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  1. Article: Comparing trimodal therapy with radical cystectomy in muscle-invasive bladder cancer: an updated meta-analysis.

    Al-Qudimat, Ahmad R / Singh, Kalpana / Ojha, Laxmi K / Moustafa, Diala Alhaj / Elaarag, Mai / Al-Zoubi, Raed M / Aboumarzouk, Omar M

    Frontiers in surgery

    2023  Volume 10, Page(s) 1276746

    Abstract: Background: We conducted this meta-analysis to compare the two muscle-invasive bladder cancer (MIBC) treatment modalities in terms of cancer-specific survival (CSS) and other outcome indicators.: Method: A systematic review and meta-analysis were ... ...

    Abstract Background: We conducted this meta-analysis to compare the two muscle-invasive bladder cancer (MIBC) treatment modalities in terms of cancer-specific survival (CSS) and other outcome indicators.
    Method: A systematic review and meta-analysis were performed in accordance with the Preferred Reporting Items for Systematic Reviews (PRISMA) guidelines. The search was conducted using various academic databases including Scopus, PubMed, Cochrane database, EMBASE, Chinese biomedical literature database, Wan fang databases, and China National Knowledge Internet databases between 1966 and December 2023. This review protocol was registered in the International Prospective Register of Systematic Reviews (PROSPERO) No. (
    Result: This study included a total of 54,816 patients diagnosed with bladder cancer from 14 studies, of which 6,228 patients were assigned to the trimodal therapy (TMT) group and 48,588 patients were assigned to the radical cystectomy (RC) group. Based on the results, the RC group exhibited a higher rate of survival than the TMT group [pooled hazard ratio (HR) = 1.23, 95% CI: 1.18-1.28,
    Conclusion: Overall, the findings of this meta-analysis suggest that RC treatment may be associated with improved overall survival. Moreover, it was observed that cancer-specific survival was significantly prolonged among patients in the RC group as opposed to those who received TMT. In addition, it was shown that patients who received TMT exhibited a higher risk of all-cause mortality when compared with those who underwent RC.
    Language English
    Publishing date 2023-12-07
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2773823-1
    ISSN 2296-875X
    ISSN 2296-875X
    DOI 10.3389/fsurg.2023.1276746
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Exploring the Impact of Cigarette Smoke Extracts on Vitamin B

    Al Zoubi, Mazhar Salim / Al-Oun, Mus'aab A / Abusahyoun, Fatima Yacoub / Abualarja, Manal Issam / Al Smadi, Asmaa / Al-Trad, Bahaa / Awadin, Sura A / Al-Batayneh, Khalid / Elaarag, Mai / Al-Zoubi, Raed M

    Biochemistry research international

    2024  Volume 2024, Page(s) 8827402

    Abstract: ... Vitamin ... ...

    Abstract Vitamin B
    Language English
    Publishing date 2024-04-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2566725-7
    ISSN 2090-2255 ; 2090-2247
    ISSN (online) 2090-2255
    ISSN 2090-2247
    DOI 10.1155/2024/8827402
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Salvage minimally invasive robotic and laparoscopic pyeloplasty in adults: a systematic review.

    Elaarag, Mai / Alashi, Hind / Aldeeb, Maya / Khalil, Ibrahim / Al-Qudimat, Ahmad R / Mansour, Abdelhamed / Al-Ansari, Abdulla A / Aboumarzouk, Omar M

    Arab journal of urology

    2022  Volume 20, Issue 4, Page(s) 204–211

    Abstract: Introduction: A UPJO is a blockage of the ureter that affects urine flow. UPJO is mainly treated by an open approach, however, in recent years minimally invasive techniques are taking place. These techniques include robotic and laparoscopic pyeloplasty. ...

    Abstract Introduction: A UPJO is a blockage of the ureter that affects urine flow. UPJO is mainly treated by an open approach, however, in recent years minimally invasive techniques are taking place. These techniques include robotic and laparoscopic pyeloplasty. Some patients require a redo after a primary intervention. A systematic review was conducted through the examinations of the efficacy and safety of a robotic redo pyeloplasty in adult patients from previous literature reviews.
    Methods: A literature search was made through PubMed. A selection process was done based on our eligibility criteria. The data were represented numerically, listed on tables and analyzed cumulatively using Microsoft Excel.
    Results: Twenty studies were included in this review, of which nine were studies on robotic outcomes () (157 patients), 10 on laparoscopic (210 patients), and one review by Zhang et al., focused on both types of surgeries. Two papers (24 patients) from the robotic studies and one paper (21 patients) from the laparoscopic studies were excluded from the intra and post-operative characteristics because not enough data were available and were only included for the success and complication rates. The success rate for the robotic studies was 88.5% while the laparoscopic studies had a success rate of 91%. However, the robotic studies had a complication rate of (11.8%) while the laparoscopic studies had a complication rate of (15.9%). Conversion surgery was required in one patient undergoing laparoscopic surgery.
    Conclusion: The minimally invasive methods are becoming more viable in adult patients with rUPJO, considering its effectiveness and fast recovery. This can lead to a new era of robotic assisted surgeries to becoming the gold standard.
    Language English
    Publishing date 2022-06-28
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2631788-6
    ISSN 2090-598X
    ISSN 2090-598X
    DOI 10.1080/2090598X.2022.2082208
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Updates on androgen replacement therapy and lower urinary tract symptoms: a narrative review.

    Al-Zoubi, Raed M / Alwani, Mustafa / Aboumarzouk, Omar M / Elaarag, Mai / Al-Qudimat, Ahmad R / Ojha, Laxmi / Yassin, Aksam

    The aging male : the official journal of the International Society for the Study of the Aging Male

    2022  Volume 25, Issue 1, Page(s) 234–241

    Abstract: Lower urinary tract symptoms (LUTS) are caused by higher tension at the bladder neck level (due to fibrosis or stiffness) or benign prostatic hyperplasia, which causes static obstruction of the bladder outlet. Both forms cause a group of symptoms such as ...

    Abstract Lower urinary tract symptoms (LUTS) are caused by higher tension at the bladder neck level (due to fibrosis or stiffness) or benign prostatic hyperplasia, which causes static obstruction of the bladder outlet. Both forms cause a group of symptoms such as hesitancy, intermittency, weak stream, nocturia, urine frequency, and urgency. Additionally, LUTS (obstructive or irritative symptoms) are common in elderly men with hypogonadism, identified as the reduced testes capability in producing sex steroids and sperm, and are categorized as testosterone deficiency. Even though the mode of action (MoA) of testosterone therapy (TTh) on hypogonadal men needs more researched and understanding, the effectiveness of TTh in the development of male genital organs has been reported in several studies. This review shows the latest updates of TTh in LUTS including potential adverse effects, advantages, and disadvantages.
    MeSH term(s) Aged ; Hormone Replacement Therapy ; Humans ; Lower Urinary Tract Symptoms/etiology ; Male ; Prostatic Hyperplasia/complications ; Semen ; Testosterone/therapeutic use
    Chemical Substances Testosterone (3XMK78S47O)
    Language English
    Publishing date 2022-09-06
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2108146-3
    ISSN 1473-0790 ; 1368-5538
    ISSN (online) 1473-0790
    ISSN 1368-5538
    DOI 10.1080/13685538.2022.2118253
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5776: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: The Association of Hypertension with Increased Mortality Rate During the COVID-19 Pandemic: An Update with Meta-analysis.

    Al-Qudimat, Ahmad R / Ameen, Ayisha / Sabir, Doaa M / Alkharraz, Heba / Elaarag, Mai / Althani, Aisha / Singh, Kalpana / Alhimoney, Wassim M / Al-Zoubi, Raed M / Aboumarzouk, Omar M

    Journal of epidemiology and global health

    2023  Volume 13, Issue 3, Page(s) 495–503

    Abstract: Background and aim: The impact of multiple risk factors on COVID-19 mortality has been previously reported in multiple systematic reviews and meta-analyses. The aim of this review is to provide a comprehensive update on the association between ... ...

    Abstract Background and aim: The impact of multiple risk factors on COVID-19 mortality has been previously reported in multiple systematic reviews and meta-analyses. The aim of this review is to provide a comprehensive update on the association between hypertension (HTN) and mortality in patients with COVID-19.
    Methods: A systematic review and meta-analysis were performed and followed the Preferred Reporting Items for Systematic Reviews (PRISMA) guidelines. A search was achieved using PubMed, Scopus, and Cochrane Databases for research publications on hypertension, COVID-19, and mortality published between December 2019 and August 2022.
    Results: A total of 23 observational studies involving 611,522 patients from 5 countries (China, Korea, the UK, Australia, and the USA) were included in our study. The confirmed number of COVID-19 with HTN cases in each study ranged from 5 to 9964. The mortality ranged from 0.17% to 31% in different studies. Pooled results show that the mortality rate of COVID-19 among the included studies ranges from a minimum of 0.39 (95% CI 0.13-1.12) to a maximum of 5.74 (95% CI 3.77-8.74). Out of the 611,522 patients, 3119 died which resulted in an overall mortality prevalence of 0.5%. Subgroup analyses indicated that patients with COVID-19 who have hypertension and male patients had slightly less risk of mortality than female patients [the percentage of men > 50%; OR 1.33: 95% CI (1.01, 1.76); the percentage of men ≤ 50%: OR 2.26; and 95% CI (1.15, 4.48)]. Meta-regression analysis results also showed a statistically significant association between hypertension and COVID-19 mortality.
    Conclusion: This systematic review and meta-analysis suggest that hypertension may not be the only risk factor associated with the increased mortality rate during the COVID-19 pandemic. In addition, a combination of other comorbidities and old age appears to increase the risk of mortality from COVID-19. The impact of hypertension on mortality rate among COVID-19 patients.
    MeSH term(s) Humans ; Male ; Female ; COVID-19/epidemiology ; Pandemics ; Hypertension/epidemiology ; Risk Factors ; Comorbidity ; Observational Studies as Topic
    Language English
    Publishing date 2023-06-15
    Publishing country Switzerland
    Document type Systematic Review ; Meta-Analysis ; Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2645324-1
    ISSN 2210-6014 ; 2210-6014
    ISSN (online) 2210-6014
    ISSN 2210-6014
    DOI 10.1007/s44197-023-00130-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Organoboronic acids/esters as effective drug and prodrug candidates in cancer treatments: challenge and hope.

    Al-Omari, Mothana K / Elaarag, Mai / Al-Zoubi, Raed M / Al-Qudimat, Ahmad R / Zarour, Ayman A / Al-Hurani, Enas A / Fares, Zainab E / Alkharraz, Leena M / Shkoor, Mohanad / Bani-Yaseen, Abdulilah D / Aboumarzouk, Omar M / Yassin, Aksam / Al-Ansari, Abdulla A

    Journal of enzyme inhibition and medicinal chemistry

    2023  Volume 38, Issue 1, Page(s) 2220084

    Abstract: Boronic acids/esters have recently emerged in the field of medicinal and pharmaceutical research due to their exceptional oxophilicity, low toxicity, and unique structure. They are known as potent enzyme inhibitors, cancer therapy capture agents, and can ...

    Abstract Boronic acids/esters have recently emerged in the field of medicinal and pharmaceutical research due to their exceptional oxophilicity, low toxicity, and unique structure. They are known as potent enzyme inhibitors, cancer therapy capture agents, and can mimic certain types of antibodies to fight infections. They have been designed and developed into drugs, and this approach has emerged in the last 20 years. Five boronic acid drugs have been approved by the FDA and Health Canada, two of which are used to treat cancer, specifically multiple myeloma. The purpose of this review is to investigate boronic acid/ester derivatives as potential pharmaceutical agents as well as the mechanism of action. It will concentrate on six types of cancer: multiple myeloma, prostate cancer, breast cancer, lung cancer, cervical cancer, and colon cancer. Some newly developed boron-containing compounds have already demonstrated highly promising activities, but further investigation is required before final conclusions can be drawn.
    MeSH term(s) Humans ; Prodrugs/pharmacology ; Prodrugs/chemistry ; Esters/chemistry ; Multiple Myeloma/drug therapy ; Boronic Acids/pharmacology ; Boron Compounds/chemistry
    Chemical Substances Prodrugs ; Esters ; Boronic Acids ; Boron Compounds
    Language English
    Publishing date 2023-06-15
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2082578-X
    ISSN 1475-6374 ; 1475-6366
    ISSN (online) 1475-6374
    ISSN 1475-6366
    DOI 10.1080/14756366.2023.2220084
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3004: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Clinical outcomes of Pfizer-BioNTech COVID-19 vaccine in children and adolescents: A systematic review.

    Al-Qudimat, Ahmad R / Al-Zoubi, Raed M / Elaarag, Mai / Nashwan, Abdulqadir J / Hamze, Afaf K / Bawadi, Hiba / Yassin, Aksam / Assim, Aseel / Aboumarzouk, Omar M / Zarour, Ahmad / Al-Ansari, Abdulla A

    Health science reports

    2022  Volume 5, Issue 4, Page(s) e740

    Abstract: Background & aims: The BioNTech-Pfizer vaccine is the only vaccine offered to children among all available vaccines. However, limited evidence is available about the clinical outcomes of COVID-19 vaccines, especially among children and adolescents. This ...

    Abstract Background & aims: The BioNTech-Pfizer vaccine is the only vaccine offered to children among all available vaccines. However, limited evidence is available about the clinical outcomes of COVID-19 vaccines, especially among children and adolescents. This review offers a comprehensive and up-to-date overview of the BioNTech-Pfizer vaccine's current information on children and adolescents.
    Methods: The review was conducted following the PRISMA guidelines; a comprehensive search was performed in PubMed, Scopus, MEDLINE, and EMBASE databases for research publications COVID-19 published between December 2019 and October 2021. All studies reporting on the outcomes of vaccinating children in their respective institutes were included.
    Results: A total of 78 vaccinated children and adolescents from six studies were included. The majority of symptomatic vaccinated pediatrics were males (71%). The mean age was 15.6 years, and the BMI was 24.1. The most common clinical symptoms were found in chest pain (35%), fever (32%), and myalgia (17%). The most common cardiac symptom in the EKG results was ST elevation, and 35% of vaccinated pediatrics had elevated serum troponin. The hospitalization, including ICU admission, was lower than in unvaccinated groups. Statistically significant associations (
    Conclusions: Although we found better outcomes in the vaccinated group versus the nonvaccinated pediatric group, more studies are still crucial to further understand the specific etiology underlying postvaccination, particularly myocarditis, psychological impact, and other cardiac clinical symptoms in children and adolescents after receiving the BioNTech-Pfizer vaccine.
    Language English
    Publishing date 2022-07-20
    Publishing country United States
    Document type Journal Article
    ISSN 2398-8835
    ISSN (online) 2398-8835
    DOI 10.1002/hsr2.740
    Database MEDical Literature Analysis and Retrieval System OnLINE

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