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  1. Book ; Thesis: "Scoop and run or stay and play"

    Youzouri, Hanan el

    Ausmaß und Umfang der präklinischen Notfallversorgung Anfang des 21. Jahrhunderts

    2013  

    Author's details vorgelegt von Hanan el Youzouri
    Language German
    Size VII, 115 Bl. : Ill., graph. Darst., Kt.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Frankfurt (Main), Univ., Diss., 2013
    HBZ-ID HT018169399
    Database Catalogue ZB MED Medicine, Health

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  2. Article ; Online: Broncho biliary fistula following interventional radiology for hepatic metastases.

    Sliwinski, Svenja / Sammons, Mary Katherine / Koca, Faruk / El Youzouri, Hanan / Vogl, Thomas / Bechstein, Wolf

    Zeitschrift fur Gastroenterologie

    2024  

    Abstract: Bronchobiliary fistulas are defined as an abnormal communication between the biliary system and the bronchial tree. They are extremely rare complications of radiofrequency or microwave ablation. A 39-year-old woman with a history of neuroendocrine ... ...

    Title translation Bronchobiliäre Fistel nach interventioneller radiologischer Therapie von Lebermetastasen.
    Abstract Bronchobiliary fistulas are defined as an abnormal communication between the biliary system and the bronchial tree. They are extremely rare complications of radiofrequency or microwave ablation. A 39-year-old woman with a history of neuroendocrine pancreatic carcinoma suffering from liver metastasis was treated with microwave ablation (MWA). In this case report, we present a case of intractable biliptysis from a bronchobiliary fistula secondary to an MWA. The patient was diagnosed by endoscopic retrograde cholangiopancreatograph and hepatobiliary scintigraphy. Treatment involved a right hemihepatectomy, a redo-hepaticojejunostomy, and the surgical placement of a transhepatic drain. After 6 weeks of drain placement, this could be removed. The fistula was thus successfully treated.
    Language English
    Publishing date 2024-04-11
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 201387-3
    ISSN 1439-7803 ; 0172-8504 ; 0044-2771
    ISSN (online) 1439-7803
    ISSN 0172-8504 ; 0044-2771
    DOI 10.1055/a-2207-7533
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Broncho biliary fistula following interventional radiology for hepatic metastases

    Sliwinski, Svenja / Sammons, Mary Katherine / Koca, Faruk / El Youzouri, Hanan / Vogl, Thomas / Bechstein, Wolf

    Zeitschrift für Gastroenterologie

    2024  

    Abstract: Bronchobiliary fistulas are defined as an abnormal communication between the biliary system and the bronchial tree. They are extremely rare complications of radiofrequency or microwave ablation. A 39-year-old woman with a history of neuroendocrine ... ...

    Abstract Bronchobiliary fistulas are defined as an abnormal communication between the biliary system and the bronchial tree. They are extremely rare complications of radiofrequency or microwave ablation. A 39-year-old woman with a history of neuroendocrine pancreatic carcinoma suffering from liver metastasis was treated with microwave ablation (MWA). In this case report, we present a case of intractable biliptysis from a bronchobiliary fistula secondary to an MWA. The patient was diagnosed by endoscopic retrograde cholangiopancreatograph and hepatobiliary scintigraphy. Treatment involved a right hemihepatectomy, a redo-hepaticojejunostomy, and the surgical placement of a transhepatic drain. After 6 weeks of drain placement, this could be removed. The fistula was thus successfully treated.
    Keywords biliptysis ; bronchobiliary fistula ; bronchial fistula ; ablation ; pancreatic neuroendocrine tumor ; Bilioptyse ; bronchobiliäre Fistel ; Bronchialfistel ; Ablation ; neuroendokriner Pankreastumor
    Language English
    Publishing date 2024-04-11
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 201387-3
    ISSN 1439-7803 ; 0044-2771 ; 0172-8504
    ISSN (online) 1439-7803
    ISSN 0044-2771 ; 0172-8504
    DOI 10.1055/a-2207-7533
    Database Thieme publisher's database

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  4. Article ; Online: A critical appraisal of the ISGLS definition of biliary leakage after liver resection.

    Sliwinski, Svenja / Heil, Jan / Franz, Josephine / El Youzouri, Hanan / Heise, Michael / Bechstein, Wolf O / Schnitzbauer, Andreas A

    Langenbeck's archives of surgery

    2023  Volume 408, Issue 1, Page(s) 77

    Abstract: Purpose: The International Study Group of Liver Surgery (ISGLS) defined post-hepatectomy biliary leakage as drain/serum bilirubin ratio > 3 at day 3 or the interventional/surgical revision due to biliary peritonitis. We investigated the definition's ... ...

