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  1. Book: Impact of genetic targets on cancer therapy

    El-Deiry, Wafik S.

    (Advances in experimental medicine and biology ; 779)

    2013  

    Author's details Wafik S. El-Deiry, ed
    Series title Advances in experimental medicine and biology ; 779
    Collection
    Keywords Cancer--Gene therapy
    Subject code 616.994042
    Language English
    Size VIII, 446 S. : Ill., 24 cm
    Publisher Springer
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT017525913
    ISBN 978-1-4614-6175-3 ; 9781461461760 ; 1-4614-6175-8 ; 1461461766
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 3192 -779- not available for loan Zeitschriften-Lesesaal

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  2. Article ; Online: Targeting Mutated p53: Naivete and Enthusiasm to Attempt the Impossible.

    El-Deiry, Wafik S

    Cancer research

    2023  Volume 83, Issue 7, Page(s) 979–982

    Abstract: Tumor suppressor TP53 is an important gene in human cancer because it is mutated in the majority of tumors, leading to loss-of-function or gain-of-function phenotypes. Mutated TP53 acts like an oncogene, driving cancer progression and causing poor ... ...

    Abstract Tumor suppressor TP53 is an important gene in human cancer because it is mutated in the majority of tumors, leading to loss-of-function or gain-of-function phenotypes. Mutated TP53 acts like an oncogene, driving cancer progression and causing poor patient outcomes. The role of mutated p53 in cancer has been known for over three decades, yet there is no FDA-approved drug to address the problem. This brief historical perspective highlights some of the insightful advances as well as challenges in therapeutic targeting of p53, especially the mutated forms. The article focuses on a functional p53 pathway restoration approach to drug discovery that years ago was not mainstream, encouraged by anyone, taught in textbooks, or embraced by medicinal chemists. With some knowledge, a clinician scientist's interest, and motivation, the author pursued a unique line of investigation leading to insights for functional bypass of TP53 mutations in human cancer. Like mutated Ras proteins, mutant p53 is fundamentally important as a therapeutic target in cancer and probably deserves a "p53 initiative" like the NCI's "Ras initiative." There is a link between naivete and enthusiasm for pursuing difficult problems, but important solutions are discovered through hard work and persistence. Hopefully, some benefit comes to patients with cancer from such drug discovery and development efforts.
    MeSH term(s) Humans ; Tumor Suppressor Protein p53/genetics ; Tumor Suppressor Protein p53/metabolism ; Neoplasms/drug therapy ; Neoplasms/genetics ; Oncogenes ; Mutation
    Chemical Substances Tumor Suppressor Protein p53
    Language English
    Publishing date 2023-04-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1432-1
    ISSN 1538-7445 ; 0008-5472
    ISSN (online) 1538-7445
    ISSN 0008-5472
    DOI 10.1158/0008-5472.CAN-22-0995
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.135/5: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Book: Death receptors in cancer therapy

    El-Deiry, Wafik S.

    (Cancer drug discovery and development)

    2005  

    Author's details ed. by Wafik S. El-Deiry
    Series title Cancer drug discovery and development
    Keywords Neoplasms / therapy ; Neoplasms / immunology ; Cell Death / immunology ; Receptors, Tumor Necrosis Factor ; Gene Therapy / methods
    Language English
    Size XI, 374 S. : Ill., graph. Darst.
    Publisher Humana Press
    Publishing place Totowa, NJ
    Publishing country United States
    Document type Book
    HBZ-ID HT013952036
    ISBN 1-58829-172-3 ; 978-1-58829-172-1
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2005 A 1961 order for loan Magazin

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  4. Book ; Conference proceedings: Tumor progression and therapeutic resistance

    El-Deiry, Wafik S.

