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  1. AU="El Sayegh, Suzanne"
  2. AU="Vaittinen, Tiina"
  3. AU="Khir, Amir S"
  4. AU=Patterson Andrew D
  5. AU="Kim, Joyce Mary"
  6. AU="Saribay, S Adil"
  7. AU="Couderc, M."
  8. AU="Macerlane de Lira Silva"
  9. AU=Neal Michael S
  10. AU="Nakai, Kozo"
  11. AU="Debatin, Jörg F."
  12. AU="Plant, Laura"
  13. AU="Manuel Tisminetzky"
  14. AU="Monaco, Carlo"
  15. AU="Srivastava, Rupesh"
  16. AU="Nathan, Jaimie D"
  17. AU="Schnegelberger, Regina D"
  18. AU=Doshi Paresh
  19. AU="Cecilia Hognon"
  20. AU="Mason, Jeremy K."
  21. AU=Hasumi Hisashi
  22. AU="Swati Sethi"
  23. AU="Martin G. Myers, Jr."
  24. AU="Marcus-Sekura, Carol"
  25. AU="Petagine, Lucy"
  26. AU="Jessa R. Alexander"
  27. AU=Rauner Martina
  28. AU="Richlen, Mindy L"
  29. AU="Merghani, Nada M"
  30. AU=Splitt M P
  31. AU="Zlatanović, Gordana"

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  1. Artikel ; Online: Association of chronic kidney disease with hidradenitis suppurativa: A retrospective study.

    Wei, Chapman / Mustafa, Ahmad / Strange, John / Grovu, Radu / Strange, Theodore / Friedman, Adam J / Bradu, Stefan / Garg, Amit / El-Sayegh, Suzanne E

    JAAD international

    2024  Band 15, Seite(n) 36–37

    Sprache Englisch
    Erscheinungsdatum 2024-01-04
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 2666-3287
    ISSN (online) 2666-3287
    DOI 10.1016/j.jdin.2023.12.005
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  2. Artikel ; Online: Underutilization of left heart catheterization in kidney transplant patients presenting with non-ST segment elevation myocardial infarction.

    Mustafa, Ahmad / Asmar, Samer / Wei, Chapman / Afif, John / Khan, Shahkar / Rizvi, Taqi / Grovu, Radu / Weinberg, Mitchell / El-Sayegh, Suzanne

    American heart journal plus : cardiology research and practice

    2023  Band 30, Seite(n) 100300

    Abstract: Background: Cardiovascular disease (CVD) is the leading cause of mortality in kidney transplant (KT) patients. The perceived risk of contrast-induced nephropathy (CIN) may create a reluctance to perform coronary angiography in patients presenting with ... ...

    Abstract Background: Cardiovascular disease (CVD) is the leading cause of mortality in kidney transplant (KT) patients. The perceived risk of contrast-induced nephropathy (CIN) may create a reluctance to perform coronary angiography in patients presenting with non-ST segment elevation myocardial infarction (NSTEMI).
    Methods: National Inpatient Sample (NIS) Database was used to sample individuals presenting with NSTEMI. Patients were stratified into KT and Non-KT cohorts. Outcomes included left heart catheterization rates, mortality, arrhythmias, acute kidney injury/acute renal failure (AKI/ARF), and extended length of hospital stay (ELOS) (>72 h). Propensity matching (1:1 ratio) and regression analyses were performed.
    Results: Out of 336,354 patients with NSTEMI, 742 patients were in the KT group. KT patients were less likely to have LHC relative to non-KT patients (22.0 % vs 18.3 %); a difference that persisted on post-match analysis (27.1 % vs 19.4 %). On pre-match analysis, KT transplant patients that underwent LHC had lower mortality (10.3 % vs 0.7 %), AKI/ARF (44.6 % vs 27.9 %), arrhythmias (30.4 % vs 20.6 %) and lower ELOS (58.6 % vs 41.9 %). Post-match, KT cohort patient that underwent LHC had lower arrhythmias (OR:0.60[0.38-0.96]), AKI/ARF (OR = 0.51[0.34-0.77]), ELOS (OR:0.49[0.34-0.73]).
    Conclusion: KT patients underwent LHC much less frequently than their non-KT counterparts for NSTEMI. Coronary angiography and subsequent revascularization were associated with a significant decrease in morbidity and mortality. This theorized risk of CIN should not outweigh the benefit of LHC in KT patients.
    Sprache Englisch
    Erscheinungsdatum 2023-05-04
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 2666-6022
    ISSN (online) 2666-6022
    DOI 10.1016/j.ahjo.2023.100300
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  3. Artikel ; Online: Heparin-Induced Thrombocytopenia in Chronic Hemodialysis Patients.

