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  1. Book ; Thesis: Untersuchung des therapeutischen Potenzials von Mesalazin bei kardialer und kutaner Fibrose in vitro und in vivo

    Hoffmann, Maximilian / El-Armouche, Ali / Adams, Volker

    2023  

    Institution Technische Universität Dresden / Institut für Pharmakologie und Toxikologie
    Author's details von Maximilian Hoffmann aus Lübeck ; Institut für Pharmakologie und Toxikologie [Dresden]
    Language German
    Size 112 Seiten, Illustrationen, Diagramme
    Publishing place Dresden
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Technische Universität Dresden, Medizinische Fakultät, 2023
    HBZ-ID HT030693357
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

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  2. Book ; Thesis: Charakterisierung des PLK2-KO-Phänotyps und Evaluation des therapeutischen Potentials von Mesalazin im Rahmen des fibrotischen Umbaus in pulmonalem, dermalem, hepatischem und renalem Gewebe

    Kant, Theresa Annika / El-Armouche, Ali / Wielockx, Ben

    2022  

    Institution Technische Universität Dresden / Institut für Pharmakologie und Toxikologie
    Author's details von Theresa Annika Kant aus Berlin-Friedrichshagen ; Institut für Pharmakologie und Toxikologie [Dresden]
    Language German
    Size 178 Blätter, Illustrationen, Diagramme
    Publishing place Dresden
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Technische Universität Dresden, Medizinische Fakultät, 2023
    HBZ-ID HT030626419
    Database Catalogue ZB MED Medicine, Health

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  3. Book ; Thesis: Progression of autonomic small fiber dysfunction in early Parkinson´s disease

    Arndt, Martin / Siepmann, Timo / El-Armouche, Ali

    a prospective observational study

    2022  

    Institution Klinik und Poliklinik für Neurologie
    Author's details von Martin Arndt aus Berlin ; Klinik und Poliklinik für Neurologie [Dresden]
    Language English
    Size ii, 124 Seiten, Illustrationen, Diagramme
    Publishing place Dresden
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Technische Universität Dresden, Medizinische Fakultät, 2023
    HBZ-ID HT030333921
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2023 E 1190 order for loan Magazin

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  4. Book ; Thesis: Neue Zellkulturmodelle zur Charakterisierung kardialer Fibrosemechanismen und zur Ableitung pharmakologischer Therapiestrategien

    Schäffer, Charlotte / El-Armouche, Ali / Morawietz, Henning

    2020  

    Institution Technische Universität Dresden / Institut für Pharmakologie und Toxikologie
    Author's details von Charlotte Schäffer aus Aalen ; Institut für Pharmakologie und Toxikologie [Dresden]
    Language German
    Size 113 Blätter, Illustrationen, Diagramme
    Publishing place Dresden
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Technische Universität Dresden, Medizinische Fakultät, 2021
    HBZ-ID HT021372230
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

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  5. Book ; Thesis: Die Rolle der linksatrialen Fibrose als Prädiktor für die Verbesserung der linksventrikulären Ejektionsfraktion nach kathetergestützter Vorhofflimmerablation

    Neudeck, Sebastian / El-Armouche, Ali / Morawietz, Henning

    2020  

    Institution Technische Universität Dresden / Institut für Pharmakologie und Toxikologie
    Author's details von Sebastian Neudeck aus Gera ; Institut für Pharmakologie und Toxikologie [Dresden]
    Language German
    Size IX, 80 Blätter, Illustrationen, Diagramme
    Publishing place Dresden
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Technische Universität Dresden, Medizinische Fakultät, 2021
    HBZ-ID HT021777250
    Database Catalogue ZB MED Medicine, Health

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  6. Book ; Thesis: Untersuchung der Effekte verschiedener bariatrischer Operationstechniken auf adrenerge und metabolische Signalwege im Herzen

    Tiepner, Anna Luise / El-Armouche, Ali / Morawietz, Henning

    2020  

    Institution Technische Universität Dresden / Institut für Pharmakologie und Toxikologie
    Author's details von Anna Luise Tiepner aus Gera ; Institut für Pharmakologie und Toxikologie [Dresden]
    Language German
    Size 97 Seiten, Illustrationen, Diagramme
    Publishing place Dresden
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Technische Universität Dresden, Medizinische Fakultät, 2021
    HBZ-ID HT021210056
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2022 E 55 order for loan Magazin

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  7. Book ; Thesis: Characterization of the PLK2-signaling pathway and its pharmacological modulation in human atrial fibroblasts

    Rausch, Johanna Sophia Elisabeth / El-Armouche, Ali / Linkermann, Andreas Günter

    2021  

    Institution Institut für Klinische Pharmakologie
    Author's details von Johanna Sophia Elisabeth Rausch aus Hamburg ; Institut für Klinische Pharmakologie [Dresden]
    Language English
    Size XI, 115 Seiten, Illustrationen, Diagramme
    Publishing place Dresden
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Technische Universität Dresden, Medizinische Fakultät, 2022
    HBZ-ID HT030629968
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

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  8. Article ; Online: Intertwined regulators: hypoxia pathway proteins, microRNAs, and phosphodiesterases in the control of steroidogenesis.

    Ariyeloye, Stephen / Kämmerer, Susanne / Klapproth, Erik / Wielockx, Ben / El-Armouche, Ali

    Pflugers Archiv : European journal of physiology

    2024  

    Abstract: Oxygen sensing is of paramount importance for maintaining cellular and systemic homeostasis. In response to diminished oxygen levels, the hypoxia-inducible factors (HIFs) orchestrate various biological processes. These pivotal transcription factors have ... ...

    Abstract Oxygen sensing is of paramount importance for maintaining cellular and systemic homeostasis. In response to diminished oxygen levels, the hypoxia-inducible factors (HIFs) orchestrate various biological processes. These pivotal transcription factors have been identified as key regulators of several biological events. Notably, extensive research from our group and others has demonstrated that HIF1α exerts an inverse regulatory effect on steroidogenesis, leading to the suppression of crucial steroidogenic enzyme expression and a subsequent decrease in steroid levels. These steroid hormones occupy pivotal roles in governing a myriad of physiological processes. Substantial or prolonged fluctuations in steroid levels carry detrimental consequences across multiple organ systems and underlie various pathological conditions, including metabolic and immune disorders. MicroRNAs serve as potent mediators of multifaceted gene regulatory mechanisms, acting as influential epigenetic regulators that modulate a broad spectrum of gene expressions. Concomitantly, phosphodiesterases (PDEs) play a crucial role in governing signal transduction. PDEs meticulously manage intracellular levels of both cAMP and cGMP, along with their respective signaling pathways and downstream targets. Intriguingly, an intricate interplay seems to exist between hypoxia signaling, microRNAs, and PDEs in the regulation of steroidogenesis. This review highlights recent advances in our understanding of the role of microRNAs during hypoxia-driven processes, including steroidogenesis, as well as the possibilities that exist in the application of HIF prolyl hydroxylase (PHD) inhibitors for the modulation of steroidogenesis.
    Language English
    Publishing date 2024-02-15
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 6380-0
    ISSN 1432-2013 ; 0031-6768
    ISSN (online) 1432-2013
    ISSN 0031-6768
    DOI 10.1007/s00424-024-02921-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uc I Zs.35: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  9. Book ; Online ; Thesis: Die Rolle von Phosphodiesterase 2 in der Herzfrequenz-Regulation und im Angiotensin-induziertem kardialen Remodeling

    Riedel, Merle Anne-Christine [Verfasser] / El-Armouche, Ali [Gutachter] / Morawietz, Henning [Gutachter]

    2024  

    Author's details Merle Anne-Christine Riedel ; Gutachter: Ali El-Armouche, Henning Morawietz
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Technische Universität Dresden
    Publishing place Dresden
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

    Full text online

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  10. Article ; Online: Function and regulation of phosphatase 1 in healthy and diseased heart.

    Klapproth, Erik / Kämmerer, Susanne / El-Armouche, Ali

    Cellular signalling

    2021  Volume 90, Page(s) 110203

    Abstract: Reversible phosphorylation of ion channels and calcium-handling proteins provides precise post-translational regulation of cardiac excitation and contractility. Serine/threonine phosphatases govern dephosphorylation of the majority of cardiac proteins. ... ...

    Abstract Reversible phosphorylation of ion channels and calcium-handling proteins provides precise post-translational regulation of cardiac excitation and contractility. Serine/threonine phosphatases govern dephosphorylation of the majority of cardiac proteins. Accordingly, dysfunction of this regulation contributes to the development and progression of heart failure and atrial fibrillation. On the molecular level, these changes include alterations in the expression level and phosphorylation status of Ca
    MeSH term(s) Calcium/metabolism ; Heart ; Heart Failure/metabolism ; Humans ; Phosphoprotein Phosphatases/metabolism ; Phosphorylation ; Protein Phosphatase 1/metabolism ; Ryanodine Receptor Calcium Release Channel/genetics ; Ryanodine Receptor Calcium Release Channel/metabolism ; Sarcoplasmic Reticulum/metabolism
    Chemical Substances Ryanodine Receptor Calcium Release Channel ; Phosphoprotein Phosphatases (EC 3.1.3.16) ; Protein Phosphatase 1 (EC 3.1.3.16) ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2021-11-22
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1002702-6
    ISSN 1873-3913 ; 0898-6568
    ISSN (online) 1873-3913
    ISSN 0898-6568
    DOI 10.1016/j.cellsig.2021.110203
    Database MEDical Literature Analysis and Retrieval System OnLINE

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