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Article ; Online: Supplementing broiler diets with bacterial selenium nanoparticles enhancing performance, carcass traits, blood indices, antioxidant status, and caecal microbiota of Eimeria tenella-infected broiler chickens.

Alsulami, Muslimah N / El-Saadony, Mohamed T

2023 Volume 102, Issue 12, Page(s) 103111

Abstract: Nanomedicine is a critical therapeutic approach for treating most poultry illnesses, particularly parasitic infections. Coccidiosis is a severe protozoan infection affecting poultry; the emergence of drug-resistant Eimeria strains demands the development ...

Abstract	Nanomedicine is a critical therapeutic approach for treating most poultry illnesses, particularly parasitic infections. Coccidiosis is a severe protozoan infection affecting poultry; the emergence of drug-resistant Eimeria strains demands the development of new, safe therapies. Consequently, the objective of this work was to investigate the efficacy of the biosynthesized selenium nanoparticles (SeNPs) by Paenibacillus polymyxa (P. polymyxa) against Eimeria tenella (E. tenella) experimental infection in broiler chickens. The prepared SeNPs absorbed the UV at 270 nm were spherical with a size of 26 nm, and had a surface negative charge of -25 mV. One hundred and fifty, 1-day-old male broiler chicks were randomly allocated into 5 groups (30 birds/group with triplicates each) as follows: T1: negative control (noninfected and nontreated with SeNPs); T2: delivered SeNPs (500 µg/kg diet) for 35 successive days, T3: E. tenella-infected (positive control birds), T4: E. tenella-infected and treated with SeNPs (500 µg/kg diet) and T5: E. tenella-infected chicks and treated with anticoccidial agent (sulfadimidine, 16% solution 8 mL/L of drinking water) for 5 successive days. At 14 d of age, each bird in infected groups was orally treated with 3 × 10
MeSH term(s)	Animals ; Male ; Eimeria tenella ; Chickens ; Antioxidants ; Selenium ; Coccidiosis/parasitology ; Coccidiosis/veterinary ; Diet/veterinary ; Eimeria ; Cecum ; Poultry Diseases/drug therapy ; Poultry Diseases/parasitology ; Oocysts
Chemical Substances	Antioxidants ; Selenium (H6241UJ22B)
Language	English
Publishing date	2023-09-14
Publishing country	England
Document type	Randomized Controlled Trial, Veterinary ; Journal Article
ZDB-ID	242586-5
ISSN	1525-3171 ; 0032-5791
ISSN (online)	1525-3171
ISSN	0032-5791
DOI	10.1016/j.psj.2023.103111
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Article: Revealing the association between vitamin D metabolic pathway gene variants and lung cancer risk: a systematic review and meta-analysis.

Elsalahaty, Mohamed I / Alkafaas, Samar Sami / Bashir, Aya O / El-Tarabily, Khaled A / El-Saadony, Mohamed T / Yousef, Eman H

Frontiers in genetics

2024 Volume 15, Page(s) 1302527

Abstract: Lung cancer is a crucial global issue, with more than one million deaths annually. While smoking is considered the main etiology of the disease, several genetic variants are associated with it. Alterations in vitamin D pathway genes have also been ... ...

Abstract	Lung cancer is a crucial global issue, with more than one million deaths annually. While smoking is considered the main etiology of the disease, several genetic variants are associated with it. Alterations in vitamin D pathway genes have also been studied in regards to lung cancer, but the findings have been inconclusive. We here present a systematic review and meta-analysis of seven genes in this pathway:
Language	English
Publishing date	2024-02-28
Publishing country	Switzerland
Document type	Systematic Review
ZDB-ID	2606823-0
ISSN	1664-8021
ISSN	1664-8021
DOI	10.3389/fgene.2024.1302527
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Article ; Online: Exploiting the role of plant growth promoting rhizobacteria in reducing heavy metal toxicity of pepper (Capsicum annuum L.).

El-Saadony, Mohamed T / Desoky, El-Sayed M / El-Tarabily, Khaled A / AbuQamar, Synan F / Saad, Ahmed M

Environmental science and pollution research international

2024 Volume 31, Issue 18, Page(s) 27465–27484

Abstract: Microorganisms are cost-effective and eco-friendly alternative methods for removing heavy metals (HM) from contaminated agricultural soils. Therefore, this study aims to identify and characterize HM-tolerant (HMT) plant growth-promoting rhizobacteria ( ... ...

