem inflammatory syndrome in children (MIS-C). Methods: This cross-sectional study included 471 samples collected from 371 patients (age<18 years) suspected of having severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The study group comprised 66/371 (18%) laboratory-confirmed pediatric COVID-19 patients: 61 (92.5%) patients tested positive on real-time reverse transcription-polymerase chain reaction tests for SARS-CoV-2, and 5 (7.5%) patients tested positive on serological tests. MIS-C was diagnosed according to the criteria of the Center for Disease Control. Results: MIS-C was diagnosed in 6/66 (9%) patients. The frequencies of diarrhea, vomiting, and/or abdominal pain (67% vs. 22%, p=0.034); pediatric SARS (67% vs. 13%, p=0.008); hypoxemia (83% vs. 23%, p=0.006); and arterial hypotension (50% vs. 3%, p=0.004) were significantly higher in patients with MIS-C than in those without MIS-C. The frequencies of C-reactive protein levels >50 mg/L (83% vs. 25%, p=0.008) and D-dimer levels >1000 ng/mL (100% vs. 40%, p=0.007) and the median D-dimer, troponin T, and ferritin levels (p<0.05) were significantly higher in patients with MIS-C. The frequencies of pediatric intensive care unit admission (100% vs. 60%, p=0.003), mechanical ventilation (83% vs. 7%, p<0.001), vasoactive agent use (83% vs. 3%, p<0.001), shock (83% vs. 5%, p<0.001), cardiac abnormalities (100% vs. 2%, p<0.001), and death (67% vs. 3%, p<0.001) were also significantly higher in patients with MIS-C. Similarly, the frequencies of oxygen therapy (100% vs. 33%, p=0.003), intravenous immunoglobulin therapy (67% vs. 2%, p<0.001), aspirin therapy (50% vs. 0%, p<0.001), and current acute renal replacement therapy (50% vs. 2%, p=0.002) were also significantly higher in patients with MIS-C. Logistic regression analysis showed that the presence of MIS-C was significantly associated with gastrointestinal manifestations [odds ratio (OR)=10.98; 95%CI (95% confidence interval)=1.20-100.86; p=0.034] and hypoxemia [OR=16.85; 95%CI=1.34-211.80; p=0.029]. Further univariate analysis showed a positive association between MIS-C and death [OR=58.00; 95%CI=6.39-526.79; p<0.0001]. Conclusions: Pediatric patients with laboratory-confirmed COVID-19 with MIS-C had a severe clinical spectrum with a high mortality rate. Our study emphasizes the importance of investigating MIS-C in pediatric patients with COVID-19 presenting with gastrointestinal involvement and hypoxemia.
MeSH term(s)	Abdominal Pain/etiology ; Betacoronavirus ; COVID-19 ; Child ; Coronavirus ; Coronavirus Infections/complications ; Coronavirus Infections/diagnosis ; Coronavirus Infections/mortality ; Coronavirus Infections/therapy ; Cross-Sectional Studies ; Diarrhea/etiology ; Fever/etiology ; Glucocorticoids/therapeutic use ; Humans ; Immunoglobulins, Intravenous/therapeutic use ; Male ; Mucocutaneous Lymph Node Syndrome/epidemiology ; Mucocutaneous Lymph Node Syndrome/therapy ; Mucocutaneous Lymph Node Syndrome/virology ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/mortality ; Pneumonia, Viral/therapy ; Respiration, Artificial ; SARS-CoV-2 ; Severity of Illness Index ; Systemic Inflammatory Response Syndrome/epidemiology ; Systemic Inflammatory Response Syndrome/therapy ; Systemic Inflammatory Response Syndrome/virology ; Vomiting/etiology
Chemical Substances	Glucocorticoids ; Immunoglobulins, Intravenous
Keywords	covid19
Language	English
Publishing date	2020-08-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	2182801-5
ISSN	1980-5322 ; 1807-5932
ISSN (online)	1980-5322
ISSN	1807-5932
DOI	10.6061/clinics/2020/e2209
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 404: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Severe clinical spectrum with high mortality in pediatric patients with COVID-19 and multisystem inflammatory syndrome

