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Article ; Online: Soy Isoflavones Induce Cell Death by Copper-Mediated Mechanism: Understanding Its Anticancer Properties.

Farhan, Mohd / El Oirdi, Mohamed / Aatif, Mohammad / Nahvi, Insha / Muteeb, Ghazala / Alam, Mir Waqas

2023 Volume 28, Issue 7

Abstract: Cancer incidence varies around the globe, implying a relationship between food and cancer risk. Plant polyphenols are a class of secondary metabolites that have recently attracted attention as possible anticancer agents. The subclass of polyphenols, ... ...

Abstract	Cancer incidence varies around the globe, implying a relationship between food and cancer risk. Plant polyphenols are a class of secondary metabolites that have recently attracted attention as possible anticancer agents. The subclass of polyphenols, known as isoflavones, includes genistein and daidzein, which are present in soybeans and are regarded as potent chemopreventive agents. According to epidemiological studies, those who eat soy have a lower risk of developing certain cancers. Several mechanisms for the anticancer effects of isoflavones have been proposed, but none are conclusive. We show that isoflavones suppress prostate cancer cell growth by mobilizing endogenous copper. The copper-specific chelator neocuproine decreases the apoptotic potential of isoflavones, whereas the iron and zinc chelators desferroxamine mesylate and histidine do not, confirming the role of copper. Reactive oxygen species (ROS) scavengers reduce isoflavone-induced apoptosis in these cells, implying that ROS are cell death effectors. Our research also clearly shows that isoflavones interfere with the expression of the two copper transporter genes,
MeSH term(s)	Copper/pharmacology ; Copper/metabolism ; Reactive Oxygen Species/metabolism ; Cell Line, Tumor ; Isoflavones/pharmacology ; Genistein/pharmacology ; Cell Death ; Glycine max/metabolism ; Polyphenols
Chemical Substances	Copper (789U1901C5) ; Reactive Oxygen Species ; Isoflavones ; Genistein (DH2M523P0H) ; Polyphenols
Language	English
Publishing date	2023-03-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules28072925
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Article ; Online: Bioassay-Guided Alkaloids Isolation from

Aatif, Mohammad / Raza, Muhammad Asam / El Oirdi, Mohamed / Farhan, Mohd / Mumtaz, Muhammad Waseem / Hamayun, Muhammad / Ashraf, Adnan / Muteeb, Ghazala

Molecules (Basel, Switzerland)

2023 Volume 28, Issue 6

Abstract: Bioassay-guided isolation ... ...

Abstract	Bioassay-guided isolation from
MeSH term(s)	Molecular Docking Simulation ; Colchicum/chemistry ; Camellia sinensis/chemistry ; Peptide Hydrolases ; Caffeine ; Alkaloids/pharmacology ; Endopeptidases ; Colchicine ; Biological Assay
Chemical Substances	Peptide Hydrolases (EC 3.4.-) ; Caffeine (3G6A5W338E) ; Alkaloids ; Endopeptidases (EC 3.4.-) ; Colchicine (SML2Y3J35T)
Language	English
Publishing date	2023-03-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules28062459
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Article: Novel Para-Aminobenzoic Acid Analogs and Their Potential Therapeutic Applications.

Haroon, Faisal / Farwa, Umme / Arif, Maimoona / Raza, Muhammad Asam / Sandhu, Zeshan Ali / El Oirdi, Mohamed / Farhan, Mohd / Alhasawi, Mohammed Ahmed Ismail

Biomedicines

2023 Volume 11, Issue 10

Abstract: A "building block" is a key component that plays a substantial and critical function in the pharmaceutical research and development industry. Given its structural versatility and ability to undergo substitutions at both the amino and carboxyl groups, ... ...