    [result of the Conference on Tumor Progression and Therapeutic Resistance, held November 8 - 9, 2004, in Philadelphia, Pennsylvania]

    (Annals of the New York Academy of Sciences ; 1059)

    2005  

    Event/congress Conference on Tumor Progression and Therapeutic Resistance (2004, PhiladelphiaPa.)
    Author's details ed. by Wafik S. El-Deiry
    Series title Annals of the New York Academy of Sciences ; 1059
    Collection
    Keywords Cell Transformation, Neoplastic / genetics ; Disease Progression ; Drug Resistance, Neoplasm ; Genes, Tumor Suppressor ; Neoplasms, Experimental / therapy ; Signal Transduction ; Tumorwachstum ; Therapieresistenz
    Language English
    Size XI, 198 S. : Ill., graph. Darst.
    Publisher New York Acad. of Sciences
    Publishing place New York, NY
    Publishing country United States
    Document type Book ; Conference proceedings
    HBZ-ID HT014700975
    ISBN 1-57331-543-5 ; 1-57331-544-3 ; 978-1-57331-543-2 ; 978-1-57331-544-9
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Se 110 -1059- verfügbar in Königswinter Königswinter

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  5. Book: Tumor suppressor genes / 1

    El-Deiry, Wafik S.

    (Methods in molecular biology ; 222)

    2003  

    Author's details ed. by Wafik S. El-Deiry
    Series title Methods in molecular biology ; 222
    Tumor suppressor genes
    Collection Tumor suppressor genes
    Language English
    Size XIX, 504 S. : Ill., graph. Darst.
    Publisher Humana Press
    Publishing place Totowa, NJ
    Publishing country United States
    Document type Book
    HBZ-ID HT013763398
    ISBN 0-89603-986-2 ; 978-0-89603-986-5
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2003 A 3264 order for loan Magazin

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  6. Book ; Collection: Tumor suppressor genes

    El-Deiry, Wafik S.

    (Methods in molecular biology ; ...)

    2003  

    Author's details ed. by Wafik S. El-Deiry
    Series title Methods in molecular biology
    ...
    Keywords Genes, Tumor Suppressor / physiology ; Signal Transduction / physiology ; Tumor Suppressor Proteins / physiology ; Neoplasms / genetics ; Neoplasms / therapy
    Language English
    Dates of publication 2003-9999
    Publisher Humana Press
    Publishing place Totowa, NJ
    Publishing country United States
    Document type Book ; Collection (display volumes)
    HBZ-ID HT013763389
    Database Catalogue ZB MED Medicine, Health

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  7. Book: Tumor suppressor genes / 2

    El-Deiry, Wafik S.

    (Methods in molecular biology ; 223)

    2003  

    Author's details ed. by Wafik S. El-Deiry
    Series title Methods in molecular biology ; 223
    Tumor suppressor genes
    Collection Tumor suppressor genes
    Language English
    Size XIX, 657 S. : Ill., graph. Darst.
    Publisher Humana Press
    Publishing place Totowa, NJ
    Publishing country United States
    Document type Book
    HBZ-ID HT013766296
    ISBN 0-89603-987-0 ; 978-0-89603-987-2
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2003 A 3265 order for loan Magazin

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  8. Article: Editorial: Expert opinions in genitourinary oncology.

    Lagos, Galina G / El-Deiry, Wafik S / Cheng, Liang

    Frontiers in oncology

    2024  Volume 13, Page(s) 1360223

    Language English
    Publishing date 2024-01-24
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2023.1360223
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Transfected SARS-CoV-2 spike DNA for mammalian cell expression inhibits p53 activation of p21(WAF1), TRAIL Death Receptor DR5 and MDM2 proteins in cancer cells and increases cancer cell viability after chemotherapy exposure.

    Zhang, Shengliang / El-Deiry, Wafik S

    Oncotarget

    2024  Volume 15, Page(s) 275–284

    Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and COVID-19 infection has led to worsened outcomes for patients with cancer. SARS-CoV-2 spike protein mediates host cell infection and cell-cell fusion that causes stabilization of tumor ... ...

    Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and COVID-19 infection has led to worsened outcomes for patients with cancer. SARS-CoV-2 spike protein mediates host cell infection and cell-cell fusion that causes stabilization of tumor suppressor p53 protein. In-silico analysis previously suggested that SARS-CoV-2 spike interacts with p53 directly but this putative interaction has not been demonstrated in cells. We examined the interaction between SARS-CoV-2 spike, p53 and MDM2 (E3 ligase, which mediates p53 degradation) in cancer cells using an immunoprecipitation assay. We observed that SARS-CoV-2 spike protein interrupts p53-MDM2 protein interaction but did not detect SARS-CoV-2 spike bound with p53 protein in the cancer cells. We further observed that SARS-CoV-2 spike suppresses p53 transcriptional activity in cancer cells including after nutlin exposure of wild-type p53-, spike-expressing tumor cells and inhibits chemotherapy-induced p53 gene activation of p21(WAF1), TRAIL Death Receptor DR5 and MDM2. The suppressive effect of SARS-CoV-2 spike on p53-dependent gene activation provides a potential molecular mechanism by which SARS-CoV-2 infection may impact tumorigenesis, tumor progression and chemotherapy sensitivity. In fact, cisplatin-treated tumor cells expressing spike were found to have increased cell viability as compared to control cells. Further observations on γ-H2AX expression in spike-expressing cells treated with cisplatin may indicate altered DNA damage sensing in the DNA damage response pathway. The preliminary observations reported here warrant further studies to unravel the impact of SARS-CoV-2 and its various encoded proteins including spike on pathways of tumorigenesis and response to cancer therapeutics. More efforts should be directed at studying the effects of the SARS-CoV-2 spike and other viral proteins on host DNA damage sensing, response and repair mechanisms. A goal would be to understand the structural basis for maximal anti-viral immunity while minimizing suppression of host defenses including the p53 DNA damage response and tumor suppression pathway. Such directions are relevant and important including not only in the context of viral infection and mRNA vaccines in general but also for patients with cancer who may be receiving cytotoxic or other cancer treatments.
    MeSH term(s) Humans ; Proto-Oncogene Proteins c-mdm2/metabolism ; Tumor Suppressor Protein p53/metabolism ; Cyclin-Dependent Kinase Inhibitor p21/metabolism ; Spike Glycoprotein, Coronavirus/metabolism ; Spike Glycoprotein, Coronavirus/genetics ; Cell Survival/drug effects ; Receptors, TNF-Related Apoptosis-Inducing Ligand/metabolism ; Receptors, TNF-Related Apoptosis-Inducing Ligand/genetics ; SARS-CoV-2/physiology ; Cell Line, Tumor ; Neoplasms/metabolism ; Neoplasms/drug therapy ; Antineoplastic Agents/pharmacology ; Transfection ; COVID-19/virology ; COVID-19/metabolism
    Chemical Substances Proto-Oncogene Proteins c-mdm2 (EC 2.3.2.27) ; Tumor Suppressor Protein p53 ; MDM2 protein, human (EC 2.3.2.27) ; Cyclin-Dependent Kinase Inhibitor p21 ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2 ; Receptors, TNF-Related Apoptosis-Inducing Ligand ; CDKN1A protein, human ; TP53 protein, human ; TNFRSF10B protein, human ; Antineoplastic Agents
    Language English
    Publishing date 2024-05-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2560162-3
    ISSN 1949-2553 ; 1949-2553
    ISSN (online) 1949-2553
    ISSN 1949-2553
    DOI 10.18632/oncotarget.28582
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: miR-6883 downregulates HIF1α in colorectal and breast cancer cells.

    Jensen-Velez, Nicole A / Carlsen, Lindsey / El-Deiry, Wafik S

    microPublication biology

    2024  Volume 2024

    Abstract: Colorectal cancer (CRC) and breast cancer (BC) are deadly diseases that rank as the second and fourth leading causes of cancer-related deaths, respectively. We have previously shown that miR-6883 targets CDK4/6 and that palbociclib-mediated CDK4/6 ... ...

    Abstract Colorectal cancer (CRC) and breast cancer (BC) are deadly diseases that rank as the second and fourth leading causes of cancer-related deaths, respectively. We have previously shown that miR-6883 targets CDK4/6 and that palbociclib-mediated CDK4/6 inhibition destabilizes HIF1α. We hypothesize that miR-6883 downregulates HIF1α in CRC and BC cells. miR-6883 was transfected into cells under normoxia or hypoxia and western blot analysis revealed that miR-6883 downregulates CDK4/6 and HIF1α in CRC and BC cells, pointing to miR-6883 as a promising therapeutic to target hypoxic tumors or HIF1α-deregulated cancer cells. Future studies will further investigate miR-6883 as a cancer biomarker, effects on HIF-related proteins, and therapeutic uses
    Language English
    Publishing date 2024-01-26
    Publishing country United States
    Document type Journal Article
    ISSN 2578-9430
    ISSN (online) 2578-9430
    DOI 10.17912/micropub.biology.000978
    Database MEDical Literature Analysis and Retrieval System OnLINE

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