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  1. Article ; Online: Magnetic iron oxide nanoparticles as drug carriers: preparation, conjugation and delivery.

    El-Boubbou, Kheireddine

    Nanomedicine (London, England)

    2018  Volume 13, Issue 8, Page(s) 929–952

    Abstract: Magnetic nanoparticles (MNPs), particularly made of iron oxides, have been extensively studied as diagnostic imaging agents and therapeutic delivery vehicles. In this review, special emphasis is set on the 'recent advancements of drug-conjugated MNPs ... ...

    Abstract Magnetic nanoparticles (MNPs), particularly made of iron oxides, have been extensively studied as diagnostic imaging agents and therapeutic delivery vehicles. In this review, special emphasis is set on the 'recent advancements of drug-conjugated MNPs used for therapeutic applications'. The most prevalent preparation methods and chemical functionalization strategies required for translational biomedical nanoformulations are outlined. Particular attention is, then, devoted to the tailored conjugation of drugs to the MNP carrier according to either noncovalent or covalent attachments, with advantages and drawbacks of both pathways conferred. Notable examples are presented to demonstrate the advantages of MNPs in respective drug-delivery applications. Understanding of the preparation, conjugation and delivery processes will definitely bring, in the next decades, a novel magneto-nanovehicle for effective theranostics.
    MeSH term(s) Drug Delivery Systems ; Ferric Compounds/chemistry ; Ferric Compounds/therapeutic use ; Humans ; Magnetite Nanoparticles/chemistry ; Magnetite Nanoparticles/therapeutic use ; Theranostic Nanomedicine
    Chemical Substances Ferric Compounds ; Magnetite Nanoparticles ; ferric oxide (1K09F3G675)
    Language English
    Publishing date 2018-03-16
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2277839-1
    ISSN 1748-6963 ; 1743-5889
    ISSN (online) 1748-6963
    ISSN 1743-5889
    DOI 10.2217/nnm-2017-0320
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  2. Article ; Online: Magnetic iron oxide nanoparticles as drug carriers: clinical relevance.

    El-Boubbou, Kheireddine

    Nanomedicine (London, England)

    2018  Volume 13, Issue 8, Page(s) 953–971

    Abstract: Significant preclinical and clinical research has explored the use of magnetic iron oxide nanoparticles (MNPs) for medical theranostics. Herein, we provide an overview of the optimal 'design-to-perform' MNPs used in cancer therapeutics, specifically ... ...

    Abstract Significant preclinical and clinical research has explored the use of magnetic iron oxide nanoparticles (MNPs) for medical theranostics. Herein, we provide an overview of the optimal 'design-to-perform' MNPs used in cancer therapeutics, specifically focusing on magnetic hyperthermia, magnetic drug targeting, and targeting delivery. An account of the progress made in the clinic using MNPs is then analyzed. We place special emphasis on past and present magnetic nanoformulations used in clinical settings or yet to be clinically approved. Regrettably, as of now, no MNP drug delivery system is employed in the clinic. Thus, identifying current limitations, misconceptions and challenges will definitely impact the clinical success of MNP delivery theranostic systems and their promising future potential in medicine.
    MeSH term(s) Drug Carriers/chemistry ; Drug Carriers/therapeutic use ; Drug Delivery Systems ; Ferric Compounds/chemistry ; Ferric Compounds/therapeutic use ; Humans ; Magnetite Nanoparticles/chemistry ; Magnetite Nanoparticles/therapeutic use ; Neoplasms/drug therapy ; Theranostic Nanomedicine
    Chemical Substances Drug Carriers ; Ferric Compounds ; Magnetite Nanoparticles ; ferric oxide (1K09F3G675)
    Language English
    Publishing date 2018-01-29
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2277839-1
    ISSN 1748-6963 ; 1743-5889
    ISSN (online) 1748-6963
    ISSN 1743-5889
    DOI 10.2217/nnm-2017-0336
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  3. Article ; Online: An easy, fast and inexpensive method of preparing a biological specimen for scanning electron microscopy (SEM)

    Nadwī, Riḍwān ʻAlī / El-Boubbou, Kheireddine / Boudjelal, Mohamed

    MethodsX. 2021, v. 8 p.101521-

    2021  

    Abstract: Biological samples usually require cumbersome preparation steps before SEM imaging. Here we propose a simple, fast and inexpensive method to prepare and visualize biological cell culture samples in a few easy steps. We have tested this method with ... ...