Abstract	A "building block" is a key component that plays a substantial and critical function in the pharmaceutical research and development industry. Given its structural versatility and ability to undergo substitutions at both the amino and carboxyl groups, para-aminobenzoic acid (PABA) is a commonly used building block in pharmaceuticals. Therefore, it is great for the development of a wide range of novel molecules with potential medical applications. Anticancer, anti-Alzheimer's, antibacterial, antiviral, antioxidant, and anti-inflammatory properties have been observed in PABA compounds, suggesting their potential as therapeutic agents in future clinical trials. PABA-based therapeutic chemicals as molecular targets and their usage in biological processes are the primary focus of this review study. PABA's unique features make it a strong candidate for inclusion in a massive chemical database of molecules having drug-like effects. Based on the current literature, further investigation is needed to evaluate the safety and efficacy of PABA derivatives in clinical investigations and better understand the specific mechanism of action revealed by these compounds.
Language	English
Publishing date	2023-09-30
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines11102686
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Article: Antiviral Defense Involves AGO4 in an ArabidopsisâPotexvirus Interaction

Brosseau, Chantal / Adurogbangba Ayooluwa / El Oirdi Mohamed / Ma Xiaofang / Moffett Peter

Molecular plant-microbe interactions. 2016 Nov., v. 29, no. 11

2016

Abstract: In plants, RNA silencing regulates gene expression through the action of Dicer-like (DCL) and Argonaute (AGO) proteins via micro RNAs and RNA-dependent DNA methylation (RdDM). In addition, RNA silencing functions as an antiviral defense mechanism by ... ...

Abstract	In plants, RNA silencing regulates gene expression through the action of Dicer-like (DCL) and Argonaute (AGO) proteins via micro RNAs and RNA-dependent DNA methylation (RdDM). In addition, RNA silencing functions as an antiviral defense mechanism by targeting virus-derived double-stranded RNA. Plants encode multiple AGO proteins with specialized functions, including AGO4-like proteins that affect RdDM and AGO2, AGO5, and AGO1, which have antiviral activities. Here, we show that AGO4 is also required for defense against the potexvirus Plantago asiatica mosaic virus (PlAMV), most likely independent of RdDM components such as DCL3, Pol IV, and Pol V. Transient assays showed that AGO4 has direct antiviral activity on PlAMV and, unlike RdDM, this activity does not require nuclear localization of AGO4. Furthermore, although PlAMV infection causes a decrease in AGO4 expression, PlAMV causes a change in AGO4 localization from a largely nuclear to a largely cytoplasmic distribution. These results indicate an important role for AGO4 in targeting plant RNA viruses as well as demonstrating novel mechanisms of regulation of and by AGO4, independent of its canonical role in regulating gene expression by RdDM.
Keywords	antiviral properties ; DNA methylation ; double-stranded RNA ; gene expression ; microRNA ; Plantago asiatica mosaic virus ; proteins ; RNA interference
Language	English
Dates of publication	2016-11
Size	p. 878-888.
Publishing place	Molecular Plant-Microbe Interactions
Document type	Article
ZDB-ID	743331-1
ISSN	1943-7706 ; 0894-0282
ISSN (online)	1943-7706
ISSN	0894-0282
DOI	10.1094%2FMPMI-09-16-0188-R
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Article: Antiviral Defense Involves AGO4 in an Arabidopsis-Potexvirus Interaction.

Brosseau, Chantal / El Oirdi, Mohamed / Adurogbangba, Ayooluwa / Ma, Xiaofang / Moffett, Peter

Molecular plant-microbe interactions : MPMI

2016 Volume 29, Issue 11, Page(s) 878–888

Abstract	In plants, RNA silencing regulates gene expression through the action of Dicer-like (DCL) and Argonaute (AGO) proteins via micro RNAs and RNA-dependent DNA methylation (RdDM). In addition, RNA silencing functions as an antiviral defense mechanism by targeting virus-derived double-stranded RNA. Plants encode multiple AGO proteins with specialized functions, including AGO4-like proteins that affect RdDM and AGO2, AGO5, and AGO1, which have antiviral activities. Here, we show that AGO4 is also required for defense against the potexvirus Plantago asiatica mosaic virus (PlAMV), most likely independent of RdDM components such as DCL3, Pol IV, and Pol V. Transient assays showed that AGO4 has direct antiviral activity on PlAMV and, unlike RdDM, this activity does not require nuclear localization of AGO4. Furthermore, although PlAMV infection causes a decrease in AGO4 expression, PlAMV causes a change in AGO4 localization from a largely nuclear to a largely cytoplasmic distribution. These results indicate an important role for AGO4 in targeting plant RNA viruses as well as demonstrating novel mechanisms of regulation of and by AGO4, independent of its canonical role in regulating gene expression by RdDM.
Language	English
Publishing date	2016-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	743331-1
ISSN	1943-7706 ; 0894-0282
ISSN (online)	1943-7706
ISSN	0894-0282
DOI	10.1094/MPMI-09-16-0188-R
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Plant signalling components EDS1 and SGT1 enhance disease caused by the necrotrophic pathogen Botrytis cinerea.