    Hamadi, Rachelle / Sakr, Fouad / Aridi, Hussam / Alameddine, Zakaria / Dimachkie, Reem / Assaad, Marc / Asmar, Samer / ElSayegh, Suzanne

    Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis

    2023  Band 29, Seite(n) 10760296231177993

    Abstract: Heparin-induced thrombocytopenia (HIT) is a disorder originating from exposure to heparin and has a spectrum of presentation ranging from asymptomatic positive antibodies to thrombotic complications. When symptomatic, it is associated with morbidity and ... ...

    Abstract Heparin-induced thrombocytopenia (HIT) is a disorder originating from exposure to heparin and has a spectrum of presentation ranging from asymptomatic positive antibodies to thrombotic complications. When symptomatic, it is associated with morbidity and mortality. The incidence of HIT in the ESRD population is yet to be defined. End-stage renal disease (ESRD) patients are at particular risk due to constant exposure to heparin. The main treatment of HIT is to avoid heparin and pursue alternative anticoagulants. Since 1 of the main advantages of heparin in ESRD patients is the ease of its use due to non-renal clearance, the use of alternative anticoagulants poses yet another challenge for this population due to cost, availability, and adverse effects on ESRD patients. Argatroban seems like the best alternative to heparin in hemodialysis (HD) patients due to its liver clearance. Despite having limited studies in HIT, direct oral anticoagulants (DOACs) were added as a potential treatment for HIT, with apixaban favored in kidney dysfunction as it is the least dependent on kidney clearance. Other treatment modalities exist but are still being studied in ESRD patients. The presence of HIT antibodies is not always associated with clinical syndrome, and some studies suggested that heparin antibodies are transient, and the reintroduction of heparin is still being evaluated as a treatment option. Hence, HIT is a challenging diagnosis in ESRD patients, a population that has frequent exposure to anticoagulants, and a risk/benefit ratio should be weighed between the risk of progression to symptomatic HIT and the benefit of switching to a non-heparin anticoagulant bearing in mind the difficulties associated with the latter.
    Mesh-Begriff(e) Humans ; Antibodies ; Anticoagulants/adverse effects ; Heparin/adverse effects ; Kidney Failure, Chronic/complications ; Kidney Failure, Chronic/therapy ; Renal Dialysis ; Thrombocytopenia/diagnosis
    Chemische Substanzen Antibodies ; Anticoagulants ; Heparin (9005-49-6)
    Sprache Englisch
    Erscheinungsdatum 2023-04-06
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review
    ZDB-ID 1237357-6
    ISSN 1938-2723 ; 1076-0296
    ISSN (online) 1938-2723
    ISSN 1076-0296
    DOI 10.1177/10760296231177993
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Renal infarction in COVID-19 patient.

    Ammous, Ahmad / Ghaffar, Madeeha Abdul / El-Charabaty, Elie / El-Sayegh, Suzanne

    Journal of nephrology

    2020  Band 34, Heft 1, Seite(n) 267–268

    Mesh-Begriff(e) Acute Kidney Injury/diagnosis ; Acute Kidney Injury/therapy ; Acute Kidney Injury/virology ; COVID-19/complications ; COVID-19/diagnosis ; COVID-19/therapy ; Humans ; Infarction/diagnosis ; Infarction/therapy ; Infarction/virology ; Kidney/blood supply ; Male ; Middle Aged
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2020-10-29
    Erscheinungsland Italy
    Dokumenttyp Case Reports ; Journal Article
    ZDB-ID 1093991-x
    ISSN 1724-6059 ; 1120-3625 ; 1121-8428
    ISSN (online) 1724-6059
    ISSN 1120-3625 ; 1121-8428
    DOI 10.1007/s40620-020-00866-2
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    Zs.A 3369: Hefte anzeigen Standort:
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  5. Artikel: Risk of Nephrolithiasis in Patients with Inflammatory Bowel Disease Receiving Biologic Treatment.

