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Article ; Online: Pumpkin seeds (Cucurbita pepo subsp. ovifera) decoction promotes Trichinella spiralis expulsion during intestinal phase via "Weep and Sweep" mechanism.

Saleh, Aml S / El-Newary, Samah A / Mohamed, Walaa A / Elgamal, Abdelbaset M / Farah, Mona A

2024 Volume 14, Issue 1, Page(s) 1548

Abstract: Trichinosis is a zoonotic disease of communal health concern as it instigated human outbreaks in several countries. Besides, the development of resistance, traditional therapy has numerous antagonistic effects. Thereby, finding efficient natural ... ...

Abstract	Trichinosis is a zoonotic disease of communal health concern as it instigated human outbreaks in several countries. Besides, the development of resistance, traditional therapy has numerous antagonistic effects. Thereby, finding efficient natural alternatives is required. In comparison to albendazole, this study evaluated the impact of pumpkin decoction on Trichinella spiralis in experimentally infected mice. The anthelmintic action of pumpkin decoction (500 mg/kg) was determined using T. spiralis infected mice in enteric phase for 5 days. Pumpkin decoction anthelmintic activity fortified by mixing with honey (1:1). Pumpkin decoction and Pumpkin decoction-honey mixture were evaluated by comprising with reference drug, albendazole (50 mg/kg). The T. spiralis adult count was significantly lower in all treated groups, with the pumpkin decoction-honey mixture showing the largest reduction (83.2%) when compared to the infected group (P ≤ 0.001). The intestinal histological changes and the level of COX-2 expression in the intestinal tissue were both significantly reduced in the same group. The pumpkin decoction improved the immune response, as evidenced by a significant decrease in nitric oxide (NO) and tumor necrosis factor (TNF-α) and a significant increase in the expression of the transforming growth factor (TGF-1β) and interleukin-17 (IL-17). The pumpkin decoction's anthelmintic action was facilitated by the TGF-1β and IL-17-driven Weep and Sweep mechanism. Both administration of pumpkin decoction beside honey showed the best treatment group that resulted in high infection reduction besides amelioration of biochemical markers and restoration of histological to normal state. In conclusion, pumpkin decoction is highly effective against T. spiralis which could be a promising alternative herbal drug and the pumpkin decoction effect was higher in the case of combination with honey.
MeSH term(s)	Mice ; Humans ; Animals ; Trichinella spiralis ; Albendazole/therapeutic use ; Cucurbita ; Interleukin-17 ; Anthelmintics/pharmacology ; Anthelmintics/therapeutic use ; Tumor Necrosis Factor-alpha
Chemical Substances	Albendazole (F4216019LN) ; Interleukin-17 ; Anthelmintics ; Tumor Necrosis Factor-alpha
Language	English
Publishing date	2024-01-18
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-51616-4
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Article ; Online: Acidic Exo-Polysaccharide Obtained from Bacillus sp. NRC5 Attenuates Testosterone-DMBA-Induced Prostate Cancer in Rats via Inhibition of 5 α-Reductase and Na+/K+ ATPase Activity Mechanisms

Ibrahim, Abeer Y. / Mahmoud, Manal G. / Asker, Mohsen S. / Youness, Eman R. / El-Newary, Samah A.

Curr Microbiol. 2023 Jan., v. 80, no. 1 p.8-8

2023

Abstract: Bacillus sp. NRC5 is a new strain that grows in Egyptian beaches. This strain produces acidic exo-polysaccharide that have excellent antioxidant, anti-inflammatory and anti-tumor properties. The current study aimed to introduce a new natural product ... ...

