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  1. Article: Kinetics of remnant liver volume and function after a major hepatectomy.

    Truant, Stéphanie / El Amrani, Mehdi / Pruvot, François-René

    Hepatobiliary surgery and nutrition

    2023  Volume 12, Issue 6, Page(s) 975–977

    Language English
    Publishing date 2023-11-08
    Publishing country China (Republic : 1949- )
    Document type Editorial ; Comment
    ZDB-ID 2812398-0
    ISSN 2304-389X ; 2304-3881
    ISSN (online) 2304-389X
    ISSN 2304-3881
    DOI 10.21037/hbsn-23-469
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  2. Article ; Online: Robotic liver resection in the posterosuperior segments as a way to extent the mini-invasive arsenal: a comparison with transthoracic laparoscopic approach.

    Denglos, Pauline / Truant, Stéphanie / El Amrani, Mehdi / Millet, Guillaume

    Surgical endoscopy

    2023  Volume 37, Issue 6, Page(s) 4478–4485

    Abstract: Background: The field of robotic liver resection (RLR) has developed in the past decades. This technique seems to improve the access to the posterosuperior (PS) segments. Evidence of a possible advantage over transthoracic laparoscopy (TTL) is not yet ... ...

    Abstract Background: The field of robotic liver resection (RLR) has developed in the past decades. This technique seems to improve the access to the posterosuperior (PS) segments. Evidence of a possible advantage over transthoracic laparoscopy (TTL) is not yet available. We aimed to compare RLR to TTL for tumors located in the PS segments of the liver in terms of feasibility, difficulty scoring, and outcome.
    Methods: This retrospective study compared patients undergoing robotic liver resections and transthoracic laparoscopic resections of the PS segments between January 2016 and December 2022 in a high-volume HPB center. Patients' characteristics, perioperative outcomes, and postoperative complications were evaluated.
    Results: In total, 30 RLR and 16 TTL were included. Only wedge resections were performed in the TTL group, while 43% of the patients in the RLR group had an anatomical resection (p < 0.001). The difficulty score according to the IWATE difficulty scoring system was significantly higher in the RLR group (p < 0.001). Total operative time was similar between the two groups. Complication rates, either overall or major, were comparable between the two techniques and hospital stay was significantly shorter in the RLR group. Patients in the TTL group were found to have more pulmonary complications (p = 0.01).
    Conclusion: RLR may provide some advantages over TTL for the resection of tumors located in the PS segments.
    MeSH term(s) Humans ; Liver Neoplasms/surgery ; Liver Neoplasms/pathology ; Retrospective Studies ; Robotic Surgical Procedures ; Hepatectomy/methods ; Laparoscopy/methods ; Postoperative Complications/epidemiology ; Postoperative Complications/etiology ; Postoperative Complications/surgery ; Length of Stay
    Language English
    Publishing date 2023-02-17
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 639039-0
    ISSN 1432-2218 ; 0930-2794
    ISSN (online) 1432-2218
    ISSN 0930-2794
    DOI 10.1007/s00464-023-09919-6
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  3. Article: Localized Small Bowel Adenocarcinoma Management: Evidence Summary.

    Turpin, Anthony / El Amrani, Mehdi / Zaanan, Aziz

    Cancers

    2022  Volume 14, Issue 12

    Abstract: Small bowel cancers are rare diseases whose prognosis is poorer than that of colon cancers. Due to disease rarity, there is little data on small bowel adenocarcinoma (SBA) treatment, and most recommendations come from expert agreements or analogies to ... ...

    Abstract Small bowel cancers are rare diseases whose prognosis is poorer than that of colon cancers. Due to disease rarity, there is little data on small bowel adenocarcinoma (SBA) treatment, and most recommendations come from expert agreements or analogies to the management of colon cancer. Although relatively high rates of local recurrence are observed for duodenal malignancies, distant metastatic relapse remains common and requires adjuvant systemic therapy. Given the similarities between SBA and colorectal cancer, radiotherapy and chemotherapy strategies used for the latter disease are frequently pursued for the former disease, specifically for tumors located in the duodenum. However, no previous randomized study has evaluated the benefit of adjuvant chemotherapy on the overall survival of SBA patients. Most previous studies on treatment outcomes and prognostic factors in this context were based on large international databases, such as the Surveillance, Epidemiology, and End Results or the National Cancer Database. Studies are required to establish and validate prognostic and predictive markers relevant in this context to inform the use of (neo) adjuvant treatment. Among those, deficient mismatch repair tumors represent 20% of SBAs, but their impact on chemosensitivity remains unknown. Herein, we summarize the current evidence on the management of localized SBA, including future perspectives.
    Language English
    Publishing date 2022-06-11
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers14122892
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  4. Article ; Online: Adjuvant chemotherapy omission after pancreatic cancer resection: a French nationwide study.

