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Article: Kinetics of remnant liver volume and function after a major hepatectomy.

Truant, Stéphanie / El Amrani, Mehdi / Pruvot, François-René

2023 Volume 12, Issue 6, Page(s) 975–977

Language	English
Publishing date	2023-11-08
Publishing country	China (Republic : 1949- )
Document type	Editorial ; Comment
ZDB-ID	2812398-0
ISSN	2304-389X ; 2304-3881
ISSN (online)	2304-389X
ISSN	2304-3881
DOI	10.21037/hbsn-23-469
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Article ; Online: Distal pancreatectomy with superior mesenteric vein resection without reconstruction for pancreatic neuroendocrine tumor.

Pecquenard, F / Boleslawski, E / El Amrani, M

Journal of visceral surgery

2020 Volume 158, Issue 3, Page(s) 279–280

Abstract: Mesenteric and portal vein involvement is seen frequently in pancreatic neoplastic disease and requires venous resection to obtain clear surgical margins. If sufficient collateral circulation is present, venous resection can be performed without ... ...

Abstract	Mesenteric and portal vein involvement is seen frequently in pancreatic neoplastic disease and requires venous resection to obtain clear surgical margins. If sufficient collateral circulation is present, venous resection can be performed without reconstruction and without substantial impact on venous drainage.
MeSH term(s)	Humans ; Mesenteric Veins/diagnostic imaging ; Mesenteric Veins/surgery ; Pancreatectomy ; Pancreatic Neoplasms/surgery ; Pancreaticoduodenectomy ; Portal Vein/diagnostic imaging ; Portal Vein/surgery
Language	English
Publishing date	2020-12-07
Publishing country	France
Document type	Journal Article
ISSN	1878-7886
ISSN (online)	1878-7886
DOI	10.1016/j.jviscsurg.2020.11.010
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Article ; Online: Robotic liver resection in the posterosuperior segments as a way to extent the mini-invasive arsenal: a comparison with transthoracic laparoscopic approach.

Denglos, Pauline / Truant, Stéphanie / El Amrani, Mehdi / Millet, Guillaume

Surgical endoscopy

2023 Volume 37, Issue 6, Page(s) 4478–4485

Abstract: Background: The field of robotic liver resection (RLR) has developed in the past decades. This technique seems to improve the access to the posterosuperior (PS) segments. Evidence of a possible advantage over transthoracic laparoscopy (TTL) is not yet ... ...

Abstract	Background: The field of robotic liver resection (RLR) has developed in the past decades. This technique seems to improve the access to the posterosuperior (PS) segments. Evidence of a possible advantage over transthoracic laparoscopy (TTL) is not yet available. We aimed to compare RLR to TTL for tumors located in the PS segments of the liver in terms of feasibility, difficulty scoring, and outcome. Methods: This retrospective study compared patients undergoing robotic liver resections and transthoracic laparoscopic resections of the PS segments between January 2016 and December 2022 in a high-volume HPB center. Patients' characteristics, perioperative outcomes, and postoperative complications were evaluated. Results: In total, 30 RLR and 16 TTL were included. Only wedge resections were performed in the TTL group, while 43% of the patients in the RLR group had an anatomical resection (p < 0.001). The difficulty score according to the IWATE difficulty scoring system was significantly higher in the RLR group (p < 0.001). Total operative time was similar between the two groups. Complication rates, either overall or major, were comparable between the two techniques and hospital stay was significantly shorter in the RLR group. Patients in the TTL group were found to have more pulmonary complications (p = 0.01). Conclusion: RLR may provide some advantages over TTL for the resection of tumors located in the PS segments.
MeSH term(s)	Humans ; Liver Neoplasms/surgery ; Liver Neoplasms/pathology ; Retrospective Studies ; Robotic Surgical Procedures ; Hepatectomy/methods ; Laparoscopy/methods ; Postoperative Complications/epidemiology ; Postoperative Complications/etiology ; Postoperative Complications/surgery ; Length of Stay
Language	English
Publishing date	2023-02-17
Publishing country	Germany
Document type	Journal Article
ZDB-ID	639039-0
ISSN	1432-2218 ; 0930-2794
ISSN (online)	1432-2218
ISSN	0930-2794
DOI	10.1007/s00464-023-09919-6
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Article: Localized Small Bowel Adenocarcinoma Management: Evidence Summary.

Turpin, Anthony / El Amrani, Mehdi / Zaanan, Aziz

Cancers

2022 Volume 14, Issue 12

Abstract: Small bowel cancers are rare diseases whose prognosis is poorer than that of colon cancers. Due to disease rarity, there is little data on small bowel adenocarcinoma (SBA) treatment, and most recommendations come from expert agreements or analogies to ... ...