Abstract	Bacillus sp. NRC5 is a new strain that grows in Egyptian beaches. This strain produces acidic exo-polysaccharide that have excellent antioxidant, anti-inflammatory and anti-tumor properties. The current study aimed to introduce a new natural product feasible for prostate cancer therapies. The anti-prostate cancer of acidic exo-polysaccharide produced from marine Bacillus sp. NRC5 (EBPS) was determined using 7,12-dimethylbenz-(a)-anthracene; DMBA-induced prostate cancer in male Sprague Dawley rats. Rats were subcutaneously injected with testosterone (3 mg/kg/day for 3 months) and a single dose of DMBA (65 mg/kg) for induction of prostate cancer. EBPS was administrated orally at dose 200 mg/kg/day for 3 months. To study protective effect of EBPS, animals received EBPS before cancer induction, meanwhile in therapeutic effect animals received EBPS after cancer induction. EBPS debug oxidative stress and inflammatory conditions associated with prostate cancer. EBPS either protective or therapeutic material considerably reduced cancer growth rate-limiting enzyme—i.e., 5-α-reductase (46.89 ± 1.72 and 44.86 ± 2.56 µg Eq/mL) and Na⁺/K⁺ ATPase (0.44 ± 0.03 and 0.42 ± 0.02 µg Eq/mL), compared to cancer control (69.68 ± 3.46 µg Eq/mL). In addition, both cancer biomarkers—i.e., prostate-specific antigen and carcinoembryonic antigen were significantly lowered as evidence of the ability of EBPS to protect and treat prostate cancer in chemically induced rats. EBPS showed protective and therapeutic efficacy on testosterone–DMBA-induced prostate cancer rats with a good safety margin. This study may go to clinical trials after a repeated study on another type of small experimental animal, their offspring, and one big experimental animal.
Keywords	Bacillus (bacteria) ; adenosinetriphosphatase ; antigens ; antioxidants ; exopolysaccharides ; laboratory animals ; males ; oxidative stress ; progeny ; prostate-specific antigen ; prostatic neoplasms ; protective effect ; sodium-potassium-exchanging ATPase ; testosterone ; therapeutics
Language	English
Dates of publication	2023-01
Size	p. 8.
Publishing place	Springer US
Document type	Article ; Online
ZDB-ID	134238-1
ISSN	1432-0991 ; 0343-8651
ISSN (online)	1432-0991
ISSN	0343-8651
DOI	10.1007/s00284-022-03098-8
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Article ; Online: Acidic Exo-Polysaccharide Obtained from Bacillus sp. NRC5 Attenuates Testosterone-DMBA-Induced Prostate Cancer in Rats via Inhibition of 5 α-Reductase and Na

Ibrahim, Abeer Y / Mahmoud, Manal G / Asker, Mohsen S / Youness, Eman R / El-Newary, Samah A

Current microbiology

2022 Volume 80, Issue 1, Page(s) 8

Abstract	Bacillus sp. NRC5 is a new strain that grows in Egyptian beaches. This strain produces acidic exo-polysaccharide that have excellent antioxidant, anti-inflammatory and anti-tumor properties. The current study aimed to introduce a new natural product feasible for prostate cancer therapies. The anti-prostate cancer of acidic exo-polysaccharide produced from marine Bacillus sp. NRC5 (EBPS) was determined using 7,12-dimethylbenz-(a)-anthracene; DMBA-induced prostate cancer in male Sprague Dawley rats. Rats were subcutaneously injected with testosterone (3 mg/kg/day for 3 months) and a single dose of DMBA (65 mg/kg) for induction of prostate cancer. EBPS was administrated orally at dose 200 mg/kg/day for 3 months. To study protective effect of EBPS, animals received EBPS before cancer induction, meanwhile in therapeutic effect animals received EBPS after cancer induction. EBPS debug oxidative stress and inflammatory conditions associated with prostate cancer. EBPS either protective or therapeutic material considerably reduced cancer growth rate-limiting enzyme-i.e., 5-α-reductase (46.89 ± 1.72 and 44.86 ± 2.56 µg Eq/mL) and Na
MeSH term(s)	Animals ; Male ; Rats ; Bacillus ; Cholestenone 5 alpha-Reductase/metabolism ; Ions ; Rats, Sprague-Dawley ; Testosterone/adverse effects ; Polysaccharides, Bacterial/pharmacology ; Prostatic Neoplasms/chemically induced ; Prostatic Neoplasms/therapy ; Sodium-Potassium-Exchanging ATPase/metabolism
Chemical Substances	Cholestenone 5 alpha-Reductase (EC 1.3.1.22) ; Ions ; Testosterone (3XMK78S47O) ; exopolysaccharide, Bacillus ; Polysaccharides, Bacterial ; Sodium-Potassium-Exchanging ATPase (EC 7.2.2.13)
Language	English
Publishing date	2022-11-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	134238-1
ISSN	1432-0991 ; 0343-8651
ISSN (online)	1432-0991
ISSN	0343-8651
DOI	10.1007/s00284-022-03098-8
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Article ; Online: Characterization and in-vitro Alzheimer's properties of exopolysaccharide from Bacillus maritimus MSM1.