    Poiraud, Charles / Lenne, Xavier / Bruandet, Amélie / Theis, Didier / Bertrand, Nicolas / Turpin, Anthony / Truant, Stephanie / El Amrani, Mehdi

    World journal of surgical oncology

    2024  Volume 22, Issue 1, Page(s) 123

    Abstract: Background: Adjuvant chemotherapy (AC) improves the prognosis after pancreatic ductal adenocarcinoma (PDAC) resection. However, previous studies have shown that a large proportion of patients do not receive or complete AC. This national study examined ... ...

    Abstract Background: Adjuvant chemotherapy (AC) improves the prognosis after pancreatic ductal adenocarcinoma (PDAC) resection. However, previous studies have shown that a large proportion of patients do not receive or complete AC. This national study examined the risk factors for the omission or interruption of AC.
    Methods: Data of all patients who underwent pancreatic surgery for PDAC in France between January 2012 and December 2017 were extracted from the French National Administrative Database. We considered "omission of adjuvant chemotherapy" (OAC) all patients who failed to receive any course of gemcitabine within 12 postoperative weeks and "interruption of AC" (IAC) was defined as less than 18 courses of AC.
    Results: A total of 11 599 patients were included in this study. Pancreaticoduodenectomy was the most common procedure (76.3%), and 31% of the patients experienced major postoperative complications. OACs and IACs affected 42% and 68% of the patients, respectively. Ultimately, only 18.6% of the cohort completed AC. Patients who underwent surgery in a high-volume centers were less affected by postoperative complications, with no impact on the likelihood of receiving AC. Multivariate analysis showed that age ≥ 80 years, Charlson comorbidity index (CCI) ≥ 4, and major complications were associated with OAC (OR = 2.19; CI
    Conclusion: Sequence surgery followed by chemotherapy is associated with a high dropout rate, especially in octogenarian and comorbid patients.
    MeSH term(s) Humans ; Female ; Male ; Pancreatic Neoplasms/surgery ; Pancreatic Neoplasms/drug therapy ; Pancreatic Neoplasms/pathology ; Aged ; Chemotherapy, Adjuvant/statistics & numerical data ; Chemotherapy, Adjuvant/methods ; France/epidemiology ; Carcinoma, Pancreatic Ductal/surgery ; Carcinoma, Pancreatic Ductal/drug therapy ; Carcinoma, Pancreatic Ductal/pathology ; Middle Aged ; Aged, 80 and over ; Prognosis ; Pancreatectomy/statistics & numerical data ; Follow-Up Studies ; Pancreaticoduodenectomy/statistics & numerical data ; Pancreaticoduodenectomy/methods ; Postoperative Complications/epidemiology ; Survival Rate ; Retrospective Studies ; Gemcitabine ; Risk Factors ; Deoxycytidine/analogs & derivatives ; Deoxycytidine/therapeutic use
    Chemical Substances Gemcitabine ; Deoxycytidine (0W860991D6)
    Language English
    Publishing date 2024-05-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 2118383-1
    ISSN 1477-7819 ; 1477-7819
    ISSN (online) 1477-7819
    ISSN 1477-7819
    DOI 10.1186/s12957-024-03393-7
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  5. Article ; Online: Sarcopenia does not affect liver regeneration and postoperative course after a major hepatectomy. A prospective study on 125 patients using CT volumetry and HIDA scintigraphy.

    Fulbert, Maxence / El Amrani, Mehdi / Baillet, Clio / Lecolle, Katia / Ernst, Olivier / Louvet, Alexandre / Pruvot, François-René / Huglo, Damien / Truant, Stéphanie

    Clinics and research in hepatology and gastroenterology

    2024  Volume 48, Issue 5, Page(s) 102332

    Abstract: Background & objectives: Sarcopenia is a morbi-mortality risk factor in digestive surgery, though its impact after major hepatectomy (MH) remains unknown. This prospective pilot study investigated whether volume and function of a regenerating liver is ... ...

