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Article ; Online: Prediction of the Epidemic Peak of Covid19 in Egypt, 2020

El Desouky, Eman D.

medRxiv

Abstract: Objectives: Since December 2019 a pandemic of new novel coronavirus has started from Wuhan, China, in Egypt, the first case reported on February 14, 2020. In this study we aimed to predict the time of possible peak and simulate the changes could be ... ...

Abstract	Objectives: Since December 2019 a pandemic of new novel coronavirus has started from Wuhan, China, in Egypt, the first case reported on February 14, 2020. In this study we aimed to predict the time of possible peak and simulate the changes could be happen by the social behavior of Egyptians during Ramadan (the holy month). Methods: SIR and SEIR compartmental models were used to predict the peak time. We simulated different expected scenarios based to examine their effects on the peak timing. Results: We found that the peak most likely to be in middle of June 2020. Simulating different transmission rate probability and R0 the earliest peak could to be in the May 20 and latest one could be in 18 July. The peak shifted much earlier to 11th April 2020 without lockdown and other mitigation strategies. Conclusion: Social behaviors of citizens during the holy month will dramatically affect the peak timing. Mitigations strategies and other lockdown measure helped to delay the expected peak. Keywords: COVID-19; compartmental models; Epidemic peak; Egypt
Keywords	covid19
Language	English
Publishing date	2020-05-05
Publisher	Cold Spring Harbor Laboratory Press
Document type	Article ; Online
DOI	10.1101/2020.04.30.20086751
Database	COVID19

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Article ; Online: Management of Incidental Uncontrolled Elevation of Intraoperative Blood Pressure: A Comparative Study on Nitroglycerine Versus Dexmedetomidine Infusion.

Elsabeeny, Walaa Y / Shehab, Nahla N / Ibrahim, Mostafa A / El Desouky, Eman D / Abed, Sayed M

Anesthesiology and pain medicine

2023 Volume 13, Issue 2, Page(s) e134806

Abstract: Background: Uncontrolled elevation of intraoperative blood pressure can result in deleterious effects with increased risk of morbidity and mortality.: Objectives: We aimed to compare nitroglycerine infusion with dexmedetomidine infusion in ... ...

Abstract	Background: Uncontrolled elevation of intraoperative blood pressure can result in deleterious effects with increased risk of morbidity and mortality. Objectives: We aimed to compare nitroglycerine infusion with dexmedetomidine infusion in controlling accidental intraoperative uncontrolled hypertension. Methods: This comparative study was conducted on 73 hypertensive patients undergoing cancer surgeries who experienced uncontrolled intraoperative hypertension. The data of 38 patients were retrieved from the medical records for the nitroglycerine group and 35 patients were prospectively enrolled for the dexmedetomidine group. Group N received nitroglycerine infusion (0.3 - 1 µg/kg/min), while group D received dexmedetomidine infusion (0.2 - 0.7 µg/kg/h). Results: Both groups were comparable regarding their demographic data and clinical characteristics. Systolic, diastolic, and mean arterial pressure (MAP) values were significantly lower in group N compared to group D during the period between 60 and 120 minutes intraoperatively (P < 0.001). Heart rate values were significantly lower in group D than in group N (P < 0.001). Postoperative sedation scores were better for group D with lower analgesic requirements (P < 0.001). Conclusions: Dexmedetomidine infusion can be used to manage the uncontrolled intraoperative elevation of blood pressure in selected patient population.
Language	English
Publishing date	2023-03-10
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	3018888-X
ISSN	2228-7531 ; 2228-7523
ISSN (online)	2228-7531
ISSN	2228-7523
DOI	10.5812/aapm-134806
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Article ; Online: Efficacy and safety of combined fractional ablative CO

Weshahy, Ragia / Abdelhamid, Mahmoud F / Sayed, Khadiga S / El Desouky, Eman D / Ramez, Shahenda A

Journal of cosmetic dermatology

2022

Abstract: Background: Acral lesions of vitiligo are most likely recalcitrant to the known lines of treatment. Ablative fractional CO: Methods: Thirty non-segmental vitiligo patients with acral lesion were included in the study. Each patient was subjected to ... ...