Selim, Manal S / Mohamed, Sahar S / Asker, Mohsen S / Ibrahim, Abeer Y / El-Newary, Samah A / El Awady, Mohamed E

Scientific reports

2023 Volume 13, Issue 1, Page(s) 11399

Abstract: Four bacterial isolates were obtained from marine sediments collected from Sahl Hashish, Hurghada Red Sea, Egypt. This study was designed to search for promising anti-Alzheimer natural polysaccharide; therefore, four isolates were screened for ... ...

Abstract	Four bacterial isolates were obtained from marine sediments collected from Sahl Hashish, Hurghada Red Sea, Egypt. This study was designed to search for promising anti-Alzheimer natural polysaccharide; therefore, four isolates were screened for exopolysaccharides (EPSs) production and acetylcholinesterase inhibition. The isolate S16 provided the highest EPS yield (7.51 g/L) and acetylcholinesterase inhibition. It was identified morphologically and genetically using 16S rRNA gene sequence analysis as Bacillus maritimus. A Physicochemical analysis of S16 exopolysaccharide (BMEPS) was estimated, which pointed to the presence of uronic acid and sulfate (24.7% and 18.3%, respectively). HPLC analysis indicated that mannuronic acid, glucuronic acid, glucose, and mannose are presented in a molar ratio of 0.8:1.0:2.8:2.3, respectively. Furthermore, FT-IR revealed an abundance of β-configurations. The GPC estimated the average molecular weight (Mw) as 4.31 × 10
MeSH term(s)	Acetylcholinesterase ; RNA, Ribosomal, 16S/genetics ; Spectroscopy, Fourier Transform Infrared ; Bacillus ; Antioxidants/chemistry ; Cholinesterase Inhibitors/chemistry
Chemical Substances	Acetylcholinesterase (EC 3.1.1.7) ; RNA, Ribosomal, 16S ; Antioxidants ; Cholinesterase Inhibitors
Language	English
Publishing date	2023-07-14
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-38172-z
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Article ; Online: Chenopodium murale

El-Newary, Samah A / Abd Elkarim, Asmaa S / Abdelwahed, Nayera A M / Omer, Elsayed A / Elgamal, Abdelbaset M / ELsayed, Wael M

Molecules (Basel, Switzerland)

2023 Volume 28, Issue 11

Abstract: Chenopodium ... ...

Abstract	Chenopodium murale
MeSH term(s)	Rats ; Animals ; Candidiasis, Oral/drug therapy ; Candidiasis, Oral/microbiology ; Antifungal Agents/therapeutic use ; Interleukin-17 ; Candida albicans ; Chromatography, Liquid ; Hydrogen Peroxide/pharmacology ; Interleukin-2/pharmacology ; Tandem Mass Spectrometry ; Candidiasis/drug therapy ; Candida ; Chenopodium
Chemical Substances	Antifungal Agents ; Interleukin-17 ; Hydrogen Peroxide (BBX060AN9V) ; Interleukin-2
Language	English
Publishing date	2023-05-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules28114304
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Article ; Online: Production, structural and biochemical characterization relevant to antitumor property of acidic exopolysaccharide produced from Bacillus sp. NRC5.

Mohamed, Sahar S / Ibrahim, Abeer Y / Asker, Mohsen S / Mahmoud, Manal G / El-Newary, Samah A

Archives of microbiology

2021 Volume 203, Issue 7, Page(s) 4337–4350

Abstract: This study targeted the production of exopolysaccharide from Bacillus sp. NRC5 grown in Egyptian seawater to use it as natural antitumor therapy. The biological activities of selected exopolysaccharide (BEPS) as an antioxidant, anti-inflammatory and ... ...