    Abstract Purpose: The International Study Group of Liver Surgery (ISGLS) defined post-hepatectomy biliary leakage as drain/serum bilirubin ratio > 3 at day 3 or the interventional/surgical revision due to biliary peritonitis. We investigated the definition's applicability.
    Methods: A retrospective evaluation of all liver resections over a 6-year period was performed. ROC analyses were performed for drain/serum bilirubin ratios on days 1, 2, and 3 including grade A to C (analysis I) and grade B and C biliary leakages (analysis II) to test specific cutoff values.
    Results: A total of 576 patients were included. One hundred nine (18.9%) postoperative bile leakages occurred (19.6% of the whole population grade A, 16.5% grade B/C). Areas under the curve (AUC) for analysis I were 0.841 (day 1), 0.846 (day 2), and 0.734 (day 3). The highest sensitivity (78% on day 1/77% on day 2) and specificity (78% on day 1/79% on day 2) in analysis I were obtained for a drain/serum bilirubin ratio of 2.0. AUCs for analysis II were similar: 0.788 (day 1), 0.791 (day 2), and 0.650 (day 3). The highest sensitivity (73% on day 1/71% on day 2) and specificity (74% on day 1/76% on day 2) in analysis II were detected for a drain/serum bilirubin ratio of 2.0 on postoperative day 2.
    Conclusion: Biliary leakages should be defined if the drain/serum bilirubin ratio is > 2.0 on postoperative day 2.
    MeSH term(s) Humans ; Hepatectomy/adverse effects ; Retrospective Studies ; Liver Neoplasms/surgery ; Bilirubin/analysis ; Postoperative Complications/diagnosis ; Postoperative Complications/etiology ; Postoperative Complications/epidemiology
    Chemical Substances Bilirubin (RFM9X3LJ49)
    Language English
    Publishing date 2023-02-03
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1423681-3
    ISSN 1435-2451 ; 1435-2443
    ISSN (online) 1435-2451
    ISSN 1435-2443
    DOI 10.1007/s00423-022-02746-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Low Platelet Count Predicts Reduced Survival in Potentially Resectable Hepatocellular Carcinoma.

    Schrecker, Christopher / Waidmann, Oliver / El Youzouri, Hanan / Trojan, Jörg / Schnitzbauer, Andreas Anton / Bechstein, Wolf Otto / Zeuzem, Stefan / Koch, Christine

    Current oncology (Toronto, Ont.)

    2022  Volume 29, Issue 3, Page(s) 1475–1487

    Abstract: The prognostic role of platelet count in hepatocellular carcinoma (HCC) remains unclear, and in fact both thrombocytopenia and thrombocytosis are reported as predictors of unfavourable outcomes. This study aimed to clarify the prognostic value of ... ...

    Abstract The prognostic role of platelet count in hepatocellular carcinoma (HCC) remains unclear, and in fact both thrombocytopenia and thrombocytosis are reported as predictors of unfavourable outcomes. This study aimed to clarify the prognostic value of preoperative platelet count in potentially resectable HCC. We retrospectively reviewed 128 patients who underwent hepatic resection for HCC at a tertiary academic centre (2007−2019). Patient data were modelled by regression analysis, and platelet count was treated as a continuous variable. 89 patients had BCLC 0/A tumours and 39 had BCLC B tumours. Platelet count was higher in patients with larger tumours and lower in patients with higher MELD scores, advanced fibrosis, and portal hypertension (p < 0.001 for all listed variables). After adjusting for BCLC stage and tumour diameter, low platelet count associated with reduced overall survival (hazard ratio 1.25 per 50/nL decrease in platelet count, 95% confidence interval (CI) 1.02−1.53, p = 0.034) and increased perioperative mortality (odds ratio 1.96 per 50/nL decrease in platelet count, 95% CI 1.19−3.53, p = 0.014). Overall, low platelet count correlates with increased liver disease severity, inferior survival, and excess perioperative mortality in resectable HCC. These insights might be applied in clinical practice to better select patients for resection.
    MeSH term(s) Carcinoma, Hepatocellular/surgery ; Humans ; Liver Neoplasms/surgery ; Platelet Count ; Retrospective Studies
    Language English
    Publishing date 2022-02-28
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1236972-x
    ISSN 1718-7729 ; 1198-0052
    ISSN (online) 1718-7729
    ISSN 1198-0052
    DOI 10.3390/curroncol29030124
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: The Safety Level of Total Central Venous Access Port Implantation Performed by Residents.