El Oirdi, Mohamed / Bouarab, Kamal

The New phytologist

2007 Volume 175, Issue 1, Page(s) 131–139

Abstract: Botrytis cinerea is a necrotrophic fungus that causes grey mould on a wide range of food plants, especially grapevine, tomato, soft fruits and vegetables. This disease brings about important economic losses in both pre- and postharvest crops. ... ...

Abstract	* Botrytis cinerea is a necrotrophic fungus that causes grey mould on a wide range of food plants, especially grapevine, tomato, soft fruits and vegetables. This disease brings about important economic losses in both pre- and postharvest crops. Successful protection of host plants against this pathogen is severely hampered by a lack of resistance genes in the hosts and the considerable phenotypic diversity of the fungus. * The aim of this study was to test whether B. cinerea manipulates the immunity-signalling pathways in plants to restore its disease. * We showed that B. cinerea caused disease in Nicotiana benthamiana through the activation of two plant signalling genes, EDS1 and SGT1, which have been shown to be essential for resistance against biotrophic pathogens; and more interestingly, virus-induced gene silencing of these two plant signalling components enhanced N. benthamiana resistance to B. cinerea. Finally, plants expressing the baculovirus antiapoptotic protein p35 were more resistant to this necrotrophic pathogen than wild-type plants. * This work highlights a new strategy used by B. cinerea to establish disease. This information is important for the design of strategies to improve plant pathogen resistance.
MeSH term(s)	Baculoviridae/pathogenicity ; Botrytis/pathogenicity ; DNA Primers ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; Glucosyltransferases/genetics ; Glucosyltransferases/metabolism ; Plant Diseases/microbiology ; Plant Diseases/virology ; Plant Leaves/microbiology ; Plant Leaves/physiology ; Plant Leaves/virology ; Plant Proteins/genetics ; Plant Proteins/metabolism ; Reverse Transcriptase Polymerase Chain Reaction ; Signal Transduction/physiology ; Nicotiana/physiology ; Nicotiana/virology
Chemical Substances	DNA Primers ; DNA-Binding Proteins ; Plant Proteins ; Glucosyltransferases (EC 2.4.1.-)
Language	English
Publishing date	2007-06-02
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	208885-x
ISSN	1469-8137 ; 0028-646X
ISSN (online)	1469-8137
ISSN	0028-646X
DOI	10.1111/j.1469-8137.2007.02086.x
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Article: The nature of tobacco resistance against Botrytis cinerea depends on the infection structures of the pathogen

El Oirdi, Mohamed / Trapani, Adeline / Bouarab, Kamal

Environmental microbiology. 2010 Jan., v. 12, no. 1

2010

Abstract: To protect themselves, plants have evolved an armoury of defences in response to pathogens and other stress situations. These include the production of pathogenesis-related (PR) proteins and the accumulation of antimicrobial molecules such as ... ...