    Alameddine, Zakaria / Abi Melhem, Racha / Dimachkie, Reem / Rabah, Hussein / Chehab, Hamed / El Khoury, Michel / Qaqish, Faris / Stefanov, Dimitre / El-Sayegh, Suzanne

    Journal of clinical medicine

    2023  Band 12, Heft 19

    Abstract: Introduction: Inflammatory bowel disease is a chronic inflammatory disorder of the gastrointestinal tract. Biologic drugs target specific molecules in the body's immune system to control inflammation. Recent studies have suggested a potential link ... ...

    Abstract Introduction: Inflammatory bowel disease is a chronic inflammatory disorder of the gastrointestinal tract. Biologic drugs target specific molecules in the body's immune system to control inflammation. Recent studies have suggested a potential link between their use and an increased risk of nephrolithiasis. We conducted a study to further investigate this association.
    Methods: The study used multiple logistic regression analysis to assess the association between the use of biologic drugs and nephrolithiasis. A
    Results: The final sample consisted of 22,895 cases, among which 5603 (24.51%) were receiving at least one biologic drug. The biologic drugs received were as follows: Adalimumab 2437 (10.66%), Infliximab 1996 (8.73%), Vedolizumab 1397 (6.11%), Ustekinumab 1304 (5.70%); Tofacitinib, 308 (1.35%); Certolizumab, 248 (1.08%); and Golimumab, 121 (0.53%). There were 1780 (7.74%) patients with Nephrolithiasis: 438 (8.0%) patients were receiving biologic treatment. We found that the use of Vedolizumab (OR = 1.307, 95% CI 1.076-1.588,
    Conclusion: Vedolizumab use was associated with an increased risk of nephrolithiasis. The use of two or more biologic drugs also increased the risk compared to no biologic treatment.
    Sprache Englisch
    Erscheinungsdatum 2023-09-22
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12196114
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  6. Artikel ; Online: Pulmonary hypertension: An unexplored risk factor for stroke in patients with atrial fibrillation.

    Khattar, Georges / Mustafa, Ahmad / Siddiqui, Fasih Sami / Gharib, Khalil El / Chapman, Wei / Abu Baker, Saif / Sattar, Saud Bin Abdul / Elsayegh, Dany / El-Hage, Halim / El Sayegh, Suzanne / Chalhoub, Michel

    Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association

    2023  Band 32, Heft 9, Seite(n) 107247

    Abstract: Background: Atrial fibrillation (Afib) is one of the most common and significant risk factors for stroke, with the CHADsVAsc score used as the tool for stroke risk assessment. Pulmonary hypertension (PH) has not been studied as an independent risk ... ...