Abstract	Background: Acral lesions of vitiligo are most likely recalcitrant to the known lines of treatment. Ablative fractional CO Methods: Thirty non-segmental vitiligo patients with acral lesion were included in the study. Each patient was subjected to fractional Carbon Dioxide Laser Treatment followed by application of 5 fluorouracil (5FU) cream for five consecutive days. Evaluation was done 3 weeks from the start of treatment and 12 weeks after the last treatment session using VESTA score, evaluation of patients' photos by blinded investigation in addition to patients' satisfaction scores. Results: Patients showed significant improvement of Vitiligo extent score for a target area (VESTA) score and developed considerable degree of repigmentation as assessed by blinded investigators. Conclusion: The combination of fractional ablative CO
Language	English
Publishing date	2022-05-27
Publishing country	England
Document type	Journal Article
ZDB-ID	2280551-5
ISSN	1473-2165 ; 1473-2130
ISSN (online)	1473-2165
ISSN	1473-2130
DOI	10.1111/jocd.15116
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Article ; Online: Plastic use for food and drinks and related knowledge, attitudes, and practices among a sample of Egyptians.

Hassan, Fatma Mohamed / El Desouky, Eman D / Salem, Marwa Rashad / Abdelsabour, Motaze Adel / Abdelmoneim, Mostafa Alaa / Elsaieed, Mohamed Mahmoud / Ali, Mona Mohamed

Frontiers in public health

2023 Volume 11, Page(s) 1146800

Abstract: Introduction: Plastic is extensively used in everyday life, particularly for food and beverage containers. The inappropriate use of these containers may lead to the leaching of various chemicals from plastic, such as bisphenol A, phthalate, and styrene, ...

Abstract	Introduction: Plastic is extensively used in everyday life, particularly for food and beverage containers. The inappropriate use of these containers may lead to the leaching of various chemicals from plastic, such as bisphenol A, phthalate, and styrene, which cause numerous adverse health effects. This study aimed to assess the knowledge, attitudes, and practices toward using plastic for food and drinks among a sample of the Egyptian population. Materials and methods: A questionnaire was designed based on scientific literature to assess sociodemographic data, knowledge, attitudes, and practices toward the use of plastic for food and drinks. A total of 639 participants were recruited by employing the convenience sampling technique. Results: More than half of the participants (347, 54%) had poor knowledge scores. Personal experiences, social media, and web pages represented the most common knowledge sources. A comparison between plastic-related knowledge scores and the studied sociodemographic characteristics revealed statistically significant differences in age, gender, education, marital status, residence, working, and socioeconomic standard. A good attitude was reported by the majority (515, 80.6%) of participants. The majority (493, 77.2%) were occasional and frequent plastic users and the practice scores were significantly associated with age, education, residence, and socioeconomic standard. Higher educational level, gender (women), and rural residence were predictors of good participants knowledge, while lower socioeconomic status and urban residence were predictors of bad participants practice in a multivariate logistic regression analysis. Conclusion: The observed unsatisfactory knowledge and practice scores vs. the high attitude indicates a knowledge gap that can help direct future improvements. We call for public awareness programs about safe plastic use and the related health hazards of plastic chemicals. We also stress upon the urgent need for a collaboration between health authorities and the plastic and food industry to guarantee that information about proper plastic use is conveyed to consumers.
MeSH term(s)	Humans ; Female ; Egypt ; Health Knowledge, Attitudes, Practice ; Educational Status ; Social Class ; Surveys and Questionnaires
Language	English
Publishing date	2023-09-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2711781-9
ISSN	2296-2565 ; 2296-2565
ISSN (online)	2296-2565
ISSN	2296-2565
DOI	10.3389/fpubh.2023.1146800
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Article ; Online: Prevalence, characteristics, and factors associated with caffeine-withdrawal headache during the first day of Ramadan.

