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Article ; Online: Integrated computational and experimental evaluation of phenolic constituents of

Rafey, Hafiz Abdul / El-Shazly, Mohamed / Khalid, Tooba / Alam, Tanveer / Niaz, Shah Iram / Farooq, Omer

Journal of biomolecular structure & dynamics

2024 , Page(s) 1–9

Abstract: The present study investigated the antioxidant profile together with the antibacterial potential of Apricot L. with the aim to find a functional food based anti-infective lead. Additionally the study evaluated the biofilm and QS inhibitory potential of ... ...

Abstract	The present study investigated the antioxidant profile together with the antibacterial potential of Apricot L. with the aim to find a functional food based anti-infective lead. Additionally the study evaluated the biofilm and QS inhibitory potential of the plant using
Language	English
Publishing date	2024-02-12
Publishing country	England
Document type	Journal Article
ZDB-ID	49157-3
ISSN	1538-0254 ; 0739-1102
ISSN (online)	1538-0254
ISSN	0739-1102
DOI	10.1080/07391102.2024.2309334
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Article: Heat Shock Proteins: Central Players in Oncological and Immuno-Oncological Tracks.

Youness, Rana A / Gohar, Asmaa / Kiriacos, Caroline Joseph / El-Shazly, Mohamed

Advances in experimental medicine and biology

2022 Volume 1409, Page(s) 193–203

Abstract: Heat shock proteins (HSPs) are a group of proteins that promote protein folding, inhibit denaturation of cellular proteins, and maintain other proteins' functional activities when cells are subjected to stress and/or high temperature. HSP classification ... ...

Abstract	Heat shock proteins (HSPs) are a group of proteins that promote protein folding, inhibit denaturation of cellular proteins, and maintain other proteins' functional activities when cells are subjected to stress and/or high temperature. HSP classification is generally based on their molecular weights into large and small HSP. The family of small HSPs includes HSPs 27, 40, 60, 70, and 90. The potential roles of HSP27 and HSP70 are quite evident in different solid malignancies, including breast, colorectal, pancreatic, and liver cancers. In this chapter, the authors focus on HSP27 and HSP70 signaling in oncology and their role in different solid malignancies as well as they shed light on the novel role of HSP70 and HSP90 in the immune-oncology field.
MeSH term(s)	Humans ; HSP27 Heat-Shock Proteins/metabolism ; Heat-Shock Proteins ; HSP70 Heat-Shock Proteins/metabolism ; HSP90 Heat-Shock Proteins/metabolism ; Liver Neoplasms
Chemical Substances	HSP27 Heat-Shock Proteins ; Heat-Shock Proteins ; HSP70 Heat-Shock Proteins ; HSP90 Heat-Shock Proteins
Language	English
Publishing date	2022-08-28
Publishing country	United States
Document type	Journal Article
ISSN	2214-8019 ; 0065-2598
ISSN (online)	2214-8019
ISSN	0065-2598
DOI	10.1007/5584_2022_736
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Article ; Online: A comprehensive review on the phytochemistry, pharmacological properties, and in vitro propagation of an endemic medicinal orchid, Dactylorhiza hatagirea.

Sharma, Subhash / Kumar, Vikas / Seth, Chandrika Attri / Sourirajan, Anuradha / El-Shazly, Mohamed / Dev, Kamal

Naunyn-Schmiedeberg's archives of pharmacology

2023

Abstract: Dactylorhiza hatagirea (D. Don) Soo, also known as Himalayan Marsh Orchid or Salam Panja, belongs to the Orchidaceae family. It is found in sub-alpine to alpine regions at 2500-5000 m above sea level. The present review aims to provide a comprehensive ... ...

Abstract	Dactylorhiza hatagirea (D. Don) Soo, also known as Himalayan Marsh Orchid or Salam Panja, belongs to the Orchidaceae family. It is found in sub-alpine to alpine regions at 2500-5000 m above sea level. The present review aims to provide a comprehensive overview of the botany, phytochemistry, medicinal uses, toxicity, and conservation status of D. hatagirea and to find the research gaps to promote progress in studies of this orchid. Secondary metabolites, including alkaloids, terpenoids, flavonoids, phenolics, and saponins, were reported from the aerial and underground parts of this medicinal orchid. Several phytocompounds, such as dactylorhins A, B, C, D, and E and dactylose A and B, were isolated from the dried roots of D. hatagirea. A wide range of in vitro and in vivo assays was used to assess the biological properties of D. hatagirea, such as antirheumatic, anti-inflammatory, antiviral, diuretic, neuroprotective, antioxidant, wound healing, hypoglycemic, antitumor, antimicrobial, antiviral, and anticancer activities. It was also reported to boost testosterone levels, improving sexual desire and arousal. Due to overexploitation and a restricted habitat range, this essential medicinal plant has reached the extinction stage; therefore, a conservation-friendly harvesting approach is needed for this medicinal herb. In vitro techniques such as micropropagation, synthetic seed generation, and hairy root technology can contribute to its conservation. This review provides comprehensive insights into the botanical features, traditional uses, phytochemicals, pharmacological importance, and toxicity evaluation of this medicinal orchid. This review also provides detailed information on the conservation status of D. hatagirea and strategies to overcome the exploitation of this orchid.
Language	English
Publishing date	2023-11-11
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	121471-8
ISSN	1432-1912 ; 0028-1298
ISSN (online)	1432-1912
ISSN	0028-1298
DOI	10.1007/s00210-023-02827-5
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Article ; Online: Correction: A review of botany, traditional applications, phytochemistry, pharmacological applications, and toxicology of Rubus ellipticus Smith fruits.

Kumar, Vikas / Sharma, Ankita / Sharma, Nitin / Saini, Rakshandha / Dev, Kamal / El-Shazly, Mohamed / Bari, Ahamed Basha Abdul

Naunyn-Schmiedeberg's archives of pharmacology

2024

Language	English
Publishing date	2024-02-09
Publishing country	Germany
Document type	Published Erratum
ZDB-ID	121471-8
ISSN	1432-1912 ; 0028-1298
ISSN (online)	1432-1912
ISSN	0028-1298
DOI	10.1007/s00210-024-02999-8
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Article ; Online: A review of botany, traditional applications, phytochemistry, pharmacological applications, and toxicology of Rubus ellipticus Smith fruits.

Kumar, Vikas / Sharma, Ankita / Sharma, Nitin / Saini, Rakshandha / Dev, Kamal / El-Shazly, Mohamed / Bari, Ahamed Basha Abdul

Naunyn-Schmiedeberg's archives of pharmacology

2024

Abstract: Rubus ellipticus Smith. (Family Rosaceae), often known as the yellow Himalayan raspberry (Yellow Hissar), is one of the most widely used edible fruits in Indian folk medicinal systems. The current review aims to identify the gap between research and ... ...

Abstract	Rubus ellipticus Smith. (Family Rosaceae), often known as the yellow Himalayan raspberry (Yellow Hissar), is one of the most widely used edible fruits in Indian folk medicinal systems. The current review aims to identify the gap between research and existing applications of this fruit to help scientists explore the current trends and opportunities for future development. Fruits of R. ellipticus are the source of several classes of compounds. Fruits of R. ellipticus are also rich in nutrients such as carbohydrates, vitamins, and minerals. It has been shown to have significant medical value in a variety of studies, including as an anti-diabetic, nephroprotective, anti-inflammatory, analgesic, antipyretic, antitumor, wound healing, antifertility, oviposition deterrent, antibacterial, and antioxidant. Fruits of R. ellipticus have been the subject of several in vitro and in vivo investigations, all of which have corroborated their wide range of biological activities and demonstrated their potential for the identification of new therapeutic candidates and the development of innovative herbal food supplements. Additional mechanism-based pharmacological evaluation and clinical research should provide an adequate scientific basis for the traditional usage of R. ellipticus fruits, which is currently not sufficiently supported by the available research on its active components and molecular mechanisms.
Language	English
Publishing date	2024-01-22
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	121471-8
ISSN	1432-1912 ; 0028-1298
ISSN (online)	1432-1912
ISSN	0028-1298
DOI	10.1007/s00210-024-02964-5
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Article: Editorial: Novel antimicrobials and antibiotics resistance modulating agents from natural products: Turning promises into Triumphs.

Mostafa, Nada M / Ayaz, Muhammad / El-Shazly, Mohamed / Singab, Abdel Nasser B

Frontiers in pharmacology

2023 Volume 14, Page(s) 1184071

Language	English
Publishing date	2023-04-11
Publishing country	Switzerland
Document type	Editorial
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2023.1184071
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Article ; Online: An Objective Evaluation of Cleft Lip Repair Deformities Based on Standardized Photographic Views.

El-Shazly, Mohamed / Sharaf, Ahmed S / Abdelkarim, Ahmed / Makboul, Mohamed / Rabie, Osama / Saleh, Medhat Araby

Annals of plastic surgery

2023 Volume 92, Issue 1, Page(s) 60–67

Abstract: Background: Several assessment systems of the cleft-related facial deformity have been reported in the medical literature. Assessments have been made from direct clinical evaluations, photographs, on-screen digital images, and 3-dimensional imaging. An ... ...

Abstract	Background: Several assessment systems of the cleft-related facial deformity have been reported in the medical literature. Assessments have been made from direct clinical evaluations, photographs, on-screen digital images, and 3-dimensional imaging. An evaluation method based on standardized photographic views is developed to evaluate the most common postoperative deformities and to detect the responsible factors for occurrence of these deformities and how to avoid them. Materials and methods: One hundred forty-five cleft lip cases (105 unilateral and 40 bilateral) were evaluated by using standard sheet and scoring system designed by Operation Smile Inc (Virginia Beach). The scoring system is based on photographic analysis of items including Cupid's bow, nasal symmetry, vermilion contour, white roll continuity, and scar quality. Results: In the unilateral cleft cases, we found 0.4% excellent, 48.57% good, 38% fair, and 2.85% poor cases. For bilateral clef lip cases, we found 27.5% excellent, 47.5% good, 17.5% fair, and 7.5% poor outcomes. The most common postoperative deformities were nasal asymmetry, scar hypertrophy, deformed Cupid's bow, and vermilion contour asymmetry. Conclusions: This objective evaluation system can determine the common cleft lip nasal deformities with detection of the responsible factors. Principles that guide optimum surgical repair have been advocated to avoid the common postoperative deformities. Scar formation is an independent factor that must be managed early and separately to maintain surgical outcomes.
MeSH term(s)	Humans ; Cleft Lip/diagnostic imaging ; Cleft Lip/surgery ; Cleft Lip/pathology ; Plastic Surgery Procedures ; Cicatrix/surgery ; Lip/surgery ; Surgical Flaps/surgery
Language	English
Publishing date	2023-12-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	423835-7
ISSN	1536-3708 ; 0148-7043
ISSN (online)	1536-3708
ISSN	0148-7043
DOI	10.1097/SAP.0000000000003728
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Zs.A 1419: Show issues

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Article ; Online: Polysaccharides (pectin, mucilage, and fructan inulin) and their fermented products: A critical analysis of their biochemical, gut interactions, and biological functions as antidiabetic agents.

El-Nashar, Heba A S / Taleb, Mohamed / El-Shazly, Mohamed / Zhao, Chao / Farag, Mohamed A

Phytotherapy research : PTR

2023 Volume 38, Issue 2, Page(s) 662–693

Abstract: Diabetes mellitus is a globally metabolic endocrine syndrome marked by a deficiency of insulin secretion (type-1 DM) or glucose intolerance arising from insulin response impairment (type-2 DM) leading to abnormal glucose metabolism. With an increasing ... ...

Abstract	Diabetes mellitus is a globally metabolic endocrine syndrome marked by a deficiency of insulin secretion (type-1 DM) or glucose intolerance arising from insulin response impairment (type-2 DM) leading to abnormal glucose metabolism. With an increasing interest in natural dietary components for diabetes management, the identification of novel agents witnessed major discoveries. Plant-derived mucilage, pectin, and inulin are important non-starch polysaccharides that exhibit effective antidiabetic properties often termed soluble dietary fiber (SDF). SDF affects sugar metabolism through multiple mechanisms affecting glucose absorption and diffusion, modulation of carbohydrate metabolizing enzymes (α-amylase and α-glucosidase), ameliorating β-pancreatic cell dysfunction, and improving insulin release or sensitivity. Certain SDFs inhibit dipeptidyl peptidase-4 and influence the expression levels of genes related to glucose metabolism. This review is designed to discuss holistically and critically the antidiabetic effects of major SDF and their underlying mechanisms of action. This review should aid drug discovery approaches in developing novel natural antidiabetic drugs from SDF.
MeSH term(s)	Humans ; Hypoglycemic Agents/pharmacology ; Hypoglycemic Agents/therapeutic use ; Hypoglycemic Agents/chemistry ; Inulin ; Pectins/pharmacology ; Pectins/therapeutic use ; Fructans ; Polysaccharides ; Insulin ; Glucose ; Diabetes Mellitus, Type 2/drug therapy
Chemical Substances	Hypoglycemic Agents ; Inulin (9005-80-5) ; Pectins (89NA02M4RX) ; Fructans ; Polysaccharides ; Insulin ; Glucose (IY9XDZ35W2)
Language	English
Publishing date	2023-11-15
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	639136-9
ISSN	1099-1573 ; 0951-418X
ISSN (online)	1099-1573
ISSN	0951-418X
DOI	10.1002/ptr.8067
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Article ; Online: Multiple integrated computational approach to analyse wound healing potential of

Rafey, Hafiz Abdul / Amin, Adnan / Ross, Samir Anis / El-Shazly, Mohamed / Zahid, Muhammad Ammar / Niaz, Shah Iram / Ul Mahmood, Fakhar / Ullah, Hammad

Natural product research

2024 , Page(s) 1–10

Abstract: The healing of wounds is the flagging concern in chronic wound cases especially when accompanied by pathogenic, diabetic comorbidities. Matrix metalloproteinases are associated with widespread pathological ailments, and the selective inhibitors for ... ...

Abstract	The healing of wounds is the flagging concern in chronic wound cases especially when accompanied by pathogenic, diabetic comorbidities. Matrix metalloproteinases are associated with widespread pathological ailments, and the selective inhibitors for metalloproteinases can be of great interest in wound healing strategies. In the present research study, six constituents of
Language	English
Publishing date	2024-03-18
Publishing country	England
Document type	Journal Article
ZDB-ID	2185747-7
ISSN	1478-6427 ; 1478-6419
ISSN (online)	1478-6427
ISSN	1478-6419
DOI	10.1080/14786419.2024.2321488
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Article ; Online: Metabolomic profiling and quantification of polyphenols from leaves of seven Acacia species by UHPLC-QTOF-ESI-MS.

Elshamy, Salma / Handoussa, Heba / El-Shazly, Mohamed / Mohammed, Eman D / Kuhnert, Nikolai

Fitoterapia

2023 Volume 172, Page(s) 105741

Abstract: The genus Acacia (Fabaceae) comprises >1350 species and has been used in traditional medicine as infusions and decoctions to treat wounds, sores, headaches, diarrhea, and cough. The leaf methanolic extracts of seven Acacia species growing in Egypt namely: ...

Abstract	The genus Acacia (Fabaceae) comprises >1350 species and has been used in traditional medicine as infusions and decoctions to treat wounds, sores, headaches, diarrhea, and cough. The leaf methanolic extracts of seven Acacia species growing in Egypt namely: Acacia saligna, Acacia seyal, Acacia xanthophloea, Acacia tortilis subsp. raddiana., Acacia tortilis, Acacia laeta, Acacia albida were analyzed using UPLC-QTOF-ESI-MS. A total of 37 polyphenols were identified and discussed in detail. They included phenolic acids, flavonoids, and procyanidins, among which sixteen polyphenols were identified in Acacia for the first time. Folin-ciocalteau assay and ferric reducing antioxidant power, cupric reducing antioxidant capacity, 2,20 -azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) cation radical and the scavenging capacity against 2,2-diphenyl-1- picrylhydrazyl radical were performed to investigate the total phenolic content and the antioxidant activity of the Acacia extracts, respectively. Furthermore, the absolute quantification of eighteen polyphenols common to most of the species was performed using UPLC-MS. It was evident that the differences in the chemical composition among the species accounted for the difference in antioxidant activity which was in line together with the total phenolic content.
MeSH term(s)	Polyphenols/chemistry ; Antioxidants/chemistry ; Chromatography, High Pressure Liquid ; Acacia/chemistry ; Chromatography, Liquid ; Tandem Mass Spectrometry ; Molecular Structure ; Flavonoids/chemistry ; Phenols/chemistry ; Plant Extracts/chemistry ; Plant Leaves/chemistry
Chemical Substances	Polyphenols ; Antioxidants ; Flavonoids ; Phenols ; Plant Extracts
Language	English
Publishing date	2023-11-10
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	412385-2
ISSN	1873-6971 ; 0367-326X
ISSN (online)	1873-6971
ISSN	0367-326X
DOI	10.1016/j.fitote.2023.105741
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