Pereira, Maria Fernanda Badue / Litvinov, Nadia / Farhat, Sylvia Costa Lima / Eisencraft, Adriana Pasmanik / Gibelli, Maria Augusta Bento Cicaroni / Carvalho, Werther Brunow de / Fernandes, Vinicius Rodrigues / Fink, Thais de Toledo / Framil, Juliana Vale´ria de Souza / Galleti, Karine Vusberg / Fante, Alice Lima / Fonseca, Maria Fernanda Mota / Watanabe, Andreia / Paula, Camila Sanson Yoshino de / Palandri, Giovanna Gavros / Leal, Gabriela Nunes / Diniz, Maria de Fatima Rodrigues / Pinho, João Renato Rebello / Silva, Clovis Artur /

Marques, Heloisa Helena de Sousa / Study Group, Pediatric COVID HC-FMUSP

Clinics; v.; e2209 ; Clinics; Vol. 75 (2020); e2209 ; Clinics; Vol 75 (2020); e2209 ; 1980-5322 ; 1807-5932

2020 Volume 75

Abstract: OBJECTIVES: To assess the outcomes of pediatric patients with laboratory-confirmed coronavirus disease (COVID-19) with or without multisystem inflammatory syndrome in children (MIS-C). METHODS: This cross-sectional study included 471 samples collected ... ...

Abstract	OBJECTIVES: To assess the outcomes of pediatric patients with laboratory-confirmed coronavirus disease (COVID-19) with or without multisystem inflammatory syndrome in children (MIS-C). METHODS: This cross-sectional study included 471 samples collected from 371 patients (ageo18 years) suspected of having severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The study group comprised 66/371 (18%) laboratory-confirmed pediatric COVID-19 patients: 61 (92.5%) patients tested positive on real-time reverse transcription-polymerase chain reaction tests for SARS-CoV-2, and 5 (7.5%) patients tested positive on serological tests. MIS-C was diagnosed according to the criteria of the Center for Disease Control. RESULTS: MIS-C was diagnosed in 6/66 (9%) patients. The frequencies of diarrhea, vomiting, and/or abdominal pain (67% vs. 22%, p=0.034); pediatric SARS (67% vs. 13%, p=0.008); hypoxemia (83% vs. 23%, p=0.006); and arterial hypotension (50% vs. 3%, p=0.004) were significantly higher in patients with MIS-C than in those without MIS-C. The frequencies of C-reactive protein levels 450 mg/L (83% vs. 25%, p=0.008) and D-dimer levels 41000 ng/mL (100% vs. 40%, p=0.007) and the median D-dimer, troponin T, and ferritin levels (po0.05) were significantly higher in patients with MIS-C. The frequencies of pediatric intensive care unit admission (100% vs. 60%, p=0.003), mechanical ventilation (83% vs. 7%, po0.001), vasoactive agent use (83% vs. 3%, po0.001), shock (83% vs. 5%, po0.001), cardiac abnormalities (100% vs. 2%, po0.001), and death (67% vs. 3%, po0.001) were also significantly higher in patients with MIS-C. Similarly, the frequencies of oxygen therapy (100% vs. 33%, p=0.003), intravenous immunoglobulin therapy (67% vs. 2%, po0.001), aspirin therapy (50% vs. 0%, po0.001), and current acute renal replacement therapy (50% vs. 2%, p=0.002) were also significantly higher in patients with MIS-C. Logistic regression analysis showed that the presence of MIS-C was significantly associated with gastrointestinal manifestations [odds ratio (OR)=10.98; 95%CI (95% confidence interval)=1.20-100.86; p=0.034] and hypoxemia [OR=16.85; 95%CI=1.34-211.80; p=0.029]. Further univariate analysis showed a positive association between MIS-C and death [OR=58.00; 95%CI=6.39- 526.79; po0.0001]. CONCLUSIONS: Pediatric patients with laboratory-confirmed COVID-19 with MIS-C had a severe clinical spectrum with a high mortality rate. Our study emphasizes the importance of investigating MIS-C in pediatric patients with COVID-19 presenting with gastrointestinal involvement and hypoxemia.
Keywords	covid19
Subject code	610 ; 616
Language	English
Publishing date	2020-08-29
Publisher	Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo
Publishing country	br
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Technical performance of a lateral flow immunoassay for detection of anti-SARS-CoV-2 IgG in the outpatient follow-up of non-severe cases and at different times after vaccination: comparison with enzyme and chemiluminescent immunoassays.

