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Article ; Online: Severe fetal anaemia due to red cell alloimmunisation in a Rh

Cuvellier, Nadège / Carlin, Andrew / Badr, Dominique A / El-Kenz, Hanane / Ruth, Isabelle / Jani, Jacques C

2023 Volume 33, Issue 5, Page(s) 420–422

Language	English
Publishing date	2023-08-10
Publishing country	England
Document type	Case Reports
ZDB-ID	1067989-3
ISSN	1365-3148 ; 0958-7578
ISSN (online)	1365-3148
ISSN	0958-7578
DOI	10.1111/tme.12990
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Zs.A 3177: Show issues

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Article ; Online: Cell-free DNA analysis for noninvasive examination of trisomy: comparing 2 targeted methods.

Conotte, Stéphanie / El Kenz, Hanane / De Marchin, Jérôme / Jani, Jacques C

American journal of obstetrics and gynecology

2022 Volume 227, Issue 3, Page(s) 539–541

MeSH term(s)	Cell-Free Nucleic Acids ; Chromosomes, Human, Pair 18 ; Female ; Humans ; Pregnancy ; Prenatal Diagnosis/methods ; Sequence Analysis, DNA ; Trisomy/diagnosis ; Trisomy/genetics ; Trisomy 13 Syndrome/diagnosis ; Trisomy 13 Syndrome/genetics ; Trisomy 18 Syndrome/diagnosis ; Trisomy 18 Syndrome/genetics
Chemical Substances	Cell-Free Nucleic Acids
Language	English
Publishing date	2022-05-14
Publishing country	United States
Document type	Letter ; Research Support, Non-U.S. Gov't
ZDB-ID	80016-8
ISSN	1097-6868 ; 0002-9378
ISSN (online)	1097-6868
ISSN	0002-9378
DOI	10.1016/j.ajog.2022.05.024
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Um I Zs.152: Show issues

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Article ; Online: Pilot study on the use of basophil activation tests and skin tests for the prevention of allergic transfusion reactions.

Akiki, Philippe / Dedeken, Laurence / Ferster, Alina / Doyen, Virginie / Dupire, Gwendy / Nagant, Carole / Smet, Julie / Ghorra, Nathalie / Ruth, Isabelle / Lauwers, Maïlis / Daubie, Valery / Corazza, Francis / El Kenz, Hanane

Frontiers in allergy

2024 Volume 4, Page(s) 1328227

Abstract: Background and objectives: Management of severe allergic transfusion reactions (ATR) is challenging. In this study, we investigate the usefulness of skin tests and basophil activation tests (BAT) in chronically transfused patients for the prevention of ... ...

Abstract	Background and objectives: Management of severe allergic transfusion reactions (ATR) is challenging. In this study, we investigate the usefulness of skin tests and basophil activation tests (BAT) in chronically transfused patients for the prevention of future ATR. Materials and methods: BAT and skin tests were carried with the supernatant of red blood cell (RBC) units for a sickle-cell disease patient under chronic exchange transfusion who has presented a severe ATR, in order to prevent potential future ATR. If the results for both BAT and skin tests were negative, the RBC units could be transfused to the patient. If either one of the results was positive, the tested RBC unit was discarded for the patient. Results: 192 RBC units were tested with both tests. The level of results concordance between the two tests was 95%. Out of the 169 negative units with both tests, 118 units were transfused to the patient for which he presented no ATR. Conclusion: In our study, combining both BAT and skin tests was associated with a good negative predictive value since we were able to safely transfuse our patient. Further studies are still necessary to confirm this result but this pilot study indicates that skin tests and BAT might help prevent ATR. When BAT is not available, skin tests may also be useful in preventing ATR.
Language	English
Publishing date	2024-01-08
Publishing country	Switzerland
Document type	Journal Article
ISSN	2673-6101
ISSN (online)	2673-6101
DOI	10.3389/falgy.2023.1328227
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Article ; Online: COVID-19 et groupes sanguins ABO - Où en est-on ?