Abstract	Small bowel cancers are rare diseases whose prognosis is poorer than that of colon cancers. Due to disease rarity, there is little data on small bowel adenocarcinoma (SBA) treatment, and most recommendations come from expert agreements or analogies to the management of colon cancer. Although relatively high rates of local recurrence are observed for duodenal malignancies, distant metastatic relapse remains common and requires adjuvant systemic therapy. Given the similarities between SBA and colorectal cancer, radiotherapy and chemotherapy strategies used for the latter disease are frequently pursued for the former disease, specifically for tumors located in the duodenum. However, no previous randomized study has evaluated the benefit of adjuvant chemotherapy on the overall survival of SBA patients. Most previous studies on treatment outcomes and prognostic factors in this context were based on large international databases, such as the Surveillance, Epidemiology, and End Results or the National Cancer Database. Studies are required to establish and validate prognostic and predictive markers relevant in this context to inform the use of (neo) adjuvant treatment. Among those, deficient mismatch repair tumors represent 20% of SBAs, but their impact on chemosensitivity remains unknown. Herein, we summarize the current evidence on the management of localized SBA, including future perspectives.
Language	English
Publishing date	2022-06-11
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers14122892
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Article ; Online: L’hypotension diastolique isolée en hémodialyse : facteur de risque de complications cardiovasculaires de novo et de mortalité toute cause.

El Amrani, M / El Kabbaj, D

Annales de cardiologie et d'angeiologie

2019 Volume 68, Issue 3, Page(s) 144–149

Abstract: Intra dialytic hypotension is the most common complication in hemodialysis. However, isolated diastolic hypotension (IDH) in hemodialysis is asymptomatic and its detection requires repeated monitoring of blood pressure during dialysis sessions. To study ... ...

Title translation	Isolated diastolic hypotension in hemodialysis: Risk factor for novel cardiovascular complications and all-cause mortality.
Abstract	Intra dialytic hypotension is the most common complication in hemodialysis. However, isolated diastolic hypotension (IDH) in hemodialysis is asymptomatic and its detection requires repeated monitoring of blood pressure during dialysis sessions. To study this phenomenon, we conducted a prospective study over a period of 5 years in 45 chronic hemodialysis patients. The IDH, was noted in 42% at inclusion, and in 59,5% of the cases at the end of the study. IDH was associated with advanced age, female gender, high relative critical blood volume, cardiac arrhythmias and diastolic dysfunction of the left ventricle. IDH was also significantly associated with novel cardiovascular complications (P=0.004) and all-cause mortality (P=0.038). Isolated diastolic hypotension is a particularly common phenomenon in hemodialysis. Our data encourage in-depth reflection on this subject in hemodialysis. In addition, our study highlights the value of screening for IDH by close monitoring of hemodynamic parameters, and calls for personalized dialysis management based on the analysis of the demonstrated risk factors and on the study of the associated comorbidities.
MeSH term(s)	Adult ; Age Factors ; Aged ; Arrhythmias, Cardiac/complications ; Asymptomatic Diseases ; Blood Volume ; Cause of Death ; Chi-Square Distribution ; Diastole ; Female ; Heart Diseases/etiology ; Humans ; Hypotension/complications ; Hypotension/diagnosis ; Hypotension/mortality ; Kaplan-Meier Estimate ; Male ; Middle Aged ; Prospective Studies ; RecQ Helicases ; Renal Dialysis/adverse effects ; Risk Factors ; Statistics, Nonparametric ; Systole ; Time Factors ; Ventricular Dysfunction, Left/complications
Chemical Substances	Bloom syndrome protein (EC 3.6.1.-) ; RecQ Helicases (EC 3.6.4.12)
Language	French
Publishing date	2019-01-22
Publishing country	France
Document type	Journal Article
ZDB-ID	418425-7
ISSN	1768-3181 ; 0003-3928
ISSN (online)	1768-3181
ISSN	0003-3928
DOI	10.1016/j.ancard.2018.09.010
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Article ; Online: Management of pancreatic ascites complicating alcoholic chronic pancreatitis.

Schneider Bordat, L / El Amrani, M / Truant, S / Branche, J / Zerbib, P

Journal of visceral surgery

2021 Volume 158, Issue 5, Page(s) 370–377

Abstract: Introduction: Pancreatic ascites (PA) is an unusual and little studied complication of chronic alcoholic pancreatitis. Management is complex and is based mainly on empirical data. The aim of this retrospective work was to analyse the management of PA at ...

