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  1. Article: Correction: Jamal et al. Preparation of 6-Mercaptopurine Loaded Liposomal Formulation for Enhanced Cytotoxic Response in Cancer Cells.

    Jamal, Alam / Asseri, Amer H / Ali, Ehab M M / El-Gowily, Afnan H / Khan, Mohamed Imran / Hosawi, Salman / Alsolami, Reem / Ahmed, Tarek A

    Nanomaterials (Basel, Switzerland)

    2024  Volume 14, Issue 5

    Abstract: In the original publication [ ... ]. ...

    Abstract In the original publication [...].
    Language English
    Publishing date 2024-02-28
    Publishing country Switzerland
    Document type Published Erratum
    ZDB-ID 2662255-5
    ISSN 2079-4991
    ISSN 2079-4991
    DOI 10.3390/nano14050443
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Differential mechanisms of autophagy in cancer stem cells: Emphasizing gastrointestinal cancers.

    El-Gowily, Afnan H / Abosheasha, Mohammed A

    Cell biochemistry and function

    2020  Volume 39, Issue 2, Page(s) 162–173

    Abstract: Gastrointestinal (GI) cancers are one of the most common forms of malignancies and still are the most important cause of cancer-related mortality worldwide. Autophagy is a conserved catabolic pathway involving lysosomal degradation and recycling of whole ...

    Abstract Gastrointestinal (GI) cancers are one of the most common forms of malignancies and still are the most important cause of cancer-related mortality worldwide. Autophagy is a conserved catabolic pathway involving lysosomal degradation and recycling of whole cellular components, which is essential for cellular homeostasis. For instance, it acts as a pivotal intracellular quality control and repair mechanism but also implicated in cell reformation during cell differentiation and development. Indeed, GI cancer stem cells (CSCs) are thought to be responsible for tumour initiation, traditional therapies resistance, metastasis and tumour recurrence. Molecular mechanisms of autophagy in normal vs CSCs gain great interest worldwide. Here, we shed light on the role of autophagy in normal stem cells differentiation for embryonic progression and its role in maintaining the activity and self-renewal capacity of CSCs which offer novel viewpoints on promising cancer therapeutic strategies based on the differential roles of autophagy in CSCs.
    MeSH term(s) AMP-Activated Protein Kinases/metabolism ; Autophagy ; Biomarkers, Tumor/metabolism ; Cell Differentiation ; Embryonic Development ; Gastrointestinal Neoplasms/metabolism ; Gastrointestinal Neoplasms/pathology ; Humans ; Neoplastic Stem Cells/cytology ; Neoplastic Stem Cells/metabolism ; Signal Transduction ; Tumor Microenvironment
    Chemical Substances Biomarkers, Tumor ; AMP-Activated Protein Kinases (EC 2.7.11.31)
    Language English
    Publishing date 2020-05-28
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 283643-9
    ISSN 1099-0844 ; 0263-6484
    ISSN (online) 1099-0844
    ISSN 0263-6484
    DOI 10.1002/cbf.3552
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1994: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Superiority of cilostazol among antiplatelet FDA-approved drugs against COVID 19 M

    Abosheasha, Mohammed A / El-Gowily, Afnan H

    Drug development research

    2020  Volume 82, Issue 2, Page(s) 217–229

    Abstract: Coronavirus disease 2019 (COVID 19) was first identified in Wuhan, China near the end of 2019. To date, COVID-19 had spread to almost 235 countries and territories due to its highly infectious nature. Moreover, there is no vaccine or Food and Drug ... ...