Le Pendu, Jacques / Breiman, Adrien / Deleers, Marie / El Kenz, Hanane / Ruvoën, Nathalie

Medecine sciences : M/S

2021 Volume 37, Issue 6-7, Page(s) 565–568

Title translation	COVID-19 and ABO blood types: Where do we stand?
MeSH term(s)	ABO Blood-Group System/immunology ; COVID-19/blood ; Disease Susceptibility ; Humans ; Immunity, Innate ; Risk Factors ; SARS-CoV-2/pathogenicity
Chemical Substances	ABO Blood-Group System
Language	French
Publishing date	2021-06-03
Publishing country	France
Document type	Journal Article
ZDB-ID	632733-3
ISSN	1958-5381 ; 0767-0974
ISSN (online)	1958-5381
ISSN	0767-0974
DOI	10.1051/medsci/2021065
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Article ; Online: Acute hemolytic transfusion reaction associated with anti-Mt

Claes, Vincent / Peyrard, Thierry / Deleers, Marie / El Kenz, Hanane

Transfusion

2019 Volume 59, Issue 11, Page(s) 3314–3318

Abstract: Background: Mt: Case report: A 38-year-old male with sickle cell disease undergoing exchange transfusion presented with shivering, nausea, dyspnea, and pain in the lower limbs. Biologic parameters showed increased hemolysis. The administered red ... ...

Abstract	Background: Mt Case report: A 38-year-old male with sickle cell disease undergoing exchange transfusion presented with shivering, nausea, dyspnea, and pain in the lower limbs. Biologic parameters showed increased hemolysis. The administered red blood cell (RBC) units had been issued by electronic crossmatch due to a negative antibody screening test. In the posttransfusion investigations, crossmatch of the transfused RBC units with the patient's serum showed incompatibility of one unit. The presence of an antibody against a low-prevalence antigen was suspected and further serologic testing was performed for identification. Results: Anti-Mt Conclusion: To our knowledge, this is the first case report of an HTR associated with anti-Mt
MeSH term(s)	Adult ; Anemia, Sickle Cell/immunology ; Erythroblastosis, Fetal/etiology ; Erythrocytes/immunology ; Exchange Transfusion, Whole Blood/adverse effects ; Humans ; MNSs Blood-Group System/immunology ; Male ; Transfusion Reaction/etiology
Chemical Substances	MNSs Blood-Group System
Language	English
Publishing date	2019-09-10
Publishing country	United States
Document type	Case Reports ; Journal Article ; Review
ZDB-ID	208417-x
ISSN	1537-2995 ; 0041-1132
ISSN (online)	1537-2995
ISSN	0041-1132
DOI	10.1111/trf.15521
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Zs.A 284: Show issues

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Article ; Online: A Tutsi family harbouring two new RHCE variant alleles and a new haplotype in the Rh blood group system.

Deleers, Marie / Thonier, Vincent / Claes, Vincent / Daelemans, Caroline / Peyrard, Thierry / El Kenz, Hanane

Vox sanguinis

2020 Volume 115, Issue 5, Page(s) 451–455

Abstract: Background: RHCE*ceEK is a rare RH allele mostly encountered in people of African descent. This allele is defined by four single nucleotide substitutions: c.48G>C, c.712A>G, c.787A>G and c.800T>A. Until now, it has only been reported to segregate with ... ...