Abstract	This study targeted the production of exopolysaccharide from Bacillus sp. NRC5 grown in Egyptian seawater to use it as natural antitumor therapy. The biological activities of selected exopolysaccharide (BEPS) as an antioxidant, anti-inflammatory and anticancer have been studied. BEPS was evaluated as an anti-inflammatory in vitro against cyclooxygenase (COX-1 and COX-2) and evaluated as an anticancer on human breast and prostate cancer cell lines (MCF-7 and PC3). In addition, BEPS antitumor activity was tested against the Ehrlich Ascites Carcinoma (EAC) model. The BEPS presented potent antioxidant activities, consisted of glucose, mannose, and mannuronic acid in a molar ratio of 1.0:1.7:0.8 with a molecular weight of 3.59 × 10
MeSH term(s)	Animals ; Antineoplastic Agents/pharmacology ; Antioxidants/pharmacology ; Bacillus/chemistry ; Bacillus/metabolism ; Cell Differentiation/drug effects ; Cell Line, Tumor ; Humans ; Longevity/drug effects ; Mice ; Polysaccharides, Bacterial/biosynthesis ; Polysaccharides, Bacterial/chemistry ; Polysaccharides, Bacterial/pharmacology
Chemical Substances	Antineoplastic Agents ; Antioxidants ; Polysaccharides, Bacterial ; exopolysaccharide, Bacillus
Language	English
Publishing date	2021-06-10
Publishing country	Germany
Document type	Journal Article
ZDB-ID	124824-8
ISSN	1432-072X ; 0302-8933
ISSN (online)	1432-072X
ISSN	0302-8933
DOI	10.1007/s00203-021-02422-3
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Zs.A 805: Show issues

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Article ; Online: Sperm quality and testicular histopathology of Wistar albino male rats treated with hydroethanolic extract of

El-Newary, Samah A / Aly, Mohamed S / Hameed, Amal R Abd El / Kotp, Mohamed S / Youssef, Abdelghany A / Ali, Naglaa A

Pharmaceutical biology

2022 Volume 60, Issue 1, Page(s) 282–293

Abstract: Context: Cordia dichotoma: Objective: This study investigates the effect of : Materials and methods: 120 Wistar albino male rats were divided into four groups (: Results: After day 56, extract at 500 mg/kg significantly reduced sperm total ... ...

Abstract	Context: Cordia dichotoma Objective: This study investigates the effect of Materials and methods: 120 Wistar albino male rats were divided into four groups ( Results: After day 56, extract at 500 mg/kg significantly reduced sperm total count, motility%, and alive%, to 47.60 ± 2.27 × 10 Conclusions: Cordia
MeSH term(s)	Animals ; Anticholesteremic Agents/administration & dosage ; Anticholesteremic Agents/isolation & purification ; Anticholesteremic Agents/toxicity ; Cordia/chemistry ; Dose-Response Relationship, Drug ; Follicle Stimulating Hormone/metabolism ; Fruit ; Luteinizing Hormone/metabolism ; Male ; Plant Extracts/administration & dosage ; Plant Extracts/toxicity ; Rats ; Rats, Wistar ; Spermatozoa/drug effects ; Testis/drug effects ; Testis/pathology ; Testosterone/metabolism
Chemical Substances	Anticholesteremic Agents ; Plant Extracts ; Testosterone (3XMK78S47O) ; Luteinizing Hormone (9002-67-9) ; Follicle Stimulating Hormone (9002-68-0)
Language	English
Publishing date	2022-02-09
Publishing country	England
Document type	Journal Article
ZDB-ID	1440131-9
ISSN	1744-5116 ; 1388-0209
ISSN (online)	1744-5116
ISSN	1388-0209
DOI	10.1080/13880209.2021.2008455
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Article: Production, structural and biochemical characterization relevant to antitumor property of acidic exopolysaccharide produced from Bacillus sp. NRC5

Mohamed, Sahar S. / Ibrahim, Abeer Y. / Asker, Mohsen S. / Mahmoud, Manal G. / El-Newary, Samah A.

