LIVIVO - Search results -

Search results

Result 1 - 10 of total 73

Search options

Article ; Online: Natural Bioactive Compounds from Medicinal Plants as Antibacterial Drugs: Mechanism Insights and Clinical Perspectives.

El Omari, Nasreddine / Guaouguaou, Fatima-Ezzahrae / Bouyahya, Abdelhakim

2022 Volume 22, Issue 13, Page(s) 1093–1103

Abstract: The coevolution in microbes has generated major functional consequences leading bacteria to develop resistance to antibiotics. Indeed, bacterial strains have been able to develop and adapt to the action of antibiotics via several resistance mechanisms. ... ...

Abstract	The coevolution in microbes has generated major functional consequences leading bacteria to develop resistance to antibiotics. Indeed, bacterial strains have been able to develop and adapt to the action of antibiotics via several resistance mechanisms. In this context, researchers are currently conducting many studies to screen natural antibacterial substances such as secondary metabolites of medicinal plants. Indeed, the potential of many plants used in traditional medicine in the treatment of infectious diseases was confirmed experimentally, namely Anethum graveolens, Elettaria cardamomum, Foeniculum vulgare, Trachyspermum ammi, Viola odorata, Dioscorea dregeana, Cheilanthes viridis, Vernonia colorata, etc. Bioactive molecules from different medicinal plants include terpenoids, flavonoids, and phenolic acids, which were shown to have significant anti- bacterial effects. The mechanisms of action of these molecules are different and can include structural, cellular, and molecular levels, which suggests them as real candidates for the development of natural antibiotics. However, the clinical trials of these molecules have not been very well studied which limits their clinical use against infectious diseases of bacterial origin.
MeSH term(s)	Anti-Bacterial Agents/pharmacology ; Bacteria ; Flavonoids ; Plant Extracts/chemistry ; Plants, Medicinal/chemistry ; Terpenes/chemistry ; Terpenes/pharmacology
Chemical Substances	Anti-Bacterial Agents ; Flavonoids ; Plant Extracts ; Terpenes
Language	English
Publishing date	2022-03-30
Publishing country	United Arab Emirates
Document type	Journal Article
ZDB-ID	2064823-6
ISSN	1873-4294 ; 1568-0266
ISSN (online)	1873-4294
ISSN	1568-0266
DOI	10.2174/1568026622666220330011255
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 5572: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article: Is —— the rhizosphere a source of applicable multi-beneficial microorganisms for plant enhancement?

Chamkhi, Imane / El Omari, Nasreddine / Balahbib, Abdelaali / El Menyiy, Naoual / Benali, Taoufiq / Ghoulam, Cherki

Saudi journal of biological sciences. 2022 Feb., v. 29, no. 2

2022

Abstract: The plant faces different pedological and climatic challenges that influence its growth and enhancement. While, plant-microbes interactions throught the rhizosphere offer several privileges to this hotspot in the service of plant, by attracting multi- ... ...

Abstract	The plant faces different pedological and climatic challenges that influence its growth and enhancement. While, plant-microbes interactions throught the rhizosphere offer several privileges to this hotspot in the service of plant, by attracting multi-beneficial mutualistic and symbiotic microorganisms as plant growth-promoting bacteria (PGPB), archaea, mycorrhizal fungi, endophytic fungi, and others…). Currently, numerous investigations showed the beneficial effects of these microbes on growth and plant health. Indeed, rhizospheric microorganisms offer to host plants the essential assimilable nutrients, stimulate the growth and development of host plants, and induce antibiotics production. They also attributed to host plants numerous phenotypes involved in the increase the resistance to abiotic and biotic stresses. The investigations and the studies on the rhizosphere can offer a way to find a biological and sustainable solution to confront these environmental problems. Therefore, the interactions between microbes and plants may lead to interesting biotechnological applications on plant improvement and the adaptation in different climates to obtain a biological sustainable agricultures without the use of chemical fertilizers.
Keywords	Archaea ; endophytes ; growth and development ; plant health ; plant improvement ; rhizosphere
Language	English
Dates of publication	2022-02
Size	p. 1246-1259.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	2515206-3
ISSN	2213-7106 ; 1319-562X
ISSN (online)	2213-7106
ISSN	1319-562X
DOI	10.1016/j.sjbs.2021.09.032
Database	NAL-Catalogue (AGRICOLA)