Abstract	Background: RHCEceEK is a rare RH allele mostly encountered in people of African descent. This allele is defined by four single nucleotide substitutions: c.48G>C, c.712A>G, c.787A>G and c.800T>A. Until now, it has only been reported to segregate with either RHD01N.01 or RHDDAR1.00. Materials and methods:* Blood samples were drawn from a 32-year-old Tutsi pregnant woman during an antenatal visit in order to perform her type and screen. To further investigate the results found in the patient, a family study was conducted. Standard haemagglutination methods were used to investigate the subjects' red blood cells and plasma. Molecular workup on RHD and RHCE genes was carried out by DNA microarray, real-time PCR and DNA sequencing techniques. Results: The patient was phenotyped as group B, D+C-E-c+e+, Hr-. A complex mixture of anti-E, anti-c, anti-Hr and anti-hr Conclusions: This case study brought out new associations between RHD and RHCE alleles encoding the rare Hr- phenotype: the conventional RHCEceEK allele linked to the RHD01 allele and an alternative RHCEceEK allele associated with the RHD01N.01 allele. A novel RHCEce variant (RHCEce
MeSH term(s)	Adult ; African Continental Ancestry Group/genetics ; Alleles ; Erythrocytes/immunology ; Female ; Haplotypes ; Humans ; Pedigree ; Pregnancy ; Rh-Hr Blood-Group System/genetics ; Sequence Analysis, DNA
Chemical Substances	RHCE protein, human ; Rh-Hr Blood-Group System
Language	English
Publishing date	2020-03-20
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	80313-3
ISSN	1423-0410 ; 0042-9007
ISSN (online)	1423-0410
ISSN	0042-9007
DOI	10.1111/vox.12905
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Article ; Online: Management of sickle cell disease during pregnancy: experience in a third-level hospital and future recommendations.

Montironi, Ramona / Cupaiolo, Roberto / Kadji, Caroline / Badr, Dominique A / Deleers, Marie / Charles, Valérie / Vanderhulst, Julien / El Kenz, Hanane / Jani, Jacques C

The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians

2020 Volume 35, Issue 12, Page(s) 2345–2354

Abstract: Objective: To describe the outcomes of sickle-cell disease in pregnancy according to the different treatments adopted before and during pregnancy and to propose a systematic approach to treat sickle-cell disease (SCD) during pregnancy.: Methods: A ... ...

Abstract	Objective: To describe the outcomes of sickle-cell disease in pregnancy according to the different treatments adopted before and during pregnancy and to propose a systematic approach to treat sickle-cell disease (SCD) during pregnancy. Methods: A retrospective descriptive study compared pregnancy outcomes among women with SCD who stopped hydroxyurea (HU) once pregnant (Group 1), were never treated before and during pregnancy (Group 2) or were treated by HU before conception who received prophylactic transfusion during pregnancy (Group 3). For each group we recorded the population's characteristics and the transfusion-related, obstetrical, perinatal and SCD complications. Results: We found 11 patients for group 1 (9/11 with at least 3 painful crises during the 12 months before conception), 4 for group 2 (3/4 with no sickle-cell complications during the year before pregnancy) and 2 for group 3 (one with previous multiorgan failure (MOF), one with previous stroke). No transfusion-related complication occurred. Group 1 and 2 developed SCD complications and a high number of acute transfusions and hospital admissions. Group 3 showed none of these complications, but one patient developed preeclampsia and preterm birth. Several obstetrical and perinatal complications occurred in group 1. Conclusion: Not treating sickle-cell during pregnancy increases maternal and perinatal morbidity, even in mildly affected women. All sickle-cell pregnancies should be treated, according to the treatment adopted before but also to patient's SCD-history. We propose chronic transfusion to women with previous stroke or MOF or already under transfusion program, and HU for severely and mildly affected patients, respectively from the second and third trimesters. Additional prospective studies are needed to validate the results of the proposed protocol.
MeSH term(s)	Anemia, Sickle Cell/complications ; Anemia, Sickle Cell/epidemiology ; Anemia, Sickle Cell/therapy ; Female ; Hospitals ; Humans ; Infant, Newborn ; Male ; Pregnancy ; Pregnancy Complications, Hematologic/prevention & control ; Pregnancy Complications, Hematologic/therapy ; Pregnancy Outcome/epidemiology ; Premature Birth ; Retrospective Studies ; Stroke/complications ; Transfusion Reaction/complications
Language	English
Publishing date	2020-07-06
Publishing country	England
Document type	Journal Article
ZDB-ID	2077261-0
ISSN	1476-4954 ; 1057-0802 ; 1476-7058
ISSN (online)	1476-4954
ISSN	1057-0802 ; 1476-7058
DOI	10.1080/14767058.2020.1786054
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Article: A case of severe foetal anaemia due to anti-Kell that could not be detected by the weekly assessment of middle cerebral artery peak systolic velocity.