Archives of microbiology. 2021 Sept., v. 203, no. 7

2021

Abstract	This study targeted the production of exopolysaccharide from Bacillus sp. NRC5 grown in Egyptian seawater to use it as natural antitumor therapy. The biological activities of selected exopolysaccharide (BEPS) as an antioxidant, anti-inflammatory and anticancer have been studied. BEPS was evaluated as an anti-inflammatory in vitro against cyclooxygenase (COX-1 and COX-2) and evaluated as an anticancer on human breast and prostate cancer cell lines (MCF-7 and PC3). In addition, BEPS antitumor activity was tested against the Ehrlich Ascites Carcinoma (EAC) model. The BEPS presented potent antioxidant activities, consisted of glucose, mannose, and mannuronic acid in a molar ratio of 1.0:1.7:0.8 with a molecular weight of 3.59 × 10⁵ g/mol. BEPS showed a promising COX-2 inhibitory effect in comparison with the reference drug celecoxib. BEPS appeared efficient anticancer property, where it killed 64.20 and 70.20% of MCF-7 and PC3 cells at 100 µg/ml, respectively (IC₅₀, 76.70, and 70.40 µg/ml, respectively). BEPS exhibited antitumor ability as it prolonged the lifespan of mice to reach 75 days instead of 20 days in the tumor control, reduced viable cancer cells count, tumor volume and weight, modulated blood components, and white blood cells differentiation. BEPS produced from Bacillus sp. NRC5 showed its antioxidant and anti-inflammatory abilities and antitumor abilities, which may all be attributed to its unique composition containing sulfated moieties and uronic acids.
Keywords	Bacillus (bacteria) ; antineoplastic activity ; antioxidants ; ascites ; breasts ; cancer therapy ; carcinoma ; drugs ; exopolysaccharides ; glucose ; humans ; longevity ; mannose ; microbiology ; models ; molecular weight ; neoplasm cells ; prostaglandin synthase ; prostatic neoplasms ; seawater
Language	English
Dates of publication	2021-09
Size	p. 4337-4350.
Publishing place	Springer Berlin Heidelberg
Document type	Article
ZDB-ID	124824-8
ISSN	1432-072X ; 0302-8933
ISSN (online)	1432-072X
ISSN	0302-8933
DOI	10.1007/s00203-021-02422-3
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Article: Vitex agnus-castus L. (Chasteberry) extracts shows in vitro and in vivo anti-inflammatory and anti-tumor propensities via reduction of cyclooxygenase-2 activity and oxidative stress complications

Ibrahim, Faten M / Ibrahim, Abeer Y / El-Newary, Samah A / Hendawy, Saber F / Mahomoodally, Mohamad F

SAAB South African journal of botany. 2021 Feb. 04,

2021

Abstract: Vitex agnus-castus, is a famous botanical remedy and a nutritional supplement to manage a panoply of human ailments. The impact of V. agnus-castus fruits aqueous-alcoholic crude extract and its fractions were evaluated for possible in vitro antioxidant, ... ...

