Article: Pharmacovigilance.
2021 Volume 17, Issue 720-1, Page(s) 80–84
Abstract: The main pharmacovigilance updates in 2020 are reviewed. Remdesivir in COVID-19: relatively safe but turns out to be less effective than expected. Hydroxychloroquine in COVID-19 : lack of efficacy and risk of arrhythmias. Cytokines storm in COVID-19: may ...
Title translation | Pharmacovigilance update. |
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Abstract | The main pharmacovigilance updates in 2020 are reviewed. Remdesivir in COVID-19: relatively safe but turns out to be less effective than expected. Hydroxychloroquine in COVID-19 : lack of efficacy and risk of arrhythmias. Cytokines storm in COVID-19: may impact pharmacokinetics. VEGF inhibitors: risk of aneurysm and artery dissection. Tofacitinib: dose-dependant risk of venous thromboembolic events. Ondansetron in the first trimester of pregnancy : a highly debated risk of orofacial cleft defects. Fingolimod : contraindicated during pregnancy due to suspected risk of congenital malformations. Ranitidine: global market withdrawal due to contamination with nitrosamines. Ulipristal for uterine fibroids : market withdrawal due to risk of severe liver injury. Ingenol mebutate : market withdrawal due to paradoxical risk of skin cancers. |
MeSH term(s) | Adenosine Monophosphate/analogs & derivatives ; Adenosine Monophosphate/therapeutic use ; Alanine/analogs & derivatives ; Alanine/therapeutic use ; COVID-19/drug therapy ; Cleft Lip/prevention & control ; Contraindications, Drug ; Cytokine Release Syndrome/virology ; Female ; Fingolimod Hydrochloride/adverse effects ; Humans ; Hydroxychloroquine/adverse effects ; Leiomyoma/drug therapy ; Norpregnadienes/therapeutic use ; Pharmacokinetics ; Pharmacovigilance ; Pregnancy ; Ranitidine/adverse effects ; Safety-Based Drug Withdrawals ; Skin Neoplasms/chemically induced |
Chemical Substances | Norpregnadienes ; remdesivir (3QKI37EEHE) ; Adenosine Monophosphate (415SHH325A) ; Hydroxychloroquine (4QWG6N8QKH) ; ulipristal (6J5J15Q2X8) ; Ranitidine (884KT10YB7) ; Fingolimod Hydrochloride (G926EC510T) ; Alanine (OF5P57N2ZX) |
Language | French |
Publishing date | 2021-01-14 |
Publishing country | Switzerland |
Document type | Journal Article ; Review |
ZDB-ID | 2177010-4 |
ISSN | 1660-9379 |
ISSN | 1660-9379 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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