    Abstract Background: Atrial fibrillation (Afib) is one of the most common and significant risk factors for stroke, with the CHADsVAsc score used as the tool for stroke risk assessment. Pulmonary hypertension (PH) has not been studied as an independent risk factor for stroke in individuals with Afib.
    Methods: In this retrospective case-control study, National Inpatient Sample Database was used to sample individuals with atrial fibrillation, and baseline demographics and comorbidities were collected using ICD-10 codes. Patients with missing data, age under 18, history of thromboembolic diseases, or stroke were excluded. Greedy propensity matching using R was performed to match patients with and without PH on age, race, gender, and 19 other comorbidities, including anticoagulation use. Binary logistic regression was performed after matching to assess whether PH was an independent risk factor for stroke. A p-value of <0.05 was considered statistically significant.
    Results: Of the 2,421,545 patients included in the study, 158,545 (6.5%) had PH. PH patients were more likely to be elderly, females, and smokers. Comorbidities were more common in the PH group. Patients with PH were more likely to have an ischemic stroke (3.6% vs. 2.9%, p<0.001), hemorrhagic stroke (2.2% vs. 0.7%, p<0.001), and transient ischemic attack (TIA) (2.3% vs. 0.7%, p<0.001). After matching, the presence of PH was associated with increased ischemic stroke (OR: 1.2 [1.1-1.2]; p<0.001), hemorrhagic stroke (OR: 2.4 [2.1-2.6]; p<0.001) and TIA (OR: 2.2 [2.0-2.4]; p<0.001). PH patients also had increased length of stay (β = 0.8; p<0.001) mortality (OR: 1.1 [1.0-1.2]; p<0.001).
    Conclusion: Apart from demonstrating the deleterious effect of PH on mortality and length of hospital stay, this study is the first to report on such a large scale that PH independently increases the incidence of all types of strokes in patients with Afib.
    Mesh-Begriff(e) Female ; Humans ; Aged ; Atrial Fibrillation/diagnosis ; Atrial Fibrillation/epidemiology ; Atrial Fibrillation/complications ; Ischemic Attack, Transient/etiology ; Retrospective Studies ; Case-Control Studies ; Hypertension, Pulmonary/diagnosis ; Hypertension, Pulmonary/epidemiology ; Hemorrhagic Stroke/complications ; Stroke/diagnosis ; Stroke/epidemiology ; Stroke/etiology ; Risk Factors ; Ischemic Stroke/complications
    Sprache Englisch
    Erscheinungsdatum 2023-07-29
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 1131675-5
    ISSN 1532-8511 ; 1052-3057
    ISSN (online) 1532-8511
    ISSN 1052-3057
    DOI 10.1016/j.jstrokecerebrovasdis.2023.107247
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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 3519: Hefte anzeigen Standort:
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  7. Artikel ; Online: Knowledge, Perceptions, and Attitudes of Medical Residents Towards Nanomedicine: Defining the Gap.

    Nassani, Najib / El-Douaihy, Youssef / Khotsyna, Yana / Shwe, Thinzar / El-Sayegh, Suzanne

    Medical science educator

    2019  Band 30, Heft 1, Seite(n) 179–186

    Abstract: Even though the general public opinion towards nanotechnology applications to health has been studied, medical residents' opinions remain unknown. The purpose of this study was to evaluate the perception, knowledge, and attitude of medical residents ... ...

    Abstract Even though the general public opinion towards nanotechnology applications to health has been studied, medical residents' opinions remain unknown. The purpose of this study was to evaluate the perception, knowledge, and attitude of medical residents towards nanomedicine using a 35-item questionnaire. Correlations between intrinsic factors, heuristics, and attitude towards nanomedicine were analyzed using the
    Sprache Englisch
    Erscheinungsdatum 2019-10-20
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 2156-8650
    ISSN (online) 2156-8650
    DOI 10.1007/s40670-019-00837-8
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  8. Artikel: Fungal infections in renal transplant patients.

    Khan, Asif / El-Charabaty, Elie / El-Sayegh, Suzanne

    Journal of clinical medicine research

    2015  Band 7, Heft 6, Seite(n) 371–378

    Abstract: Organ transplantation has always been considered to be the standard therapeutic interventions in patients with end-stage organ failure. In 2008, more than 29,000 organ transplants were performed in US. Survival rates among transplant recipients have ... ...

