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  1. Article: Robotic resection of left renal vein with preservation of left kidney for leiomyosarcoma: Case report and review of the literature.

    Lodoli, Claudio / El Halabieh, Miriam Attalla / Santullo, Francesco / Abatini, Carlo / Gallotta, Valerio / Pacelli, Fabio

    International journal of surgery case reports

    2024  Volume 116, Page(s) 109381

    Abstract: Introduction: Radical surgical resection with negative margins is the mainstay of treatment for retroperitoneal vascular leiomyosarcomas. Given the retroperitoneal location of these tumors, open surgery is, historically, the chosen surgical approach, ... ...

    Abstract Introduction: Radical surgical resection with negative margins is the mainstay of treatment for retroperitoneal vascular leiomyosarcomas. Given the retroperitoneal location of these tumors, open surgery is, historically, the chosen surgical approach, however, it is burdened with high postoperative morbidity. In selected cases, the small dimension of the tumor and a favorable location, allow to perform a minimally invasive treatment.
    Presentation of case: A 67-year-old female patient with a diagnosis of a leiomyosarcoma arising from the left renal vein underwent a robotic resection of the left renal vein with preservation of the left kidney and a relative outflow trough the gonadal vessels. The patient was discharged on the fourth postoperative day without any complications and there was no tumor recurrence noted during the 24-month follow-up period.
    Discussion: Vascular retroperitoneal leiomyosarcomas are very rare tumors requiring a complete en bloc gross tumor resection in order to achieving microscopically negative margins on the vein of origin. Thanks to the preoperative histological diagnosis and radiological study of the neoplasm, it was possible to proceed to a highly personalized and minimally invasive treatment with respect of oncological criteria.
    Conclusion: In selected cases, a minimally invasive surgery of vascular leiomyosarcoma could be a feasible and safe treatment option.
    Language English
    Publishing date 2024-02-15
    Publishing country Netherlands
    Document type Case Reports
    ISSN 2210-2612
    ISSN 2210-2612
    DOI 10.1016/j.ijscr.2024.109381
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Systemic chemotherapy and pressurized intraperitoneal aerosol chemotherapy (PIPAC): A bidirectional approach for gastric cancer peritoneal metastasis.

    Di Giorgio, Andrea / Schena, Carlo Alberto / El Halabieh, Miriam Attalla / Abatini, Carlo / Vita, Emanuele / Strippoli, Antonia / Inzani, Frediano / Rodolfino, Elena / Romanò, Bruno / Pacelli, Fabio / Rotolo, Stefano

    Surgical oncology

    2020  Volume 34, Page(s) 270–275

    Abstract: Background: Few patients affected by gastric cancer peritoneal metastasis (GCPM) are offered locoregional treatment, despite several proof-of-efficacy trials. Pressurized intraperitoneal aerosol chemotherapy (PIPAC) has emerged in recent years as a ... ...

    Abstract Background: Few patients affected by gastric cancer peritoneal metastasis (GCPM) are offered locoregional treatment, despite several proof-of-efficacy trials. Pressurized intraperitoneal aerosol chemotherapy (PIPAC) has emerged in recent years as a promising tool to control peritoneal carcinomatosis. The combination of PIPAC with systemic chemotherapy may offer a greater clinical benefit than standard treatment alone.
    Methods: A single-center cohort of 28 consecutive patients affected by GCPM was scheduled for bidirectional treatment, comprising PIPAC and systemic chemotherapy, from September 2017 to September 2019. Data recorded included safety, efficacy and survival outcomes. Ascite volumes, the Peritoneal Cancer Index (PCI) and pathological response through the Peritoneal Regression Grading Score (PRGS) were compared in those patients who underwent more than one PIPAC procedure.
    Results: Forty-six PIPAC procedures were administered, with a mean of 1.7 PIPAC procedures per patient. The median time to resume systemic chemotherapy after PIPAC was 6 days (range 4-7). Concerning safety, two grade 3-4 CTCAE (Common Terminology Criteria for Adverse Events v4.0) toxicity events and one intraoperative complication were recorded. Thirteen patients repeated PIPAC. A pathological response was recorded in 61.5% of patients (one with complete and seven with partial regression). The median overall survival was 12.3 months in the overall population and 15.0 months in patients undergoing more than one PIPAC procedure.
    Conclusions: A bidirectional approach for GCPM was feasible and safe, as the PIPAC procedure integrates well with several systemic chemotherapy regimens. The pathological response demonstrated the antitumoral efficacy of PIPAC. The proposed bidirectional approach may be further investigated in the first-line treatment of metastatic gastric cancer.
    MeSH term(s) Adult ; Aerosols ; Aged ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Cisplatin/administration & dosage ; Doxorubicin/administration & dosage ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Peritoneal Neoplasms/drug therapy ; Peritoneal Neoplasms/secondary ; Pressure ; Prognosis ; Prospective Studies ; Retrospective Studies ; Stomach Neoplasms/drug therapy ; Stomach Neoplasms/pathology ; Survival Rate
    Chemical Substances Aerosols ; Doxorubicin (80168379AG) ; Cisplatin (Q20Q21Q62J)
    Language English
    Publishing date 2020-06-03
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1107810-8
    ISSN 1879-3320 ; 0960-7404
    ISSN (online) 1879-3320
    ISSN 0960-7404
    DOI 10.1016/j.suronc.2020.05.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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