    Schreckenbach, Teresa / Münch, Indra / El Youzouri, Hanan / Bechstein, Wolf Otto / Habbe, Nils

    Journal of surgical education

    2018  Volume 76, Issue 1, Page(s) 182–192

    Abstract: Objective: The implantation of totally implantable venous access ports (TIVAPs) is one of the first procedures surgical residents learn. Complications after implantation procedures have a major impact on patient outcomes, as it may lead to a delay of ... ...

    Abstract Objective: The implantation of totally implantable venous access ports (TIVAPs) is one of the first procedures surgical residents learn. Complications after implantation procedures have a major impact on patient outcomes, as it may lead to a delay of chemotherapy regimens or of parenteral nutrition. The aim of this study was to compare the outcomes after totally implantable venous access ports implantations done by resident and attending surgeons.
    Design: The study was performed as a retrospective analysis.
    Setting: The study took place in primary care at the Department of General and Visceral Surgery at Frankfurt University Hospital.
    Participants: A total of 760 primary totally implantable venous access ports implantations performed between March 2008 and December 2016 were included in a database. Three groups of surgeons doing the implantations were defined: Group A (residents alone), Group B (resident with help), and Group C (attending surgeons).
    Results: There was a significant difference between the surgeon groups in operation time (p < 0.001). The groups differed between Group A (mean, 49; SD, 22) and Group C (mean, 39; SD, 20); p < 0.001) and Group B (mean, 53; SD, 23) and Group C (mean, 39; SD, 20; p < 0.001). The incidence of surgical site infections between Groups A and C (3.6% vs. 0.3%; p = 0.003) and Groups B and C (2.5% vs. 0.3%; p = 0.027) differed also significantly. Based on multivariable logistic regression analysis operation time in minutes (OR, 1.04; 95%CI, 1.03-1.06; p < 0.001) was an independent risk factor for any intraoperative complications. For any postoperative complications younger age of the patient (OR, 0.98; 95%CI, 0.97-0.99; p = 0.004) and benign primary disease (OR, 3.25; 95%CI, 1.55-6.64; p = 0.002) were independent risk factors based on multivariable regression analysis. Based on multivariable regression analysis a lower body mass index of the patient (OR, 0.93; 95%CI, 0.86-0.99; p = 0.044), benign primary disease (OR, 2.89; 95%CI, 1.07-7.79; p = 0.036), and no chemotherapy (OR, 3.55; 95%CI, 1.50-8.39; p = 0.004) were independent risk factors for postoperative catheter infections. Surgeon group was no risk factor, neither for intraoperative and postoperative complications, nor for catheter explantation due to complications.
    Conclusion: Residents performing alone or residents performing with help can safely handle a central venous access port implantation. In patients with several risk factors, however, an attending should assist.
    MeSH term(s) Aged ; Catheterization, Central Venous/standards ; Catheters, Indwelling ; Female ; Humans ; Incidence ; Internship and Residency ; Male ; Middle Aged ; Patient Safety ; Retrospective Studies ; Risk Factors ; Surgical Wound Infection/epidemiology
    Language English
    Publishing date 2018-08-14
    Publishing country United States
    Document type Comparative Study ; Journal Article
    ZDB-ID 2277538-9
    ISSN 1878-7452 ; 1931-7204
    ISSN (online) 1878-7452
    ISSN 1931-7204
    DOI 10.1016/j.jsurg.2018.07.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Identification of factors predictive of postoperative morbidity and short-term mortality in older patients after colorectal carcinoma resection: A single-center retrospective study.

    Schreckenbach, Teresa / Zeller, Matthias Valentin / El Youzouri, Hanan / Bechstein, Wolf Otto / Woeste, Guido

    Journal of geriatric oncology

    2018  Volume 9, Issue 6, Page(s) 649–658

    Abstract: Objectives: The aim of this study is to investigate the effect of age on patient outcome after colorectal carcinoma (CRC) resection in patients over 65 years of age.: Methods: This study included patients aged 65 years and older who underwent CRC ... ...

