Article ; Online: Brij® integrated bilosomes for improving the transdermal delivery of niflumic acid for effective treatment of osteoarthritis: In vitro characterization, ex vivo permeability assessment, and in vivo study.
International journal of pharmaceutics
2023 Volume 640, Page(s) 123024
Abstract: Bilosomes are innovative vesicular carriers containing bile salt with a non-ionic surfactant. Being highly flexible, bilosomes can squeeze themselves through the skin carrying the drug to the action site and improving its skin penetration. The objective ... ...
Abstract | Bilosomes are innovative vesicular carriers containing bile salt with a non-ionic surfactant. Being highly flexible, bilosomes can squeeze themselves through the skin carrying the drug to the action site and improving its skin penetration. The objective of this research was to encapsulate niflumic acid (NA), a non-steroidal anti-inflammatory drug into Brij® integrated bilosomes (BIBs) for effective treatment of osteoarthritis through transdermal delivery. BIBs were formulated using 100 mg of Span 20 with different amounts of sodium cholate (NaC), sodium taurocholate (NaTC), or sodium glycocholate (NaGC) as bile salt, with the addition of 5 mg of Brij-93 or Brij-35. BIBs were prepared utilizing ethanol injection method with the application of (3 |
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MeSH term(s) | Rats ; Animals ; Niflumic Acid/pharmacology ; Liposomes/pharmacology ; Administration, Cutaneous ; Skin ; Bile Acids and Salts ; Permeability ; Particle Size ; Drug Delivery Systems |
Chemical Substances | Niflumic Acid (4U5MP5IUD8) ; Liposomes ; Bile Acids and Salts |
Language | English |
Publishing date | 2023-05-06 |
Publishing country | Netherlands |
Document type | Journal Article |
ZDB-ID | 428962-6 |
ISSN | 1873-3476 ; 0378-5173 |
ISSN (online) | 1873-3476 |
ISSN | 0378-5173 |
DOI | 10.1016/j.ijpharm.2023.123024 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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