Deleers, Marie / Guizani, Meriem / Jani, Jacques / Hulot, Martine / El Kenz, Hanane

Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis

2018 Volume 57, Issue 1, Page(s) 111–113

MeSH term(s)	Adult ; Erythroblastosis, Fetal/blood ; Erythroblastosis, Fetal/diagnosis ; Female ; Fetomaternal Transfusion/blood ; Fetomaternal Transfusion/diagnosis ; Humans ; Isoantibodies/blood ; Kell Blood-Group System/blood ; Pregnancy
Chemical Substances	Isoantibodies ; Kell Blood-Group System
Language	English
Publishing date	2018-01-31
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	2046795-3
ISSN	1878-1683 ; 1473-0502
ISSN (online)	1878-1683
ISSN	1473-0502
DOI	10.1016/j.transci.2018.01.005
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Article ; Online: Transfusion-related acute lung injury.

El Kenz, Hanane / Van der Linden, Philippe

European journal of anaesthesiology

2014 Volume 31, Issue 7, Page(s) 345–350

Abstract: Transfusion-related acute lung injury (TRALI) is defined as the onset or the worsening of respiratory distress within 6 h of the transfusion of a plasma-containing blood component. It is currently considered to be one of the leading causes of severe ... ...

Abstract	Transfusion-related acute lung injury (TRALI) is defined as the onset or the worsening of respiratory distress within 6 h of the transfusion of a plasma-containing blood component. It is currently considered to be one of the leading causes of severe posttransfusion morbidity and acute mortality in countries with a high development index. Understanding of the pathogenesis of TRALI has resulted in the development of preventive measures that have contributed to reducing its incidence. Early recognition of the clinical symptoms allow the clinician to identify the syndrome and to undertake therapeutic measures that may reduce the morbidity and mortality associated with this complication.
MeSH term(s)	Acute Lung Injury/epidemiology ; Acute Lung Injury/etiology ; Acute Lung Injury/prevention & control ; Blood Transfusion/methods ; Humans ; Incidence ; Plasma ; Time Factors ; Transfusion Reaction
Language	English
Publishing date	2014-07
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	605770-6
ISSN	1365-2346 ; 0265-0215
ISSN (online)	1365-2346
ISSN	0265-0215
DOI	10.1097/EJA.0000000000000015
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Article ; Online: Lack of the human choline transporter-like protein SLC44A2 causes hearing impairment and a rare red blood phenotype.

EMBO molecular medicine

2023 Volume 15, Issue 3, Page(s) e16320

Abstract: Blood phenotypes are defined by the presence or absence of specific blood group antigens at the red blood cell (RBC) surface, due to genetic polymorphisms among individuals. The recent development of genomic and proteomic approaches enabled the ... ...

Abstract	Blood phenotypes are defined by the presence or absence of specific blood group antigens at the red blood cell (RBC) surface, due to genetic polymorphisms among individuals. The recent development of genomic and proteomic approaches enabled the characterization of several enigmatic antigens. The choline transporter-like protein CTL2 encoded by the SLC44A2 gene plays an important role in platelet aggregation and neutrophil activation. By investigating alloantibodies to a high-prevalence antigen of unknown specificity, found in patients with a rare blood type, we showed that SLC44A2 is also expressed in RBCs and carries a new blood group system. Furthermore, we identified three siblings homozygous for a large deletion in SLC44A2, resulting in complete SLC44A2 deficiency. Interestingly, the first-ever reported SLC44A2-deficient individuals suffer from progressive hearing impairment, recurrent arterial aneurysms, and epilepsy. Furthermore, SLC44A2
MeSH term(s)	Humans ; Proteomics ; Membrane Transport Proteins/genetics ; Membrane Transport Proteins/metabolism ; Hearing Loss/genetics ; Phenotype ; Membrane Glycoproteins/metabolism
Chemical Substances	choline transporter ; Membrane Transport Proteins ; SLC44A2 protein, human ; Membrane Glycoproteins
Language	English
Publishing date	2023-01-25
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2467145-9
ISSN	1757-4684 ; 1757-4676
ISSN (online)	1757-4684
ISSN	1757-4676
DOI	10.15252/emmm.202216320
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