Barreira, Gabriel Acca / Santos, Emilly Henrique Dos / Pereira, Maria Fernanda Bádue / Rodrigues, Karen Alessandra / Rocha, Mussya Cisotto / Kanunfre, Kelly Aparecida / Marques, Heloisa Helena de Sousa / Okay, Thelma Suely / Eisencraft, Adriana Pasmanik / Rossi Junior, Alfio / Fante, Alice Lima / Cora, Aline Pivetta / Costa Reis, Amelia Gorete A de / Ferrer, Ana Paula Scoleze / Andrade, Anarella Penha Meirelles de / Watanabe, Andreia / Gonçalves, Angelina Maria Freire / Waetge, Aurora Rosaria Pagliara / Silva, Camila Altenfelder /

Ceneviva, Carina / Lazari, Carolina Dos Santos / Abellan, Deipara Monteiro / Sabino, Ester Cerdeira / Bianchini, Fabíola Roberta Marim / Alcantara, Flávio Ferraz de Paes / Ramos, Gabriel Frizzo / Leal, Gabriela Nunes / Rodriguez, Isadora Souza / Pinho, João Renato Rebello / Carneiro, Jorge David Avaizoglou / Paz, Jose Albino / Ferreira, Juliana Carvalho / Ferranti, Juliana Ferreira / Ferreira, Juliana de Oliveira Achili / Framil, Juliana Valéria de Souza / Silva, Katia Regina da / Bastos, Karina Lucio de Medeiros / Galleti, Karine Vusberg / Cristofani, Lilian Maria / Suzuki, Lisa / Campos, Lucia Maria Arruda / Perondi, Maria Beatriz de Moliterno / Diniz, Maria de Fatima Rodrigues / Fonseca, Maria Fernanda Mota / Cordon, Mariana Nutti de Almeida / Pissolato, Mariana / Peres, Marina Silva / Garanito, Marlene Pereira / Imamura, Marta / Dorna, Mayra de Barros / Luglio, Michele / Aikawa, Nadia Emi / Degaspare, Natalia Viu / Sakita, Neusa Keico / Udsen, Nicole Lee / Scudeller, Paula Gobi / Gaiolla, Paula Vieira de Vincenzi / Severini, Rafael da Silva Giannasi / Rodrigues, Regina Maria / Toma, Ricardo Katsuya / Paula, Ricardo Iunis Citrangulo de / Palmeira, Patricia / Forsait, Silvana / Farhat, Sylvia Costa Lima / Sakano, Tânia Miyuki Shimoda / Koch, Vera Hermina Kalika / Cobello Junior, Vilson

Revista do Instituto de Medicina Tropical de Sao Paulo

2022 Volume 64, Page(s) e49

Abstract: This study assessed the technical performance of a rapid lateral flow immunochromatographic assay (LFIA) for the detection of anti-SARS-CoV-2 IgG and compared LFIA results with chemiluminescent immunoassay (CLIA) results and an in-house enzyme ... ...

Abstract	This study assessed the technical performance of a rapid lateral flow immunochromatographic assay (LFIA) for the detection of anti-SARS-CoV-2 IgG and compared LFIA results with chemiluminescent immunoassay (CLIA) results and an in-house enzyme immunoassay (EIA). To this end, a total of 216 whole blood or serum samples from three groups were analyzed: the first group was composed of 68 true negative cases corresponding to blood bank donors, healthy young volunteers, and eight pediatric patients diagnosed with other coronavirus infections. The serum samples from these participants were obtained and stored in a pre-COVID-19 period, thus they were not expected to have COVID-19. In the second group of true positive cases, we chose to replace natural cases of COVID-19 by 96 participants who were expected to have produced anti-SARS-CoV-2 IgG antibodies 30-60 days after the vaccine booster dose. The serum samples were collected on the same day that LFIA were tested either by EIA or CLIA. The third study group was composed of 52 participants (12 adults and 40 children) who did or did not have anti-SARS-CoV-2 IgG antibodies due to specific clinical scenarios. The 12 adults had been vaccinated more than seven months before LFIA testing, and the 40 children had non-severe COVID-19 diagnosed using RT-PCR during the acute phase of infection. They were referred for outpatient follow-up and during this period the serum samples were collected and tested by CLIA and LFIA. All tests were performed by the same healthcare operator and there was no variation of LFIA results when tests were performed on finger prick whole blood or serum samples, so that results were grouped for analysis. LFIA's sensitivity in detecting anti-SARS-CoV-2 IgG antibodies was 90%, specificity 97.6%, efficiency 93%, PPV 98.3%, NPV 86.6%, and likelihood ratio for a positive or a negative result were 37.5 and 0.01 respectively. There was a good agreement (Kappa index of 0.677) between LFIA results and serological (EIA or CLIA) results. In conclusion, LFIA analyzed in this study showed a good technical performance and agreement with reference serological assays (EIA or CLIA), therefore it can be recommended for use in the outpatient follow-up of non-severe cases of COVID-19 and to assess anti-SARS-CoV-2 IgG antibody production induced by vaccination and the antibodies decrease over time. However, LFIAs should be confirmed by using reference serological assays whenever possible.
MeSH term(s)	Adult ; Antibodies, Viral ; COVID-19/diagnosis ; COVID-19/prevention & control ; Child ; Follow-Up Studies ; Humans ; Immunoassay/methods ; Immunoglobulin G ; Immunoglobulin M ; Outpatients ; Sensitivity and Specificity ; Vaccination
Chemical Substances	Antibodies, Viral ; Immunoglobulin G ; Immunoglobulin M
Language	English
Publishing date	2022-07-13
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	128928-7
ISSN	1678-9946 ; 0036-4665
ISSN (online)	1678-9946
ISSN	0036-4665
DOI	10.1590/S1678-9946202264049
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 292: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Severe clinical spectrum with high mortality in pediatric patients with COVID-19 and multisystem inflammatory syndrome