Abstract	Vitex agnus-castus, is a famous botanical remedy and a nutritional supplement to manage a panoply of human ailments. The impact of V. agnus-castus fruits aqueous-alcoholic crude extract and its fractions were evaluated for possible in vitro antioxidant, anti-inflammatory, and in vivo antitumor efficacy. The inhibitory action of the tested extract and fractions on cyclooxygenase enzymes (COX-1&2) were assessed. In addition, scavenging ability on different radicals and molecule were evaluated together with the chelating character, lipid peroxide inhibitory action and reducing power. The efficient fraction was then evaluated for possible anti-tumor agent in immunomodulatory model (Ehrlich Ascites Carcinoma). The aqueous-alcoholic extract and ethyl acetate fractions significantly (p<0.05) and selectively suppressed COX-2 (IC₅₀=100 and 110 µg/ml, respectively). The crude extract and its fractions showed promising radical scavenging properties. The two crude vitex extracts significantly reduced the viable Ehrlich cell count and increased non-viable cells also improved the hematological indicators. These ameliorations were obvious from the increasing median survival time and a marked increase in life span. It is argued that the anti-tumor activity of vitex fruits crude extract may be qualified to its anti-inflammatory activity against COX-2, which leads to a reduction in prostaglandin production. Overall, these anti-tumor results for vitex crude aqueous-alcoholic extract can be justified on the antioxidant/anti-inflammatory properties. This study tend to show that vitex extract/fractions possess anti-inflammatory, antioxidant propensities and cyclooxygenase inhibitory properties which could justify the promising antitumor properties and be further studied in the development of biomedicine.
Keywords	Vitex agnus-castus ; anti-inflammatory activity ; antineoplastic activity ; antineoplastic agents ; ascites ; carcinoma ; ethyl acetate ; humans ; lipid peroxides ; longevity ; medicine ; models ; oxidative stress ; prostaglandin synthase ; prostaglandins
Language	English
Dates of publication	2021-0204
Publishing place	Elsevier B.V.
Document type	Article
Note	NAL-AP-2-clean ; Pre-press version
ZDB-ID	2126918-X
ISSN	0254-6299
ISSN	0254-6299
DOI	10.1016/j.sajb.2021.02.001
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Article ; Online: Sperm quality and testicular histopathology of Wistar albino male rats treated with hydroethanolic extract of Cordia dichotoma fruits

El-Newary, Samah A. / Aly, Mohamed S. / Hameed, Amal R. Abd El / Kotp, Mohamed S. / Youssef, Abdelghany A. / Ali, Naglaa A.

Pharmaceutical Biology. 2022 Dec. 31, v. 60, no. 1 p.282-293

2022

Abstract: Cordia dichotoma Forst. (Boraginaceae) has potent pharmacological impact. Meanwhile, its effect on fertility is unclear. This study investigates the effect of Cordia fresh fruits hydroethanolic extract on fertility. 120 Wistar albino male rats were ... ...

Abstract	Cordia dichotoma Forst. (Boraginaceae) has potent pharmacological impact. Meanwhile, its effect on fertility is unclear. This study investigates the effect of Cordia fresh fruits hydroethanolic extract on fertility. 120 Wistar albino male rats were divided into four groups (n = 30). The first group was negative control, and the second, third, and fourth groups received 125, 250, and 500 mg extract/kg bodyweight for 56 days. After 56 days, Cordia force-feeding stopped, and all groups were kept under laboratory conditions for another month to study the recovering effect. After day 56, extract at 500 mg/kg significantly reduced sperm total count, motility%, and alive%, to 47.60 ± 2.27 × 10⁶ sperm/mL, 43.33% ± 1.49, and 63.67% ± 1.19, respectively, abnormalities% increased considerably (26.67% ± 0.54), compared to the negative control. Also, significant depletion on follicle-stimulating hormone (2.66 ± 0.21 mIU/L), luteinizing hormone (1.07 ± 0.06 mIU/L), and testosterone (2.69 ± 0.13 nmol/L) level was recorded, compared to the negative control. Cordia negative effect showed on histopathological studies of testes, prostate, and seminal vesicles. Fortunately, these adverse effects of Cordia recovered remarkably after stopping administration for one month. Cordia antifertility effect may be due to its hypocholesterolemic effect, where cholesterol, the steroid cycle precursor, was significantly reduced. This study can be incorporated in clinical research after being repeated on another small experimental animal, their offspring, and one large experimental animal, then going to a clinical study that we plan to do in the future.
Keywords	Cordia dichotoma ; albino ; antifertility effect ; biomedical research ; body weight ; cholesteremic effect ; cholesterol ; follicle-stimulating hormone ; histopathology ; laboratory animals ; luteinizing hormone ; males ; progeny ; sperm quality ; testes ; testosterone ; Seminal quality ; FSH and LH production ; histopathological studies
Language	English
Dates of publication	2022-1231
Size	p. 282-293.
Publishing place	Taylor & Francis
Document type	Article ; Online
ZDB-ID	1440131-9
ISSN	1744-5116 ; 1388-0209
ISSN (online)	1744-5116
ISSN	1388-0209
DOI	10.1080/13880209.2021.2008455
Database	NAL-Catalogue (AGRICOLA)

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