Order via subito

Article ; Online: Expediting Multiple Biological Properties of Limonene and α-Pinene: Main Bioactive Compounds of

El Omari, Nasreddine / Mrabti, Hanae Naceiri / Benali, Taoufiq / Ullah, Riaz / Alotaibi, Amal / Abdullah, Amar Daud Iskandar / Goh, Khang Wen / Bouyahya, Abdelhakim

Frontiers in bioscience (Landmark edition)

2023 Volume 28, Issue 9, Page(s) 229

Abstract: Background: Screening new natural molecules with pharmacological and/or cosmetic properties remains a highly sought-after area of research. Moreover, essential oils and volatile compounds have recently garnered significant interest as natural substance ... ...

Abstract	Background: Screening new natural molecules with pharmacological and/or cosmetic properties remains a highly sought-after area of research. Moreover, essential oils and volatile compounds have recently garnered significant interest as natural substance candidates. In this study, the volatile components of Methods: In vitro Results: Antioxidant tests showed that PLEO has the best activity (ranging from 29.64 ± 3.04 to 73.80 ± 3.96 µg/mL) compared to its main selected molecules (ranging from 74 ± 3.72 to 107.23 ± 5.03 µg/mL). The α-glucosidase and α-amylase assays demonstrated that the elements tested have a promising antidiabetic potential with IC50values ranging from 78.03 ± 2.31 to 116.03 ± 7.42 µg/mL and 74.39 ± 3.08 to 112.35 ± 4.92 µg/mL for the α-glucosidase and α-amylase assays, respectively, compared to the standard drug. For the tyrosinase test, we found that the EOs (IC50 = 57.72 ± 2.86 µg/mL) followed by limonene (IC50 = 74.24 ± 2.06 µg/mL) and α-pinene (IC50 = 97.45 ± 5.22 µg/mL) all exhibited greater inhibitory effects than quercetin (IC50 = 246.90 ± 2.54 µg/mL). Conclusions: Our results suggest that the biological activities of PLEO, as well as its main compounds, make them promising candidates for the development of new strategies aimed at improving dermatoprotection and treating diseases associated with diabetes mellitus and oxidative stress.
MeSH term(s)	Oils, Volatile/pharmacology ; Oils, Volatile/chemistry ; Limonene/pharmacology ; Antioxidants/pharmacology ; Antioxidants/chemistry ; Pistacia ; alpha-Glucosidases ; Hypoglycemic Agents/pharmacology ; Hypoglycemic Agents/chemistry ; alpha-Amylases
Chemical Substances	Oils, Volatile ; Limonene (9MC3I34447) ; Antioxidants ; alpha-pinene (JPF3YI7O34) ; alpha-Glucosidases (EC 3.2.1.20) ; Hypoglycemic Agents ; alpha-Amylases (EC 3.2.1.1)
Language	English
Publishing date	2023-09-26
Publishing country	Singapore
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2704569-9
ISSN	2768-6698 ; 2768-6698
ISSN (online)	2768-6698
ISSN	2768-6698
DOI	10.31083/j.fbl2809229
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Innovative Encapsulation Strategies for Food, Industrial, and Pharmaceutical Applications.

Aanniz, Tarık / El Omari, Nasreddine / El Ouafy, Youssef / Benali, Taoufiq / Zengin, Gokhan / Khalid, Asaad / Abdalla, Ashraf N / Sakran, Ashraf M / Bouyahya, Abdelhakim

Chemistry & biodiversity

2024 , Page(s) e202400116

Abstract: Encapsulation has emerged as a vitally important tool for protecting the integrity of critical chemicals and improving the delivery mechanisms of natural/synthetic drugs, enabling the controlled release of ingredients and the maintenance of their ... ...