    Abstract Coronavirus disease 2019 (COVID 19) was first identified in Wuhan, China near the end of 2019. To date, COVID-19 had spread to almost 235 countries and territories due to its highly infectious nature. Moreover, there is no vaccine or Food and Drug Administration (FDA)-approved drug. More time is needed to establish one of them. Consequently, the drug repurposing approach seems to be the most attractive and quick solution to accommodate this crisis. In this regard, we performed molecular docking-based virtual screening of antiplatelet FDA-approved drugs on the key two viral target proteins: main protease (M
    MeSH term(s) COVID-19/drug therapy ; Cilostazol/metabolism ; Cilostazol/therapeutic use ; Coronavirus 3C Proteases/metabolism ; Drug Approval ; Drug Evaluation, Preclinical ; Drug Repositioning ; Eicosapentaenoic Acid/analogs & derivatives ; Eicosapentaenoic Acid/metabolism ; Eicosapentaenoic Acid/therapeutic use ; Epoprostenol/metabolism ; Epoprostenol/therapeutic use ; Humans ; Iloprost/metabolism ; Iloprost/therapeutic use ; Molecular Docking Simulation ; Platelet Aggregation Inhibitors/metabolism ; Platelet Aggregation Inhibitors/therapeutic use ; Prasugrel Hydrochloride/metabolism ; Prasugrel Hydrochloride/therapeutic use ; SARS-CoV-2/metabolism ; Spike Glycoprotein, Coronavirus/metabolism ; United States ; United States Food and Drug Administration
    Chemical Substances Platelet Aggregation Inhibitors ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2 ; eicosapentaenoic acid ethyl ester (6GC8A4PAYH) ; Eicosapentaenoic Acid (AAN7QOV9EA) ; Epoprostenol (DCR9Z582X0) ; Coronavirus 3C Proteases (EC 3.4.22.28) ; Prasugrel Hydrochloride (G89JQ59I13) ; Iloprost (JED5K35YGL) ; Cilostazol (N7Z035406B)
    Keywords covid19
    Language English
    Publishing date 2020-09-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604587-x
    ISSN 1098-2299 ; 0272-4391
    ISSN (online) 1098-2299
    ISSN 0272-4391
    DOI 10.1002/ddr.21743
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2542: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Potential antiviral properties of antiplatelet agents against SARS-CoV-2 infection: an in silico perspective.

    Abosheasha, Mohammed A / El-Gowily, Afnan H / Elfiky, Abdo A

    Journal of thrombosis and thrombolysis

    2021  Volume 53, Issue 2, Page(s) 273–281

    Abstract: SARS-CoV-2 represents the causative agent of the current pandemic (COVID-19). The drug repurposing technique is used to search for possible drugs that can bind to SARS-CoV-2 proteins and inhibit viral replication. In this study, the FDA-approved ... ...

    Abstract SARS-CoV-2 represents the causative agent of the current pandemic (COVID-19). The drug repurposing technique is used to search for possible drugs that can bind to SARS-CoV-2 proteins and inhibit viral replication. In this study, the FDA-approved antiplatelets are tested against the main protease and spike proteins of SARS-CoV-2 using in silico methods. Molecular docking and molecular dynamics simulation are used in the current study. The results suggest the effectiveness of vorapaxar, ticagrelor, cilostazol, cangrelor, and prasugrel in binding the main protease (M
    MeSH term(s) Antiviral Agents/pharmacology ; COVID-19/drug therapy ; Cilostazol ; Coronavirus 3C Proteases/antagonists & inhibitors ; Humans ; Lactones ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Platelet Aggregation Inhibitors/pharmacology ; Pyridines ; SARS-CoV-2/drug effects ; Spike Glycoprotein, Coronavirus/antagonists & inhibitors ; Ticagrelor
    Chemical Substances Antiviral Agents ; Lactones ; Platelet Aggregation Inhibitors ; Pyridines ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2 ; 3C-like proteinase, SARS-CoV-2 (EC 3.4.22.-) ; Coronavirus 3C Proteases (EC 3.4.22.28) ; Ticagrelor (GLH0314RVC) ; Cilostazol (N7Z035406B) ; vorapaxar (ZCE93644N2)
    Language English
    Publishing date 2021-09-12
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1230645-9
    ISSN 1573-742X ; 0929-5305
    ISSN (online) 1573-742X
    ISSN 0929-5305
    DOI 10.1007/s11239-021-02558-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4352: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: Regulation of Protein-Induced Apoptosis and Autophagy in Human Hepatocytes Treated with Metformin and Paclitaxel In Silico and In Vitro.

    Al-Zahrani, Norah Saeed / Zamzami, Mazin Abdulaziz / Baghdadi, Mohammed A / El-Gowily, Afnan H / Ali, Ehab M M

    Biomedicines

    2023  Volume 11, Issue 10

    Abstract: Metformin and paclitaxel therapy offer promising outcomes in the treatment of liver cancer. Combining paclitaxel with metformin enhances treatment effectiveness and mitigates the adverse effects associated with paclitaxel alone. This study explored the ... ...