Abstract	To protect themselves, plants have evolved an armoury of defences in response to pathogens and other stress situations. These include the production of pathogenesis-related (PR) proteins and the accumulation of antimicrobial molecules such as phytoalexins. Here we report that resistance of tobacco to Botrytis cinerea is cultivar specific. Nicotiana tabacum cv. Petit Havana but not N. tabacum cv. Xanthi or cv. samsun is resistant to B. cinerea. This resistance is correlated with the accumulation of the phytoalexin scopoletin and PR proteins. We also show that this resistance depends on the type of B. cinerea stage. Nicotiana tabacum cv. Petit Havana is more resistant to spores than to mycelium of B. cinerea. This reduced resistance of N. tabacum cv. Petit Havana to the mycelium compared with spores is correlated with the suppression of PR proteins accumulation and the capacity of the mycelium, not the spores, to metabolize scopoletin. These data present an important advance in understanding the strategies used by B. cinerea to establish its disease on tobacco plants.
Keywords	Botrytis cinerea ; Nicotiana tabacum ; antimicrobial proteins ; cultivars ; mycelium ; pathogens ; phytoalexins ; plant diseases and disorders ; scopoletin ; spores ; tobacco
Language	English
Dates of publication	2010-01
Size	p. 239-253.
Publisher	Blackwell Publishing Ltd
Publishing place	Oxford, UK
Document type	Article
ZDB-ID	2020213-1
ISSN	1462-2920 ; 1462-2912
ISSN (online)	1462-2920
ISSN	1462-2912
DOI	10.1111/j.1462-2920.2009.02063.x
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: The conjugated auxin indole-3-acetic acid-aspartic acid promotes plant disease development.

González-Lamothe, Rocío / El Oirdi, Mohamed / Brisson, Normand / Bouarab, Kamal

The Plant cell

2012 Volume 24, Issue 2, Page(s) 762–777

Abstract: Auxin is a pivotal plant hormone that regulates many aspects of plant growth and development. Auxin signaling is also known to promote plant disease caused by plant pathogens. However, the mechanism by which this hormone confers susceptibility to ... ...

Abstract	Auxin is a pivotal plant hormone that regulates many aspects of plant growth and development. Auxin signaling is also known to promote plant disease caused by plant pathogens. However, the mechanism by which this hormone confers susceptibility to pathogens is not well understood. Here, we present evidence that fungal and bacterial plant pathogens hijack the host auxin metabolism in Arabidopsis thaliana, leading to the accumulation of a conjugated form of the hormone, indole-3-acetic acid (IAA)-Asp, to promote disease development. We also show that IAA-Asp increases pathogen progression in the plant by regulating the transcription of virulence genes. These data highlight a novel mechanism to promote plant susceptibility to pathogens through auxin conjugation.
MeSH term(s)	Arabidopsis/genetics ; Arabidopsis/metabolism ; Arabidopsis/microbiology ; Arabidopsis Proteins/genetics ; Arabidopsis Proteins/metabolism ; Aspartic Acid/metabolism ; Aspartic Acid/pharmacology ; Botrytis/pathogenicity ; Cyclopentanes/metabolism ; Gene Expression Regulation, Plant ; Host-Pathogen Interactions ; Indoleacetic Acids/metabolism ; Indoleacetic Acids/pharmacology ; Indoles/metabolism ; Oxylipins/metabolism ; Plant Diseases/microbiology ; Plant Growth Regulators/metabolism ; Plant Growth Regulators/pharmacology ; Pseudomonas syringae/pathogenicity ; Salicylic Acid/metabolism ; Signal Transduction ; Thiazoles/metabolism ; Virulence
Chemical Substances	Arabidopsis Proteins ; Cyclopentanes ; Indoleacetic Acids ; Indoles ; Oxylipins ; Plant Growth Regulators ; Thiazoles ; camalexin ; Aspartic Acid (30KYC7MIAI) ; jasmonic acid (6RI5N05OWW) ; indoleacetic acid (6U1S09C61L) ; Salicylic Acid (O414PZ4LPZ)
Language	English
Publishing date	2012-02-28
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	623171-8
ISSN	1532-298X ; 1040-4651
ISSN (online)	1532-298X
ISSN	1040-4651
DOI	10.1105/tpc.111.095190
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Article ; Online: The nature of tobacco resistance against Botrytis cinerea depends on the infection structures of the pathogen.