    Abstract Biological samples usually require cumbersome preparation steps before SEM imaging. Here we propose a simple, fast and inexpensive method to prepare and visualize biological cell culture samples in a few easy steps. We have tested this method with success on several adherent breast cancer and non-adherent leukemia cell lines. This method gives results comparable to other well-established techniques, and it can be convenient in day-to-day biological sample preparation for SEM imaging.•An easy and rapid method to visualize biological specimens under SEM.•Cells are grown on carbon tapes and gold coated.•Air drying without compromising the image quality.
    Keywords air ; breast neoplasms ; carbon ; cell culture ; electron microscopy ; gold ; neoplasm cells ; rapid methods ; Fast and Easy method of preparing biological specimen for SEM ; Scanning electron microscopy ; Cancer cells ; SEM preparation ; HDMS ; Biological samples
    Language English
    Publishing place Elsevier B.V.
    Document type Article ; Online
    ZDB-ID 2830212-6
    ISSN 2215-0161
    ISSN 2215-0161
    DOI 10.1016/j.mex.2021.101521
    Database NAL-Catalogue (AGRICOLA)

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  4. Article ; Online: Preparation and characterization of various PVPylated divalent metal-doped ferrite nanoparticles for magnetic hyperthermia.

    El-Boubbou, Kheireddine / Lemine, O M / Algessair, Saja / Madkhali, Nawal / Al-Najar, Basma / AlMatri, Enas / Ali, Rizwan / Henini, Mohamed

    RSC advances

    2024  Volume 14, Issue 22, Page(s) 15664–15679

    Abstract: There is an incessant demand to keep improving on the heating responses of polymeric magnetic nanoparticles (MNPs) under magnetic excitation, particularly in the pursuit for them to be utilized for clinical hyperthermia applications. Herein, we report ... ...

    Abstract There is an incessant demand to keep improving on the heating responses of polymeric magnetic nanoparticles (MNPs) under magnetic excitation, particularly in the pursuit for them to be utilized for clinical hyperthermia applications. Herein, we report the fabrication of a panel of PVP-capped divalent metal-doped MFe
    Language English
    Publishing date 2024-05-14
    Publishing country England
    Document type Journal Article
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/d4ra01600a
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Assessing the Heat Generation and Self-Heating Mechanism of Superparamagnetic Fe

    Lemine, O M / Algessair, Saja / Madkhali, Nawal / Al-Najar, Basma / El-Boubbou, Kheireddine

    Nanomaterials (Basel, Switzerland)

    2023  Volume 13, Issue 3

    Abstract: Magnetite nanoparticles (MNPs) exhibit favorable heating responses under magnetic excitation, which makes them particularly suited for various hyperthermia applications. Herein, we report the detailed self-heating mechanisms of MNPs prepared via ... ...

    Abstract Magnetite nanoparticles (MNPs) exhibit favorable heating responses under magnetic excitation, which makes them particularly suited for various hyperthermia applications. Herein, we report the detailed self-heating mechanisms of MNPs prepared via the
    Language English
    Publishing date 2023-01-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662255-5
    ISSN 2079-4991
    ISSN 2079-4991
    DOI 10.3390/nano13030453
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: An easy, fast and inexpensive method of preparing a biological specimen for scanning electron microscopy (SEM).