    Abstract Objectives: The aim of this study is to investigate the effect of age on patient outcome after colorectal carcinoma (CRC) resection in patients over 65 years of age.
    Methods: This study included patients aged 65 years and older who underwent CRC resection between 2003 and 2013 at a single-center institution. Patients were divided into two groups: Group A (65-74 years old) and Group B (≥75 years old).
    Results: Multivariable logistic analysis of 415 patients revealed serum albumin levels on the third postoperative day (POD) (Odds Ratio (OR), 0.44; 95% CI, 0.21-0.94; P = 0.03) and C-reactive protein (CRP) levels (OR, 1.05; 95% CI, 1.00-1.01; P = 0.04) in patients with colon cancer as predictive factors for morbidity. In addition, the multivariable logistic analysis revealed serum albumin levels (OR, 0.27; 95% CI, 0.08-0.87; P = 0.03) in patients with rectal cancer as predictive factors for morbidity. The multivariate Cox Proportional Hazards Model identified re-intervention for colon cancer (Hazard Ratio (HR), 4.57; 95% CI, 1.36-15.4 P = 0.01) and for rectal cancer (HR, 11.8; 95% CI, 1.08-129 P = 0.04) as a predictive factor for 30-day mortality. Serum albumin level on the third POD was predictive of 30-day mortality (HR, 0.30; 95% CI, 0.13-0.71; P = 0.01) and of 1-year mortality (HR, 0.34; 95% CI, 0.17-0.66; P < 0.01) in patients with colon cancer.
    Conclusion: Age is not predictive of postoperative morbidity and mortality in patients with CRC. Serum albumin levels on the third POD can predict morbidity and mortality for colon and rectal carcinoma in older patients undergoing colorectal resections.
    MeSH term(s) Age Factors ; Aged ; Aged, 80 and over ; Colonic Neoplasms/mortality ; Colonic Neoplasms/surgery ; Digestive System Surgical Procedures/statistics & numerical data ; Female ; Frailty/epidemiology ; Geriatric Assessment ; Humans ; Male ; Postoperative Complications/mortality ; Postoperative Period ; Proportional Hazards Models ; Rectal Neoplasms/mortality ; Rectal Neoplasms/surgery ; Retrospective Studies
    Language English
    Publishing date 2018-05-18
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2556813-9
    ISSN 1879-4076 ; 1879-4068
    ISSN (online) 1879-4076
    ISSN 1879-4068
    DOI 10.1016/j.jgo.2018.05.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Characteristics and management of penetrating abdominal injuries in a German level I trauma center.

    Malkomes, Patrizia / Störmann, Philipp / El Youzouri, Hanan / Wutzler, Sebastian / Marzi, Ingo / Vogl, Thomas / Bechstein, Wolf Otto / Habbe, Nils

    European journal of trauma and emergency surgery : official publication of the European Trauma Society

    2018  Volume 45, Issue 2, Page(s) 315–321

    Abstract: Purpose: Penetrating abdominal injuries caused by stabbing or firearms are rare in Germany, thus there is lack of descriptive studies. The management of hemodynamically stable patients is still under dispute. The aim of this study is to review and ... ...

    Abstract Purpose: Penetrating abdominal injuries caused by stabbing or firearms are rare in Germany, thus there is lack of descriptive studies. The management of hemodynamically stable patients is still under dispute. The aim of this study is to review and improve our management of penetrating abdominal injuries.
    Methods: We retrospectively reviewed a 10-year period from the Trauma Registry of our level I trauma center. The data of all patients regarding demographics, clinical and outcome parameters were examined. Further, charts were reviewed for FAST and CT results and correlated with intraoperative findings.
    Results: A total of 115 patients with penetrating abdominal trauma (87.8% men) were analyzed. In 69 patients, the injuries were caused by interpersonal violence and included 88 stab and 4 firearm wounds. 8 patients (6.9%) were in a state of shock at presentation. 52 patients (44.8%) suffered additional extraabdominal injuries. 38 patients were managed non-operatively, while almost two-thirds of all patients underwent surgical treatment. Hereof, 20 laparoscopies and 3 laparotomies were nontherapeutic. There were two missed injuries, but no patient experienced morbidity or mortality related to delay in treatment. 106 (92.2%) FAST and 91 (79.3%) CT scans were performed. Sensitivity and specificity of FAST were 59.4 and 94.2%, while those of CT were 93.2 and 85.1%, respectively.
    Conclusion: In hemodynamically stable patients presenting with penetrating abdominal trauma, CT is indicated and the majority of injuries can be managed conservatively. If surgical treatment is required, diagnostic laparoscopy for stable patients is feasible to avoid nontherapeutic laparotomy.
    MeSH term(s) Abdominal Injuries/diagnostic imaging ; Abdominal Injuries/therapy ; Adolescent ; Adult ; Female ; Germany/epidemiology ; Hemodynamics ; Humans ; Laparotomy/statistics & numerical data ; Male ; Practice Guidelines as Topic ; Retrospective Studies ; Tomography, X-Ray Computed/statistics & numerical data ; Trauma Centers ; Unnecessary Procedures/statistics & numerical data ; Wounds, Gunshot ; Wounds, Penetrating/diagnostic imaging ; Wounds, Penetrating/therapy ; Wounds, Stab
    Language English
    Publishing date 2018-01-22
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2275480-5
    ISSN 1863-9941 ; 1863-9933
    ISSN (online) 1863-9941
    ISSN 1863-9933
    DOI 10.1007/s00068-018-0911-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: DIALAPP: a prospective validation of a new diagnostic algorithm for acute appendicitis.