Abstract	Encapsulation has emerged as a vitally important tool for protecting the integrity of critical chemicals and improving the delivery mechanisms of natural/synthetic drugs, enabling the controlled release of ingredients and the maintenance of their chemical, physical, and biological properties. It is well known that essential oils (EOs) provide a valuable alternative for food preservation, as they help reducing the deterioration of foodstuffs as well as the proliferation of pathogens. Nevertheless, EOs are highly volatile and lipophilic, rendering them insoluble in aqueous systems. In addition, their secondary metabolites are extremely susceptible to environmental factors such as humidity, temperature, light, and oxygen. Therefore, encapsulation of EOs is an innovative option not only for preserving these substances but also for promoting their stability, controlling their release, and optimizing their efficiency and bioavailability. In this sense, this review aimed to describe current techniques and approaches used to incorporate natural hydrophobic compounds, covering EOs. It also examines whether encapsulation technology can be used efficiently in drug discovery and development. Studies have shown that microencapsulation, the use of nanoparticle, and liposomal are the most effective techniques for encapsulating EOs. Other encapsulation systems included spray drying, coacervation, and emulsification.
Language	English
Publishing date	2024-03-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2139001-0
ISSN	1612-1880 ; 1612-1872
ISSN (online)	1612-1880
ISSN	1612-1872
DOI	10.1002/cbdv.202400116
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Natural bioactive compounds targeting DNA methyltransferase enzymes in cancer: Mechanisms insights and efficiencies.

Aanniz, Tarik / Bouyahya, Abdelhakim / Balahbib, Abdelaali / El Kadri, Kawtar / Khalid, Asaad / Makeen, Hafiz A / Alhazmi, Hassan A / El Omari, Nasreddine / Zaid, Younes / Wong, Rebecca Shin-Yee / Yeo, Chien Ing / Goh, Bey Hing / Bakrim, Saad

Chemico-biological interactions

2024 Volume 392, Page(s) 110907

Abstract: The regulation of gene expression is fundamental to health and life and is essentially carried out at the promoter region of the DNA of each gene. Depending on the molecular context, this region may be accessible or non-accessible (possibility of ... ...

Abstract	The regulation of gene expression is fundamental to health and life and is essentially carried out at the promoter region of the DNA of each gene. Depending on the molecular context, this region may be accessible or non-accessible (possibility of integration of RNA polymerase or not at this region). Among enzymes that control this process, DNA methyltransferase enzymes (DNMTs), are responsible for DNA demethylation at the CpG islands, particularly at the promoter regions, to regulate transcription. The aberrant activity of these enzymes, i.e. their abnormal expression or activity, can result in the repression or overactivation of gene expression. Consequently, this can generate cellular dysregulation leading to instability and tumor development. Several reports highlighted the involvement of DNMTs in human cancers. The inhibition or activation of DNMTs is a promising therapeutic approach in many human cancers. In the present work, we provide a comprehensive and critical summary of natural bioactive molecules as primary inhibitors of DNMTs in human cancers. The active compounds hold the potential to be developed as anti-cancer epidrugs targeting DNMTs.
MeSH term(s)	Humans ; DNA (Cytosine-5-)-Methyltransferases/genetics ; Neoplasms/metabolism ; DNA (Cytosine-5-)-Methyltransferase 1/genetics ; CpG Islands ; DNA Methylation ; Epigenesis, Genetic
Chemical Substances	DNA (Cytosine-5-)-Methyltransferases (EC 2.1.1.37) ; DNA (Cytosine-5-)-Methyltransferase 1 (EC 2.1.1.37)
Language	English
Publishing date	2024-02-21
Publishing country	Ireland
Document type	Journal Article ; Review
ZDB-ID	218799-1
ISSN	1872-7786 ; 0009-2797
ISSN (online)	1872-7786
ISSN	0009-2797
DOI	10.1016/j.cbi.2024.110907
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 686: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Bioactive compounds from nature: Antioxidants targeting cellular transformation in response to epigenetic perturbations induced by oxidative stress.

Bouyahya, Abdelhakim / Bakrim, Saad / Aboulaghras, Sara / El Kadri, Kawtar / Aanniz, Tarik / Khalid, Asaad / Abdalla, Ashraf N / Abdallah, Ahmed A / Ardianto, Chrismawan / Ming, Long Chiau / El Omari, Nasreddine

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2024 Volume 174, Page(s) 116432

Abstract: Oxidative stress results from a persistent imbalance in oxidation levels that promotes oxidants, playing a crucial role in the early and sustained phases of DNA damage and genomic and epigenetic instability, both of which are intricately linked to the ... ...