    Abstract Metformin and paclitaxel therapy offer promising outcomes in the treatment of liver cancer. Combining paclitaxel with metformin enhances treatment effectiveness and mitigates the adverse effects associated with paclitaxel alone. This study explored the anticancer properties of metformin and paclitaxel in HepG2 liver cancer cells, MCF-7 breast cancer cells, and HCT116 colon cancer cells. The results demonstrated that the combination of these agents exhibited a lower IC50 in the tested cell lines compared to paclitaxel monotherapy. Notably, treating the HepG2 cell line with this combination led to a reduction in the G0/G1 phase and an increase in the S and G2/M phases, ultimately triggering early apoptosis. To further investigate the interaction between the cellular proteins with paclitaxel and metformin, an in silico study was conducted using proteins chosen from a protein data bank (PDB). Among the proteins studied, AMPK-α, EGFRK, and FKBP12-mTOR exhibited the highest binding free energy, with values of -11.01, -10.59, and -15.63 kcal/mol, respectively, indicating strong inhibitory or enhancing effects on these proteins. When HepG2 cells were exposed to both paclitaxel and metformin, there was an upregulation in the gene expression of
    Language English
    Publishing date 2023-09-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines11102688
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Masking Strategy Constructed Metal Coordination Hydrogels with Improved Mechanical Properties for Flexible Electronic Sensors.

    Guan, Xiaoyu / Zheng, Sai / Zhang, Bingyuan / Sun, Xuhui / Meng, Kai / Elafify, Mohamed S / Zhu, Yanxia / El-Gowily, Afnan H / An, Meng / Li, Dongping / Han, Qingxin

    ACS applied materials & interfaces

    2024  Volume 16, Issue 4, Page(s) 5168–5182

    Abstract: Metal coordination hydrogels (MC-HGs) that introduce dynamically coordinate bonds together with metal ionic conduction have attracted considerable attention in flexible electronics. However, the ... ...

    Abstract Metal coordination hydrogels (MC-HGs) that introduce dynamically coordinate bonds together with metal ionic conduction have attracted considerable attention in flexible electronics. However, the traditional
    Language English
    Publishing date 2024-01-17
    Publishing country United States
    Document type Journal Article
    ISSN 1944-8252
    ISSN (online) 1944-8252
    DOI 10.1021/acsami.3c18077
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Tioconazole and Chloroquine Act Synergistically to Combat Doxorubicin-Induced Toxicity via Inactivation of PI3K/AKT/mTOR Signaling Mediated ROS-Dependent Apoptosis and Autophagic Flux Inhibition in MCF-7 Breast Cancer Cells.

    El-Gowily, Afnan H / Loutfy, Samah A / Ali, Ehab M M / Mohamed, Tarek M / Mansour, Mohammed A

    Pharmaceuticals (Basel, Switzerland)

    2021  Volume 14, Issue 3

    Abstract: Cancer is a complex devastating disease with enormous treatment challenges, including chemo- and radiotherapeutic resistance. Combination therapy demonstrated a promising strategy to target hard-to-treat cancers and sensitize cancer cells to conventional ...

    Abstract Cancer is a complex devastating disease with enormous treatment challenges, including chemo- and radiotherapeutic resistance. Combination therapy demonstrated a promising strategy to target hard-to-treat cancers and sensitize cancer cells to conventional anti-cancer drugs such as doxorubicin. This study aimed to establish molecular profiling and therapeutic efficacy assessment of chloroquine and/or tioconazole (TIC) combination with doxorubicin (DOX) as anew combination model in MCF-7 breast cancer. The drugs are tested against apoptotic/autophagic pathways and related redox status. Molecular docking revealed that chloroquine (CQ) and TIC could be potential PI3K and ATG4B pathway inhibitors. Combination therapy significantly inhibited cancer cell viability, PI3K/AkT/mTOR pathway, and tumor-supporting autophagic flux, however, induced apoptotic pathways and altered nuclear genotoxic feature. Our data revealed that the combination cocktail therapy markedly inhibited tumor proliferation marker (KI-67) and cell growth, along with the accumulation of autophagosomes and elevation of LC3-II and p62 levels indicated autophagic flux blockage and increased apoptosis. Additionally, CQ and/or TIC combination therapy with DOX exerts its activity on the redox balance of cancer cells mediated ROS-dependent apoptosis induction achieved by GPX3 suppression. Besides, Autophagy inhibition causes moderately upregulation in ATGs 5,7 redundant proteins strengthened combinations induced apoptosis, whereas inhibition of PI3K/AKT/mTOR pathway with Beclin-1 upregulation leading to cytodestructive autophagy with overcome drug resistance effectively in curing cancer. Notably, the tumor growth inhibition and various antioxidant effects were observed in vivo. These results suggest CQ and/or TIC combination with DOX could act as effective cocktail therapy targeting autophagy and PI3K/AKT/mTOR pathways in MCF-7 breast cancer cells and hence, sensitizes cancer cells to doxorubicin treatment and combat its toxicity.
    Language English
    Publishing date 2021-03-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph14030254
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Superiority of cilostazol among antiplatelet FDA-approved drugs against COVID 19 Mpro and spike protein: Drug repurposing approach

    Abosheasha, Mohammed A / El-Gowily, Afnan H

    Drug dev. res

    Abstract: Coronavirus disease 2019 (COVID 19) was first identified in Wuhan, China near the end of 2019. To date, COVID-19 had spread to almost 235 countries and territories due to its highly infectious nature. Moreover, there is no vaccine or Food and Drug ... ...

    Abstract Coronavirus disease 2019 (COVID 19) was first identified in Wuhan, China near the end of 2019. To date, COVID-19 had spread to almost 235 countries and territories due to its highly infectious nature. Moreover, there is no vaccine or Food and Drug Administration (FDA)-approved drug. More time is needed to establish one of them. Consequently, the drug repurposing approach seems to be the most attractive and quick solution to accommodate this crisis. In this regard, we performed molecular docking-based virtual screening of antiplatelet FDA-approved drugs on the key two viral target proteins: main protease (Mpro ) and spike glycoprotein (S) as potential inhibitor candidates for COVID-19. In the present study, 15 antiplatelet FDA-approved drugs were investigated against the concerned targets using the Molecular Docking Server. Our study revealed that only cilostazol has the most favorable binding interaction on Mpro (PDB ID: 6LU7) and cilostazol, iloprost, epoprostenol, prasugrel, and icosapent ethyl have a higher binding affinity on spike glycoprotein (S) (PDB ID: 6VYB) compared with recent anti-CoVID-19. Therefore, cilostazol is a promising FDA drug against COVID-19 by inhibiting both Mpro and S protein. The insights gained in this study may be useful for quick approach against COVID-19 in the future.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #798845
    Database COVID19

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  9. Article ; Online: Superiority of cilostazol among antiplatelet FDA ‐approved drugs against COVID 19 M pro and spike protein

    Abosheasha, Mohammed A. / El‐Gowily, Afnan H.

    Drug Development Research ; ISSN 0272-4391 1098-2299

    Drug repurposing approach

    2020  

    Keywords Drug Discovery ; covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    DOI 10.1002/ddr.21743
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article: Preparation of 6-Mercaptopurine Loaded Liposomal Formulation for Enhanced Cytotoxic Response in Cancer Cells.

    Jamal, Alam / Asseri, Amer H / Ali, Ehab M M / El-Gowily, Afnan H / Khan, Mohamed Imran / Hosawi, Salman / Alsolami, Reem / Ahmed, Tarek A

    Nanomaterials (Basel, Switzerland)

    2022  Volume 12, Issue 22

    Abstract: 6-Mercaptopurine (6-MP) is a well-known immunosuppressive medication with proven anti-proliferative activities. 6-MP possesses incomplete and highly variable oral absorption due to its poor water solubility, which might reduce its anti-cancer properties. ...

    Abstract 6-Mercaptopurine (6-MP) is a well-known immunosuppressive medication with proven anti-proliferative activities. 6-MP possesses incomplete and highly variable oral absorption due to its poor water solubility, which might reduce its anti-cancer properties. To overcome these negative effects, we developed neutral and positively charged drug-loaded liposomal formulations utilizing the thin-film hydration technique. The prepared liposomal formulations were characterized for their size, polydispersity index (PDI), zeta potential, and entrapment efficiency. The average size of the prepared liposomes was between 574.67 ± 37.29 and 660.47 ± 44.32 nm. Positively charged liposomes (F1 and F3) exhibited a lower PDI than the corresponding neutrally charged ones (F2 and F4). Entrapment efficiency was higher in the neutral liposomes when compared to the charged formulation. F1 showed the lowest IC
    Language English
    Publishing date 2022-11-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662255-5
    ISSN 2079-4991
    ISSN 2079-4991
    DOI 10.3390/nano12224029
    Database MEDical Literature Analysis and Retrieval System OnLINE

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