Magdy, Rehab / El Desouky, Eman D / Hammad, El-Sayed Mah / Salem, Marwa Rashad / Mahfouz, Noha A / Fathy, Wael / Al-Azayem, Salsabil Abo / Naguib, Esraa M / Hussein, Mona

Headache

2023 Volume 63, Issue 3, Page(s) 360–367

Abstract: Background: Data regarding prevalence, characteristics, and factors associated with caffeine-withdrawal headache are lacking. This work aimed to study the prevalence of caffeine-withdrawal headache among caffeine consumers during Ramadan's first day and ...

Abstract	Background: Data regarding prevalence, characteristics, and factors associated with caffeine-withdrawal headache are lacking. This work aimed to study the prevalence of caffeine-withdrawal headache among caffeine consumers during Ramadan's first day and describe its characteristics and associated factors. Methods: This analytical cross-sectional study targeted 755 caffeine consumers eligible to fast on the first day of Ramadan. Two methodological approaches were followed: an online open survey and a face-to-face interview. Using an adjusted form of food frequency questionnaire, eligible participants were requested to report their intake of caffeine-containing products during the last week of Shaaban month, the month preceding Ramadan. Results: The prevalence of caffeine-withdrawal headache on the first day of Ramadan was 419 (55.5%), with 95% confidence interval (CI; 51.9-59.0%). The headache in the majority of the participants was throbbing in character (249/419, 59.4%), diffuse (146/419, 34.8%), and moderate in intensity (227/419, 54.2%). Participants who developed caffeine-withdrawal headache had significantly higher body mass index (27.2 ± 5.1 vs. 26.3 ± 5 [mean ± standard deviation], p-value = 0.012), daily caffeine intake, mg (316 [185.2-537.8] vs. 144.4 [60.0-312.4] [median interquartile range (IQR)], p-value < 0.001), and caffeine intake mg/kg body weight (4.7 [2.6-7.2] vs. 1.9 [0.8-4.4] [median (IQR)], p-value < 0.001) than participants who did not develop it. Mild, moderate, and severe caffeine use disorder were found to have adjusted associations with developing caffeine-withdrawal headache. They increased the odds of headache by 5.3 (95% CI = 3.40-8.3), 10.2 (95% CI = 5.9-17.5), and 15.5 (95% CI = 9.0-26.8) times, respectively. The optimal cut-off value of daily caffeine intake/Kg body weight was determined at 1.97 mg/kg with an area under the curve of 0.722 and sensitivity and specificity of 85.1% and 50.2%, respectively. Conclusion: Daily caffeine intake/kg body weight and caffeine use disorder are significantly associated with a caffeine-withdrawal headache.
MeSH term(s)	Humans ; Caffeine/adverse effects ; Prevalence ; Cross-Sectional Studies ; Headache/chemically induced ; Headache/epidemiology ; Substance Withdrawal Syndrome/epidemiology ; Body Weight
Chemical Substances	Caffeine (3G6A5W338E)
Language	English
Publishing date	2023-03-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	410130-3
ISSN	1526-4610 ; 0017-8748
ISSN (online)	1526-4610
ISSN	0017-8748
DOI	10.1111/head.14483
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Article: Violence and sociodemographic related factors among a sample of Egyptian women during the COVID-19 pandemic.

Moawad, Asmaa Mohammad / El Desouky, Eman D / Salem, Marwa Rashad / Elhawary, Ahmed Sallam / Hussein, Sara M / Hassan, Fatma Mohamed

Egyptian journal of forensic sciences

2021 Volume 11, Issue 1, Page(s) 29

Abstract: Background: Violence against women is a worldwide problem that affects different social and economic classes, and this violence has almost increased with pandemics as the COVID-19 pandemic. The present survey aimed to assess the prevalence of violence ... ...

Abstract	Background: Violence against women is a worldwide problem that affects different social and economic classes, and this violence has almost increased with pandemics as the COVID-19 pandemic. The present survey aimed to assess the prevalence of violence against women in Egypt during the COVID-19 pandemic and to identify the relationship between sociodemographic factors and violence exposure. A total of 509 women were recruited using a self-completion e-form questionnaire. Results: The prevalence of violence experienced by women was (43.8%); the most common type was the emotional representing (96.0%) of exposed women, while sexual violence was the least common (13.5%). Violence exposure was affected significantly by residence governorates, husbands' working status, reduced husbands' working hours, and history of violence exposure. Conclusions: Violence against women in Egypt was increased during the COVID-19 pandemic, which raises the need for a strong and urgent anti-violence program to control this problem.
Language	English
Publishing date	2021-10-18
Publishing country	Egypt
Document type	Journal Article
ZDB-ID	2631791-6
ISSN	2090-5939 ; 2090-536X
ISSN (online)	2090-5939
ISSN	2090-536X
DOI	10.1186/s41935-021-00243-5
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Article ; Online: Early-Onset Colorectal Cancer in Egypt: Pathological Characters, Patterns of Care, and Survival Compared to Average-Age Onset Colorectal Cancer: A Retrospective Multicenter Study.

Rashad, Noha / Eid Salem, Salem / Meheissen, Mohamed A M / Refaat, Ghada / Mahmoud Sami, Heba / Temerik, Abdelsalam / Kordy, Nashwa / Daniel, Mina A / El-Kaffas, Mohamed / Esam, Mohamed / El Mansy, Hazem / Elkerm, Yasser / Abdelaziz Elsaid, Amr / Attia Ismail, Abdelsalam / Saber Abdelhalim, Mohyeldin / Moustafa Ahmad, Lamiaa / Akram Mahmoud, Mai / El Desouky, Eman D

JCO global oncology

2024 Volume 10, Page(s) e2300372

Abstract: Purpose: Early-onset colorectal cancer (EOCRC) is a rising health problem. The incidence of EOCRC has increased over the past 2 decades all over the world. Reports from Egypt since the 1990s have reported a higher incidence among young populations with ... ...

Abstract	Purpose: Early-onset colorectal cancer (EOCRC) is a rising health problem. The incidence of EOCRC has increased over the past 2 decades all over the world. Reports from Egypt since the 1990s have reported a higher incidence among young populations with no identifiable risk factors. The aim of this study was to assess EOCRC in Egypt regarding incidence, characteristics, treatment pattern, and survival compared with average age onset and elderly patients. Materials and methods: This was a retrospective, record-based, cohort study combining data from four different cancer centers in Egypt. We grouped patients according to age into three categories: the EOCRC group for patients age ≤45 years and the average age onset and elderly cancer group (for patients age ≥65 years). Results: The study included 1,310 patients with histopathologically proven colorectal cancer, representing four different geographical areas in Egypt. Patients with EOCRC represented 42.4% of the study population. Female patients were 50.6% among the EOCRC group and 52.5% among the average age group. Rectal tumors were significantly higher in EOCRC (54.7% Conclusion: A comprehensive framework for the study of EOCRC is required in Egypt as well as a genomic analysis to identify possible underlying genetic alterations responsible for the high incidence of EOCRC.
MeSH term(s)	Aged ; Humans ; Female ; Middle Aged ; Cohort Studies ; Egypt/epidemiology ; Retrospective Studies ; Disease-Free Survival ; Colorectal Neoplasms/epidemiology ; Colorectal Neoplasms/therapy
Language	English
Publishing date	2024-03-29
Publishing country	United States
Document type	Multicenter Study ; Journal Article
ISSN	2687-8941
ISSN (online)	2687-8941
DOI	10.1200/GO.23.00372
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Article ; Online: Capecitabine-Based Chemoendocrine Combination as First-Line Treatment for Metastatic Hormone-Positive Metastatic Breast Cancer: Phase 2 Study.