Clinics (Sao Paulo)

Abstract	OBJECTIVES: To assess the outcomes of pediatric patients with laboratory-confirmed coronavirus disease (COVID-19) with or without multisystem inflammatory syndrome in children (MIS-C). METHODS: This cross-sectional study included 471 samples collected from 371 patients (age<18 years) suspected of having severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The study group comprised 66/371 (18%) laboratory-confirmed pediatric COVID-19 patients: 61 (92.5%) patients tested positive on real-time reverse transcription-polymerase chain reaction tests for SARS-CoV-2, and 5 (7.5%) patients tested positive on serological tests. MIS-C was diagnosed according to the criteria of the Center for Disease Control. RESULTS: MIS-C was diagnosed in 6/66 (9%) patients. The frequencies of diarrhea, vomiting, and/or abdominal pain (67% vs. 22%, p=0.034); pediatric SARS (67% vs. 13%, p=0.008); hypoxemia (83% vs. 23%, p=0.006); and arterial hypotension (50% vs. 3%, p=0.004) were significantly higher in patients with MIS-C than in those without MIS-C. The frequencies of C-reactive protein levels >50 mg/L (83% vs. 25%, p=0.008) and D-dimer levels >1000 ng/mL (100% vs. 40%, p=0.007) and the median D-dimer, troponin T, and ferritin levels (p<0.05) were significantly higher in patients with MIS-C. The frequencies of pediatric intensive care unit admission (100% vs. 60%, p=0.003), mechanical ventilation (83% vs. 7%, p<0.001), vasoactive agent use (83% vs. 3%, p<0.001), shock (83% vs. 5%, p<0.001), cardiac abnormalities (100% vs. 2%, p<0.001), and death (67% vs. 3%, p<0.001) were also significantly higher in patients with MIS-C. Similarly, the frequencies of oxygen therapy (100% vs. 33%, p=0.003), intravenous immunoglobulin therapy (67% vs. 2%, p<0.001), aspirin therapy (50% vs. 0%, p<0.001), and current acute renal replacement therapy (50% vs. 2%, p=0.002) were also significantly higher in patients with MIS-C. Logistic regression analysis showed that the presence of MIS-C was significantly associated with gastrointestinal manifestations [odds ratio (OR)=10.98; 95%CI (95% confidence interval)=1.20-100.86; p=0.034] and hypoxemia [OR=16.85; 95%CI=1.34-211.80; p=0.029]. Further univariate analysis showed a positive association between MIS-C and death [OR=58.00; 95%CI=6.39-526.79; p<0.0001]. CONCLUSIONS: Pediatric patients with laboratory-confirmed COVID-19 with MIS-C had a severe clinical spectrum with a high mortality rate. Our study emphasizes the importance of investigating MIS-C in pediatric patients with COVID-19 presenting with gastrointestinal involvement and hypoxemia.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #749235
Database	COVID19

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾

To top

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Kategorien

Inter-library loan at ZB MED