Abstract	Introduction: Pancreatic ascites (PA) is an unusual and little studied complication of chronic alcoholic pancreatitis. Management is complex and is based mainly on empirical data. The aim of this retrospective work was to analyse the management of PA at our centre. Patients and methods: A total of 24 patients with PA complicating chronic alcoholic pancreatitis were managed at the Lille University Hospital between 2004 and 2018. Treatment was initially medical and then, in case of failure, interventional (endoscopic, radiological and/or surgical). Data regarding epidemiology, therapeutic and follow-up data were collected retrospectively. Results: Twenty-four patients were analysed; median follow-up was 18.5 months [6.75-34.25]. Exclusively medical treatment was effective in three of four patients, but, based on intention to treat, medical therapy alone was effective in only two out of 24 patients. Of 17 patients treated endoscopically, treatment was successful in 15 of them. Of the 15 who underwent surgery, external surgical drainage was effective in 13. Multimodal treatment, initiated after 6.5 days [4-13.5] of medical treatment, was effective in 12 out of 14 patients. In total, 21 patients were successfully treated (87%) with a morbidity rate of 79% and a mortality rate of 12.5% (n=3). Conclusion: PA gives rise to significant morbidity and mortality. Conservative medical treatment has only a limited role. If medical treatment fails, endoscopic and then surgical treatment allow a favourable outcome in more than 80% of patients.
MeSH term(s)	Ascites/etiology ; Ascites/therapy ; Drainage/adverse effects ; Humans ; Pancreatic Pseudocyst/etiology ; Pancreatitis, Alcoholic/complications ; Pancreatitis, Alcoholic/therapy ; Retrospective Studies ; Treatment Outcome
Language	English
Publishing date	2021-01-16
Publishing country	France
Document type	Journal Article
ISSN	1878-7886
ISSN (online)	1878-7886
DOI	10.1016/j.jviscsurg.2020.11.015
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Article ; Online: Sarcopenia does not affect liver regeneration and postoperative course after a major hepatectomy. A prospective study on 125 patients using CT volumetry and HIDA scintigraphy.

Fulbert, Maxence / El Amrani, Mehdi / Baillet, Clio / Lecolle, Katia / Ernst, Olivier / Louvet, Alexandre / Pruvot, François-René / Huglo, Damien / Truant, Stéphanie

Clinics and research in hepatology and gastroenterology

2024 Volume 48, Issue 5, Page(s) 102332

Abstract: Background & objectives: Sarcopenia is a morbi-mortality risk factor in digestive surgery, though its impact after major hepatectomy (MH) remains unknown. This prospective pilot study investigated whether volume and function of a regenerating liver is ... ...

Abstract	Background & objectives: Sarcopenia is a morbi-mortality risk factor in digestive surgery, though its impact after major hepatectomy (MH) remains unknown. This prospective pilot study investigated whether volume and function of a regenerating liver is influenced by body composition. Methods: From 2011 to 2016, 125 consecutive patients had computed tomography and 99mTc-labelled-mebrofenin SPECT-scintigraphy before and after MH at day 7 and 1 month for measurements of liver volumes and functions. L3 vertebra muscle mass identified sarcopenia. Primary endpoint was the impact of sarcopenia on regeneration capacities (i.e. volume/function changes and post-hepatectomy liver failure (PHLF) rate). Secondary endpoint was 3-month morbi-mortality. Results: Sarcopenic patients (SP; N = 69) were significantly older than non-sarcopenic (NSP), with lower BMI and more malignancies, but with comparable liver function/volume at baseline. Postoperatively, SP showed higher rates of ISGLS_PHLF (24.6 % vs 10.9 %; p = 0.05) but with comparable rates of severe morbidity (23.2 % vs 16.4 %; p = 0.35), overall (8.7 % vs 3.6 %; p = 0.3) and PHLF-related mortality (8,7 % vs 1.8 %; p = 0.075). After matching on the extent of resection or using propensity score, regeneration and PHLF rates were similar. Conclusion: This prospective study using first sequential SPECT-scintigraphy showed that sarcopenia by itself does not affect liver regeneration capacities and short-term postoperative course after MH.
Language	English
Publishing date	2024-04-02
Publishing country	France
Document type	Journal Article
ZDB-ID	2594333-9
ISSN	2210-741X ; 2210-7401
ISSN (online)	2210-741X
ISSN	2210-7401
DOI	10.1016/j.clinre.2024.102332
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Article ; Online: Facteurs de risque de progression des calcifications des artères coronaires après 5 ans d’évolution en dialyse.

Alayoud, A / El Amrani, M / Belarbi, M / El Kharras, A / Chtioui, M / Elfilali, K

Annales de cardiologie et d'angeiologie

2020 Volume 69, Issue 2, Page(s) 81–85

Abstract: Background: Although progression of coronary artery calcification (CAC) has been established as an important marker for cardiovascular morbidity, very few studies have studied it in end-stage renal disease patients. Thus we examined and evaluate risk ... ...

Title translation	Risk factors for progression of coronary artery calcification over 5 years in hemodialysis patients.
Abstract	Background: Although progression of coronary artery calcification (CAC) has been established as an important marker for cardiovascular morbidity, very few studies have studied it in end-stage renal disease patients. Thus we examined and evaluate risk factors of calcification changes in dialysis patients. Method: Among 28 hemodialysis (HD) patients, CAC was measured in Agatston units at baseline and after five years using the 64 multi-slice ultra-fast CT. The HD patients were classified as progressors or no progressors according to the change in the CAC score across these 2 measurements. Results: Over an average 63 months follow-up, participants without CAC at baseline had no incident CAC. The progression of CAC was slow and was found only in 6 patients (21.4%). It was significantly associated with several cardiovascular risk factors, namely, older age (P=0.03), diabetes (P=0.05), male sex (P=0.02), hypercholesterolemia (P=0.05), anemia (P=0.017), inflammation (P=0.05), and hyperphosphataemia (P=0.012). However, calcemia, parathormone levels, dialysis duration, tobacco, high blood pressure and dialysis dose did not seem to influence the progression of CAC in our series. A strong association was found between basal calcification scores and Delta increment at 5 years. Conclusions: Our study suggests that CAC progression in dialysis is a complex phenomenon, associated with several risk factors with special regard to elevated basal scores. This progression can be avoided or slowed with appropriate management, which must begin in the early stages of chronic kidney disease.
MeSH term(s)	Adult ; Age Factors ; Aged ; Anemia/complications ; Coronary Artery Disease/diagnostic imaging ; Coronary Artery Disease/pathology ; Diabetic Angiopathies/complications ; Disease Progression ; Female ; Humans ; Hypercholesterolemia/complications ; Hyperphosphatemia/complications ; Male ; Middle Aged ; Renal Dialysis/adverse effects ; Renal Dialysis/statistics & numerical data ; Risk Factors ; Sex Factors ; Time Factors ; Vascular Calcification/diagnostic imaging ; Vascular Calcification/pathology
Language	French
Publishing date	2020-02-29
Publishing country	France
Document type	Journal Article
ZDB-ID	418425-7
ISSN	1768-3181 ; 0003-3928
ISSN (online)	1768-3181
ISSN	0003-3928
DOI	10.1016/j.ancard.2020.01.004
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Article: Membranoproliferative Glomerulonephritis Associated with a Human Immunodeficiency Virus Infection.

Rafik, H / El Amrani, M / El Kabbaj, D

Indian journal of nephrology

2017 Volume 27, Issue 4, Page(s) 319–320

Abstract: Type 1 membranoproliferative glomerulonephritis (MPGN) is an uncommon manifestation of human immunodeficiency virus (HIV)-associated renal disease in patients coinfected with hepatitis C virus. We report a case of MPGN characterized by nephrotic syndrome ...

Abstract	Type 1 membranoproliferative glomerulonephritis (MPGN) is an uncommon manifestation of human immunodeficiency virus (HIV)-associated renal disease in patients coinfected with hepatitis C virus. We report a case of MPGN characterized by nephrotic syndrome associated with HIV without hepatitis C coinfection. The patient had a favorable response to highly active antiretroviral therapy and angiotensin-converting enzyme inhibitors. Recognition of the MPGN lesion in HIV infection devoid of hepatitis C coinfection must be considered.
Language	English
Publishing date	2017-07-31
Publishing country	India
Document type	Case Reports
ZDB-ID	2134388-3
ISSN	1998-3662 ; 0971-4065
ISSN (online)	1998-3662
ISSN	0971-4065
DOI	10.4103/0971-4065.202838
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Article ; Conference proceedings: Effects of heat treatment on emicizumab and an alternative approach to eliminate interfering FVIII activity prior to functional analysis

Hamedani, N. S. / Donners, A.A.M. T. / van Luin, M. / Gasper, S. / Rühl, H. / Klein, C. / Albert, T. / El Amrani, M. / Pötzsch, B. / Oldenburg, J. / Müller, J.

Hämostaseologie

2024 Volume 44, Issue S 01

Event/congress	GTH Congress 2024 - 68th Annual Meeting of the Society of Thrombosis and Haemostasis Research - Building Bridges in Coagulation, Vienna, Austria, 2024-03-27
Language	English
Publishing date	2024-02-01
Publisher	Georg Thieme Verlag
Publishing place	Stuttgart ; New York
Document type	Article ; Conference proceedings
ZDB-ID	801512-0
ISSN	2567-5761 ; 0720-9355
ISSN (online)	2567-5761
ISSN	0720-9355
DOI	10.1055/s-0044-1779215
Database	Thieme publisher's database

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