Abstract	Oxidative stress results from a persistent imbalance in oxidation levels that promotes oxidants, playing a crucial role in the early and sustained phases of DNA damage and genomic and epigenetic instability, both of which are intricately linked to the development of tumors. The molecular pathways contributing to carcinogenesis in this context, particularly those related to double-strand and single-strand breaks in DNA, serve as indicators of DNA damage due to oxidation in cancer cases, as well as factors contributing to epigenetic instability through ectopic expressions. Oxidative stress has been considered a therapeutic target for many years, and an increasing number of studies have highlighted the promising effectiveness of natural products in cancer treatment. In this regard, we present significant research on the therapeutic targeting of oxidative stress using natural molecules and underscore the essential role of oxidative stress in cancer. The consequences of stress, especially epigenetic instability, also offer significant therapeutic prospects. In this context, the use of natural epi-drugs capable of modulating and reorganizing the epigenetic network is beginning to emerge remarkably. In this review, we emphasize the close connections between oxidative stress, epigenetic instability, and tumor transformation, while highlighting the role of natural substances as antioxidants and epi-drugs in the anti-tumoral context.
Language	English
Publishing date	2024-03-22
Publishing country	France
Document type	Journal Article ; Review
ZDB-ID	392415-4
ISSN	1950-6007 ; 0753-3322 ; 0300-0893
ISSN (online)	1950-6007
ISSN	0753-3322 ; 0300-0893
DOI	10.1016/j.biopha.2024.116432
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ud II Zs.198: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Is the rhizosphere a source of applicable multi-beneficial microorganisms for plant enhancement?

Chamkhi, Imane / El Omari, Nasreddine / Balahbib, Abdelaali / El Menyiy, Naoual / Benali, Taoufiq / Ghoulam, Cherki

Saudi journal of biological sciences

2021 Volume 29, Issue 2, Page(s) 1246–1259

Abstract	The plant faces different pedological and climatic challenges that influence its growth and enhancement. While, plant-microbes interactions throught the rhizosphere offer several privileges to this hotspot in the service of plant, by attracting multi-beneficial mutualistic and symbiotic microorganisms as plant growth-promoting bacteria (PGPB), archaea, mycorrhizal fungi, endophytic fungi, and others…). Currently, numerous investigations showed the beneficial effects of these microbes on growth and plant health. Indeed, rhizospheric microorganisms offer to host plants the essential assimilable nutrients, stimulate the growth and development of host plants, and induce antibiotics production. They also attributed to host plants numerous phenotypes involved in the increase the resistance to abiotic and biotic stresses. The investigations and the studies on the rhizosphere can offer a way to find a biological and sustainable solution to confront these environmental problems. Therefore, the interactions between microbes and plants may lead to interesting biotechnological applications on plant improvement and the adaptation in different climates to obtain a biological sustainable agricultures without the use of chemical fertilizers.
Language	English
Publishing date	2021-09-20
Publishing country	Saudi Arabia
Document type	Journal Article ; Review
ZDB-ID	2515206-3
ISSN	2213-7106 ; 1319-562X
ISSN (online)	2213-7106
ISSN	1319-562X
DOI	10.1016/j.sjbs.2021.09.032
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Vegetables and Their Bioactive Compounds as Anti-Aging Drugs.

Mechchate, Hamza / El Allam, Aicha / El Omari, Nasreddine / El Hachlafi, Naoufal / Shariati, Mohammad Ali / Wilairatana, Polrat / Mubarak, Mohammad S / Bouyahya, Abdelhakim

Molecules (Basel, Switzerland)

2022 Volume 27, Issue 7

Abstract: Aging is a continuous process over time that is mainly related to natural alterations in mechanical-biological processes. This phenomenon is due to several factors, including the time and energy of biological processes. Aging can be attributed to ... ...

Abstract	Aging is a continuous process over time that is mainly related to natural alterations in mechanical-biological processes. This phenomenon is due to several factors, including the time and energy of biological processes. Aging can be attributed to biological factors such as oxidative stress, cell longevity, and stem cell senescence. Currently, aging is associated with several diseases, such as neurodegenerative diseases, cancer, and other diseases related to oxidative stress. In addition, certain natural molecules, including those derived from vegetables, have shown the ability to delay the aging process. Their effects are linked to different mechanisms of action, such as tissue regeneration and the activation of longevity and anti-senescence genes. The present work discusses the impact of vegetables, and bioactive compounds isolated from vegetables, against the physiological and pathological aging process and accompanying human diseases.
MeSH term(s)	Aging/physiology ; Cellular Senescence ; Humans ; Longevity ; Neurodegenerative Diseases/drug therapy ; Oxidative Stress ; Vegetables
Language	English
Publishing date	2022-04-02
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules27072316
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.MO 81: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Mechanisms, Anti-Quorum-Sensing Actions, and Clinical Trials of Medicinal Plant Bioactive Compounds against Bacteria: A Comprehensive Review.