    Malkomes, Patrizia / Edmaier, Franziska / Liese, Juliane / Reinisch-Liese, Alexander / El Youzouri, Hanan / Schreckenbach, Teresa / Bucher, Andreas M / Bechstein, Wolf Otto / Schnitzbauer, Andreas A

    Langenbeck's archives of surgery

    2020  Volume 406, Issue 1, Page(s) 141–152

    Abstract: Purpose: The management of patients with suspected appendicitis remains a challenge in daily clinical practice, and the optimal management algorithm is still being debated. Negative appendectomy rates (NAR) continue to range between 10 and 15%. This ... ...

    Abstract Purpose: The management of patients with suspected appendicitis remains a challenge in daily clinical practice, and the optimal management algorithm is still being debated. Negative appendectomy rates (NAR) continue to range between 10 and 15%. This prospective study evaluated the accuracy of a diagnostic pathway in acute appendicitis using clinical risk stratification (Alvarado score), routine ultrasonography, gynecology consult for females, and selected CT after clinical reassessment.
    Methods: Patients presenting with suspected appendicitis between November 2015 and September 2017 from age 18 years and above were included. Decision-making followed a clear management pathway. Patients were followed up for 6 months after discharge. The hypothesis was that the algorithm can reduce the NAR to a value of under 10%.
    Results: A total of 183 patients were included. In 65 of 69 appendectomies, acute appendicitis was confirmed by histopathology, corresponding to a NAR of 5.8%. Notably, all 4 NAR appendectomies had other pathologies of the appendix. The perforation rate was 24.6%. Only 36 patients (19.7%) received a CT scan. The follow-up rate after 30 days achieved 69%, including no patients with missed appendicitis. The sensitivity and specificity of the diagnostic pathway was 100% and 96.6%, respectively. The potential saving in costs can be as much as 19.8 million €/100,000 cases presenting with the suspicion of appendicitis.
    Conclusion: The risk-stratified diagnostic algorithm yields a high diagnostic accuracy for patients with suspicion of appendicitis. Its implementation can safely reduce the NAR, simultaneously minimizing the use of CT scans and optimizing healthcare-related costs in the treatment of acute appendicitis.
    Trial registration: ClinicalTrials.gov Identifier: NCT02627781 (December 2015).
    MeSH term(s) Acute Disease ; Algorithms ; Appendectomy ; Appendicitis/diagnostic imaging ; Appendicitis/surgery ; Female ; Humans ; Infant, Newborn ; Prospective Studies ; Sensitivity and Specificity ; Ultrasonography
    Language English
    Publishing date 2020-11-19
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1423681-3
    ISSN 1435-2451 ; 1435-2443
    ISSN (online) 1435-2451
    ISSN 1435-2443
    DOI 10.1007/s00423-020-02022-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Conference proceedings: Portimplantation als Einsteigeroperation? – Unterschiede der Ergebnisse nach Portimplantation zwischen Assistenz- und Fachärzten

    Schreckenbach, Teresa / El Youzouri, Hanan / Bechstein, Wolf Otto / Habbe, Nils

    2016  , Page(s) 16dgch254

    Event/congress 133. Kongress der Deutschen Gesellschaft für Chirurgie; Berlin; Deutsche Gesellschaft für Chirurgie; 2016
    Keywords Medizin, Gesundheit
    Publishing date 2016-04-21
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/16dgch254
    Database German Medical Science

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