    Ali, Rizwan / El-Boubbou, Kheireddine / Boudjelal, Mohamed

    MethodsX

    2021  Volume 8, Page(s) 101521

    Abstract: Biological samples usually require cumbersome preparation steps before SEM imaging. Here we propose a simple, fast and inexpensive method to prepare and visualize biological cell culture samples in a few easy steps. We have tested this method with ... ...

    Abstract Biological samples usually require cumbersome preparation steps before SEM imaging. Here we propose a simple, fast and inexpensive method to prepare and visualize biological cell culture samples in a few easy steps. We have tested this method with success on several adherent breast cancer and non-adherent leukemia cell lines. This method gives results comparable to other well-established techniques, and it can be convenient in day-to-day biological sample preparation for SEM imaging.•An easy and rapid method to visualize biological specimens under SEM.•Cells are grown on carbon tapes and gold coated.•Air drying without compromising the image quality.
    Language English
    Publishing date 2021-09-20
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2830212-6
    ISSN 2215-0161
    ISSN 2215-0161
    DOI 10.1016/j.mex.2021.101521
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: MICaFVi: A Novel Magnetic Immuno-Capture Flow Virometry Nano-Based Diagnostic Tool for Detection of Coronaviruses.

    Samman, Nosaibah / El-Boubbou, Kheireddine / Al-Muhalhil, Khawlah / Ali, Rizwan / Alaskar, Ahmed / Alharbi, Naif Khalaf / Nehdi, Atef

    Biosensors

    2023  Volume 13, Issue 5

    Abstract: COVID-19 has resulted in a pandemic that aggravated the world's healthcare systems, economies, and education, and caused millions of global deaths. Until now, there has been no specific, reliable, and effective treatment to combat the virus and its ... ...

    Abstract COVID-19 has resulted in a pandemic that aggravated the world's healthcare systems, economies, and education, and caused millions of global deaths. Until now, there has been no specific, reliable, and effective treatment to combat the virus and its variants. The current standard tedious PCR-based tests have limitations in terms of sensitivity, specificity, turnaround time, and false negative results. Thus, an alternative, rapid, accurate, and sensitive diagnostic tool that can detect viral particles, without the need for amplification or viral replication, is central to infectious disease surveillance. Here, we report MICaFVi (
    MeSH term(s) Humans ; COVID-19/diagnosis ; SARS-CoV-2 ; Middle East Respiratory Syndrome Coronavirus ; COVID-19 Testing ; Magnetic Phenomena
    Language English
    Publishing date 2023-05-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662125-3
    ISSN 2079-6374 ; 2079-6374
    ISSN (online) 2079-6374
    ISSN 2079-6374
    DOI 10.3390/bios13050553
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Iron Oxide Mesoporous Magnetic Nanostructures with High Surface Area for Enhanced and Selective Drug Delivery to Metastatic Cancer Cells.

    El-Boubbou, Kheireddine / Ali, Rizwan / Al-Humaid, Sulaiman / Alhallaj, Alshaimaa / Lemine, O M / Boudjelal, Mohamed / AlKushi, Abdulmohsen

    Pharmaceutics

    2021  Volume 13, Issue 4

    Abstract: This work reports the fabrication of iron oxide mesoporous magnetic nanostructures (IO-MMNs) via the nano-replication method using acid-prepared mesoporous spheres (APMS) as the rigid silica host and iron (III) nitrate as the iron precursor. The obtained ...

    Abstract This work reports the fabrication of iron oxide mesoporous magnetic nanostructures (IO-MMNs) via the nano-replication method using acid-prepared mesoporous spheres (APMS) as the rigid silica host and iron (III) nitrate as the iron precursor. The obtained nanosized mesostructures were fully characterized by SEM, TEM, DLS, FTIR, XRD, VSM, and nitrogen physisorption. IO-MMNs exhibited relatively high surface areas and large pore volumes (
    Language English
    Publishing date 2021-04-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics13040553
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Glyco-nanomaterials: translating insights from the "sugar-code" to biomedical applications.