    Abstract Organ transplantation has always been considered to be the standard therapeutic interventions in patients with end-stage organ failure. In 2008, more than 29,000 organ transplants were performed in US. Survival rates among transplant recipients have greatly improved due to better understanding of transplant biology and more effective immunosuppressive agents. After transplant, the extent of the immune response is influenced by the amount of interleukin 2 (IL-2) being produced by the T-helper cells. Transplant immunosuppressive therapy primarily targets T cell-mediated graft rejection. Calcineurin inhibitor, which includes cyclosporine, pimecrolimus and tacrolimus, impairs calcineurin-induced up-regulation of IL-2 expression, resulting in increased susceptibility to invasive fungal diseases. This immunosuppressive state allows infectious complication, leading to a high mortality rate. Currently, overall mortality due to invasive fungal infections (IFIs) in solid organ transplant recipients ranges between 25% and 80%. The risk of IFI following renal transplant is associated with the dosage of immunosuppressive agents given, environmental factors and post-transplant duration. Most fungal infections occur in the first 6 months after transplant because of the use of numerous immunosuppressors. Candida spp. and Cryptococcus spp. are the yeasts most frequently isolated, while most frequent filamentous fungi (molds) isolated are Aspergillus spp. The symptoms of systemic fungal infections are non-specific and early detection of fungal infections and proper therapy are important in improving survival and reducing mortality. This article will provide an insight on the risk factors and clinical presentation, compare variation in treatment of IFIs in renal transplant patients, and evaluate the role of prophylactic therapy in this group of patients. We also report the course and management of two renal transplant recipients admitted to Staten Island University Hospital, both of whom developed pulmonary complications secondary to Aspergillus infection.
    Sprache Englisch
    Erscheinungsdatum 2015-04-08
    Erscheinungsland Canada
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2548987-2
    ISSN 1918-3011 ; 1918-3003
    ISSN (online) 1918-3011
    ISSN 1918-3003
    DOI 10.14740/jocmr2104w
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  9. Artikel: Predictors of 15-Day Survival for the Intensive Care Unit Patient on Continuous Renal Replacement Therapy: A Retrospective Analysis.

    Siddiqui, Abdul Hasan / Valecha, Gautam / Modi, Jwalant / Saqib, Amina / Weerasinghe, Chanudi / Siddiqui, Faraz / El Sayegh, Suzanne

    Cureus

    2020  Band 12, Heft 5, Seite(n) e8175

    Abstract: Purpose In the intensive care unit (ICU), acute renal failure is mostly part of multiple organ dysfunction syndromes with mortality ranging from 28%-90%, continuous renal replacement therapy (CRRT) is the predominant mode of RRT used in ICU. The main ... ...

    Abstract Purpose In the intensive care unit (ICU), acute renal failure is mostly part of multiple organ dysfunction syndromes with mortality ranging from 28%-90%, continuous renal replacement therapy (CRRT) is the predominant mode of RRT used in ICU. The main objective of the study was to evaluate the outcomes in patients with acute kidney injury (AKI) on CRRT in the ICU. Methods A retrospective chart review was conducted for all ICU patients with acute renal failure on CRRT in a tertiary care teaching hospital. A subgroup analysis was conducted between 15 days in hospital survivors and non-survivors to look for predictors of survival for patients on CRRT. Results Two-hundred twenty-six patients underwent CRRT from January 2007 to December 2013. The overall in-hospital mortality was 84.1%. Fifty-six patients (24.77%) survived to the 15-day post-CRRT mark. Acute respiratory failure requiring mechanical ventilation was associated with significantly increased mortality; 89.2% vs. 97.6% (P=0.008), ICU length of stay was significantly longer in the survivor group than the nonsurvivor group. Median±IQR; {20±24 vs 6±7(P: <0.0001)} and so were the ventilator-associated days {16±24 vs 4±6.5 (P: <0.0001)} and duration of CRRT {4.5±5.5 vs 2±2.0(P: <0.0001)}. Patients who survived had a lower incidence of metabolic acidosis {44.6% vs 62.9% (P: 0. 016)} and uremic encephalopathy {12.5% vs 26.5%; (P: 0.031)} but a greater incidence of volume overload {28.6% vs 15.9% (P: 0.031)} as compared to the non-survivor. Acute Physiology And Chronic Health Evaluation II (APACHE II) scores were significantly higher in the non-survivor group (mean SD) 26.9±28.0 vs. 23.9±25.8 (P: 0.0136). Conclusions This observational study in patients undergoing CRRT in an ICU setting revealed that the overall mortality was 84.1%. Fluid overload as an indication of CRRT was associated with improved 15 days' survival whereas higher APACHE II scores and the use of mechanical ventilation were associated with reduced 15 days' survival.
    Sprache Englisch
    Erscheinungsdatum 2020-05-18
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.8175
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