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  1. Article: Colocolic Intussusception in an Adult Patient Secondary to Caecal Adenocarcinoma.

    Elmajdoubi, Hicham / Baiss, Marouane / El Absi, Mohamed / El Alami, El Hassan El Faricha / Ouanani, Mohamed El / Echarrab, El Mahjoub / El Amraoui, Mohamed / Errougani, Abdelkader

    Case reports in gastrointestinal medicine

    2021  Volume 2021, Page(s) 5534918

    Abstract: Acute intestinal invagination is the pathology of infants and small children. Its occurrence in adults is rare, and it represents 1 to 5% of intestinal occlusions often leading to the discovery of an organic cause that may be tumor. We report the case of ...

    Abstract Acute intestinal invagination is the pathology of infants and small children. Its occurrence in adults is rare, and it represents 1 to 5% of intestinal occlusions often leading to the discovery of an organic cause that may be tumor. We report the case of a 72-year-old patient admitted to the emergency room of Ibn Sina Rabat, Morocco, for intestinal occlusion. The abdominal CT scan showed a voluminous intestinal invagination on a very probable heterogeneous digestive mass. The treatment was an open right hemicolectomy. The histopathological examination of the surgical specimen concluded a colonic well-differentiated adenocarcinoma with a 30% mucinous component. By review of literature, we discuss diagnostic and therapeutic procedures in emergency.
    Language English
    Publishing date 2021-04-21
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2627636-7
    ISSN 2090-6536 ; 2090-6528
    ISSN (online) 2090-6536
    ISSN 2090-6528
    DOI 10.1155/2021/5534918
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: AKT1 Polymorphism (rs10138227) and Risk of Colorectal Cancer in Moroccan Population: A Case Control Study.

    Allam, Loubna / Arrouchi, Housna / Ghrifi, Fatima / El Khazraji, Abdelhak / Kandoussi, Ilham / Bendahou, Mohammed Amine / El Amri, Hamid / El Absi, Mohamed / Ibrahimi, Azeddine

    Asian Pacific journal of cancer prevention : APJCP

    2020  Volume 21, Issue 11, Page(s) 3165–3170

    Abstract: Background: LMTK3 and AKT1 each have a role in carcinogenesis and tumor progression. The analysis of single nucleotide polymorphisms of AKT1 and LMTK3 could lead to more complete and accurate risk estimates for colorectal cancer.: Aim: We evaluated ... ...

    Abstract Background: LMTK3 and AKT1 each have a role in carcinogenesis and tumor progression. The analysis of single nucleotide polymorphisms of AKT1 and LMTK3 could lead to more complete and accurate risk estimates for colorectal cancer.
    Aim: We evaluated the association between single nucleotide polymorphisms (SNPs) of AKT1 and LMTK3 and the risk of colorectal cancer in a case-control study in Moroccan population.
    Methods: Genomic DNA from 70 colorectal cancer patients and 50 healthy control subjects was extracted from whole blood. Genotyping was performed by direct sequencing after polymerase chain reactions for the 7 SNPs (AKT1rs1130214G/T, AKT1rs10138227C/T, AKT1rs3730358C/T, AKT1rs1000559097G/A, AKT1rs2494737A/T, LMTK3rs8108419G/A, and LMTK3rs9989661A/G.). Study subjects provided detailed information during the collection. All P values come from bilateral tests.
    Results: In the logistic regression analysis, a significantly high risk of colorectal cancer was associated with TC/TT genotypes of rs10138227 with adjusted odds ratio [OR] equal to 2.82 and 95% confidence interval [CI] of 1.15 to 6.91.
    Conclusion: Our results suggest that the SNP AKT1rs10138227 could affect susceptibility to CRC, probably by modulating the transcriptional activity of AKT1. However, larger independent studies are needed to validate our results.
    MeSH term(s) Biomarkers, Tumor/genetics ; Case-Control Studies ; Colorectal Neoplasms/epidemiology ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/pathology ; Female ; Follow-Up Studies ; Genetic Predisposition to Disease ; Genotype ; Humans ; Male ; Middle Aged ; Morocco/epidemiology ; Polymorphism, Single Nucleotide ; Prognosis ; Proto-Oncogene Proteins c-akt/genetics ; Risk Factors
    Chemical Substances Biomarkers, Tumor ; AKT1 protein, human (EC 2.7.11.1) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1)
    Language English
    Publishing date 2020-11-01
    Publishing country Thailand
    Document type Journal Article
    ZDB-ID 2218955-5
    ISSN 2476-762X ; 1513-7368
    ISSN (online) 2476-762X
    ISSN 1513-7368
    DOI 10.31557/APJCP.2020.21.11.3165
    Database MEDical Literature Analysis and Retrieval System OnLINE

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