    Abstract Background & objectives: Sarcopenia is a morbi-mortality risk factor in digestive surgery, though its impact after major hepatectomy (MH) remains unknown. This prospective pilot study investigated whether volume and function of a regenerating liver is influenced by body composition.
    Methods: From 2011 to 2016, 125 consecutive patients had computed tomography and 99mTc-labelled-mebrofenin SPECT-scintigraphy before and after MH at day 7 and 1 month for measurements of liver volumes and functions. L3 vertebra muscle mass identified sarcopenia. Primary endpoint was the impact of sarcopenia on regeneration capacities (i.e. volume/function changes and post-hepatectomy liver failure (PHLF) rate). Secondary endpoint was 3-month morbi-mortality.
    Results: Sarcopenic patients (SP; N = 69) were significantly older than non-sarcopenic (NSP), with lower BMI and more malignancies, but with comparable liver function/volume at baseline. Postoperatively, SP showed higher rates of ISGLS_PHLF (24.6 % vs 10.9 %; p = 0.05) but with comparable rates of severe morbidity (23.2 % vs 16.4 %; p = 0.35), overall (8.7 % vs 3.6 %; p = 0.3) and PHLF-related mortality (8,7 % vs 1.8 %; p = 0.075). After matching on the extent of resection or using propensity score, regeneration and PHLF rates were similar.
    Conclusion: This prospective study using first sequential SPECT-scintigraphy showed that sarcopenia by itself does not affect liver regeneration capacities and short-term postoperative course after MH.
    MeSH term(s) Humans ; Sarcopenia/diagnostic imaging ; Sarcopenia/etiology ; Sarcopenia/complications ; Prospective Studies ; Male ; Hepatectomy ; Female ; Liver Regeneration/physiology ; Aged ; Middle Aged ; Pilot Projects ; Tomography, X-Ray Computed ; Tomography, Emission-Computed, Single-Photon ; Organ Size ; Postoperative Complications/etiology ; Postoperative Complications/diagnostic imaging ; Radiopharmaceuticals ; Organotechnetium Compounds ; Imino Acids ; Liver Failure/diagnostic imaging ; Liver Failure/etiology ; Liver Failure/surgery ; Aniline Compounds ; Glycine
    Chemical Substances Radiopharmaceuticals ; Organotechnetium Compounds ; Imino Acids ; technetium Tc 99m mebrofenin (F2NQ468L52) ; Aniline Compounds ; Glycine (TE7660XO1C)
    Language English
    Publishing date 2024-04-02
    Publishing country France
    Document type Journal Article
    ZDB-ID 2594333-9
    ISSN 2210-741X ; 2210-7401
    ISSN (online) 2210-741X
    ISSN 2210-7401
    DOI 10.1016/j.clinre.2024.102332
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  6. Article ; Online: COVID 19 et cancer : quelles sont les conséquences de la réorganisation des soins oncologiques ?

    El Amrani, Mehdi / Truant, Stéphanie / Turpin, Anthony

    Bulletin du cancer

    2020  Volume 107, Issue 5, Page(s) 538–540

    Title translation COVID 19 and cancer: What are the consequences of the cancer care reorganization?
    MeSH term(s) Betacoronavirus ; COVID-19 ; China/epidemiology ; Coronavirus Infections/complications ; Coronavirus Infections/epidemiology ; Coronavirus Infections/prevention & control ; France/epidemiology ; Humans ; Incidence ; Medical Oncology/organization & administration ; Medical Oncology/standards ; Neoplasms/complications ; Neoplasms/therapy ; Pandemics/prevention & control ; Pneumonia, Viral/complications ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/prevention & control ; Risk Factors ; SARS-CoV-2 ; Societies, Medical/standards ; Surgical Oncology/organization & administration ; Surgical Oncology/standards
    Keywords covid19
    Language French
    Publishing date 2020-04-23
    Publishing country France
    Document type Practice Guideline
    ZDB-ID 213270-9
    ISSN 1769-6917 ; 0007-4551
    ISSN (online) 1769-6917
    ISSN 0007-4551
    DOI 10.1016/j.bulcan.2020.04.001
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  7. Article ; Online: Surgical ampullectomy with resection of the common bile duct for biliary papillomatosis.

    Khodr, Justine / Truant, Stéphanie / El Amrani, Mehdi

    Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract

    2020  Volume 25, Issue 4, Page(s) 1087–1088

    Abstract: Background: Intraductal papillary neoplasm of the bile duct (IPNB) or biliary papillomatosis is a precursor lesion of papillary cholangiocarcinoma.1 IPNB is recognized as a biliary counterpart of IPMN (pancreatic intraductal papillary mucinous neoplasm). ...

