Article ; Online: Baseline characteristics and analysis of predictors of the Outcome of septic pulmonary embolism in children: a retrospective observational study.
2023 Volume 23, Issue 1, Page(s) 215
Abstract: Background: Septic pulmonary embolism is a rare disease in children. We aimed to assess the clinical, microbiological, and radiological characteristics and outcomes of pediatric septic pulmonary embolism (SPE) and to identify any predictive factors for ... ...
| Abstract | Background: Septic pulmonary embolism is a rare disease in children. We aimed to assess the clinical, microbiological, and radiological characteristics and outcomes of pediatric septic pulmonary embolism (SPE) and to identify any predictive factors for in-hospital mortality in patients with this unusual disease to enhance prognosis and treatment. Methods: A retrospective study to search the electronic medical records of children admitted to the pediatric pulmonology unit, Tanta University hospital with the diagnosis of SPE between January 2015 and June 2022. Results: Seventeen pediatric patients were identified; ten males and seven females with a mean age of 9.4 ± 5.2 years. The most common presenting complaints were fever and shortness of breath (n = 17) followed by chest pain (n = 9), pallor (n = 5), limb swelling (n = 4), and back pain (n = 1). Methicillin-resistant Staphylococcus aureus (MRSA) was the most common causative pathogen in nine patients. The most common extra-pulmonary septic foci were septic arthritis in five patients (29.4%), septic thrombophlebitis in four patients (23.5%), and infective endocarditis in two patients (11.8%). All patients exhibited wedge-shaped peripheral lesions and feeding vessel sign in CT chest, whereas bilateral diffuse lesions, nodular lesions, and cavitation were present in 94.1% of patients, pleural effusion was identified in 58.8% of patients, and pneumothorax was detected in 41.2% of patients. Fifteen patients improved and survived (88.2%), while two patients died (11.8%). Conclusion: Early diagnosis of SPE with vigorous early therapy is critical for a better outcome, including appropriate antibiotics and timely surgical interference to eradicate extra-pulmonary septic foci. |
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| MeSH term(s) | Male ; Female ; Humans ; Child ; Child, Preschool ; Adolescent ; Methicillin-Resistant Staphylococcus aureus ; Retrospective Studies ; Pulmonary Embolism/complications ; Pulmonary Embolism/therapy ; Sepsis/diagnosis ; Lung ; Staphylococcal Infections/drug therapy |
| Language | English |
| Publishing date | 2023-05-05 |
| Publishing country | England |
| Document type | Observational Study ; Journal Article |
| ZDB-ID | 2041342-7 |
| ISSN | 1471-2431 ; 1471-2431 |
| ISSN (online) | 1471-2431 |
| ISSN | 1471-2431 |
| DOI | 10.1186/s12887-023-03998-z |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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