Abstract	Microorganisms are cost-effective and eco-friendly alternative methods for removing heavy metals (HM) from contaminated agricultural soils. Therefore, this study aims to identify and characterize HM-tolerant (HMT) plant growth-promoting rhizobacteria (PGPR) isolated from industry-contaminated soils to determine their impact as bioremediators on HM-stressed pepper plants. Four isolates [Pseudomonas azotoformans (Pa), Serratia rubidaea (Sr), Paenibacillus pabuli (Pp) and Bacillus velezensis (Bv)] were identified based on their remarkable levels of HM tolerance in vitro. Field studies were conducted to evaluate the growth promotion and tolerance to HM toxicity of pepper plants grown in HM-polluted soils. Plants exposed to HM stress showed improved growth, physio-biochemistry, and antioxidant defense system components when treated with any of the individual isolates, in contrast to the control group that did not receive PGPR. The combined treatment of the tested HMT PGPR was, however, relatively superior to other treatments. Compared to no or single PGPR treatment, the consortia (Pa+Sr+Pp+Bv) increased the photosynthetic pigment contents, relative water content, and membrane stability index but lowered the electrolyte leakage and contents of malondialdehyde and hydrogen peroxide by suppressing the (non) enzymatic antioxidants in plant tissues. In pepper, Cd, Cu, Pb, and Ni contents decreased by 88.0-88.5, 63.8-66.5, 66.2-67.0, and 90.2-90.9% in leaves, and 87.2-88.1, 69.4-70.0%, 80.0-81.3, and 92.3%% in fruits, respectively. Thus, these PGPR are highly effective at immobilizing HM and reducing translocation in planta. These findings indicate that the application of HMT PGPR could be a promising "bioremediation" strategy to enhance growth and productivity of crops cultivated in soils contaminated with HM for sustainable agricultural practices.
MeSH term(s)	Capsicum/microbiology ; Metals, Heavy/toxicity ; Soil Pollutants/toxicity ; Biodegradation, Environmental ; Bacillus ; Soil Microbiology
Chemical Substances	Metals, Heavy ; Soil Pollutants
Language	English
Publishing date	2024-03-21
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-024-32874-1
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Article ; Online: Paenibacillus polymyxa (LM31) as a new feed additive: Antioxidant and antimicrobial activity and its effects on growth, blood biochemistry, and intestinal bacterial populations of growing Japanese quail

Alagawany, Mahmoud / Madkour, Mahmoud / El-Saadony, Mohamed T. / Reda, Fayiz M.

Animal Feed Science and Technology. 2021 June, v. 276 p.114920-

2021

Abstract: This study investigated the effect of Paenibacillus polymyxa LM31 supplementation on growth performance, antioxidative status, immune response, cecal microbiota, and biochemical parameters of growing Japanese quail. Identification of Paenibacillus ... ...

Abstract	This study investigated the effect of Paenibacillus polymyxa LM31 supplementation on growth performance, antioxidative status, immune response, cecal microbiota, and biochemical parameters of growing Japanese quail. Identification of Paenibacillus polymyxa was identified and the volatile organic compounds and antibacterial activity of selected isolate supernatant were determined. A total of 225 unsexed one-wk-old Japanese quail chicks were randomly allocated to 5 treatments (5 pens, 9 birds/pen) and fed either a basal diet as a control group or a basal diet supplemented with four different levels of Paenibacillus polymyxa 0.1, 0.2, 0.3 and 0.4 mg / kg feed. The results of the GC mass profile revealed that several organic compounds were secreted by Paenibacillus polymyxa in the supernatant. The diet supplemented with Paenibacillus polymyxa supernatant showed potent antibacterial properties against gram negative and gram positive bacteria as well as fungi. Paenibacillus polymyxa significantly improved the growth performance of growing quails. Paenibacillus polymyxa administration up to 0.4 mg/kg diet significantly reduced plasma total cholesterol (TC), low density lipoprotein (LDL), very low density lipoprotein (VLDL), and triglycerides (TG). The use of Paenibacillus polymyxa at 0.3 or 0.4 mg/kg diet significantly (P = 0.0042) increased high density lipoprotein (HDL) compared to the control. In addition, dietary supplementation of 0.3 mg Paenibacillus polymyxa /kg diet significantly improved superoxide dismutase (SOD), total antioxidant capacity (TAC), immunoglobulin M (IgM) and Immunoglobulin G (IgG) whereas significantly reduced plasma lipid peroxidation (MDA). Furthermore, Paenibacillus polymyxa administration modulated ceacal microbiota by significantly reducing the count of E. coli and Enterococcus spp. whereas increased lactic acid bacteria. In conclusion, Paenibacillus polymyxa could improve productive performance and body health status of Japanese quail via improving antioxidative status and immune response, increasing the count of beneficial bacteria and reducing E. coli count.
Keywords	Coturnix japonica ; Enterococcus ; Escherichia coli ; Paenibacillus polymyxa ; antibacterial properties ; antioxidant activity ; antioxidants ; blood lipids ; cholesterol ; dietary supplements ; feed additives ; feeds ; growth performance ; health status ; high density lipoprotein ; immune response ; immunoglobulin G ; intestinal microorganisms ; intestines ; lactic acid ; lipid peroxidation ; low density lipoprotein ; superoxide dismutase ; technology ; very low density lipoprotein ; volatile organic compounds ; TC ; LDL ; VLDL ; TG ; HDL ; SOD ; TAC ; IgM ; IgG ; MDA ; TBC ; TYMC ; VOCs ; FCR ; ALB ; TP ; GLO ; AST ; ALT ; CAT ; AMP ; Performance ; Blood biochemistry ; Intestinal microbiota ; Quail
Language	English
Dates of publication	2021-06
Publishing place	Elsevier B.V.
Document type	Article ; Online
ZDB-ID	196563-3
ISSN	0377-8401
ISSN	0377-8401
DOI	10.1016/j.anifeedsci.2021.114920
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Molecular detection of highly pathogenic avian influenza H5N8 in commercial broiler chicken farms from 2019 to 2022 [Corrigendum: June 2023, 102(6), p. 102777]

Setta, Ahmed / Yehia, Nahed / Shakak, Amani Osman / Al-Quwaie, Diana A. / Al-Otaibi, Aljohara M. / El-Saadony, Mohamed T. / El-Tarabily, Khaled A. / Salem, Heba

Poultry Science. 2023 June, v. 102, no. 6, p. 102639

2023 , Page(s) 102639

Abstract: Highly pathogenic avian influenza (HPAI) is a serious viral infection that causes massive economic losses in poultry. The current study investigated the HPAI virus prevalence in commercial broiler chicken flocks from 2019 to 2022. Organ samples, ... ...

Abstract	Highly pathogenic avian influenza (HPAI) is a serious viral infection that causes massive economic losses in poultry. The current study investigated the HPAI virus prevalence in commercial broiler chicken flocks from 2019 to 2022. Organ samples, including trachea, cecal tonsils, spleen, brain, as well as tracheal and cloacal swabs, were harvested from 111 problematic broiler chicken flocks that suffered from variable mortalities accompanied with respiratory signs (103 H5-vaccinated and 8 nonvaccinated flocks) in Egypt during the observation duration. Molecular tools were used to analyze the samples, including real-time reverse transcription-polymerase chain reaction (rRT-PCR) and sequence analysis of some PCR positive strains. The results indicated that 24 flocks were positive for HPAI H5N8, representing 21.6%, with 22.3% (23/103) prevalence and 12.5% (1/8) detection in vaccinated and nonvaccinated flocks, respectively, and they were almost detected in the autumn and winter seasons. Phylogenetic evaluation of the hemagglutinin (HA) gene showed that the 6 Egyptian strains were clustered in clade 2.3.4.4b and allocated into 2 groups (I and II). The samples recovered in 2019 were clustered in new subgroup A, and samples recovered in 2020 to 2022 were clustered in new subgroup B with 10 nucleotide mutations (R72S, A83D, T140A). In conclusion, HPAI H5N8 is a serious threat even in vaccinated birds; to control such problems, periodic molecular monitoring with vaccine efficacy evaluation and the use of preventive strategies are recommended.
Keywords	Influenza A virus ; autumn ; avian influenza ; brain ; broiler chickens ; cloaca ; genes ; hemagglutinins ; phylogeny ; reverse transcriptase polymerase chain reaction ; sequence analysis ; spleen ; vaccines ; Egypt ; avian influenza virus ; PCR ; phylogenetic analysis ; poultry ; sequencing
Language	English
Dates of publication	2023-06
Size	p. 102639
Publishing place	Elsevier Inc.
Document type	Article ; Online
Note	Use and reproduction
ZDB-ID	242586-5
ISSN	1525-3171 ; 0032-5791
ISSN (online)	1525-3171
ISSN	0032-5791
DOI	10.1016/j.psj.2023.102639
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Current situation and genomic characterization of fowlpox virus in lower Egypt during 2022

Yehia, Nahed / Elsayed, Sabry / Al-Saeed, Fatimah A. / Ahmed, Ahmed Ezzat / El-Tarabily, Khaled A. / El-Saadony, Mohamed T. / Abdelhalim, Ahmed

Poultry Science. 2023 May 03, p. 102769

2023 , Page(s) 102769

Abstract: A total of 45 samples of vaccinated and nonvaccinated layer chickens were collected from farms in the Egyptian governorates of Sharquia, Ismalia, Monofia, Gharbia, Kafer Elsheikh, Qalibia, and Dakhlia in the year 2022. They exhibited nodular lesions on ... ...

Abstract	A total of 45 samples of vaccinated and nonvaccinated layer chickens were collected from farms in the Egyptian governorates of Sharquia, Ismalia, Monofia, Gharbia, Kafer Elsheikh, Qalibia, and Dakhlia in the year 2022. They exhibited nodular lesions on their combs, mouth corners, and eyelids, suggesting they were infected with pox disease, which was associated with a 3 to 5% mortality rate. The samples were grown on the chorioallantoic-membrane of embryonated chicken eggs to ensure their viability. In both vaccinated and nonvaccinated farms, 35 of 45 virus isolates were confirmed positive via polymerase chain reaction (PCR) of fpv167 (P4b). Based on the amplicon length of the fpv167 gene locus, 6 strains from various Egyptian governorates were chosen for sequencing and genetic characterization. When the fowlpox-AN1, AN4, and AN5 strains were compared to commercial vaccine strains HP1-444-(FP9) and TKPV13401, they had 98.6% identity, whereas the fowlpox strains AN2, AN3, and AN6 had 100% identity. This mutation research showed that the fowlpox strains AN1, AN4, and AN5 had acquired novel mutations: AN1 had R201G and T204A, while AN4 and AN5 had L141F and H157P. Further investigation is required to evaluate the efficacy of the complete genome sequence and the currently available vaccine.
Keywords	Fowlpox virus ; chickens ; chorioallantoic membrane ; fowl pox ; genes ; genomics ; loci ; mortality ; mouth ; mutation ; nucleotide sequences ; polymerase chain reaction ; vaccines ; viability ; viruses ; Egypt ; fowlpox ; molecular characterization ; p4b gene ; poultry ; viral mutation
Language	English
Dates of publication	2023-0503
Size	p. 102769
Publishing place	Elsevier Inc.
Document type	Article ; Online
Note	Pre-press version ; Use and reproduction
ZDB-ID	242586-5
ISSN	1525-3171 ; 0032-5791
ISSN (online)	1525-3171
ISSN	0032-5791
DOI	10.1016/j.psj.2023.102769
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Impacts of polyphenols on laying hens' productivity and egg quality: A review

Abd El‐Hack, Mohamed E. / Salem, Heba M. / Khafaga, Asmaa F. / Soliman, Soliman M. / El‐Saadony, Mohamed T.

Journal of Animal Physiology and Animal Nutrition. 2023 May, v. 107, no. 3 p.928-947

2023

Abstract: There has been a rapid increase in the world's output of main poultry products (meat and eggs). This reflects customer desire for these high‐quality and safe products and the comparatively low price. Recently, natural feed additives, plants and products ... ...

Abstract	There has been a rapid increase in the world's output of main poultry products (meat and eggs). This reflects customer desire for these high‐quality and safe products and the comparatively low price. Recently, natural feed additives, plants and products have been increasingly popular in the poultry and livestock industries to maintain and improve their health and production. Polyphenols are a type of micronutrient that is plentiful in our diet. They are phytochemicals that have health benefits, notably cardiovascular, cognitive function, antioxidant, anti‐mutagenic, anti‐inflammatory, antistress, anti‐tumour, anti‐pathogen, detoxification, growth‐promoting and immunomodulating activities. On the other hand, excessive polyphenol levels have an unclear and sometimes negative impact on gastrointestinal tract health, nutrient digestion, digestive enzyme activity, vitamin, mineral absorption, laying hens performance and egg quality. As a result, this review illuminated polyphenols' various sources, classifications, biological activities, potential usage restrictions and effects on poultry, layer productivity and egg external and internal quality.
Keywords	absorption ; animal nutrition ; antioxidants ; cognition ; diet ; digestion ; digestive enzymes ; digestive tract ; egg quality ; enzyme activity ; meat ; phytochemicals ; polyphenols ; poultry ; prices
Language	English
Dates of publication	2023-05
Size	p. 928-947.
Publishing place	John Wiley & Sons, Ltd
Document type	Article ; Online
Note	REVIEW
ZDB-ID	232729-6
ISSN	0931-2439
ISSN	0931-2439
DOI	10.1111/jpn.13758
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Article: Ameliorating effect of the biological Zinc nanoparticles in abamectin induced hepato-renal injury in a rat model: Implication of oxidative stress, biochemical markers and COX-2 signaling pathways.

Aioub, Ahmed A A / Abdelnour, Sameh A / Shukry, Mustafa / Saad, Ahmed M / El-Saadony, Mohamed T / Chen, Zhongli / Elsobki, Ahmed E A

Frontiers in pharmacology

2022 Volume 13, Page(s) 947303

Abstract: Extensive use of abamectin (ABM) as an anthelmintic in veterinary systems adversely affects the health and welfare of animals and humans. Zinc nanoparticles (ZnNPs) have therapeutic benefits and ameliorate the effect of environmental pollutants. In this ... ...

Abstract	Extensive use of abamectin (ABM) as an anthelmintic in veterinary systems adversely affects the health and welfare of animals and humans. Zinc nanoparticles (ZnNPs) have therapeutic benefits and ameliorate the effect of environmental pollutants. In this study, we assessed the ameliorative effect of ZnNPs against the sub-lethal toxicity of ABM in rats. Forty healthy rats were randomly selected into four groups (
Language	English
Publishing date	2022-09-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2022.947303
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Article: Plant Growth-Promoting Rhizobacteria Improve Growth, Morph-Physiological Responses, Water Productivity, and Yield of Rice Plants Under Full and Deficit Drip Irrigation.

Abd El-Mageed, Taia A / Abd El-Mageed, Shimaa A / El-Saadony, Mohamed T / Abdelaziz, Sayed / Abdou, Nasr M

Rice (New York, N.Y.)

2022 Volume 15, Issue 1, Page(s) 16

Abstract: Inoculating rice plants by plant growth promoting rhizobacteria (PGPR) may be used as a practical and eco-friendly approach to sustain the growth and yield of drought stressed rice plants. The effect of rice inoculation using plant growth hormones was ... ...

Abstract	Inoculating rice plants by plant growth promoting rhizobacteria (PGPR) may be used as a practical and eco-friendly approach to sustain the growth and yield of drought stressed rice plants. The effect of rice inoculation using plant growth hormones was investigated under drip full irrigation (FI; 100% of evapotranspiration (ETc), and deficit irrigation (DI; 80% of ETc) on growth, physiological responses, yields and water productivities under saline soil (ECe = 6.87 dS m
Language	English
Publishing date	2022-03-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	2457103-9
ISSN	1939-8433 ; 1939-8425
ISSN (online)	1939-8433
ISSN	1939-8425
DOI	10.1186/s12284-022-00564-6
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Article: The Biological Activity of

Attia, Marwa M / Alzahrani, Amal M / Hanna, Magdy I / Salem, Heba M / Abourehab, Mohammed A S / El-Saadony, Mohamed T / Thabit, Hasnaa

Life (Basel, Switzerland)

2022 Volume 12, Issue 12

Abstract: ... Lernaea ... ...

Abstract	Lernaea cyprinacea
Language	English
Publishing date	2022-12-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662250-6
ISSN	2075-1729
ISSN	2075-1729
DOI	10.3390/life12122054
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