Rashad, Noha / Abdelhamid, Thoraya / Shouman, Samia A / Nassar, Hanan / Omran, Mervat A / El Desouky, Eman D / Khaled, Hussein

Clinical breast cancer

2020 Volume 20, Issue 3, Page(s) 228–237

Abstract: Background: Preclinical studies have suggested a synergistic effect of tamoxifen and capecitabine in estrogen receptor-positive cell lines. We evaluated the safety and efficacy of first-line chemoendocrine treatment in patients with metastatic breast ... ...

Abstract	Background: Preclinical studies have suggested a synergistic effect of tamoxifen and capecitabine in estrogen receptor-positive cell lines. We evaluated the safety and efficacy of first-line chemoendocrine treatment in patients with metastatic breast cancer. Biochemical assessment was performed of serum levels of thymidine phosphorylase enzyme (TP), serum tamoxifen, hydroxytamoxifen, and 5-fluorouracil in relationship to efficacy. Patients and methods: This prospective phase 2 interventional study studied patients with estrogen receptor-positive, HER2 Results: Forty women with a median age of 49.3 years were enrolled. For the whole study group, median progression-free survival (PFS) was 10 months and median overall survival (OS) was 23.3 months. The overall response rate was 60% and the clinical benefit rate 82.5%. Progesterone receptor positivity was associated with significantly longer PFS (12 vs. 7 months, P = .021). The most frequent adverse events were palmar-plantar erythrodysesthesia (62.5%), fatigue (62.5%), diarrhea (30%), abdominal pain (12.5%), and constipation (10%). Changes in serum level of TP were not correlated to response to treatment, PFS, or OS. Higher serum levels of tamoxifen and hydroxytamoxifen were correlated with higher response rates and longer PFS but not OS. Conclusion: Chemoendocrine treatment is well tolerated, with no evidence of contradictory effects between the combination components. However, the efficacy data need more validation.
MeSH term(s)	Abdominal Pain/chemically induced ; Abdominal Pain/epidemiology ; Adult ; Antimetabolites, Antineoplastic/administration & dosage ; Antimetabolites, Antineoplastic/adverse effects ; Antineoplastic Agents, Hormonal/administration & dosage ; Antineoplastic Agents, Hormonal/adverse effects ; Antineoplastic Agents, Hormonal/pharmacokinetics ; Antineoplastic Combined Chemotherapy Protocols/administration & dosage ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Antineoplastic Combined Chemotherapy Protocols/pharmacokinetics ; Biomarkers, Tumor/analysis ; Biomarkers, Tumor/metabolism ; Breast Neoplasms/blood ; Breast Neoplasms/drug therapy ; Breast Neoplasms/mortality ; Breast Neoplasms/pathology ; Capecitabine/administration & dosage ; Capecitabine/adverse effects ; Capecitabine/pharmacokinetics ; Constipation/chemically induced ; Constipation/epidemiology ; Diarrhea/chemically induced ; Diarrhea/epidemiology ; Female ; Hand-Foot Syndrome/epidemiology ; Hand-Foot Syndrome/etiology ; Humans ; Letrozole/administration & dosage ; Letrozole/adverse effects ; Letrozole/pharmacokinetics ; Middle Aged ; Progression-Free Survival ; Prospective Studies ; Receptor, ErbB-2/analysis ; Receptors, Estrogen/analysis ; Receptors, Estrogen/metabolism ; Receptors, Progesterone/analysis ; Receptors, Progesterone/metabolism ; Tamoxifen/administration & dosage ; Tamoxifen/adverse effects ; Tamoxifen/pharmacokinetics
Chemical Substances	Antimetabolites, Antineoplastic ; Antineoplastic Agents, Hormonal ; Biomarkers, Tumor ; Receptors, Estrogen ; Receptors, Progesterone ; Tamoxifen (094ZI81Y45) ; Capecitabine (6804DJ8Z9U) ; Letrozole (7LKK855W8I) ; ERBB2 protein, human (EC 2.7.10.1) ; Receptor, ErbB-2 (EC 2.7.10.1)
Language	English
Publishing date	2020-01-07
Publishing country	United States
Document type	Clinical Trial, Phase II ; Journal Article
ZDB-ID	2106734-X
ISSN	1938-0666 ; 1526-8209
ISSN (online)	1938-0666
ISSN	1526-8209
DOI	10.1016/j.clbc.2019.12.012
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Article ; Online: Downregulation of interleukin 36γ and its cleaver cathepsin G following treatment with narrow-band ultraviolet B phototherapy in psoriasis vulgaris.