El Oirdi, Mohamed / Trapani, Adeline / Bouarab, Kamal

Environmental microbiology

2009 Volume 12, Issue 1, Page(s) 239–253

Abstract	To protect themselves, plants have evolved an armoury of defences in response to pathogens and other stress situations. These include the production of pathogenesis-related (PR) proteins and the accumulation of antimicrobial molecules such as phytoalexins. Here we report that resistance of tobacco to Botrytis cinerea is cultivar specific. Nicotiana tabacum cv. Petit Havana but not N. tabacum cv. Xanthi or cv. samsun is resistant to B. cinerea. This resistance is correlated with the accumulation of the phytoalexin scopoletin and PR proteins. We also show that this resistance depends on the type of B. cinerea stage. Nicotiana tabacum cv. Petit Havana is more resistant to spores than to mycelium of B. cinerea. This reduced resistance of N. tabacum cv. Petit Havana to the mycelium compared with spores is correlated with the suppression of PR proteins accumulation and the capacity of the mycelium, not the spores, to metabolize scopoletin. These data present an important advance in understanding the strategies used by B. cinerea to establish its disease on tobacco plants.
MeSH term(s)	Botrytis/metabolism ; Botrytis/pathogenicity ; Gene Expression Regulation, Plant ; Immunity, Innate ; Mycelium/metabolism ; Mycelium/pathogenicity ; Plant Diseases/genetics ; Plant Diseases/immunology ; Plant Diseases/microbiology ; Plant Proteins/genetics ; Plant Proteins/immunology ; Plant Proteins/metabolism ; Scopoletin/immunology ; Scopoletin/metabolism ; Spores, Fungal/metabolism ; Spores, Fungal/pathogenicity ; Nicotiana/genetics ; Nicotiana/immunology ; Nicotiana/microbiology
Chemical Substances	Plant Proteins ; Scopoletin (KLF1HS0SXJ)
Language	English
Publishing date	2009-10-02
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2020213-1
ISSN	1462-2920 ; 1462-2912
ISSN (online)	1462-2920
ISSN	1462-2912
DOI	10.1111/j.1462-2920.2009.02063.x
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Agrobacterium -mediated transformation of rough lemon ( Citrus jambhiri Lush) with yeast HAL2 gene

Ali Shawkat / Mannan Abdul / El Oirdi Mohamed / Waheed Abdul / Mirza Bushra

BMC Research Notes, Vol 5, Iss 1, p

2012 Volume 285

Abstract: Abstract Background Rough lemon ( Citrus jambhiri Lush.) is the most commonly used Citrus rootstock in south Asia. It is extremely sensitive to salt stress that decreases the growth and yield of Citrus crops in many areas worldwide. Over expression of ... ...

Abstract	Abstract Background Rough lemon ( Citrus jambhiri Lush.) is the most commonly used Citrus rootstock in south Asia. It is extremely sensitive to salt stress that decreases the growth and yield of Citrus crops in many areas worldwide. Over expression of the yeast halotolerant gene ( HAL2) results in increasing the level of salt tolerance in transgenic plants. Results Transformation of rough lemon was carried out by using Agrobacterium tumefaciens strains LBA4404 harboring plasmid pJRM17. Transgenic shoots were selected on kanamycin 100 mg L -1 along with 250 mg L -1 each of cefotaxime and vancomycin for effective inhibition of Agrobacterium growth. The Murashige and Skoog (MS) medium containing 200 μM acetoseryngone (AS) proved to be the best inoculation and co-cultivation medium for transformation. MS medium supplemented with 3 mg L -1 of 6-benzylaminopurine (BA) showed maximum regeneration efficiency of the transformed explants. The final selection of the transformed plants was made on the basis of PCR and Southern blot analysis. Conclusion Rough lemon has been successfully transformed via Agrobacterium tumefaciens with β-glucuronidase ( GUS) and HAL2. Various factors affecting gene transformation and regeneration efficiency were also investigated.
Keywords	Genetic transformation ; Yeast halotolerant gene ( HAL2 ) ; Citrus jambhiri Lush and Agrobacterium tumefaciens ; Medicine ; R ; Biology (General) ; QH301-705.5 ; Science (General) ; Q1-390
Subject code	333
Language	English
Publishing date	2012-06-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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