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  1. Article ; Online: Corrigendum to "Design, synthesis, and bioactivity of dihydropyrimidine derivatives as kinesin spindle protein inhibitors" [Bioorg. Med. Chem. 27 (2019) 115126].

    Tawfik, Haytham O / El-Moselhy, Tarek F / El-Din, Nabaweya S / El-Hamamsy, Mervat H

    Bioorganic & medicinal chemistry

    2020  Volume 28, Issue 19, Page(s) 115687

    Language English
    Publishing date 2020-08-18
    Publishing country England
    Document type Published Erratum
    ZDB-ID 1161284-8
    ISSN 1464-3391 ; 0968-0896
    ISSN (online) 1464-3391
    ISSN 0968-0896
    DOI 10.1016/j.bmc.2020.115687
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3815: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Corrigendum to "Design, synthesis, and bioactivity of dihydropyrimidine derivatives as kinesin spindle protein inhibitors" [Bioorg. Med. Chem. 27 (2019) 115126].

    Tawfik, Haytham O / El-Moselhy, Tarek F / El-Din, Nabaweya S / El-Hamamsy, Mervat H

    Bioorganic & medicinal chemistry

    2019  Volume 28, Issue 2, Page(s) 115255

    Language English
    Publishing date 2019-12-17
    Publishing country England
    Document type Published Erratum
    ZDB-ID 1161284-8
    ISSN 1464-3391 ; 0968-0896
    ISSN (online) 1464-3391
    ISSN 0968-0896
    DOI 10.1016/j.bmc.2019.115255
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 3815: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Design, synthesis, and bioactivity of dihydropyrimidine derivatives as kinesin spindle protein inhibitors.

    Tawfik, Haytham O / El-Moselhy, Tarek F / El-Din, Nabaweya S / El-Hamamsy, Mervat H

    Bioorganic & medicinal chemistry

    2019  Volume 27, Issue 23, Page(s) 115126

    Abstract: A series of twenty-one 3,4-dihydropyrimidine derivatives bearing the heterocyclic 1,3-benzodioxole at position 4 in addition to different substituents at positions 2, 3 and 5 were designed and synthesized as monastrol analogs. The novel synthesized ... ...

    Abstract A series of twenty-one 3,4-dihydropyrimidine derivatives bearing the heterocyclic 1,3-benzodioxole at position 4 in addition to different substituents at positions 2, 3 and 5 were designed and synthesized as monastrol analogs. The novel synthesized compounds were screened for their cytotoxic activity towards 60 cancer cell lines according to NCI (USA) protocol. Compounds 10b and 15 showed the best antitumor activity against most cell lines. Compound 15 was subsequently tested in 5-doses mode and displayed high selectivity towards CNS, prostate and leukemia subpanel with selectivity ratios of 22.30, 15.38 and 12.56, respectively at GI
    MeSH term(s) Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Cell Cycle/drug effects ; Cell Line, Tumor ; Drug Design ; Drug Screening Assays, Antitumor ; HEK293 Cells ; Humans ; Kinesin/antagonists & inhibitors ; Kinesin/metabolism ; Molecular Docking Simulation ; Neoplasms/drug therapy ; Neoplasms/metabolism ; Pyrimidines/chemistry ; Pyrimidines/pharmacology
    Chemical Substances 1,4-dihydropyrimidine ; Antineoplastic Agents ; KIF11 protein, human ; Pyrimidines ; Kinesin (EC 3.6.4.4)
    Language English
    Publishing date 2019-10-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 1161284-8
    ISSN 1464-3391 ; 0968-0896
    ISSN (online) 1464-3391
    ISSN 0968-0896
    DOI 10.1016/j.bmc.2019.115126
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 3815: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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