    El-Boubbou, Kheireddine / Huang, Xuefei

    Current medicinal chemistry

    2011  Volume 18, Issue 14, Page(s) 2060–2078

    Abstract: Over the past decade, diagnostics and therapeutics have changed gradually towards the use of more specific and targeted approaches. The most profound impact has been in the nanotechnology sectors, where an explosion in directing biomolecules to specific ... ...

    Abstract Over the past decade, diagnostics and therapeutics have changed gradually towards the use of more specific and targeted approaches. The most profound impact has been in the nanotechnology sectors, where an explosion in directing biomolecules to specific biomarkers has illustrated great potentials not only in detection but also in targeted therapy. Increased knowledge of the diseases at the molecular level catalyzed a shift towards identifying new biological indicators. In particular, carbohydrate-mediated molecular recognitions using nano-vehicles are likely to increasingly affect medicine opening a new area of biomedical applications. This article provides an overview of the recent progress made in recruiting the "sugar code" functionalized on various nano-platforms to decipher cellular information for both in vitro and in vivo applications. Today's glyco-technologies are enabling better detection with great therapeutic potentials. Tomorrow they are likely to bring a full understanding of the "cell-glyconanomaterial bio-conversation" where major biomedical problems will be overcome translating insights from the "glyco-nanoworld" into clinical practice.
    MeSH term(s) Animals ; Carbohydrates/chemistry ; Carbohydrates/therapeutic use ; Humans ; Magnetic Resonance Imaging/methods ; Nanomedicine/methods ; Nanostructures/chemistry ; Nanostructures/therapeutic use ; Nanotechnology/methods
    Chemical Substances Carbohydrates
    Language English
    Publishing date 2011-04-22
    Publishing country United Arab Emirates
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
    ZDB-ID 1319315-6
    ISSN 1875-533X ; 0929-8673
    ISSN (online) 1875-533X
    ISSN 0929-8673
    DOI 10.2174/092986711795656144
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4432: Show issues Location:
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  10. Article ; Online: Preparation of iron oxide mesoporous magnetic microparticles as novel multidrug carriers for synergistic anticancer therapy and deep tumor penetration.

    El-Boubbou, Kheireddine / Ali, Rizwan / Al-Zahrani, Hajar / Trivilegio, Thadeo / Alanazi, Abdullah H / Khan, Abdul Latif / Boudjelal, Mohamed / AlKushi, Abdulmohsen

    Scientific reports

    2019  Volume 9, Issue 1, Page(s) 9481

    Abstract: The preparation of mesoporous iron oxides with controllable physiochemical properties for effective therapeutic drug delivery remains a formidable challenge. Herein, iron oxide mesoporous magnetic microparticles (IO-MMMs) were prepared by a modified ... ...

    Abstract The preparation of mesoporous iron oxides with controllable physiochemical properties for effective therapeutic drug delivery remains a formidable challenge. Herein, iron oxide mesoporous magnetic microparticles (IO-MMMs) were prepared by a modified reverse hard-templating approach using, for the first time, acid-prepared mesoporous spheres (APMS) as the hard silica template. The obtained mesostructures exhibited remarkably high surface area and large pore volumes (S
    MeSH term(s) Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacokinetics ; Antineoplastic Agents/pharmacology ; Cell Line, Tumor ; Drug Carriers/chemistry ; Drug Carriers/pharmacokinetics ; Drug Carriers/pharmacology ; Humans ; Neoplasms/drug therapy ; Neoplasms/metabolism ; Neoplasms/pathology ; Porosity ; Silicon Dioxide/chemistry ; Silicon Dioxide/pharmacokinetics ; Silicon Dioxide/pharmacology
    Chemical Substances Antineoplastic Agents ; Drug Carriers ; Silicon Dioxide (7631-86-9)
    Language English
    Publishing date 2019-07-01
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-019-46007-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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