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  1. Article ; Online: dTrmt10A impacts Hsp70 chaperone m

    Perlegos, Alexandra E / Quan, Xiuming / Donnelly, Kirby M / Shen, Hui / Shields, Emily J / Elashal, Heidi / Fange Liu, Kathy / Bonini, Nancy M

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 22999

    Abstract: Chronic cellular stress has a profound impact on the brain, leading to degeneration and accelerated aging. Recent work has revealed the vital role of RNA modifications, and the proteins responsible for regulating them, in the stress response. In our ... ...

    Abstract Chronic cellular stress has a profound impact on the brain, leading to degeneration and accelerated aging. Recent work has revealed the vital role of RNA modifications, and the proteins responsible for regulating them, in the stress response. In our study, we defined the role of CG14618/dTrmt10A, the Drosophila counterpart of human TRMT10A a N
    MeSH term(s) Animals ; Humans ; Drosophila/genetics ; HSP70 Heat-Shock Proteins/genetics ; HSP70 Heat-Shock Proteins/metabolism ; Molecular Chaperones/metabolism ; Methyltransferases/genetics ; Methyltransferases/metabolism ; Brain/metabolism ; RNA
    Chemical Substances HSP70 Heat-Shock Proteins ; Molecular Chaperones ; Methyltransferases (EC 2.1.1.-) ; RNA (63231-63-0) ; TRMT10A protein, human (EC 2.1.1.-)
    Language English
    Publishing date 2023-12-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-50272-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Noncatalytic regulation of 18

    Gonskikh, Yulia / Stoute, Julian / Shen, Hui / Budinich, Krista / Pingul, Bianca / Schultz, Kollin / Elashal, Heidi / Marmorstein, Ronen / Shi, Junwei / Liu, Kathy Fange

    Genes & development

    2023  Volume 37, Issue 7-8, Page(s) 321–335

    Abstract: Several rRNA-modifying enzymes install rRNA modifications while participating in ribosome assembly. Here, we show that ... ...

    Abstract Several rRNA-modifying enzymes install rRNA modifications while participating in ribosome assembly. Here, we show that 18
    MeSH term(s) Humans ; Cell Nucleolus/metabolism ; Cell Nucleus/metabolism ; Leukemia, Myeloid, Acute/genetics ; Methyltransferases/metabolism ; RNA Processing, Post-Transcriptional ; RNA, Ribosomal, 18S/metabolism
    Chemical Substances Methyltransferases (EC 2.1.1.-) ; RNA, Ribosomal, 18S ; DIMT1 protein, human (EC 2.1.1.-)
    Language English
    Publishing date 2023-04-06
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 806684-x
    ISSN 1549-5477 ; 0890-9369
    ISSN (online) 1549-5477
    ISSN 0890-9369
    DOI 10.1101/gad.350298.122
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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    Jg. 1995 - 2021: Lesesall (2.OG)
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    Zs.MG 54: Show issues

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  3. Article ; Online: Oxazolidinone-Mediated Sequence Determination of One-Bead One-Compound Cyclic Peptide Libraries.

    Elashal, Hader E / Cohen, Ryan D / Elashal, Heidi E / Raj, Monika

    Organic letters

    2018  Volume 20, Issue 8, Page(s) 2374–2377

    Abstract: A novel one-bead one-compound (OBOC) dual ring-opening/cleavage approach for cyclic peptide sequencing was developed. The method selectively modifies serine, cysteine, threonine, and/or glutamic acid to an oxazolidinone-derived moiety, thereby increasing ...

    Abstract A novel one-bead one-compound (OBOC) dual ring-opening/cleavage approach for cyclic peptide sequencing was developed. The method selectively modifies serine, cysteine, threonine, and/or glutamic acid to an oxazolidinone-derived moiety, thereby increasing the susceptibility of the modified peptide backbone toward hydrolysis. The resulting linear peptide was then sequenced in 1 min by tandem mass spectrometry on a quadrupole time-of-flight instrument incorporating two-dimensional liquid chromatography and ion mobility spectrometry separation. To evaluate this approach, a library of cyclic peptides was successfully sequenced with 98% overall accuracy, demonstrating its robustness and broad substrate scope.
    MeSH term(s) Amino Acid Sequence ; Molecular Structure ; Oxazolidinones/chemistry ; Peptide Library ; Peptides, Cyclic ; Sequence Analysis
    Chemical Substances Oxazolidinones ; Peptide Library ; Peptides, Cyclic
    Language English
    Publishing date 2018-04-04
    Publishing country United States
    Document type Journal Article
    ISSN 1523-7052
    ISSN (online) 1523-7052
    DOI 10.1021/acs.orglett.8b00717
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Mettl3-catalyzed m

    Maldonado López, Alexandra M / Ko, Eun Kyung / Huang, Sijia / Pacella, Gina / Kuprasertkul, Nina / D'souza, Carina A / Reyes Hueros, Raúl A / Shen, Hui / Stoute, Julian / Elashal, Heidi / Sinkfield, Morgan / Anderson, Amy / Prouty, Stephen / Li, Hua-Bing / Seykora, John T / Liu, Kathy Fange / Capell, Brian C

    Science advances

    2023  Volume 9, Issue 35, Page(s) eadg5234

    Abstract: ... ...

    Abstract N6
    MeSH term(s) Animals ; Mice ; Histones ; Methyltransferases/genetics ; Adenosine ; Cell Adhesion ; RNA, Messenger ; Catalysis
    Chemical Substances Histones ; Methyltransferases (EC 2.1.1.-) ; Adenosine (K72T3FS567) ; RNA, Messenger ; Mettl3 protein, mouse (EC 2.1.1.-)
    Language English
    Publishing date 2023-09-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2810933-8
    ISSN 2375-2548 ; 2375-2548
    ISSN (online) 2375-2548
    ISSN 2375-2548
    DOI 10.1126/sciadv.adg5234
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Cyclic and Lasso Peptides: Sequence Determination, Topology Analysis, and Rotaxane Formation.

    Elashal, Hader E / Cohen, Ryan D / Elashal, Heidi E / Zong, Chuhan / Link, A James / Raj, Monika

    Angewandte Chemie (International ed. in English)

    2018  Volume 57, Issue 21, Page(s) 6150–6154

    Abstract: A broadly applicable chemical cleavage methodology to facilitate MS/MS sequencing was developed for macrocyclic and lasso peptides, which hold promise as exciting new therapeutics. Existing methods such as Edman degradation, CNBr cleavage, and enzymatic ... ...

    Abstract A broadly applicable chemical cleavage methodology to facilitate MS/MS sequencing was developed for macrocyclic and lasso peptides, which hold promise as exciting new therapeutics. Existing methods such as Edman degradation, CNBr cleavage, and enzymatic digestion are either limited in scope or completely fail in cleavage of constrained nonribosomal peptides. Importantly, the new method was utilized for synthesizing a unique peptide-based rotaxane (both cyclic and threaded) from the lasso peptide, benenodin-1 ΔC5.
    MeSH term(s) Chromatography, Liquid ; Molecular Structure ; Peptides/analysis ; Rotaxanes/chemical synthesis ; Rotaxanes/chemistry ; Tandem Mass Spectrometry
    Chemical Substances Peptides ; Rotaxanes
    Language English
    Publishing date 2018-04-27
    Publishing country Germany
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2011836-3
    ISSN 1521-3773 ; 1433-7851
    ISSN (online) 1521-3773
    ISSN 1433-7851
    DOI 10.1002/anie.201801299
    Database MEDical Literature Analysis and Retrieval System OnLINE

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