Bouyahya, Abdelhakim / Chamkhi, Imane / Balahbib, Abdelaali / Rebezov, Maksim / Shariati, Mohammad Ali / Wilairatana, Polrat / Mubarak, Mohammad S / Benali, Taoufiq / El Omari, Nasreddine

Molecules (Basel, Switzerland)

2022 Volume 27, Issue 5

Abstract: Bacterial strains have developed an ability to resist antibiotics via numerous mechanisms. Recently, researchers conducted several studies to identify natural bioactive compounds, particularly secondary metabolites of medicinal plants, such as terpenoids, ...

Abstract	Bacterial strains have developed an ability to resist antibiotics via numerous mechanisms. Recently, researchers conducted several studies to identify natural bioactive compounds, particularly secondary metabolites of medicinal plants, such as terpenoids, flavonoids, and phenolic acids, as antibacterial agents. These molecules exert several mechanisms of action at different structural, cellular, and molecular levels, which could make them candidates or lead compounds for developing natural antibiotics. Research findings revealed that these bioactive compounds can inhibit the synthesis of DNA and proteins, block oxidative respiration, increase membrane permeability, and decrease membrane integrity. Furthermore, recent investigations showed that some bacterial strains resist these different mechanisms of antibacterial agents. Researchers demonstrated that this resistance to antibiotics is linked to a microbial cell-to-cell communication system called quorum sensing (QS). Consequently, inhibition of QS or quorum quenching is a promising strategy to not only overcome the resistance problems but also to treat infections. In this respect, various bioactive molecules, including terpenoids, flavonoids, and phenolic acids, exhibit numerous anti-QS mechanisms via the inhibition of auto-inducer releases, sequestration of QS-mediated molecules, and deregulation of QS gene expression. However, clinical applications of these molecules have not been fully covered, which limits their use against infectious diseases. Accordingly, the aim of the present work was to discuss the role of the QS system in bacteria and its involvement in virulence and resistance to antibiotics. In addition, the present review summarizes the most recent and relevant literature pertaining to the anti-quorum sensing of secondary metabolites and its relationship to antibacterial activity.
MeSH term(s)	Quorum Sensing
Language	English
Publishing date	2022-02-22
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules27051484
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.MO 81: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Dietary Phenolic Compounds as Anticancer Natural Drugs: Recent Update on Molecular Mechanisms and Clinical Trials.

Bakrim, Saad / El Omari, Nasreddine / El Hachlafi, Naoufal / Bakri, Youssef / Lee, Learn-Han / Bouyahya, Abdelhakim

Foods (Basel, Switzerland)

2022 Volume 11, Issue 21

Abstract: Given the stochastic complexity of cancer diseases, the development of chemotherapeutic drugs is almost limited by problems of selectivity and side effects. Furthermore, an increasing number of protective approaches have been recently considered as the ... ...

Abstract	Given the stochastic complexity of cancer diseases, the development of chemotherapeutic drugs is almost limited by problems of selectivity and side effects. Furthermore, an increasing number of protective approaches have been recently considered as the main way to limit these pathologies. Natural bioactive compounds, and particularly dietary phenolic compounds, showed major protective and therapeutic effects against different types of human cancers. Indeed, phenolic substances have functional groups that allow them to exert several anti-cancer mechanisms, such as the induction of apoptosis, autophagy, cell cycle arrest at different stages, and the inhibition of telomerase. In addition, in vivo studies show that these phenolic compounds also have anti-angiogenic effects via the inhibition of invasion and angiogenesis. Moreover, clinical studies have already highlighted certain phenolic compounds producing clinical effects alone, or in combination with drugs used in chemotherapy. In the present work, we present a major advance in research concerning the mechanisms of action of the different phenolic compounds that are contained in food medicinal plants, as well as evidence from the clinical trials that focus on them.
Language	English
Publishing date	2022-10-23
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2704223-6
ISSN	2304-8158
ISSN	2304-8158
DOI	10.3390/foods11213323
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito