LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 4 of total 4

Search options

  1. Article: Summer Spores of Birch Rust Fungus in Papanicolaou Smears from Healthy Mass Screening Participants

    Korhonen, Anna-Maija / Issakainen, Jouni / Ekfors, Tauno / Talve, Lauri / Rantio-Lehtimäki, Auli

    Acta Cytologica

    2011  Volume 45, Issue 5, Page(s) 679–682

    Institution From Pathology Laboratory of South-Western Finland Ltd., and Pathology Unit, Turku University Central Hospital, Turku, Finland
    Language English
    Publishing date 2011-04-12
    Publisher S. Karger AG
    Publishing place Basel, Switzerland
    Document type Article
    Note Original Articles
    ZDB-ID 80003-x
    ISSN 1938-2650 ; 0001-5547
    ISSN (online) 1938-2650
    ISSN 0001-5547
    DOI 10.1159/000328287
    Database Karger publisher's database

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 358: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article: Molecular profiling of human chondrosarcomas for matrix production and cancer markers.

    Söderström, Mirva / Böhling, Tom / Ekfors, Tauno / Nelimarkka, Lassi / Aro, Hannu T / Vuorio, Eero

    International journal of cancer

    2002  Volume 100, Issue 2, Page(s) 144–151

    Abstract: Chondrosarcoma is the second most common malignant bone tumor, characterized by production of abundant extracellular matrix resembling hyaline cartilage. To better understand the molecular pathogenesis of chondrosarcoma, we analyzed 12 chondrosarcomas ... ...

    Abstract Chondrosarcoma is the second most common malignant bone tumor, characterized by production of abundant extracellular matrix resembling hyaline cartilage. To better understand the molecular pathogenesis of chondrosarcoma, we analyzed 12 chondrosarcomas for their production of connective tissue components and SOX9, a key regulator of normal chondrocyte differentiation. Furthermore, 10 chondrosarcoma samples were screened for additional changes in gene expression using cDNA array analysis. In Northern analysis, several tumors were found to express type II collagen mRNA at levels comparable to fetal cartilage used as a control. Interestingly, the highest levels of type II collagen mRNA were seen in 2 of the 3 grade 3 chondrosarcomas, which also exhibited the highest mRNA levels of SOX9 and "prechondrogenic" pro alpha 1(IIA) collagen. Expression of SOX9 in human chondrosarcomas is novel and suggests that chondrosarcomas originate from a multipotent stem cell committed to differentiation along the chondrogenic pathway. Results of the cDNA array analyses emphasize the heterogeneous nature of chondrosarcoma as no single transcript was systematically up- or downregulated in all tumors analyzed. Among the interesting changes observed was upregulation of decorin mRNA in 7 of the 10 tumors analyzed. Further studies are needed to determine whether decorin plays a role in the pathogenesis of chondrosarcoma. The cDNA arrays also revealed discrepancies from Northern and RNase protection analyses in transcript levels of matrix components, emphasizing the need to validate cDNA array data with other techniques.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Biomarkers, Tumor/biosynthesis ; Biomarkers, Tumor/genetics ; Blotting, Northern ; Bone Neoplasms/genetics ; Bone Neoplasms/metabolism ; Bone Neoplasms/pathology ; Cell Differentiation/physiology ; Chondrosarcoma/genetics ; Chondrosarcoma/metabolism ; Chondrosarcoma/pathology ; Extracellular Matrix Proteins/biosynthesis ; Extracellular Matrix Proteins/genetics ; Female ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic ; High Mobility Group Proteins/biosynthesis ; High Mobility Group Proteins/genetics ; Humans ; Immunoenzyme Techniques ; Male ; Middle Aged ; Oligonucleotide Array Sequence Analysis ; RNA, Messenger/metabolism ; RNA, Neoplasm/isolation & purification ; SOX9 Transcription Factor ; Sequence Analysis, DNA ; Transcription Factors/biosynthesis ; Transcription Factors/genetics ; Tumor Cells, Cultured/cytology ; Tumor Cells, Cultured/physiology
    Chemical Substances Biomarkers, Tumor ; Extracellular Matrix Proteins ; High Mobility Group Proteins ; RNA, Messenger ; RNA, Neoplasm ; SOX9 Transcription Factor ; SOX9 protein, human ; Transcription Factors
    Language English
    Publishing date 2002-07-10
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 218257-9
    ISSN 1097-0215 ; 0020-7136
    ISSN (online) 1097-0215
    ISSN 0020-7136
    DOI 10.1002/ijc.10457
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 478: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 576: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article: No improvement in the overall survival of 194 patients with chondrosarcoma in Finland in 1971-1990.

    Söderström, Mirva / Ekfors, Tauno O / Böhling, Tom O / Teppo, Lyly H I / Vuorio, Eero I / Aro, Hannu T

    Acta orthopaedica Scandinavica

    2003  Volume 74, Issue 3, Page(s) 344–350

    Abstract: We describe the clinicopathologic profile and survival of 306 patients with chondrosarcoma reported to the Finnish Cancer Registry in 1971-1990. 218 cases were available for reevaluation. Owing to their various clinicopathologic characteristics, we ... ...

    Abstract We describe the clinicopathologic profile and survival of 306 patients with chondrosarcoma reported to the Finnish Cancer Registry in 1971-1990. 218 cases were available for reevaluation. Owing to their various clinicopathologic characteristics, we excluded the histologic variants of chondrosarcoma. Therefore, the final study population included 194 patients. The minimum follow-up was 9 years. The study population included 69 grade 1 tumors, 114 grade 2 tumors, and 11 grade 3 tumors. The commonest tumor sites were the chest, pelvis and femur. A local recurrence developed in 25% of the patients and metastatic lesions in 18%. The patients were treated in 31 hospitals (in 22 hospitals during the 1970s and in 26 in the 1980s), and the number of patients biopsied before the referral remained about the same from the 1970s (15%) to the 1980s (18%). The 5-and 10-year disease-specific survival rates were 70% and 57%, respectively. Multivariate analysis showed that the most important independent predictors of shortened survival were high histologic grade, age 50 years or older, and a diagnosis in the 1980s, as compared to the 1970s. Most findings accorded with reports from specialist treatment centers, but to our surprise, the survival rate declined among patients diagnosed in the 1980s versus the 1970s. The failure to improve patient survival is probably due to treatment of the patients in 31 hospitals rather than in a few centers dealing with treatment of cancer.
    MeSH term(s) Adolescent ; Adult ; Age Distribution ; Aged ; Aged, 80 and over ; Analysis of Variance ; Bone Neoplasms/mortality ; Bone Neoplasms/pathology ; Bone Neoplasms/therapy ; Child ; Child, Preschool ; Chondrosarcoma/mortality ; Chondrosarcoma/pathology ; Chondrosarcoma/therapy ; Combined Modality Therapy ; Female ; Finland/epidemiology ; Humans ; Infant ; Life Tables ; Male ; Middle Aged ; Neoplasm Recurrence, Local/mortality ; Neoplasm Recurrence, Local/pathology ; Neoplasm Recurrence, Local/therapy ; Neoplasm Staging ; Population Surveillance ; Proportional Hazards Models ; Registries ; Retrospective Studies ; Risk Factors ; Sex Distribution ; Survival Analysis ; Survival Rate ; Treatment Outcome
    Language English
    Publishing date 2003-06
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 210369-2
    ISSN 1651-1964 ; 0001-6470
    ISSN (online) 1651-1964
    ISSN 0001-6470
    DOI 10.1080/00016470310014292
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Uk I Zs.99: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Pigmented Primitive Neuroectodermal Tumor with Multipotential Differentiation in Cerebellum (Pigmented Medullomyoblastoma)

    Kalimo, Hannu / Paljärvi, Leo / Ekfors, Tauno / Pelliniemi, Lauri J.

    Pediatric Neurosurgery

    A Case with Light- and Electron-Microscopic, and Immunohistochemical Analysis

    1987  Volume 13, Issue 4, Page(s) 188–195

    Abstract: A 5-year-old girl had a midline cerebellar primitive neuroectodermal tumor (PNET) with neuronal, astrocytic, rhabdomyoblastic and melanocytic differentiation (a variant of pigmented medullomyoblastoma). The tumor recurred following surgery and radiation ... ...

    Abstract A 5-year-old girl had a midline cerebellar primitive neuroectodermal tumor (PNET) with neuronal, astrocytic, rhabdomyoblastic and melanocytic differentiation (a variant of pigmented medullomyoblastoma). The tumor recurred following surgery and radiation therapy and the child died within 6 months. Autopsy revealed spread into cerebellar hemispheres, subarachnoidal space and brain stem. Neuronal differentiation was verified by electron microscopy and antiserum against neurofilament protein. Neoplastic astrocytes were identified by use of antisera to glial fibrillary acidic and S-100 proteins. Rhabdomyoblasts were identified by the use of antisera against skeletal muscle type 2 myosin and myoglobin, as well as by electron microscopy. This tumor is compared with 20 previously reported cases of cerebellar PNETs containing muscle, 2 of which showed a similar pattern of multipotential differentiation. The oncogenesis of these tumors is in dispute although origin of both the neuroectodermal and mesenchymal components from the neural crest (mesectodermal differentiation) is most widely accepted.
    Keywords Primitive neuroectodermal tumor ; Medullomyoblastoma ; Neurofilament ; Glial fibrillary acidic protein ; Myosins ; Electron microscopy
    Language English
    Publisher S. Karger AG
    Publishing place Basel
    Publishing country Switzerland
    Document type Article ; Online
    ZDB-ID 1091757-3
    ISSN 1423-0305 ; 1016-2291 ; 1016-2291
    ISSN (online) 1423-0305
    ISSN 1016-2291
    DOI 10.1159/000120328
    Database Karger publisher's database

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1133: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top