El-Kalioby, Mona / El-Komy, Mohamed H M / Said, Eman R / Amer, Marwa Ahmed / Saadi, Dina G / Nouredin Mohammed, Faisal / Rashed, Laila A / El Desouky, Eman D / AlOrbani, Aya M

The Journal of dermatological treatment

2021 Volume 33, Issue 4, Page(s) 2358–2363

Abstract: Background: Growing evidence suggests the important role of IL-36 in the pathogenesis of psoriasis. Cathepsin G is a neutrophil-derived protease that can activate IL-36γ.: Objective: To assess the expression of IL-36γ and cathepsin G in psoriasis and ...

Abstract	Background: Growing evidence suggests the important role of IL-36 in the pathogenesis of psoriasis. Cathepsin G is a neutrophil-derived protease that can activate IL-36γ. Objective: To assess the expression of IL-36γ and cathepsin G in psoriasis and to quantify the impact of treatment with narrow-band ultraviolet B phototherapy (NB-UVB) on their levels. Methods: This case-control study involved 26 patients with moderate-severe psoriasis and 25 healthy volunteers. Psoriasis patients eligible for phototherapy received 24 NB-UVB sessions. Punch skin biopsies were obtained from all participants at recruitment and after phototherapy from patients. Real-time PCR was utilized for quantitative assessment of IL-36γ and cathepsin G expression in tissue samples. Results: The expression of IL-36γ and cathepsin G was significantly higher in psoriasis before NB-UVB therapy compared to controls ( Conclusion: IL-36γ and cathepsin G expression is upregulated in psoriatic lesions, supporting their role as mediators of inflammation in psoriasis. Downregulation of IL-36γ and cathepsin G is a possible mechanism for psoriasis improvement after NB-UVB therapy. IL-36 and cathepsin G can be considered as therapeutic targets for psoriasis.
MeSH term(s)	Case-Control Studies ; Cathepsin G/metabolism ; Down-Regulation ; Humans ; Interleukin-1/metabolism ; Interleukins ; Phototherapy ; Psoriasis/pathology ; Psoriasis/radiotherapy ; Ultraviolet Therapy
Chemical Substances	IL36G protein, human ; Interleukin-1 ; Interleukins ; CTSG protein, human (EC 3.4.21.20) ; Cathepsin G (EC 3.4.21.20)
Language	English
Publishing date	2021-08-23
Publishing country	England
Document type	Journal Article
ZDB-ID	1036299-x
ISSN	1471-1753 ; 0954-6634
ISSN (online)	1471-1753
ISSN	0954-6634
DOI	10.1080/09546634.2021.1967265
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Article: Impact of Global DNA Methylation in Treatment Outcome of Colorectal Cancer Patients.

Fouad, Mariam A / Salem, Salem E / Hussein, Marwa M / Zekri, Abdel Rahman N / Hafez, Hafez F / El Desouky, Eman D / Shouman, Samia A

Frontiers in pharmacology

2018 Volume 9, Page(s) 1173

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2018-10-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2018.01173
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