    Abstract Background: Intraductal papillary neoplasm of the bile duct (IPNB) or biliary papillomatosis is a precursor lesion of papillary cholangiocarcinoma.1 IPNB is recognized as a biliary counterpart of IPMN (pancreatic intraductal papillary mucinous neoplasm). IPNB is a rare disease involving entire (diffuse type) or one part (localized type) of biliary tree. Patients without distant metastasis are considered for surgical resection. For patients with distal bile duct papillomatosis, pancreaticoduodenectomy (PD) is recommended for patients with invasive distal bile duct IPNB. PD is a high complex procedure associated with the deterioration of endocrine and exocrine functions leading to a significant impact on quality of life.2 Some authors have reported a new surgical approach leading to a complete resection of the common bile duct without pancreatectomy.3 METHODS: We report the case of a 71-year-old female presented to our department with jaundice. At endoscopic ultrasound with cholangioscopy and CT scan, 2-cm distal bile duct mass tumor with villous component was seen. All needle biopsies were benign, and no distant disease was found. According to the risk of degeneration of this tumor, a surgical resection was decided.
    Results: Intraoperative frozen section assessed the benignity of peripancreatic lymph nodes. We performed surgical ampullectomy with resection of the common bile duct. The intrapancreatic common bile duct was completely mobilized between the ampullectomy area and the upper edge of the pancreas. Frozen sections on distal and proximal margins of common bile duct were performed to discard malignancy. Finally, reconstruction consisted on the main pancreatic duct reimplantation to the duodenum and choledochoduodenostomy. The histological analysis confirmed the diagnosis of biliary papillomatosis with low-grade dysplasia.
    Conclusion: This procedure allows complete resection of benign tumors with endobiliary extension and preserve intestinal continuity and pancreatic parenchyma.
    MeSH term(s) Aged ; Bile Duct Neoplasms/diagnostic imaging ; Bile Duct Neoplasms/surgery ; Bile Ducts, Intrahepatic ; Common Bile Duct/diagnostic imaging ; Common Bile Duct/surgery ; Female ; Humans ; Papilloma/diagnostic imaging ; Papilloma/surgery ; Quality of Life
    Language English
    Publishing date 2020-11-25
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2012365-6
    ISSN 1873-4626 ; 1934-3213 ; 1091-255X
    ISSN (online) 1873-4626 ; 1934-3213
    ISSN 1091-255X
    DOI 10.1007/s11605-020-04851-9
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    Zs.MO 354: Show issues

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  8. Article: Comment on: Failure to rescue in patients with distal pancreatectomy: a nationwide analysis of 10,632 patients.

    Marchese, Ugo / Fuks, David / Truant, Stephanie / El Amrani, Mehdi

    Hepatobiliary surgery and nutrition

    2021  Volume 10, Issue 2, Page(s) 229–231

    Language English
    Publishing date 2021-04-23
    Publishing country China (Republic : 1949- )
    Document type Editorial ; Comment
    ZDB-ID 2812398-0
    ISSN 2304-389X ; 2304-3881
    ISSN (online) 2304-389X
    ISSN 2304-3881
    DOI 10.21037/hbsn-21-105
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  9. Article ; Online: Seuil d’activité minimale pour la chirurgie des cancers digestifs en France : quels sont les enjeux ?

    El Amrani, Mehdi / Turpin, Anthony / Pruvot, François-René

    Bulletin du cancer

    2019  Volume 106, Issue 6, Page(s) 512–513

    Title translation Minimum activity threshold for digestive cancer surgery in France: What are the issues?
    MeSH term(s) Cancer Care Facilities/organization & administration ; Cancer Care Facilities/statistics & numerical data ; Digestive System Neoplasms/surgery ; Digestive System Surgical Procedures/statistics & numerical data ; France ; Health Policy ; Humans ; Procedures and Techniques Utilization ; Prognosis
    Language French
    Publishing date 2019-05-15
    Publishing country France
    Document type Editorial
    ZDB-ID 213270-9
    ISSN 1769-6917 ; 0007-4551
    ISSN (online) 1769-6917
    ISSN 0007-4551
    DOI 10.1016/j.bulcan.2019.03.018
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  10. Article: COVID 19 et cancer : quelles sont les conséquences de la réorganisation des soins oncologiques ?/ [COVID 19 and cancer: What are the consequences of the cancer care reorganization?]

    El Amrani, Mehdi / Truant, Stéphanie / Turpin, Anthony

    Bull Cancer

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #154513
    Database COVID19

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